EXHIBIT 10.12


              SPLIT-DOLLAR LIFE INSURANCE AGREEMENT
             THIRD PARTY OWED COLLATERALLY ASSIGNED
         RESTRICTIVE AGREEMENT FOR MAJORITY SHAREHOLDER


This Agreement made this 17th  day of  September, 1999 by and
between Schwartz Irrevocable Descendants Trust, hereinafter
referred to as the ("Trust"), and Bio-Rad Laboratories, Inc.,
hereinafter referred to as the ("Corporation").


                           WITNESSETH:

WHEREAS, David Schwartz, hereinafter referred to as the Employee,
is and has been employed by the Corporation for over forty (40)
years, and his wife, Alice N. Schwartz, was formerly an employee
of the Corporation and has been a director for approximately 35
years and they both have performed unique and valuable services
for the establishment, growth and development of the Corporation;
and

WHEREAS, the Corporation has determined that in the event of the
demise of Employee and his wife, their heirs might be required to
sell a significant amount of their holdings in the Corporation in
order to satisfy estate taxes, which the Corporation believes
might result in a major disruption in the trading of the
Corporation's stock.

WHEREAS, the Corporation is willing to assist said Employee and
his wife in providing insurance protection for their family which
would provide proceeds to the heirs for the payment of a portion
of the aforementioned estate taxes; and

WHEREAS, the Employee and his wife (collectively, the "Insureds")
have established the Trust as a trust for the purpose of
receiving such insurance proceeds.

NOW, THEREFORE, in consideration of past services and future
services to be rendered, the parties agree that:


                              1




     1.   A $20,586,468 life insurance policy (the "Policy") on the
          life of the Insureds will be purchased from Pacific Life
          Insurance Company (the "Insurance Company").  The Trust will be
          the owner of the Policy, subject to a split-dollar assignment to
          the Corporation.  Except to the extent that the Policy is needed
          to secure the Corporation's interest in the Policy as hereinafter
          provided, the Trust will retain all incidents of ownership
          (including the right to dividends, if any, the right to surrender
          or cancel the Policy and the right to borrow or withdraw against
          the Policy).

     2.   All premiums due on the Policy shall be paid by the
          Corporation to the Trust for payment to the Insurance Company.

     3.   The Corporation's interest in the cash surrender value of
          the Policy shall be an amount equal to the lesser of the entire
          cash surrender value or the Corporation's cumulative net premium
          payments.

     4.   If the Insureds should die while this Agreement and the
          Policy are in effect, the Corporation will be entitled to receive
          an amount equal to its cumulative net premium payments.  The
          remainder of the death benefit, if any, shall belong to the
          Trust.

     5.   The Trust agrees not to sell, assign, surrender or otherwise
          terminate the Policy while this Agreement is in effect without
          the consent of the Corporation.

     6.   This Agreement may be terminated as follows:

          (a)  For the period commencing on the date hereof and
               continuing until September 16, 2009, by mutual
               consent of the parties hereto.

          (b)        For the period commencing on September 16, 2009 and
               continuing until the termination of the Agreement or the Policy:

               (i)        Either party may terminate this Agreement while no
                    premium under said Policy is overdue by written notice to
                    the other part sent by hand or registered mail to such
                    party's last known address.  The effective date of such
                    termination shall be the date of mailing; or

               (ii) By mutual consent of the parties hereto.

     7.   In the event of the termination of this Agreement under
          Paragraph 6 hereof, the Trust shall pay to the Corporation an
          amount equal to the Corporation's interest in the cash surrender
          value of the Policy as stated in Paragraph 3, and upon such
          payment the Corporation will release the collateral assignment
          made to it.  Should the Trust fail to pay the Corporation's total
          interest in the cash surrender value within 60 days of
          termination, the Corporation shall have the right to enforce any
          rights it may have under the collateral assignment.

                              2





          The Insurance Company and all persons having any
          interest in the Policy may in any instance conclusively
          rely upon the Corporation's certification that all
          conditions precedent to its right to receive its
          interest have occurred and shall be released from any
          and all claims, demands and responsibility in acting
          upon this certification and making payment to the
          Corporation of its entire interest upon the
          Corporation's sole signatures.  The Corporation shall
          pay over to the Trust any amount collected by it which
          is in excess of the amount due to it.

IN WITNESS WHEREOF, the parties hereto have executed this
Agreement the day first above written.


                         BIO-RAD LABORATORIES, INC.



/s/ David Lehman              BY:  /s/ Thomas C. Chesterman
(Witness)                     Thomas C. Chesterman
                              Vice President and Chief Financial Officer

                         SCHWARTZ IRREVOCABLE
                             DESCENDANTS TRUST



/s/ Deborah L. Tannenbaum     BY:  /s/ Howard Foster
(Witness)                     Howard Foster
                              Trustee




                              3


 </TEXT>
 </DOCUMENT>
<DOCUMENT>
<TYPE>EX-13
<SEQUENCE>7
<DESCRIPTION>EXHIBIT 13.1 - EXCERPT FROM 1999 ANNUAL REPORT
<TEXT>

   

   EXHIBIT 13.1


   Bio-Rad Laboratories, Inc.
   SUMMARY OF OPERATIONS (In thousands, except per share data)
   
   
   ________________________________________________________________________________________________________________________
                                                              1999        1998        1997        1996        1995       1994
                                                                                                   
      Net sales                                           $549,489    $441,942    $426,914    $418,789    $396,618   $355,299
        Cost of goods sold (1)                             255,223     202,438     189,331     182,046     171,942    155,805
      Gross profit                                         294,266     239,504     237,583     236,743     224,676    199,494

        Selling, general and administrative expense        194,457     166,978     164,792     155,516     150,272    132,591
        Product research and development expense            51,210      41,381      46,138      39,580      34,714     30,172
        Purchased in-process research and
         development expense                                15,500           -           -           -           -          -
        Restructuring costs                                      -           -           -       2,700       1,500          -
      Income from operations                                33,099      31,145      26,653      38,947      38,190     36,731

      Other income (expense):
        Interest expense                                   (12,741)     (3,731)     (1,216)     (3,027)     (4,465)    (6,138)
        Other, net                                          (3,942)      6,814      (2,709)        553        (183)    (6,596)

      Income before taxes and extraordinary charge          16,416      34,228      22,728      36,473      33,542     23,997
        Provision for income taxes                           4,695       9,926       6,364       9,118       8,386      8,399
      Income before extraordinary charge                    11,721      24,302      16,364      27,355      25,156     15,598
        Extraordinary charge (2)                                 -           -           -      (1,176)          -          -

      Net income                                          $ 11,721    $ 24,302    $ 16,364    $ 26,179    $ 25,156   $ 15,598

      Basic earnings per share before
       extraordinary charge (3)                              $0.97       $1.98       $1.33       $2.23       $2.06      $1.29
        Extraordinary charge (2)(3)                              -           -           -        (.10)          -          -
      Basic earnings per share (3)                           $0.97       $1.98       $1.33       $2.13       $2.06      $1.29

      Weighted average common shares (3)                    12,110      12,264      12,260      12,273      12,206     12,113

      Cash dividends paid per common share                       -           -           -           -           -          -

      Total assets                                        $668,862    $367,299    $351,876    $284,925    $285,098   $263,650

      Long-term debt, net of current maturities           $239,211    $ 42,339    $ 38,952    $  6,721    $ 20,922   $ 26,287
      _______________________________________________________________________________________________________________________
      <FN>
      (1) In 1996, cost of goods sold includes a charge of $2.1 million for a write-down of inventory associated with the
          restructuring costs.

      (2) Extraordinary charge for redemption of subordinated debt:  1996 - $1,176, net of tax effect of $817.

      (3) Restated to give effect to a stock split in the form of a 50% stock dividend in 1996.

      
                                                                 1
      

      Bio-Rad Laboratories, Inc.
      Consolidated Balance Sheets
      (In thousands)

      
      
     ________________________________________________________________________________________
                                                                       December 31,
      Assets                                                       1999             1998
                                                                           
      Current Assets:
        Cash and cash equivalents                               $ 17,087         $ 10,081
        Accounts receivable, less allowance of $9,582 in 1999
           and $3,629 in 1998                                    193,898          106,010

        Inventories:
          Raw materials                                           32,398           26,038
          Work in process                                         31,936           21,614
          Finished goods                                          61,943           44,759
            Total inventories                                    126,277           92,411

        Deferred tax assets                                       20,584           18,340
        Prepaid expenses and other current assets                 20,871            8,547
            Total current assets                                 378,717          235,389

      Property, Plant and Equipment:
        Land and improvements                                      8,937            8,057
        Buildings and leasehold improvements                      73,230           56,280
        Equipment                                                168,401          133,838
            Total property, plant and equipment                  250,568          198,175
        Accumulated depreciation                                (124,626)        (116,045)
            Net property, plant and equipment                    125,942           82,130

      Marketable Securities                                        1,169            6,174
      Goodwill                                                   105,350           18,616
      Other Assets                                                57,684           24,990

      Total Assets                                              $668,862         $367,299

      ________________________________________________________________________________________

      

      The accompanying notes are an integral part of these statements.




                                                       2
          


      Bio-Rad Laboratories, Inc.
      Consolidated Balance Sheets
      (In thousands, except share data)
      
      
      __________________________________________________________________________________________
                                                                             December 31,
      Liabilities and Stockholders' Equity                                1999          1998
                                                                                
      Current Liabilities:
        Notes payable                                                   $ 11,547      $  8,721
        Current maturities of long-term debt                              10,413           672
        Accounts payable                                                  64,737        26,706
        Accrued payroll and employee benefits                             59,919        27,351
        Sales, income and other taxes payable                             14,086         6,396
        Other current liabilities                                         41,819        27,398
             Total current liabilities                                   202,521        97,244

      Long-Term Debt, net of current maturities                          239,211        42,339
      Deferred Tax Liabilities                                             7,016        13,382
             Total liabilities                                           448,748       152,965

      Commitments and Contingent Liabilities

      Stockholders' Equity:
        Preferred stock, $1.00 par value, 2,300,000 shares authorized;
          none outstanding                                                     -             -
        Class A common stock, $1.00 par value, 15,000,000 shares
          authorized; outstanding 1999 - 9,977,862;
          1998 - 9,973,679                                                 9,978         9,974
        Class B common stock, $1.00 par value, 6,000,000 shares
          authorized; outstanding 1999 - 2,484,716;
          1998 - 2,452,899                                                 2,485         2,453
        Additional paid-in capital                                        18,830        18,523
        Class A treasury stock, 335,450 shares in 1999 and                (7,392)       (7,047)
          306,368 shares in 1998 at cost
        Retained earnings                                                200,993       189,838
        Accumulated other comprehensive income:
          Currency translation                                            (4,741)           92
          Net unrealized holding gain (loss) on marketable securities        (39)          501

             Total stockholders' equity                                  220,114       214,334

      Total Liabilities and Stockholders' Equity                        $668,862      $367,299
      __________________________________________________________________________________________
      
      The accompanying notes are an integral part of these statements.


