Exhibit 10.4.1

                                     APPENDIX "A"

                     AMENDMENT TO THE BIO-RAD LABORATORIES, INC.
                                1994 STOCK OPTION PLAN


          This Amendment to the Bio-Rad Laboratories, Inc. 1994 Stock
          Option Plan (the "Amendment") is adopted by Bio-Rad Laboratories,
          Inc., a Delaware corporation (the"Company"), effective as of
          April 28, 1998.

                                      RECITALS:

          A.   The Company's 1994 Stock Option Plan (the "Stock Option
               Plan") was adopted by the Board of Directors (the
               "Board") on February 2, 1994, and approved by the
               stockholders of the Company on April 26, 1994.

          B.   The Stock Option Plan currently states that shares of
               the Company's Class A common stock or Class B common
               stock (the "Common Stock") subject to the Stock Option
               Plan shall not exceed 675,000.  This amendment
               increases the aggregate number of shares of Common
               Stock subject to the Stock Option Plan from 675,000 to
               1,175,000.

          C.   The Stock Option Plan currently states that no officer
               or director of the Company shall be granted options to
               purchase more than 337,500 shares of Common Stock.
               To keep this limitation proportionate to the amended
               number of shares subject to the Stock Option Plan, this
               amendment increases the individual limitation on
               options to 587,500 shares of Common Stock in the aggregate.

          D.   Section 9 of the Stock Option Plan provides that the
               Board may amend the Stock Option Plan, subject in
               certain instances to receipt of approval of the
               stockholders of the Company.

          E.   Effective March 11, 1998, the Board unanimously
               recommended and the Board unanimously adopted this
               Amendment in the form given below (the "Amendment").

          F.   The Amendment was approved by the stockholders of the
               Company at its Annual Meeting of Stockholders held on
               April 28, 1998.

  

                                      AMENDMENT

          1.   Section 4 of the Stock Option Plan is hereby amended
               to read in its entirety as follows:

           4 Shares Subject to Plan


          Options may be granted by the Company from time to time
          to Key Employees to purchase an aggregate of up to
          1,175,000 shares of Stock, which shares may be shares
          of either Class A or Class B Common Stock, and that
          number of shares of each such Class shall be reserved
          for options granted under the Plan (subject to
          adjustment as provided in paragraph 7(g)); provided,
          that no officer or director of the Company shall be
          granted options to purchase an aggregate of more than
          587,500 shares of Stock.  If any option granted under
          the Plan terminates, expires or, with the consent of
          the optionee, is canceled, new options may thereafter
          be granted covering such shares.

          The undersigned, Sanford S. Wadler, Secretary of the
          Company, hereby certifies that the Board and the
          stockholders of the Company adopted the foregoing
          Amendment as stated above.

          Executed at Hercules, California this 28th day of April,
          1998.



                                   /s/ Sanford S.Wadler
                                   Sanford S. Wadler, Secretary



                                                 Exhibit 10.4.2


          SECOND AMENDMENT TO THE BIO-RAD LABORATORIES, INC.
                        1994 STOCK OPTION PLAN


  This Second Amendment to the Bio-Rad Laboratories, Inc. 1994
  Stock Option Plan ("Second Amendment") is adopted by Bio-Rad
  Laboratories, Inc. a Delaware corporation ("Company"), effective
  as of December 6, 1999.

  1.   The third sentence of Section 5 of the Plan shall be
       amended to read as follows:

       "Options shall be granted pursuant to Section 6 of the Plan
       by a Committee that consists solely of two or more directors
       who are not employees of the Company, appointed by and
       holding office at the pleasure of the Board, each of whom is
       a 'non-employee director' as defined by Rule 16b-3 under the
       Exchange Act."


  2.   The second sentence of Section 6 of the Plan shall be
       amended to read as follows:

       "If, by their terms, such Incentive Stock Options taken
       together otherwise would vest at a faster rate, and unless
       otherwise provided by the Board, the vesting limitation
       described above shall be applied by taking Incentive Stock
       Options into account in the order in which they were granted
       in accordance with the ordering rule of Section 422(d)(2) of
       the Code, such that the earlier granted Incentive Stock
       Options (and portions thereof) shall vest before any later
       granted Incentive Stock Options, up to the maximum dollar
       limit described above."


