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                             July 25, 2023

       Alyssa J. Rapp
       Chief Executive Officer
       HWEL Holdings Corp.
       1001 Green Bay Rd, #227
       Winnetka, IL 60093

                                                        Re: HWEL Holdings Corp.
                                                            Amendment No. 1 to
Registration Statement on Form S-4
                                                            Filed July 13, 2023
                                                            File No. 333-271952

       Dear Alyssa J. Rapp:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our June
9, 2023 letter.

       Amendment No. 1 to Registration Statement on Form S-4

       Q: What conditions must be satisfied to complete the Business
Combination?, page xviii

   1.                                                   We note your response
to prior comment 7 and reissue in part. Please further revise to
                                                        clarify that you may
not waive the condition of "no law or order" prohibiting the
                                                        transaction or advise.
Please also identify any other conditions which the parties would be
                                                        unable to waive.
       Pubco, page 1

   2.                                                   We note your revised
disclosure in response to prior comment 9 that Nasdaq listing is a
                                                        closing condition that
could be waived by the parties without recirculation or
                                                        resolicitation. Please
provide us with your analysis as to why recirculation or
 Alyssa J. Rapp
FirstName  LastNameAlyssa J. Rapp
HWEL Holdings   Corp.
Comapany
July       NameHWEL Holdings Corp.
     25, 2023
July 25,
Page  2 2023 Page 2
FirstName LastName
         resolicitation would not be required if this condition was to be
waived. Please include in
         your analysis why the stockholders of HWEL and Starton would not view
the listing on
         Nasdaq as a material part of their voting or investment decision.
Organizational Structure, page 8

3.       In an appropriate location, disclose when and under what circumstances
the Exchange
         Shares will be exchanged for shares of Pubco Class C Common Stock and
when and
         under what circumstances will the Pubco Class C Common Stock be
redeemed for Pubco
         Class A Common Stock.
Prior Disclosures, page 9

4.       Please include risk factor disclosure explaining the potential risks
to investors arising from
         the claims made by Starton's Chief Executive Officer on the "Unicorn
Hunters" Television
         Program on June 7, 2021. Your risk factor should include a discussion
of any steps
         Starton has taken to remediate these representations and clarify that
Starton   s
         investigational reformulation of Revlimid will require clinical
testing and may never be
         approved by the FDA or comparable foreign regulators.
Selected Unaudited Pro forma Condensed Combined Financial Information, page 21

5.       Please explain to us why you are presenting a no redemption scenario
in your summary
         pro forma information given that your disclosures throughout the
filing indicate a
         minimum of 8,625,000 shares will be redeemed.
Conditions to the Closing of the Business Combination, page 80

6.       We note your disclosure that it is a condition to the closing of the
Business Combination
         that immediately after the Closing, the Starton Shareholders shall own
a number of voting
         shares of Pubco representing, in the aggregate, no less than 51% of
the total voting power
         of all issued and outstanding shares of Pubco. We also note from your
response to
         comment 12 that approximately 50% to 60% of Starton   s outstanding
shares are believed
         to be held by Canadian shareholders and that Canadian shareholders may
elect to receive
         Exchange Shares in ExchangeCo. Given that portion of your response,
please tell us how
         this condition to closing would be satisfied and revise your
disclosure as appropriate.
Background of the Business Combination, page 88