                                                 3

      

      Bio-Rad Laboratories, Inc.
      Consolidated Statements of Income
      (In thousands, except per share data)
      
      
      ______________________________________________________________________________________________________________________
                                                                                       Year Ended December 31,
                                                                              1999               1998                1997
                                                                                                          
      Net sales                                                             $549,489           $441,942            $426,914
        Cost of goods sold                                                   255,223            202,438             189,331

      Gross profit                                                           294,266            239,504             237,583
        Selling, general and administrative expense                          194,457            166,978             164,792
        Product research and development expense                              51,210             41,381              46,138
        Purchased in-process research and development expense                 15,500                  -                   -

      Income from operations                                                  33,099             31,145              26,653

      Other income (expense):
        Interest expense                                                     (12,741)            (3,731)             (1,216)
        Investment income, net                                                   873              8,790               1,601
        Other, net                                                            (4,815)            (1,976)             (4,310)
      Income before taxes                                                     16,416             34,228              22,728
        Provision for income taxes                                             4,695              9,926               6,364

      Net income                                                            $ 11,721           $ 24,302            $ 16,364
      Basic earnings per share:

        Net income                                                             $0.97              $1.98               $1.33
        Weighted average common shares                                        12,110             12,264              12,260

      Diluted earnings per share:
        Net income                                                             $0.96              $1.97               $1.32
        Weighted average common shares                                        12,165             12,358              12,394

      __________________________________________________________________________________________________________________
      
      The accompanying notes are an integral part of these statements.


                                                                  4
      


      Bio-Rad Laboratories, Inc.
      Consolidated Statements of Cash Flows
      (In thousands)
      
      
      ________________________________________________________________________________________________________
                                                                             Year Ended December 31,
                                                                          1999         1998        1997
                                                                                       
      Cash flows from operating activities:
           Cash received from customers                                 $527,132    $436,029    $414,694
           Cash paid to suppliers and employees                         (453,266)   (395,265)   (381,489)
           Interest paid                                                  (9,307)     (3,833)     (1,155)
           Income tax payments                                           (17,237)     (9,370)    (10,950)
           Miscellaneous receipts (payments)                              (2,341)       (226)          9

           Net cash provided by operating activities                      44,981      27,335      21,109

      Cash flows from investing activities:
           Capital expenditures, net                                     (27,275)    (21,176)    (23,571)
           Payments for acquisitions                                    (202,828)          -     (31,238)
           Purchases of marketable securities and investments             (2,216)    (19,086)     (8,352)
           Sales of marketable securities and investments                  6,600      16,367       3,419
           Foreign currency hedges, net                                    2,401      (1,360)      3,817

           Net cash used in investing activities                        (223,318)    (25,255)    (55,925)

      Cash flows from financing activities:
           Net borrowings under line-of-credit arrangements              (13,493)     (1,365)      4,665
           Long-term borrowings                                          353,108     133,710      87,275
           Payments on long-term debt                                   (151,788)   (130,666)    (55,329)
           Arrangement and other fees for
             long-term acquisition financing                              (5,008)         --          --
      Proceeds from issuance of common stock                                 343         103       1,459
           Purchase of treasury stock                                     (2,233)     (4,665)     (5,302)
           Reissuance of treasury stock                                    1,322       1,978         750

           Net cash provided by (used in) financing activities           182,251        (905)     33,518


      Effect of exchange rate changes on cash                              3,092      (1,937)      2,751
      Net increase (decrease) in cash and cash equivalents                 7,006        (762)      1,453

      Cash and cash equivalents at beginning of year                      10,081      10,843       9,390
      Cash and cash equivalents at end of year                          $ 17,087    $ 10,081    $ 10,843

      ________________________________________________________________________________________________________
      

      The accompanying notes are an integral part of these statements.

                                                          5
      


      Bio-Rad Laboratories, Inc.
      Consolidated Statements of Changes in Stockholders' Equity
      (In thousands)
      
      
      ______________________________________________________________________
                                                 Year Ended December 31,
                                              1999        1998       1997
                                                          
      Common Stock, $1.00 par value:
        Balance at beginning of year         $12,427    $ 12,421   $ 12,321
        Issuance of common stock                  36           6        100
        Balance at end of year                12,463      12,427     12,421

      Additional Paid-In Capital:
        Balance at beginning of year          18,523      18,426     17,067
        Issuance of common stock                 307          97      1,359
        Balance at end of year                18,830      18,523      18,426

      Treasury Stock:
        Balance at beginning of year          (7,047)     (6,006)    (1,639)
        Purchase of treasury stock            (2,233)     (4,665)    (5,302)
        Reissuance of treasury stock           1,888       3,624        935
        Balance at end of year                (7,392)     (7,047)    (6,006)

      Retained Earnings:
        Balance at beginning of year         189,838     167,182    151,003
        Net income                            11,721      24,302     16,364
        Reissuance of treasury stock at
          less than cost                        (566)     (1,646)      (185)
        Balance at end of year               200,993     189,838    167,182

      Accumulated Other Comprehensive Income:
        Balance at beginning of year             593       4,654      4,756
        Currency translation adjustments      (4,833)      1,241     (4,719)
        Net unrealized holding gains              66         819      5,746
        Reclassification adjustment for
          gains included in net income          (606)     (6,121)    (1,129)
        Balance at end of year                (4,780)        593      4,654
                                            ________    ________   ________

      Total Stockholders' Equity            $220,114    $214,334   $196,677


      Comprehensive Income:
        Net income                          $ 11,721    $ 24,302   $ 16,364
        Currency translation adjustments      (4,833)      1,241     (4,719)
        Net unrealized holding gains              66         819      5,746
        Reclassification adjustments for
          gains included in net income          (606)     (6,121)    (1,129)

      Total Comprehensive Income            $  6,348    $ 20,241   $ 16,262
      _________________________________________________________________________
      

      The accompanying notes are an integral part of these statements.

                                                                    6

      


   Bio-Rad Laboratories, Inc.

   Notes to Consolidated Financial Statements
   (In thousands of dollars, except share and per share data)
   _________________________________________________________________

   1.  Significant Accounting Policies

   Basis of Presentation

   The consolidated financial statements include the accounts of Bio-Rad
   Laboratories, Inc. and all subsidiaries ("Bio-Rad" or the "Company")
   after elimination of intercompany balances and transactions.  The
   preparation of financial statements in conformity with generally
   accepted accounting principles requires management to make estimates
   and assumptions that affect the amounts reported in the financial
   statements and accompanying notes.  Changes in such estimates may
   affect amounts reported in the future.  Certain amounts in the
   financial statements of prior years have been reclassified to be
   consistent with the 1999 presentation.

   Cash and Cash Equivalents

   Cash and cash equivalents consist of cash and highly liquid in-
   vestments with original maturities of three months or less which are
   readily convertible into cash.  Cash equivalents are stated at cost,
   which approximates market value.

   Concentration of Credit Risk

   Financial instruments that potentially subject the Company to
   concentration of credit risk consist primarily of trade accounts
   receivable.  The Company performs credit evaluation procedures and
   with the exception of certain developing countries, generally does not
   require collateral.  As a result of increased risk in these countries,
   some Bio-Rad sales are subject to collateral letters of credit.
   Credit risk is limited due to the large number of customers and their
   dispersion across many geographic areas.  However, a significant
   amount of trade receivables are with national healthcare systems in
   countries within the European Economic Community.  The Company does
   not currently anticipate a credit risk associated with these receiv-
   ables.

   Inventory Valuation

   Inventories are valued at the lower of average cost or market and
   include material, labor and overhead costs.

   Property, Plant and Equipment

   Property, plant and equipment are carried at historical cost.
   Depreciation is computed on a straight-line basis over the estimated
   useful lives of the assets ranging from two to thirty years.
   Leasehold improvements are amortized over the lives of the respective
   leases or the lives of the improvements, whichever is shorter.

                                      7
   


   Marketable Securities

   The Company's marketable securities are classified as available-for-
   sale and are recorded at current market value.  Unrealized holding
   gains and losses are included as a separate component of stockholders'
   equity.  Realized gains and losses are included in investment income.
   For the purpose of determining realized gains and losses, the cost of
   securities sold is based upon specific identification.

   Goodwill

   Goodwill, representing the excess of the cost over the net tangible
   and identifiable intangible assets of acquired businesses, is stated
   at cost and is amortized on a straight-line basis over the estimated
   future periods to be benefited, typically ten to fifteen years.
   Goodwill, other intangibles and other long-lived assets are
   periodically reviewed for impairment to ensure they are properly
   valued.

   Revenue Recognition and Warranty

   Bio-Rad recognizes revenues when products are shipped or services are
   rendered and all significant obligations of the Company have been met.
   Where appropriate, the Company also establishes a concurrent reserve
   for returns and allowances.

   The Company warrants certain equipment against defects in design,
   materials and workmanship, generally for one year.  Upon shipment of
   equipment sold at a price which includes a warranty, the Company
   establishes, as part of cost of goods sold, a provision for the
   expected costs of such warranty.

   Foreign Currency Translation

   Balance sheet accounts of international subsidiaries are translated at
   the current exchange rate as of the end of the accounting period.
   Income statement items are translated at average exchange rates.  The
   resulting translation adjustment is recorded as a separate component
   of stockholders' equity.