  3.   The following sentence shall be added as the last sentence
       of subparagraph 7(j) of the Plan:

       "Notwithstanding any other provision of this Plan, the
       number of shares of Stock which may be withheld from the
       number of shares otherwise issuable upon the exercise of a
       Nonqualified Stock Option under the Plan in order to satisfy
       the holder's federal and state income and payroll tax
       liabilities with respect to the exercise of such
       Nonqualified Stock Option shall be limited to the number of
       shares which have a fair market value, as determined by the
       Committee, equal to the aggregate amount of such liabilities
       based on the minimum statutory withholding rates for federal
       and state tax income and payroll tax purposes that are
       applicable to such supplemental taxable income."


  4.   The heading of subparagraph 7(c) of the Plan shall be
       amended to read as follows:

       "Exercise in the Event of Death, Termination of Employment
       or Retirement."


       IN WITNESS WHEREOF, the Company has caused this Second
   Amendment to be executed this 6th day of December, 1999.

                                         BIO-RAD LABORATORIES, INC.



                              By:/s/ Sanford S. Wadler
                                    _______________________________
                                          Sanford S. Wadler
                                          Vice President and
                                          General Counsel

 
                                               Exhibit 10.4.3


                            Exhibit A

        THIRD AMENDMENT TO THE BIO-RAD LABORATORIES, INC.
                      1994 STOCK OPTION PLAN

             This Third Amendment ("Third Amendment") to the
   Bio-Rad Laboratories, Inc. 1994 Stock Option Plan ("the
   Plan") is adopted by Bio-Rad Laboratories, Inc. a Delaware
   corporation ("Company"), effective as of September 19, 2000.

        1.   Section 2 of Annex A of the Plan and Section
   2 of Annex B of the Plan shall be amended to read as
   follows:

     "Expiration Date.  Unless otherwise earlier terminated as
     provided herein, except for any option granted in 1999,
     the Option shall expire ten years after the date hereof."


        2.   Effective January 1, 2001, Section 3(a) of
   Annex A of the Plan shall be amended to read as
   follows:

        "(a)  Subject to the limitations provided in paragraph
     6(c)(ii) of the Plan, the Option shall become exercisable
     in five equal annual cumulative installments such that
     the Option shall become exercisable with respect to
     twenty percent (20%) of the Shares (of each class, if
     Shares of both classes may be purchased hereunder) on and
     after each of the first, second, third, fourth and fifth
     anniversary dates of this Agreement.  Each such
     installment which becomes exercisable shall remain
     exercisable until the Option expires as provided in this
     Agreement."

        3.   Effective January 1, 2001, Section 3(a) of
   Annex B of the Plan shall be amended to read as
   follows:

        "(a)  The Option shall become exercisable in five
     equal annual cumulative installments such that the Option
     shall become exercisable with respect to twenty percent
     (20%) of the Shares (of each class, if Shares of both
     classes may be purchased hereunder) on and after each of
     the first, second, third, fourth and fifth anniversary
     dates of this Agreement.  Each such installment which
     becomes exercisable shall remain exercisable until the
     Option expires as provided in this Agreement."

        4.   Section 7(c)(2) of the Plan, Section 6(b) of
   Annex A of the Plan and Section 6(b) of Annex B of the
   Plan shall be amended to read as follows:

     "If an optionee's employment terminates for any reason
     other than death or retirement, all right to exercise his
     or her option shall terminate at the date of such

  


     termination of employment.  If an optionee's employment
     terminates by reason of the optionee's retirement, all
     right to exercise his or her option shall terminate on
     the date of such termination of employment unless the
     Committee (in its sole discretion) extends the right to
     exercise his or her option by no more than four (4) years
     from the date of termination, or such lesser period
     specified in the option agreement; provided however, in
     no event shall an option be exercisable after the
     expiration date of the option."



        IN WITNESS WHEREOF, the Company has caused this Third
   Amendment to be executed this 19 day of September, 2000.


                       BIO-RAD LABORATORIES, INC.

                       By:/s/ Sanford S. Wadler