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                          February 17, 2023

       Natalie Bogdanos
       General Counsel
       CONTRAFECT Corp
       28 Wells Avenue, Third Floor
       Yonkers, New York 10701

                                                        Re: CONTRAFECT Corp
                                                            Registration
Statement on Form S-3
                                                            Filed February 9,
2023
                                                            File No. 333-269673

       Dear Natalie Bogdanos:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Lauren
Hamill at 303-844-1008 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Wesley Holmes