7.       We note your disclosure that the valuation and consideration in the
March 21, 2023
         amended letter of intent was based on HWEL's understanding of Starton
 s
         clinical protocols and "other things." Please disclose any other
specific factors that led to
         the changes in the total proposed consideration over the course of
your negotiations
         related to the Business Combination.
8.       We note from your revised disclosure in response to prior comment 18
that Healthwell   s
         initial proposal of a valuation of $375 million for Starton was
provided by SAP and based
 Alyssa J. Rapp
FirstName  LastNameAlyssa J. Rapp
HWEL Holdings   Corp.
Comapany
July       NameHWEL Holdings Corp.
     25, 2023
July 25,
Page  3 2023 Page 3
FirstName LastName
         on a select discounted cashflow valuation methodology that was
performed by a reputable
         third party in connection with a previous proposed transaction
involving Starton to which
         Heathwell was not a party. Please provide the relevant disclosure
regarding the third party
         as required by Item 4(b) of Form S-4, including the identity of the
third party and also
         disclose the reasons for how the Healthwell board determined to rely
on this valuation for
         purposes of its initial negotiations with Starton.
9.       We note that the HWEL Board initially proposed a $375 million
valuation of Starton
         based on a valuation provided to the Board from a previous proposed
transaction
         involving Starton to which Healthwell was not a party. Please revise
to discuss the
         financial analyses conducted by the HWEL Board resulting in the
decision to propose this
         valuation for Starton. To the extent the HWEL Board's analysis was
limited to reviewing
         the prior valuation and the list of comparable companies prepared by
Jeffries, please
         revise to make that clear.
HWEL Management Financial Analysis, page 96

10.      We note your response to prior comment 27 and reissue in part. Please
further revise to
         clarify how the $375 million pro forma equity value for Starton was
used in negotiating
         the transaction and implemented in the Business Combination Agreement.
Unaudited Pro Forma Condensed Combined Financial Information, page 129

11.      We note your disclosures on page F-7 indicating that the company will
proceed with a
         business combination only if net tangible assets are at least
$5,000,001 either prior to or
         upon such consummation of a business combination. Given that your pro
forma balance
         sheets do not appear to present a scenario where net tangible assets
are at least
         $5,000,001, please tell us how you determined that your pro forma
information depicts a
         probable outcome. Refer to Rules 11-01(a)(8) and 11-02(a)(10) of
Regulation S-X.
Unaudited Pro Forma Condensed Combined Statements of Operations, page 131

12.      Please provide a note that discloses how the weighted average common
shares outstanding
         was determined for the both the minimum and maximum redemption
scenarios.
Note 3 - Adjustments to the Unaudited Pro Forma Condensed Combined Statements
of
Operations, page 135

13.      We note your response and revised disclosures to prior comment 31.
Please address the
         following:

                You disclose on page 3 that one-third of the Earnout Shares are
issuable upon the
              volume weighted average price of the shares of Pubco Common Stock
equaling or
              exceeding $12.00 per share. Explain how you determined this
tranche of shares is
              not considered to be indexed to the issuer   s own stock under
ASC 815.
                Revise your pro forma disclosures to provide a discussion of
the expected accounting
 Alyssa J. Rapp
HWEL Holdings Corp.
July 25, 2023
Page 4
           treatment for the earnout shares and disclose the significant
assumptions used in
           determining the fair value of the earnout shares.
             Revise your disclosures in note 3(b) to provide a sensitivity
analysis that quantifies
           how changes in the assumptions related to the fair value of the
earnout shares could
           impact your pro forma balance sheet and statements of operations.
Our Strategy, page 155

14.    We note your statement that you intend to develop drug candidates for
your continuous
       delivery platform and commercialize them "once we receive regulatory
approval." Please
       revise this statement, and similar statements throughout the Business
section, to remove
       the implication that you will receive regulatory approval, as such
approvals are not
       entirely within your control.
Intellectual Property, page 167

15.    Please disclose the potential expiration date, if granted, for each
pending patent
       application described in this section.
Executive Compensation, page 193

16.    Please revise your summary compensation table to provide compensation
information for
       Starton's named executive officers for the last two completed fiscal
years. Refer to Item
       402 of Regulation S-K for guidance.
       You may contact Eric Atallah at 202-551-3663 or Daniel Gordon at
202-551-3486 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Tyler Howes at 202-551-3370 or Tim Buchmiller at 202-551-3635 with any
other
questions.



                                                              Sincerely,
FirstName LastNameAlyssa J. Rapp
                                                              Division of
Corporation Finance
Comapany NameHWEL Holdings Corp.
                                                              Office of Life
Sciences
July 25, 2023 Page 4
cc:       Lijia Sanchez, Esq.
FirstName LastName