United States securities and exchange commission logo





                              February 16, 2023

       Michael Willisch, Esq.
       Partner
       Davis Polk & Wardwell LLP
       Paseo de la Castellana, 41
       Madrid, Spain 28046

                                                        Re: Banco Santander
Mexico S.A., Institucion de Banca Multiple, Grupo
                                                            Financiero
Santander Mexico
                                                            Schedule TO-T and
Schedule 13E-3 filed by Banco Santander, S.A.
                                                            Filed February 7,
2023
                                                            File No. 005-90381

       Dear Michael Willisch:

              We have reviewed your filings and have the following comments. In
some of our
       comments, we may ask you to provide us with information so we may better
understand your
       disclosure.

               Please respond to these comments by providing the requested
information or advise us as
       soon as possible when you will respond. If you do not believe our
comments apply to your facts
       and circumstances, please tell us why in your response.

            After reviewing your response to these comments, we may have
additional
       comments. All defined terms have the same meaning as in your offer
materials.

       Schedule 13E-3 and Schedule TO-T filed February 7, 2023

       Special Factors-Section 4. Position of Purchaser Regarding Fairness of
the U.S. Offer, page 21

   1.                                                   The factors listed in
Instruction 2 to Item 1014 of Regulation M-A are generally relevant
                                                        to each filing person's
fairness determination and should be discussed in reasonable
                                                        detail. See Questions
Nos. 20 and 21 of Exchange Act Release No. 34-17719 (April 13,
                                                        1981). Please revise
this section to discuss how the Purchaser considered the historical
                                                        prices versus the price
being paid in the offer. See Instruction 2(ii) to Item 1014.
                                                        Alternatively, explain
why such factor was not deemed material or relevant to its fairness
                                                        determination.
   2.                                                   Refer to paragraph 2 in
this section on page 21 of the offer to purchase. We note the
                                                        disclosure there that
Purchaser did not receive an analysis or report from a third party
                                                        "with respect to the
fairness of the U.S. Offer Price to the Unaffiliated Shareholders."
 Michael Willisch, Esq.
FirstName
Davis Polk LastNameMichael
           & Wardwell LLP Willisch, Esq.
Comapany16,
February   NameDavis
             2023      Polk & Wardwell LLP
February
Page 2 16, 2023 Page 2
FirstName LastName
         This statement and the sentence that follows are focused on a report
or opinion relating
         specifically to fairness of the offer price. However, Item 1015(a) of
Regulation M-A and
         Item 9 of Schedule 13E-3 require disclosure about any report, opinion
or appraisal that is
         materially related to the transaction, not simply the fairness of the
price being offered.
         Please revise to state (if accurate) that neither the Purchaser nor
its affiliates received any
         reports from a third party materially related to this transaction.
Note that oral reports or
         presentations are encompassed within the scope of Item 1015 and must
be summarized in
         considerable detail in the offer materials. Please revise or advise.
3.       Refer to the last paragraph in this section on page 22. Please delete
the qualifier
         "believes" in the first sentence of the last paragraph. Purchaser is
responsible for
         describing all material factors in its fairness analysis.
The U.S. Offer- Section 7. Certain Information Concerning the Company, page 45

4.       Expand this section to include all of the financial projections
provided to Purchaser by the
         Company. In addition, summarize the material assumptions and
limitations underlying
         the projected figures.
The US Offer-Section 8. Certain Information Concerning Purchaser, page 46

5.       Please describe any transaction in the Company's securities during the
past 60 days by the
         Purchaser and those persons listed on Schedule A. See Item 8 of
Schedule TO, Item 11 of
         Schedule 13E-3 and Item 1008(b) of Regulation M-A.
6.       Please disclose the amount of shares of Santander, S.A. that are
beneficially owned by
         each individual listed in Schedule A. See Item 8 of Schedule TO, Item
11 of Schedule
         13E-3 and Item 1008(a) of Regulation M-A. See also, Instruction 3 to
Item 1008(a) of
         Regulation M-A.
The U.S. Offer- Section 11. Conditions to the U.S. Offer, page 47

7.       We note the following statement on page 48: "The failure by Purchaser
at any time to
         exercise any of the foregoing rights shall not be deemed a waiver of
any such right and
         each such right shall be deemed an ongoing right that may be asserted
prior to the
         Expiration Time on the Expiration Date." When an event occurs that
implicates an offer
         condition, the bidder must promptly notify target security holders
whether it will waive
         the condition or proceed with the offer, or assert the condition and
terminate. This
         statement implies that Purchaser is not under an obligation to
promptly advise security
         holders what it will do when such event occurs. Please revise.
8.       When satisfaction of an offer condition is within the sole discretion
of the Purchaser, it
         raises concerns that the offer is illusory in contravention of
Regulation 14E. Please revise
         the second sentence in the last paragraph of this section on page 48.
 Michael Willisch, Esq.
Davis Polk & Wardwell LLP
February 16, 2023
Page 3
The U.S. Offer- Section 14. Fees and Expenses, page 51

9.       Please provide a reasonably-detailed list of expenses incurred or
expected to be incurred
         by the Purchaser in connection with the tender offer. See Item 10 of
Schedule 13E-3 and
         Item 1007(c) of Regulation M-A.
        We remind you that the filing persons are responsible for the accuracy
and adequacy of
their disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

       Please direct any questions to Michael Killoy at (202) 551-7576 or
Christina Chalk at
(202) 551-3263.



FirstName LastNameMichael Willisch, Esq.                      Sincerely,
Comapany NameDavis Polk & Wardwell LLP
                                                              Division of
Corporation Finance
February 16, 2023 Page 3                                      Office of Mergers
& Acquisitions
FirstName LastName