United States securities and exchange commission logo December 9, 2022 Howard Berman, Ph.D. Chief Executive Officer Coya Therapeutics, Inc. 5850 San Felipe St. Suite 500 Houston, TX 77057 Re: Coya Therapeutics, Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed December 5, 2022 File No. 333-268482 Dear Howard Berman: We have reviewed your amended registration statement and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comments apply to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to these comments, we may have additional comments. Unless we note otherwise, our references to prior comments are to comments in our November 29, 2022 letter. Amendment No. 1 to Form S-1 filed December 5, 2022 Risks Related to Our Securities and the Offering, page 42 1. We note recent instances of extreme stock price run-ups followed by rapid price declines and stock price volatility seemingly unrelated to company performance following a number of recent initial public offerings, particularly among companies with relatively smaller public floats. Revise to include a separate risk factor addressing the potential for rapid and substantial price volatility and any known factors particular to your offering that may add to this risk and discuss the risks to investors when investing in stock where the price is changing rapidly. Clearly state that such volatility, including any stock-run up, may be unrelated to your actual or expected operating performance and financial condition or prospects, making it difficult for prospective investors to assess the rapidly Howard Berman, Ph.D. Coya Therapeutics, Inc. December 9, 2022 Page 2 changing value of your stock. You may contact Tara Harkins at 202-551-3639 or Kevin Kuhar at 202-551-3662 if you have questions regarding comments on the financial statements and related matters. Please contact Jane Park at 202-551-7439 or Tim Buchmiller at 202-551-3635 with any other questions. Sincerely, FirstName LastNameHoward Berman, Ph.D. Division of Corporation Finance Comapany NameCoya Therapeutics, Inc. Office of Life Sciences December 9, 2022 Page 2 cc: Steven M. Skolnick, Esq. FirstName LastName