   Forward Exchange Contracts

   The Company does not use derivative financial instruments for
   speculative or trading purposes.  As part of distributing its
   products, the Company regularly enters into intercompany transactions.
   The Company enters into forward foreign exchange contracts to hedge
   against future movements in foreign exchange rates that affect foreign
   currency denominated intercompany receivables and payables.  These
   contracts generally have maturity dates of 60 days or less, relate
   primarily to currencies of industrial countries and are marked to
   market at each balance sheet date.  The resulting gains or losses are
   included in other income and expense and offset exchange losses or
   gains on the related receivables and payables.  Unrealized gains and
   losses are not deferred.  Exchange gains and losses on these contracts
   are net of premiums and discounts which result from interest rate

                                      8
   


   differentials between the U.S. and the countries of the currencies
   being traded.  The cash flows related to these contracts are
   classified as cash flows from investing activities in the Statement of
   Cash Flows.

   Stock Compensation Plans

   Stock-based compensation is recognized using the intrinsic value
   method.  For disclosure purposes, pro forma net income and earnings
   per share are provided as if the fair value method had been applied.

   Earnings Per Share

   Basic earnings per share are calculated on the basis of the weighted
   average number of common shares outstanding for each period.  Diluted
   earnings per share are calculated assuming the exercise of certain
   stock options.  Treasury stock is not considered outstanding for
   purposes of calculating weighted average shares.

   Fair Value of Financial Instruments

   For certain of the Company's financial instruments, including cash and
   cash equivalents, accounts receivable, notes payable, accounts
   payable, long-term debt and forward exchange contracts, the carrying
   amounts approximate fair value.  The fair values of other instruments
   are disclosed in relevant notes to the financial statements.

   2.  Acquisitions

   In October 1999, the Company acquired Pasteur Sanofi Diagnostics S.A.,
   a French corporation (PSD), from its shareholders, Sanofi-Synthelabo
   S.A. and Institut Pasteur.  The Company paid $202,828 for all of the
   capital stock of PSD (and certain ancillary assets and assumed
   liabilities related to PSD).  PSD was founded by the Institut Pasteur
   and operates in the HIV and infectious disease diagnostic product
   market.  The purchase of PSD was financed with the proceeds from a
   $200,000 Senior Credit Agreement and a $100,000 Senior Subordinated
   Credit Agreement (see Note 5).  The acquisition was accounted for
   using the purchase method of accounting.  The operating results of PSD
   have been included in the Consolidated Statement of Income from the
   date of acquisition.

   As a result of the acquisition, the Company recorded $88,630 of
   goodwill.  Goodwill reflects the excess of the purchase price,
   purchase liabilities and liabilities assumed over the fair value of
   net identifiable assets and in-process research and development
   projects acquired.  Acquired in-process research and development of
   $15,500 was charged to expense in the fourth quarter in accordance
   with generally accepted accounting principles.  Purchase liabilities
   recorded included approximately $14,000 for severance and other

                                      9

   


   employee costs and $4,000 for the consolidation and closure of certain
   leased facilities.  The Company expects to complete its workforce
   reduction by September 30, 2000.  The closure of facilities identified
   by the Company will be completed in fiscal 2000, with lease payments,
   net of sublease revenues, continuing until all contractual obligations
   are met.  For the year 1999 no material amounts were charged to the
   purchase liability for severance and facility closures.  The Company
   does not believe that the final purchase price allocation will differ
   significantly from the preliminary purchase price allocation recorded
   in the current fiscal year.

   As the Company's 1999 financial statements include only three months
   of operations of PSD, the following selected unaudited pro forma
   information is being provided to present a summary of the combined
   results of Bio-Rad and PSD as if the acquisition had occurred as of
   January 1, 1998, giving effect to purchase accounting adjustments and
   actual costs of financing.  The pro forma data is for informational
   purposes only and may not necessarily reflect the results of
   operations of Bio-Rad had PSD operated as part of the Company for the
   years ended December 31, 1999 and 1998.

                                           Unaudited Pro Forma
                                          Year Ended December 31,
                                            1999            1998

        Sales                             $722,000        $669,800
        Net income (loss)                   $6,300         $(5,000)
        Basic earnings (loss)per share       $0.52          $(0.41)


   The pro forma amounts reflect the results of operations for Bio-Rad
   and PSD and the following purchase accounting adjustments for the
   periods presented:

        Amortization of intangible assets and goodwill based on the
        purchase price allocation for the period presented.

        Amortization of debt financing fees and expenses over the
        relative term of the following debt: Senior Credit
        Agreement,  Senior Subordinated Credit Facility and Senior
        Subordinated Notes.

        The additional interest expense on debt incurred to finance
        the acquisition offset by a reduction of historical interest
        resulting from the elimination of PSD's debt.

        The estimated income tax effect on the pro forma
        adjustments, including a limitation on the deductibility of
        goodwill amortization.

        The pro forma statements do not include the $15,500 write-
        off of in-process research and  development.  This charge is
        included in the Consolidated Statements of Operations of the
        Company for 1999.


                                     10

   


   3. Marketable Securities

   The Company's portfolio is comprised principally of equity securities
   with an aggregate market value of $1,169 and $6,174 and cost of $1,224
   and $5,469 at December 31, 1999 and 1998, respectively.  At December
   31, 1999, gross unrealized holding gains and losses were $104 and
   $159, respectively.  At December 31, 1998, gross unrealized holding
   gains and losses were $1,044 and $339, respectively.

   
   Information regarding the proceeds and gross realized gains and losses
   from sales of securities is as follows:
   

                                       Year Ended December 31,
                                    1999        1998        1997
                                                 
   Proceeds                       $  6,600    $ 16,367    $ 3,419

   Gross realized gains           $  1,260    $  9,168    $ 1,211
   Gross realized losses              (410)       (548)       (82)
   Net realized gains             $    850    $  8,620    $ 1,129

   

   4.  Investment in Affiliates

   In December 1997, Bio-Rad began investing in Instrumentation
   Laboratory, S.p.A. (IL), an Italian based clinical diagnostics
   company.  At December 31, 1999, Bio-Rad held approximately 27% of the
   outstanding stock of IL.  A privately held company based in Spain
   controls over 50% of the outstanding stock of IL.  The most recently
   published financial statements for IL are as of February 28, 1999.

   Given the limited availability of financial information and the low
   volume of shares traded, Bio-Rad management does not believe there is
   a sufficient liquid market for IL stock.  Accordingly, the investment
   is reported as Other Assets.  Additionally, since Bio-Rad does not
   have the ability to significantly influence the operating and
   financial policies of IL, the investment has been recorded at its cost
   of $18,830.

   An unrealized holding gain of $652 was included in comprehensive
   income in 1997.  This amount was reversed in 1998 when the investment
   in IL was reclassified to Other Assets.

   5.  Notes Payable and Long-Term Debt

   Notes payable include local credit lines maintained by the Company's
   subsidiaries aggregating approximately $32,742, of which $21,195 was
   unused at December 31, 1999.  The weighted average interest rate on
   these lines was 5.76% and 5.14% at December 31, 1999 and 1998,
   respectively.  The parent company guarantees most of these credit
   lines.


                                     11

   


   The principal components of long-term debt are as follows:
   
                                               December 31,
                                           1999            1998
                                                   
   Senior Subordinated Credit
     Agreement                          $100,000         $     -
   Term loan                             100,000               -
   Revolving credit agreement             49,000          42,000
   Capitalized leases                        624             606
   Other                                       -             405
                                         249,624          43,011
   Less current maturities                10,413             672
   Long-Term Debt                       $239,211         $42,339

   

   On September 30, 1999, the Company entered into a $200,000 Senior
   Credit Agreement and a $100,000 Senior Subordinated Credit Agreement
   to finance the acquisition of PSD and certain related assets and to
   provide funds for working capital needs.  The Senior Credit Agreement
   included a term loan and revolving facility, each in the amount of
   $100,000.  Debt issue costs related to these financings were $8,600.

   The $100,000 Senior Subordinated Credit Agreement was replaced on
   January 31, 2000 (see Note 14).

   The term loan and revolving facility are secured by an interest in the
   Company's assets.  Interest on both loans is based upon either the
   Eurodollar, the Federal Funds effective or corporate based (prime)
   rate.  The term loan interest rate was 8.92% at December 31, 1999.
   The revolving credit agreement provides for borrowings on a secured
   basis through September 2004.  The interest rate at December 31, 1999
   was 9.13%.  A commitment fee ranging from .30% to .50% annually is
   charged on the daily unborrowed portion of the revolving credit
   agreement.

   The Company entered into interest rate swap agreements to reduce the
   impact of changing interest rates on its revolving credit agreement.
   At December 31, 1999, the Company had two interest rate swap
   agreements with commercial banks, having an aggregate notional amount
   of $25,000.  The agreements essentially fix the Company's interest
   rate exposure on $25,000 worth of floating rate loans under its
   revolving credit agreement at 8.50%.  The agreements mature December
   29, 2000 and June 30, 2002.  The resulting applicable interest rate
   was 8.81% on the revolving facility versus an effective rate of 9.13%.
   In terms of the interest rate swap, the Company is exposed to credit
   loss in the event of nonperformance by a counterparty, however the
   Company has not experienced such nonperformance to date and considers
   such a possibility remote.

   The Senior Credit Agreement (including amendments) requires the
   Company, among other things, to comply with certain financial ratios.
   The Company was in compliance with all financial ratios as of December
   31, 1999.  This agreement also contains certain other restrictions,
   including limitations on payment of cash dividends, sales of assets,
   incurrence of indebtedness, the creation of liens, making certain
   investments and engaging in sale/leaseback transactions.

                                     12

   


   Maturities of long-term debt at December 31, 1999, are as follows:
   2000 - $10,413; 2001 - $15,137; 2002 - $20,074; 2003 - $25,000;
   2004 - $79,000; thereafter - $100,000.

   6.  Income Taxes

   The U.S. and international components of income before taxes are
   as follows:
   
                                      Year Ended December 31,
                                    1999       1998        1997
                                                
   U.S.                           $ 15,176   $ 24,173    $ 11,343
   International                     1,240     10,055      11,385

   Income before taxes            $ 16,416   $ 34,228    $ 22,728
   

   The provision for income taxes consists of:
   
                                      Year Ended December 31,
                                    1999       1998        1997
                                                
   Current:
     U.S. Federal                 $  4,583   $  8,564    $  3,277
     International                   8,323      4,974       3,226
     U.S. State                        853        374         552
                                    13,759     13,912       7,055
   Deferred                         (9,064)    (3,986)       (691)

   Provision for income taxes     $  4,695   $  9,926    $  6,364

   

   The Company's income tax provision differs from the amount
   computed by applying the U.S. federal statutory rate to income
   before taxes as follows:
   

                                       Year Ended December 31,
                                    1999        1998        1997
                                                   
   U.S. statutory tax rate           35%        35%         35%
   State taxes, net of
     federal income tax benefit       2         (1)          1
   Foreign Sales Corporation
     tax benefit                    (10)        (5)         (6)
   Research and development
     tax credit                      (1)        (1)         (2)
   International taxes in excess
     of U.S. Foreign Tax Credit      12          -           1
   Loss carryforwards utilized       (5)        (1)         (6)
   Amortization of goodwill           4          -           2
   Foreign losses in connection
     with the PSD acquisition
     not benefited                   31          -           -
   Favorable resolution of U.S.
     income tax disputes            (40)         -           -
   Other                              1          2            3
   Provision for income taxes        29%        29%         28%
   

                                   13

   



   Deferred income taxes reflect the net tax effect of temporary
   differences between the carrying amounts of assets and
   liabilities for financial reporting purposes and the amounts used
   for income tax purposes.  Significant components of deferred tax
   assets and liabilities are as follows:

   
                                                December 31,
                                            1999            1998
                                                   
   Deferred Tax Assets:
     Reserves for obsolete inventory,
       warranty and bad debts            $ 12,622        $ 12,102
     Eliminated intercompany profit         3,661           3,265
     Tax benefit of foreign loss
       carryforwards                       16,457           4,732
     Other                                 11,975           3,583
                                           44,715          23,682
     Valuation allowance                  (24,131)         (5,342)
     Deferred Tax Assets                 $ 20,584        $ 18,340

   Deferred Tax Liabilities:
     Deferred gain on condemnation       $  3,522        $  4,473
     Depreciation                           1,567           1,174
     Development cost of Hercules
       facility                             1,385           1,413
     Other                                    542           6,322
     Deferred Tax Liabilities            $  7,016        $ 13,382

   

   The valuation allowance is needed to reduce the deferred tax
   assets to an amount that is more likely than not to be realized.
   The net change in the valuation allowance in 1999 was an increase
   of $18,789, primarily resulting from an increase in tax loss
   carryforwards.  The net change in 1998 was an increase of $2,057,
   primarily resulting from an increase in tax loss carryforwards.

   At December 31, 1999, Bio-Rad's international subsidiaries had
   combined net operating loss carryforwards of $40,231.  A portion
   of these loss carryforwards will expire in the following years:
   2000 - $809; 2001 - $394; 2002 - $754; 2003 - $150; 2004 - $178;
   2005 - $1,639 and 2008 - $393.  The remainder of these loss
   carryforwards have no expiration date.  The utilization of these
   carryforwards is limited to the separate taxable income of each
   individual subsidiary.

   Bio-Rad does not provide for taxes which would be payable if the
   cumulative undistributed earnings of its international subsidiaries,
   approximately $36,916 at December 31, 1999, were remitted to the U.S.
   parent company.  Unless it becomes advantageous for tax or foreign
   exchange reasons to remit a subsidiary's earnings, such earnings are
   indefinitely reinvested in subsidiary operations.  The withholding tax
   and U.S. federal income taxes on these earnings, if remitted, would in
   large part be offset by tax credits.


                                     14

   



   7.  Stockholders' Equity

   Stock Classification

   The Company's outstanding stock consists of Class A Common Stock
   (Class A) and Class B Common Stock (Class B).   Each share of Class A
   and Class B participates equally in the earnings of Bio-Rad, and is
   identical in most respects except that Class A has limited voting
   rights.  Each share of Class A is entitled to one-tenth of a vote on
   most matters, and each share of Class B is entitled to one vote.
   Additionally, Class A stockholders are entitled to elect 25% of the
   Board of Directors and Class B stockholders are entitled to elect the
   balance of the directors.  Cash dividends may be paid on Class A
   shares without paying a cash dividend on Class B shares but no cash
   dividend may be paid on Class B shares unless at least an equal cash
   dividend is paid on Class A shares.  Class B shares are convertible at
   any time into Class A shares on a one-for-one basis at the option of
   the stockholder.

   Stock Option Plans

   Bio-Rad maintains incentive and non-qualified fixed stock option plans
   for officers and certain other key employees.  Under the Amended 1994
   Stock Option Plan, the Company may grant options to its employees for
   up to 1,175,000 shares of common stock provided that no option shall
   be granted after March 1, 2004.  Under the plans, Class A and Class B
   options are granted at prices not less than fair market value on the
   date of grant, are exercisable on a cumulative basis at a rate not
   greater than 25% per annum commencing one year after the date of grant
   and expire five years after the date of grant.

   The Company has made no charge to income with respect to any stock
   options.  At the time options are exercised, the par value of the
   shares is credited to common stock and the excess is credited to
   additional paid-in capital.  The Company may receive income tax
   benefits from the exercise of non-qualified stock options and from
   certain dispositions of stock received by employees under qualified or
   incentive stock options.  The fair value of each option granted since
   January 1, 1995, was estimated on the date of the grant using the
   Black-Scholes option-pricing model with the following assumptions for
   grants in 1999, 1998 and 1997, respectively:  no dividend yield for
   all periods; expected lives of 2.2 and 3.0 years in 1999, 2.0 and 2.9
   years in 1998 and 1.8 and 2.8 years in 1997; expected volatility of
   34%, 35% and 33%; and risk-free interest rates ranging from 4.72% to
   4.82%, 5.39% to 5.48% and 5.63% to 6.15%.



                                   15

   

   
   Activity under the plans is summarized below (amounts reported in the Price columns
   represent the weighted average exercise price):

   

                                                                 Year Ended December 31,
                                                1999                        1998                      1997
                                        Shares         Price        Shares         Price      Shares         Price
                                                                                          
     Outstanding at beginning of year   561,047        $23.73       517,018       $21.40      482,900       $16.34
     Granted                            166,080         19.89       150,653        23.54      147,050        32.54
     Exercised                          (60,914)         8.47       (89,625)       10.09      (90,445)       11.88
     Forfeited                          (19,712)        25.10       (14,677)       25.07      (19,909)       25.38
     Expired                             (1,386)         7.37        (2,322)        9.46       (2,578)       12.04
     Outstanding at end of year         645,115        $24.18       561,047       $23.73      517,018       $21.40

     Options exercisable at year-end    280,825                     222,539                   172,689


     Weighted average fair value of
       options granted during the year    $6.46                       $7.62                    $10.76

   

   

   The following summarizes information about fixed stock options outstanding at December 31, 1999:
   
                                   Options Outstanding                                  Options Exercisable

                             Number        Weighted Average                         Number
           Range of        Outstanding         Remaining       Weighted Average  Exercisable    Weighted Average
        Exercise Prices    at 12/31/99     Contractual Life     Exercise Price   at 12/31/99     Exercise Price
                                                                                 
        $18.00 - $19.69      206,131          2.4 years            $19.04           85,851          $18.13
        $19.80 - $23.94      184,916          3.2                   22.49           44,441           22.63
        $25.92 - $29.33      124,813          1.3                   26.50           85,909           26.51
        $31.63 - $35.89      129,255          2.1                   32.53           64,624           32.53
        $18.00 - $35.89      645,115          2.4                   24.18          280,825           24.72

   


                                                             16
   


   Employee Stock Purchase Plan

   Under the Amended and Restated 1988 Employee Stock Purchase Plan (the
   Plan), the Company has authorized the sale of 745,000 shares of Class
   A to eligible employees.  The purchase price of the shares under the
   Plan is the lesser of 85% of the fair market value on the first day of
   each calendar quarter, or 85% of the fair market value on the last day
   of each calendar quarter.  Employees may designate up to 10% of their
   compensation for the purchase of stock.  Under the Plan, the Company
   sold 58,762 shares for $1,098, 51,446 shares for $1,129 and 43,785
   shares for $982 to employees in 1999, 1998 and 1997, respectively.  At
   December 31, 1999, 105,364 shares remained authorized under the Plan.

   The fair value of the employees' purchase rights since 1995 was
   estimated using the Black-Scholes model with the following assumptions
   for 1999, 1998 and 1997, respectively:  no dividend yield for all
   periods; an expected life of three months for all periods; expected
   volatility ranging from 22% to 35%, from 28% to 38% and from 19% to
   30%; and risk-free interest rates ranging from 4.28% to 4.88%, from
   4.27% to 5.23% and from 5.02% to 5.41%.  The weighted average fair
   value of those purchase rights granted in 1999, 1998 and 1997 was
   $4.74, $5.55 and $5.50, respectively.

   Pro Forma Disclosures

   If compensation cost for the Company's stock-based compensation plans
   had been determined based upon the fair value at grant dates for
   awards under those plans consistent with the method of Statement of
   Financial Accounting Standards (SFAS) No. 123, "Accounting for Stock-
   Based Compensation", the Company's net income and earnings per share
   would have been reduced to the pro forma amounts indicated below:
   
                                            Year Ended December 31,
                                          1999       1998        1997
                                                   
   Net income             As reported    $11,721    $24,302    $16,364
                          Pro forma      $10,469    $23,026    $15,173

   Diluted earnings per   As reported      $0.96      $1.97      $1.32
     share                Pro forma        $0.86      $1.86      $1.22
   

   Under the requirements of SFAS No. 123, the above disclosures
   relate only to options granted after December 15, 1994, and do
   not include the impact of outstanding options that were made
   prior to the period for which SFAS No. 123 is effective.  Since
   employee stock options vest over several years, and additional
   grants are likely to be made in the future, during the phase-in
   period of SFAS No. 123 the disclosures are not likely to be
   representative of the effects on reported pro forma net income or
   earnings per share in future years.


                                   17
   



   8. Earnings Per Share

   Weighted average shares used for diluted earnings per share
   include the dilutive effect of outstanding stock options of
   55,000, 94,000 and 134,000 shares, for the years ended
   December 31, 1999, 1998 and 1997, respectively.

   Options to purchase 261,000, 229,000 and 133,000 shares of common
   stock were outstanding during 1999, 1998 and 1997, respectively,
   but were excluded from the computation of diluted earnings per
   share because the exercise price of the options was greater than
   the average market price of the common shares.  The options were
   still outstanding at the end of 1999.

   9.  Other Income and Expense

   Other, net includes the following income and (expense)
   components:

   
                                         Year Ended December 31,
                                      1999        1998        1997
                                                  
   Amortization of goodwill         $(3,813)    $(2,068)   $(1,612)
   Exchange gains (losses)             (886)         22       (711)
   Other non-operating litigation
     costs, net                          73         117     (1,606)
   Miscellaneous other items           (189)        (47)      (381)
   Other, net                       $(4,815)    $(1,976)   $(4,310)
   

   Exchange gains (losses) include premiums and discounts on forward
   foreign exchange contracts.

   10.  Supplemental Cash Flow Information

   The reconciliation of net income to net cash provided by operating
   activities is as follows:

   


                                                     Year Ended December 31,
                                                     1999      1998      1997
                                                              
   Net income                                      $11,721   $24,302   $16,364
   Adjustments to reconcile net income to
    net cash provided by operating activities:
     Depreciation and amortization                  27,495    20,975    19,470
     Foreign currency hedge transactions, net       (2,401)    1,360    (4,001)
     Gains on dispositions of marketable securities   (850)   (8,620)   (1,129)
     Increase in accounts receivable, net          (16,082)   (5,739)   (6,176)
     (Increase) decrease in inventories              4,095      (166)  (14,831)
     (Increase) decrease in other current assets     5,609     4,629    (6,369)
     Increase (decrease) in accounts payable and
      other current liabilities                     26,153    (4,808)   18,775
     Increase in income taxes payable                4,804     1,040     1,122
     Decrease in deferred taxes                    (16,946)   (5,292)   (1,276)
     Other                                           1,383      (346)     (840)
   Net cash provided by operating activities       $44,981   $27,335   $21,109

   

                                        18

   



   11.  Commitments and Contingent Liabilities

   Rents and Leases

   Net rental expense under operating leases was $13,607 in 1999,
   $12,622 in 1998 and $11,339 in 1997.  Leases are principally
   for facilities and automobiles.

   Annual future minimum lease payments at December 31, 1999, under
   operating leases are as follows: 2000 - $10,166; 2001 - $7,554; 2002 -
   $4,914; 2003 - $3,605; 2004 - $2,769; subsequent to 2004 - $7,084.

   Deferred Profit Sharing Retirement Plan

   The Company has a profit sharing plan covering substantially all U.S.
   employees.  Contributions are made at the discretion of the Board of
   Directors.  Bio-Rad has no liability other than for the current year's
   contribution.  Contributions charged to income were $4,030,
   $3,566 and $3,285 in 1999, 1998 and 1997, respectively.

   Foreign Exchange Contracts

   The Company enters into forward foreign exchange contracts as a hedge
   against foreign currency denominated intercompany receivables and
   payables.  At December 31, 1999, the Company had contracts maturing in
   January 2000 to sell foreign currency with a market value of $64,390 and
   to purchase foreign currency with a market value of $6,339.
   At December 31, 1998, the Company had contracts maturing in January 1999
   to sell foreign currency with a market value of $48,053 and to purchase
   foreign currency with a market value of $1,811.

   12. Legal Proceedings

   The Company is a party to various claims, legal actions and complaints
   arising in the ordinary course of business.  In the opinion of
   management, the outcome of these claims, legal actions and complaints
   would have no material adverse effect on the future results of operations
   or the financial position of the Company.

   13.  Segment Information

   The Company adopted SFAS No. 131, "Disclosures about Segments of an
   Enterprise and Related Information" in 1998 which changed the way the
   Company reports information about its operating segments.

   Bio-Rad is a multinational manufacturer and worldwide distributor of life
   science research products, clinical diagnostics and analytical
   instruments.  Bio-Rad has three reportable segments:  Life Science,
   Clinical Diagnostics and Analytical Instruments.  These reportable
   segments are strategic business lines that offer different products and
   services and require different marketing strategies.

   The Life Science segment develops, manufactures, sells and services liquid
   chromatography, electrophoresis, gene amplification and transformation,
   imaging and image analysis, DNA sequencing and sample preparation products.

                                        19

   


   These products are sold to university and medical school laboratories,
   pharmaceutical and biotechnology companies, and government and industrial
   research facilities.

   The Clinical Diagnostics segment develops, manufactures, sells and services
   automated test systems, informatics systems, test kits and specialized
   quality controls for the healthcare market.  These products are sold to
   reference laboratories, hospital laboratories, state newborn screening
   facilities, physicians office laboratories, and insurance and forensic
   testing laboratories.

   The Analytical Instruments segment develops, manufactures, sells and
   services FT-IR spectroscopy systems, semiconductor test and manufacturing
   instruments, spectral reference publications and software.  These products
   are sold to industrial companies, government institutions, academia and
   forensic analysis laboratories.

   The accounting policies of the segments are the same as those described in
   Significant Accounting Policies (see Note 1).  Segment profit or loss used
   for corporate management purposes includes an allocation of corporate
   expense based upon sales and an allocation of interest expense based upon
   accounts receivable and inventories.  In addition, certain items that are
   classified as non-operating expenses and reported as other income and
   expense on a consolidated basis are included in segment profit or loss.
   Segments are expected to manage only assets completely under their control.
   Accordingly, segment assets include primarily accounts receivable,
   inventories and gross machinery and equipment.

   Information regarding industry segments at December 31, 1999, 1998 and 1997
   and for the years then ended is as follows:

   

                                             Life     Clinical    Analytical
                                            Science  Diagnostics Instruments
                                                     
        Segment net sales            1999  $234,696    $249,243    $ 67,974
                                     1998   209,655     170,002      66,100
                                     1997   205,704     150,095      75,800


        Allocated interest expense   1999  $  3,761    $  7,775    $  1,206
                                     1998     1,501       1,464         571
                                     1997       550         428         212

        Depreciation and
          amortization               1999  $  8,003    $ 15,466    $  1,335
                                     1998     7,328      11,242       1,652
                                     1997     7,258       7,553       3,768


        Segment profit (loss)        1999  $ 16,643    $ 16,661    $  2,928
                                     1998    12,649      18,160      (2,166)
                                     1997     6,816      19,257      (1,003)

        Segment assets               1999   $131,689    $320,419   $ 35,387
                                     1998    124,219     129,089     38,607
                                     1997    116,289     111,453     44,964


                                          20

   


        Capital expenditures         1999   $ 10,673    $ 13,388   $  1,378
                                     1998      6,487      15,213      1,912
                                     1997      7,461      14,432      1,991

   

   Capital expenditures include capitalized leases of $100, $311 and
   $331 in 1999, 1998 and 1997, respectively.

   Inter-segment sales are primarily from Life Science to Clinical
   Diagnostics and are priced to give Life Science a market
   representative gross margin.  This represents the difference
   between total segment net sales and consolidated net sales.  The
   difference between total segment allocated interest expense,
   depreciation and amortization, and capital expenditures and the
   corresponding consolidated amounts is attributable to the
   Company's corporate headquarters.  The following reconciles total
   segment profit to consolidated income before taxes:

   

                                           Year Ended December 31,
                                          1999       1998       1997
                                                     
   Total segment profit                 $36,232    $28,643    $25,070

   Gross profit on inter-segment sales   (1,204)    (1,925)    (2,338)
   Net corporate operating, interest
     and other expense not allocated
     to segments                         (3,985)    (1,280)    (1,605)
   Purchased in-process research and
     development                        (15,500)        --         --
   Investment income, net                   873      8,790      1,601

   Consolidated income before taxes     $16,416    $34,228    $22,728

   


   The following reconciles total segment assets to consolidated total
   assets:

   

                                                December 31,
                                          1999       1998       1997
                                                    
   Total segment assets                $487,495   $291,915   $272,706
   Cash and other current assets         58,542     36,968     39,025
   Net property, plant and
     equipment excluding segment
     specific gross machinery and
     equipment                          (41,378)   (11,364)    (5,635)
   Other long-term assets               164,203     49,780     45,780

   Total assets                        $668,862   $367,299   $351,876

   


                                     21

  



   The following presents sales to external customers by geographic area
   based primarily on the location of the use of the product or service:
   

                                             Year Ended December 31,
                                         1999       1998       1997
                                                    
   Europe                              $188,969   $141,004   $132,551
   Pacific Rim                          110,729     88,917     98,070
   United States                        225,795    195,309    184,533
   Other (primarily Canada
     and Latin America)                  23,996     16,712     11,760

   Total net sales                     $549,489   $441,942   $426,914
   

   The following presents long-lived assets by geographic area based upon
   the location of the asset:
   
                                                 December 31,
                                          1999       1998       1997
                                                    
   Europe                              $ 34,129   $  7,860   $  7,004
   Pacific Rim                            6,954      4,933      3,885
   United States                        247,293    118,628    112,967
   Other (primarily Canada
     and Latin America)                   1,769        489        602

   Total long-lived assets             $290,145   $131,910   $124,458
   


   14.  Subsequent Event

   The Company entered into a $100,000 Senior Subordinated Credit
   Agreement dated January 31, 2000.  This agreement had a one-year term
   and provided for an automatic rollover for an additional term maturing
   in September 2005.  The proceeds of this transaction were used to
   replace the Senior Subordinated Credit Agreement dated September 30,
   1999.  Fees paid in January 2000 to replace and initiate the Senior
   Subordinated Credit Agreements were $4,000.  The replacement loan was
   repaid in February 2000.

   The Company sold $150,000 aggregate principal amount of Senior
   Subordinated Notes due in 2007 under an indenture dated February 17,
   2000.  The notes were offered at 98.832% of par and pay a fixed rate
   of interest of 11.625% per year.  The notes are redeemable at the
   Company's option prior to the due date under certain terms and
   conditions.  The Company's obligations under the notes are not secured
   and rank junior to all of the Company's existing and future senior
   debt.  The indenture requires the Company, among other things, to
   comply with certain financial ratios and covenants.  The proceeds from
   this transaction were used (1) to repay the $100,000 Senior
   Subordinated Credit Agreement dated January 31, 2000, (2) to
   permanently retire $20,000 of the $100,000 term loan, and (3) to repay
   a portion of the outstanding borrowings under the revolving facility.



                                     22
   




   15.  Quarterly Financial Data - (unaudited)

   Summarized quarterly financial data for 1999 and 1998 are as follows:
   

                                First      Second       Third    Fourth
                               Quarter     Quarter     Quarter   Quarter

      1999
                                                    
   Net sales                  $125,738    $115,794    $113,527  $194,430
   Gross profit                 70,182      65,241      61,628    97,215
   Net income (loss)            10,802       7,881       4,253   (11,215)
   Basic earnings (loss)
     per share                   $0.89       $0.65       $0.35    $(0.92)
   Diluted earnings (loss)
     per share                   $0.89       $0.65       $0.35    $(0.92)

      1998

   Net sales                  $116,174    $107,898    $ 98,982  $118,888
   Gross profit                 64,076      58,857      53,577    62,994
   Net income                    8,776       7,151       1,938     6,437
   Basic earnings per share      $0.72       $0.58       $0.16     $0.52
   Diluted earnings per share    $0.71       $0.58       $0.16     $0.52

   


   16.  Information Concerning Common Stock - (unaudited)

   The Company's Class A and Class B Common Stock are listed on the
   American Stock Exchange with the symbols BIO.A and BIO.B,
   respectively.  The following sets forth, for the periods indicated,
   the high and low prices for the Company's Class A and Class B Common
   Stock.
   
                                Class A              Class B
                             High      Low        High      Low
        1999
                                               
   First Quarter            21-3/4    18-7/8     21-3/8    19-3/8
   Second Quarter           29        20-3/8     27-1/2    23-3/8
   Third Quarter            28        25-5/8     27        25-7/8
   Fourth Quarter           27-1/2    22-1/2     27-1/8    23-1/8

        1998

   First Quarter            27        22-1/2     26-3/8    23-1/4
   Second Quarter           34-1/8    24-1/8     33-3/4    27
   Third Quarter            31-7/8    23-5/16    29-1/2    24-1/4
   Fourth Quarter           24-3/4    19-1/2     22-3/8    19-3/4

   

   On February 28, 2000, the Company had 570 holders of record of
   Class A Common Stock and 265 holders of record of Class B Common
   Stock.  Bio-Rad has never paid a cash dividend and has no present
   plans to pay cash dividends.





                                     23

      

      REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

      To the Stockholders and Board of Directors of
        Bio-Rad Laboratories, Inc.:

      We have audited the accompanying consolidated balance sheets of
      Bio-Rad Laboratories, Inc. (a Delaware Corporation) and
      subsidiaries as of December 31, 1999 and 1998, and the related
      consolidated statements of income, cash flows and changes in
      stockholders' equity for each of the three years in the period
      ended December 31, 1999.  These financial statements are the
      responsibility of the Company's management.  Our responsibility is
      to express an opinion on these financial statements based on our
      audits.

      We conducted our audits in accordance with auditing standards
      generally accepted in the United States.  Those standards require
      that we plan and perform the audit to obtain reasonable assurance
      about whether the financial statements are free of material
      misstatement.  An audit includes examining, on a test basis,
      evidence supporting the amounts and disclosures in the financial
      statements.  An audit also includes assessing the accounting
      principles used and significant estimates made by management, as
      well as evaluating the overall financial statement presentation.
      We believe that our audits provide a reasonable basis for our
      opinion.

      In our opinion, the consolidated financial statements referred to
      above present fairly, in all material respects, the financial
      position of Bio-Rad Laboratories, Inc. and subsidiaries as of
      December 31, 1999 and 1998, and the results of their operations and
      their cash flows for each of the three years in the period ended
      December 31, 1999 in conformity with accounting principles
      generally accepted in the United States.






                                              /s/ Arthur Andersen LLP
                                                  ARTHUR ANDERSEN LLP




      San Francisco, California, February 9, 2000,
      except for Note 14, as to which the date is
      February 17, 2000




                                       24

      

      Bio-Rad Laboratories, Inc.

      Management's Discussion and Analysis
      ________________________________________________________________

      MANAGEMENT'S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS AND

                             FINANCIAL CONDITION

      This discussion should be read in conjunction with the
      information contained in the Company's Consolidated Financial
      Statements and the accompanying notes which are an integral part
      of the statements.  References are to the Notes to Consolidated
      Financial Statements.

      The following shows operating income and expense items as a
      percentage of net sales:

      
                                               Year Ended December 31,
                                                1999    1998    1997
                                                      
      Net sales                                100.0   100.0   100.0
        Cost of goods sold                      46.5    45.8    44.3
      Gross profit                              53.5    54.2    55.7
        Selling, general and
          administrative expense                35.4    37.8    38.7
        Product research and
          development expense                    9.3     9.4    10.8
        Purchased in-process
          research and development               2.8       -       -

      Income from operations                     6.0     7.0     6.2
                                               =====   =====   =====
      Net income                                 2.1     5.5     3.8
                                               =====   =====   =====

      

      The year 1999 is highlighted by the October 1, 1999 acquisition
      of Pasteur Sanofi Diagnostics, S.A. (PSD).  The details of the
      acquisition are discussed and disclosed throughout the remainder
      of the Management Discussion and Analysis of Operations of the
      1999 Annual Report.  The significance of this transaction is that
      the acquisition enhances Bio-Rad's clinical diagnostics market
      position in the following ways:  the companies have complementary
      product lines with few actual overlapping products.  The combined
      company has increased geographic reach.  There is an opportunity
      to apply emerging Bio-Rad technologies to the combined product
      portfolio.  Finally, the Company expects to achieve operational
      efficiencies.  Profit performance in 2000 and 2001 could be
      impacted when compared to prior years or until fully assimilated
      and reorganized.



                                      25
      



      Corporate Results -- Sales, Margins and Expenses

      Bio-Rad's net sales (sales) in 1999 were $549.5 million, an
      increase of 24.3% over 1998 sales.  Included in the 1999 fourth
      quarter sales was $60.2 million from the recently acquired PSD
      operations (see Note 2).  Excluding this amount, Bio-Rad's sales
      grew by 10.7% over the year 1998.  For the year 1999, the impact
      from currency translation on sales was less than $1.0 million.
      The strengthening of the Japanese Yen offset the negative impact
      from most European currencies.  Excluding any impact from
      currency for 1999, the Life Science and Clinical Diagnostics
      segments (excluding the PSD acquisition) grew by 11.9% and 11.2%,
      respectively.  The growth in the Life Science segment is
      attributable to laboratory products and scientific imaging
      equipment excellent performance.  The Clinical Diagnostics
      segment growth was a result of the continuing demand for the
      Company's diabetes monitoring and quality control systems.  The
      Analytical Instruments segment grew by 2.8% as the market for the
      Company's semiconductor test and manufacturing equipment grew
      significantly in the second half of 1999.

      Bio-Rad's sales in 1998 amounted to $441.9 million, an increase
      of 3.5% over sales in 1997.  The effect of a strengthening U.S.
      dollar caused a reduction in sales growth of 2.5% or
      approximately $10.5 million.  When 1998 sales are compared to
      1997 at constant 1997 exchange rates, sales for the Company grew
      6.0%.  Eliminating the effect of a strengthened U.S. dollar,
      sales increased 16% and 4% in the Clinical Diagnostics and Life
      Science segments, respectively.  The Analytical Instruments
      segment experienced lower sales as the markets it served
      contracted almost worldwide.  The growth in the Clinical
      Diagnostics segment was attributed to the December 1997 purchase
      of the controls business from Chiron Diagnostics Corporation.
      The Life Science segment experienced strong growth in the U.S.
      especially in the imaging and microscopy product lines.

      Consolidated gross margins were 53.5% for 1999 compared to 54.2%
      in the prior year.  After adjusting for the acquisition of PSD,
      gross margins for the businesses operated for twelve months were
      55.3%, an improvement over the 54.2% recorded in 1998.  The Life
      Science segment's gross margin improved by 1% as sales growth
      provided the opportunity to lower fixed factory overhead and new
      product pricing remained firm.  The Clinical Diagnostics
      segment's gross margin declined slightly, (0.3%), as pricing
      pressure in the healthcare industry remained a considerable
      factor.  Also, the cost of foreign sourced products rose as the
      Yen strengthened when compared to the dollar.  The Analytical
      Instruments segment's gross margin improved as demand increased
      and pricing improved for the Company's semiconductor test and
      manufacturing equipment.  Cost reductions begun in prior years
      have been fully implemented across this segment.


                                      26
      



      Consolidated gross margins were 54.2% for 1998 compared to 55.7%
      for 1997.  Gross margins overall were adversely affected by lower
      prices on international sales caused by the strengthening U.S.
      dollar and a majority of manufacturing costs being U.S. dollar
      denominated. The Life Science segment margins declined from
      higher service and warranty costs, and were particularly impacted
      in Asia. The Clinical Diagnostics segment gross margins declined
      3.1% of sales, in part from the Chiron acquisition, where several
      large supply agreements existed.  Continued consolidation in the
      diagnostic laboratory and the role of government in diagnostic
      reimbursement maintained severe pressure on prices received for
      diagnostics products.  Analytical Instruments segment margins
      were negatively impacted by an increasingly weak semiconductor
      market and the strengthening dollar.

      Consolidated selling, general and administrative expense (SG&A)
      decreased to 35.4% of sales in 1999 when compared to 37.8% for
      1998.  After adjusting for the PSD acquisition, SG&A expense for
      the Company was 36.2%, a decline of 1.6% of sales from the prior
      year.  For the Company excluding PSD, total SG&A grew by less
      than 60% of sales growth.  The Company continues to make the
      efficient use of SG&A expense a priority.  The acquisition of PSD
      should allow the Company to further leverage this expense in a
      larger sales environment through the elimination of redundant
      facilities and positions.  In absolute dollars, the largest
      increase in SG&A expense was in the Life Science segment as the
      Clinical Diagnostics segment grew only slightly and Analytical
      Instruments segment declined.

      SG&A decreased to 37.8% of sales in 1998 from 38.7% in 1997.
      Spending increased in absolute dollars only in the Clinical
      Diagnostics segment, yet at a growth rate of approximately half
      that in sales.  The Life Science and Analytical Instruments
      segments each had declines in absolute spending both from the
      currency effect on foreign incurred SG&A and cost elimination
      programs begun in late 1997.

      Product research and development expense (R&D) increased by 23.7%
      in 1999 to $51.2 million including the operations of PSD compared
      to $41.4 million for the year 1998.  Both Life Science and
      Clinical Diagnostics segments (excluding PSD) increased R&D
      spending at a rate higher than sales growth as the Company is
      focusing on programs to increase sales both through new product
      development and the acquisition of existing businesses.  Future
      spending levels are expected to be at or near current levels as a
      percentage of sales.  Included in income from operations is the
      write-off of $15.5 million "purchased in-process research and
      development expense" (IPR&D).  IPR&D represents the value
      assigned in a purchase business combination to research and
      development projects of the acquired business that have been
      commenced but not completed at acquisition.  In accordance with
      SFAS No. 2, "Accounting for Research and Development Costs" the

                                      27

      


      value of IPR&D must be charged to expense as part of the
      allocation of the purchase price.

      R&D decreased in 1998 by 10% to $41.4 million compared to $46.1
      million for the year 1997.  Spending declined in the Life Science
      and Analytical Instruments segments and increased 3% in the
      Clinical Diagnostics segment.  Declines in the Life Science and
      Analytical Instruments segments were due to the completion or
      termination of projects.

      Corporate Results -- Non-Operating Items

      Interest expense increased substantially for the year 1999 as the
      purchase of PSD was financed almost entirely with borrowed funds.
      The Company borrowed approximately $225 million on October 1,
      1999 to pay for the acquisition, including one time bank charges
      and fees for a $200 million Credit Facility and an interim $100
      million Senior Subordinated Credit Facility.  Costs associated
      with the Credit Facility were capitalized and will be amortized
      over the five year life of the revolver and term loan.  Expenses
      for the Senior Subordinated Credit Facility amounted to $3.6
      million to December 31, 1999.  Going forward, the Company expects
      to experience significantly higher interest expense.  At December
      31, 1999 the debt to equity ratio was 119% compared to 24% at
      December 31, 1998.  Average borrowings for the years 1999 and
      1998 were $97.8 million and $52.3 million, respectively.

      Investment income in 1999, 1998 and 1997 includes gains on sales
      of marketable securities.  During 1999, Bio-Rad realized $0.9
      million of investment income as it liquidated its investment of
      marketable securities to raise cash just prior to the PSD
      acquisition.  During 1998, Bio-Rad realized significant income,
      $8.6 million, as it sold some of its investment in marketable
      securities to increase its investment in Instrumentation
      Laboratory (see Note 4).

      Net other income and expense for 1999 is comprised principally of
      amortization of goodwill and exchange losses (see Note 9).  Net
      other income and expense for 1998 was principally amortization of
      goodwill.  Net other income and expense for 1997 was principally
      non-operating litigation costs and amortization of goodwill.
      Bio-Rad's hedging program is limited to nonspeculative forward
      foreign exchange contracts (with major financial institutions)
      which hedge the exposure of intercompany receivables and
      payables.  The net exchange gain or loss results from the
      estimating inherent in projecting intercompany balances and from
      transaction charges.

      Bio-Rad's consolidated effective tax rate was 29%, 29% and 28% in
      1999, 1998 and 1997, respectively.  The tax rate for all years
      reflects the utilization of loss carryforwards, foreign sales
      corporation benefits and foreign tax credits.  The effective tax

                                      28

      


      rate in future periods is expected to rise as the deductibility
      of goodwill amortization, interest expense as well as the
      utilization of loss carry-forwards are dependent on the source
      and amount of income generated by the Company.

      Financial Condition

      As a result of the substantial amount of debt and debt service
      obligations undertaken in relation to the acquisition of PSD, the
      Company now faces increased risk from inadequate levels of
      liquidity and capital resources.

      The Company became substantially leveraged as it entered into new
      credit facilities.  The Company entered into a $200 million
      Credit Facility (consisting of a $100 million term loan and a
      $100 million revolving facility) on September 30, 1999, replacing
      the $100 million credit agreement previously in place.  The new
      facility provides for borrowing on a secured basis through
      September 30, 2004.  Interest is based upon the Eurodollar rate,
      the Federal Funds effective rate or corporate based (prime)rate.

      The Company also entered into an interim $100 million Senior
      Subordinated Credit Agreement on September 30, 1999.  This
      agreement had a one year term and provided for an automatic
      rollover for an additional term expiring September 30, 2005.
      This credit facility was replaced on January 29, 2000 with a new
      interim $100 million Senior Subordinated Credit Agreement.  The
      Company repaid amounts outstanding under this agreement with
      proceeds from the February 2000 issuance of $150.0 million
      aggregate principal amount of Senior Subordinated Notes due 2007.

      The lenders have placed restrictions on the Company's ability to:
      borrow further, service this and other debt, make expenditures
      for capital improvements, pay dividends, repurchase the Company's
      own stock and/or make strategic and tactical investments in
      support of operating the business.  The Company is also required
      to comply with certain financial ratios.  The amount of debt
      undertaken in connection with this acquisition could materially
      impact the financial condition of the Company should management's
      plan for operating the new entity not be successful.

      At December 31, 1999, the Company had available $17.1 million in
      cash and cash equivalents, $21.2 million under its international
      lines of credit, $51.0 million under its principal revolving
      credit agreement (see Note 5) and marketable securities with a
      market value of  $1.2 million. We believe that this availability,
      together with cash flow from operations, will be adequate to meet
      our current objectives for operations, research and development
      and investment in our systems and equipment.

      Net cash provided by operations was $45.0 million, $27.3 million
      and $21.1 million in 1999, 1998 and 1997, respectively.

                                      29

      



      Consolidated net accounts receivable increased approximately $90
      million in 1999 when compared to 1998.  This increase is
      primarily attributable to receivables acquired from PSD of
      approximately $75 million and an increase in fourth quarter sales
      of $15 million for Bio-Rad's same period comparable operations.
      Bio-Rad's management regularly reviews the allowance for
      uncollectible receivables and believes net receivables are fully
      realizable.

      For the year ended December 1999, consolidated inventories rose
      $34.0 million to $126.3 million.  The PSD acquisition added
      approximately $36.0 million to the Clinical Diagnostics segment
      inventories.  Inventory changes for comparable segments were
      generally in line with sales activity, rising in the Life Science
      segment, and declining in the Analytical Instruments segment.
      Management regularly reviews the impact of obsolescence on
      current inventory caused by the introduction of new products.
      Management will continue its focus on inventory control in the
      coming year to moderate capital requirements.

      A valuation reserve is necessary for deferred tax assets (see
      Note 6) primarily because realization of tax attributable to
      foreign loss carryforwards is uncertain.

      Net capital expenditures in 1999 totaled $27.3 million compared
      to $21.2 million and $23.6 million in 1998 and 1997,
      respectively.  Expenditures in all years include clinical
      diagnostic equipment placed with customers to be used with the
      Company's diagnostic reagents.  Expenditures in 1998 include
      additions to the Clinical Diagnostics segment's southern
      California manufacturing facilities to accommodate the
      consolidation of operations and assets acquired in the fourth
      quarter of 1997.  Management regularly approves capital spending
      in the normal course of business.

      The Board of Directors authorized the Company to repurchase up to
      $18 million of common stock over an indefinite period of time.
      Through January 2000, the Company has repurchased 567,786 shares
      of Class A Common Stock and 30,000 shares of Class B Common Stock
      for a total of $14.1 million.  The indenture restricts the
      Company's ability to repurchase its own stock to an amount not to
      exceed $4.0 million in the aggregate.  Share repurchases made
      during 1999 amounted to $2.2 million.  The repurchase is designed
      to improve shareholder value and to satisfy the Company's
      obligations under the employee stock purchase and stock option
      plans.



                                      30

      



      Euro - A New European Currency

      On January 1, 1999, certain member countries of the European
      Union began to fix the conversion rates between their national
      currencies and a common currency, the "Euro".   Over the period
      January 1, 1999 through January 1, 2002 participating countries
      will gradually transition from their national currencies to the
      Euro.

      This transition will have business implications including the
      need to adjust internal systems to accommodate the Euro and
      cross-border price transparency.  A group of Corporate and
      European managers have been assigned the task of preparing and
      accommodating the changes required to continue to do business in
      the European Union.  The Company does not presently expect that
      the efforts involved will have a material impact on operations,
      financial position or liquidity.  There will be increased
      competitive pressures, and marketing strategies will need to be
      continuously evaluated until the transition is complete.  As a
      result of competitive forces and emerging government regulations,
      the Company cannot guarantee that all problems will be foreseen
      and remediated, and that no material disruption will occur.

      Year 2000

      The scope of the Year 2000 compliance effort included (i) IT,
      such as software and hardware; (ii) non-IT systems or embedded
      technology for manufacturing and laboratory equipment,
      environmental and safety systems, facilities and utilities (iii)
      date-sensitive Company products; and (iv) the readiness of key
      third party suppliers and customers.

      From inception of the Company's effort on the Year 2000 issues
      through December 31, 1999, the Company spent an estimated $8.0
      million related to the Year 2000 readiness issue.  The costs
      captured include external consultants, and purchased software and
      hardware.  No internal costs were captured as they principally
      related to payroll costs for the information systems group
      working on the Year 2000 project.  The Company expensed as
      incurred costs related to assessment and remediation.  These
      costs were funded through operating cash flows.  From December
      31, 1999 to February 18, 2000, no material problems were reported
      in any of the Company's facilities or operations.  As of the date
      of this filing, the Company had not experienced any material Year
      2000 problems with its IT or non-IT systems or products, nor had
      the Company experienced any material problems with any of its key
      customers or suppliers.  The Company has no indication of any
      problems related to any customers or vendors.

      Initial orders and shipments for the first six weeks of the new
      year indicate that there may have been some accelerated

                                      31

      


      purchasing during the fourth quarter of 1999.  The Company,
      however, feels given the nature of its products that any anomaly
      to its established sales cycle will be short-lived.

      Financial Risk Management

      Bio-Rad uses derivative financial instruments to reduce the
      Company's exposure to fluctuations in foreign exchange rates and
      interest rates.  No derivative financial instruments are entered
      into for the purpose of speculating or trading.  Company policy
      limits all derivative positions exclusively to reducing risk by
      hedging an underlying economic exposure that can be effectively
      correlated to the Company's chosen hedging vehicle.  Changes in
      the value of the derivative are generally offset by reciprocal
      changes in Bio-Rad's underlying asset.

      Bio-Rad operates and conducts business in many foreign countries
      and is exposed to movements in foreign currency exchange rates.
      Additionally, Bio-Rad's consolidated net equity is impacted by
      the conversion of the net assets of international subsidiaries
      for which the functional currency is not the U.S. dollar.
      Foreign currency exposures are managed on a centralized basis by
      the Company's Treasury Department.  This allows for the netting
      of natural offsets and lowers transaction costs and exposures.
      Bio-Rad currently makes more than 50% of its sales outside the
      United States and weakening in one currency can often be offset
      by strengthening in another.

      Bio-Rad typically enters into forward exchange contracts to sell
      its foreign currency.  Contracts are entered into typically for
      30 to 60 days, primarily in British Sterling, Japanese Yen,
      Italian Lira and German Marks.  The costs are recognized in
      income monthly and generally are the reciprocal of the change in
      underlying assets.  Bio-Rad does not hold any derivative
      contracts that hedge its foreign currency denominated net asset
      exposures.

      Bio-Rad uses sensitivity analysis to assess the market risk
      associated with its foreign currency exchange risk.  Market risk
      is the potential change in fair value of derivative positions
      from an adverse movement in currency exchange rates.  The forward
      foreign exchange contracts at December 31, 1999 had a net fair
      value of $58.1 million.  A 10% adverse loss on quoted foreign
      currency exchange rates would result in a $5.8 million loss.
      This impact, of a change in exchange rates, excludes from the
      analysis the offset derived from the change in the Company's
      underlying assets and liabilities, which could reduce the effect
      to zero.


                                      32

      



      New Financial Accounting Standards

      In June 1998, the Financial Accounting Standards Board (FASB)
      issued Statement of Financial Accounting Standards (SFAS) No.
      133, "Accounting for Derivative Instruments and Hedging
      Activities" effective for fiscal years beginning after June 15,
      1999, with early adoption permitted.  The FASB has now delayed
      the SFAS No. 133 for all fiscal quarters of all fiscal years
      beginning after June 15, 2000.  This statement establishes
      accounting and reporting standards requiring companies to record
      all derivatives on the balance sheet as either assets or
      liabilities and measure those instruments at fair value.  The
      manner in which companies are to record gains or losses resulting
      from changes in the values of those derivatives depends on the
      use of the derivative and whether it qualifies for hedge
      accounting.  The impact of SFAS No. 133 on the Company's
      financial statements will depend on a variety of factors,
      including future interpretive guidance from the FASB, the future
      level of forecasted and actual foreign currency transactions, the
      extent of the Company's hedging activities, the types of hedging
      instruments used and the effectiveness of such instruments.
      However, the Company does not expect the effect of adopting SFAS
      No. 133 to have a material effect on its financial statements.

      Forward Looking Statements

      Other than statements of historical fact, statements made in this
      Annual Report include forward looking statements, such as
      statements with respect to the Company's future financial
      performance, operating results, plans and objectives.  We have
      based these forward looking statements on our current
      expectations and projections about future events.  However,
      actual results may differ materially from those currently
      anticipated depending on a variety of risk factors including
      among other things: our ability to successfully integrate with
      PSD, which we recently renamed "Bio-Rad Pasteur"; our substantial
      leverage and ability to service our debt; our ability to
      successfully develop and market new products; our reliance on and
      access to necessary intellectual property; competition in and
      government regulation of the industries in which we operate; and
      the monetary policies of various countries.  We undertake no
      obligation to publicly update or revise any forward looking
      statements, whether as a result of new information, future
      events, or otherwise.



                                      33


      </TEXT>
      </DOCUMENT>
<DOCUMENT>
<TYPE>EX-21
<SEQUENCE>8
<DESCRIPTION>EXHIBIT 21.1 - LISTING OF SUBSIDIARIES
<TEXT>

      

      EXHIBIT 21.1 - LISTING OF SUBSIDIARIES


                                                      JURISDICTION OF
      SUBSIDIARY                                       ORGANIZATION


      Bio-Rad Laboratories Pty. Limited                 Australia
      Sanofi Diagnostics Pasteur Pty.                   Australia
      Bio-Rad Laboratories Ges.m.b.H.                   Austria
      Sanofi Diagnostics Pasteur HgmbH                  Austria
      Bio-Rad International, Inc. (FSC)                 Barbados
      Bio-Rad Laboratories S.A.-N.V.                    Belgium
      RSL N.V.                                          Belgium
      Bio-Metrics Properties, Limited                   California, USA
      Bio-Rad Laboratories (Israel) Inc.                California, USA
      Bio-Rad Leasing Corporation                       California, USA
      Bio-Rad Pacific Limited                           California, USA
      Bio-Rad Laboratories (Canada) Limited             Canada
      Sanofi Diagnositcs Pasteur Inc.                   Canada
      Beijing Bio-Rad Analytical
        Biochemistry Instrument Co., Ltd.               China
      SoftShell International, Ltd.                     Colorado, USA
      Bio-Metrics, Limited                              Delaware, USA
      Bio-Rad Export, Inc. (DISC)                       Delaware, USA
      Bio-Metrics (U.K.) Limited                        England
      Bio-Rad Laboratories Europe Limited               England
      Bio-Rad Laboratories Limited                      England
      Bio-Rad Lasersharp Limited                        England
      Bio-Rad Limited                                   England
      Bio-Rad Micromeasurements Limited                 England
      Bio-Rad Microscience Limited                      England
      Micromeasurements Limited                         England
      Sadtler Research Laboratories Limited             England
      Sanofi Diagnostics Pasteur Ltd.                   England
      Bio-Rad S.A.                                      France
      Sanofi Diagnostics                                France
      Sanofi Diagnostics Pasteur                        France
      ADIL Instruments S.A.                             France
      Bio-Rad Laboratories G.m.b.H.                     Germany
      Sanofi Diagnostics GMB                            Germany
      Bio-Rad China Limited                             Hong Kong
      Bio-Rad Laboratories(India)Private Limited        India
      Bio-Rad Laboratories Israel Limited               Israel
      Bio-Rad Laboratories S.r.l.                       Italy
      Sanofi Diagnostics Pasteur S.r.l.                 Italy
      Nippon Bio-Rad Laboratories K.K.                  Japan
      Sanofi Fujirebio                                  Japan
      Bio-Rad Korea Ltd.                                Korea
      Bio-Rad Micromeasurements, Inc.                   Massachusetts, USA
      Bio-Rad Laboratories Mexico, S.A. de C.V.         Mexico
      Sanofi Diagnostics Pasteur                        Mexico
      Bio-Rad Laboratories B.V.                         The Netherlands
      Sanofi Diagnostics Pasteur BV                     The Netherlands
      Sandia Systems, Inc.                              New Mexico, USA
      Polaron Instruments, Inc.                         Pennsylvania, USA
      Sanofi Polska SP ZOO                              Poland
      Sanofi Diagnostics Pasteur LDA                    Portugal
      Bio-Rad Laboratories Ltd.                         Russia
      Bio-Rad Laboratories (Singapore) Pte.Limited      Singapore
      Sanofi Africa Ltd.                                South Africa
      Bio-Rad Laboratories S.A.                         Spain
      Sanofi Diagnostics Pasteur ESP                    Spain
      Bio-Rad Laboratories AB                           Sweden
      Bio-Rad Laboratories AG                           Switzerland
      Sanofi Diagnostics Pasteur S.A.                   Switzerland
      Sanofi Pacific Diagnostics Ltd.                   Thailand
      Blood Virus Diagnostics Inc.                      Washington, USA
      Genetic Systems Corporation                       Washington, USA
      Sanofi Diagnostics Pasteur Inc.                   Washington, USA

      </TEXT>
      </DOCUMENT>
<DOCUMENT>
<TYPE>EX-23
<SEQUENCE>9
<DESCRIPTION>EXHIBIT 23.1 - CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
<TEXT>


      

      EXHIBIT 23.1 - CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

      As independent public accountants, we hereby consent to the
      incorporation of our reports included or incorporated by
      reference in this Form 10-K, into the Company's previously filed
      Registration Statements on Form S-8 (File Nos. 33-53335 and
      33-53337).  It should be noted that we have not audited any
      financial statements of the Company subsequent to December 31,
      1999 or performed any audit procedures subsequent to the date of
      our report.





                                          /s/ Arthur Andersen LLP
                                              ARTHUR ANDERSEN LLP



      San Francisco, California,
        March 28, 2000

      </TEXT>

      </DOCUMENT>
<DOCUMENT>
<TYPE>EX-27
<SEQUENCE>10
<DESCRIPTION>EXHIBIT 27.1 FINANCIAL DATA SCHEDULE
<TEXT>

  




      <ARTICLE> 5
      <LEGEND>
         This schedule contains summary financial information extracted
         from Bio-Rad Laboratories, Inc. Form 10-K for the year ended
         December 31, 1999 and is qualified in its entirety by reference
         to such financial statements.
      </LEGEND>
      <MULTIPLIER> 1,000

                                                    
      <PERIOD-TYPE>                                    YEAR
      <FISCAL-YEAR-END>                          DEC-31-1999
      <PERIOD-END>                               DEC-31-1999
      <CASH>                                           17,087
      <SECURITIES>                                          0
      <RECEIVABLES>                                   203,480
      <ALLOWANCES>                                      9,582
      <INVENTORY>                                     126,277
      <CURRENT-ASSETS>                                378,717
      <PP&E>                                          250,568
      <DEPRECIATION>                                  124,626
      <TOTAL-ASSETS>                                  668,862
      <CURRENT-LIABILITIES>                           202,521
      <BONDS>                                         239,211
      <PREFERRED-MANDATORY>                                 0
      <PREFERRED>                                           0
      <COMMON>                                         12,463
      <OTHER-SE>                                      207,651
      <TOTAL-LIABILITY-AND-EQUITY>                    668,862
      <SALES>                                         549,489
      <TOTAL-REVENUES>                                549,489
      <CGS>                                           255,223
      <TOTAL-COSTS>                                   255,223
      <OTHER-EXPENSES>                                      0
      <LOSS-PROVISION>                                      0
      <INTEREST-EXPENSE>                               12,741
      <INCOME-PRETAX>                                  16,416
      <INCOME-TAX>                                      4,695
      <INCOME-CONTINUING>                              11,721
      <DISCONTINUED>                                        0
      <EXTRAORDINARY>                                       0
      <CHANGES>                                             0
      <NET-INCOME>                                     11,721
      <EPS-BASIC>                                      0.97
      <EPS-DILUTED>                                      0.96