Bio-Rad Laboratories, Inc.
   SUMMARY OF OPERATIONS (In thousands, except per share data)
   
   
   ________________________________________________________________________________________________________________________
                                                                           Year Ended December 31,
                                                          2000        1999        1998        1997        1996       1995
                                                                                                 
   Net sales (1)                                       $725,884    $555,399    $447,863    $432,078    $423,262    $400,935

     Cost of goods sold (2)                             343,364     255,223     202,438     189,331     182,046     171,942

   Gross profit                                         382,520     300,176     245,425     242,747     241,216     228,993
     Selling, general and administrative expense (1)    247,613     200,367     172,899     169,956     159,989     154,589
     Product research and development expense            68,140      51,210      41,381      46,138      39,580      34,714
     Purchased in-process research and
      development expense                                     -      15,500           -           -           -           -
     Restructuring costs                                      -           -           -           -       2,700       1,500

   Income from operations                                66,767      33,099      31,145      26,653      38,947      38,190
   Other income (expense):
     Interest expense                                   (30,612)    (12,741)     (3,731)     (1,216)     (3,027)     (4,465)
     Other, net                                           9,288      (3,942)      6,814      (2,709)        553        (183)
   Income before taxes, extraordinary charge
    and cumulative effect of change in accounting
    principle                                            45,443      16,416      34,228      22,728      36,473      33,542
     Provision for income taxes                          13,633       4,695       9,926       6,364       9,118       8,386

   Income before extraordinary charge and cumulative
    effect of change in accounting principle             31,810      11,721      24,302      16,364      27,355      25,156
     Extraordinary charge (3)                                -           -           -           -      (1,176)         -
     Cumulative effect of change in accounting
      principle, net of taxes of $515 (4)                  (710)          -           -           -           -          -

   Net income                                          $ 31,100    $ 11,721    $ 24,302    $ 16,364    $ 26,179    $ 25,156

   Basic earnings per share before
    extraordinary charge and cumulative effect
    of change in accounting principle (5)                 $2.61       $0.97       $1.98       $1.33       $2.23       $2.06
     Extraordinary charge (3)(5)                              -           -           -           -       (0.10)         -
     Cumulative effect of change in accounting
      principle (4)                                       (0.06)          -           -           -           -          -
   Basic earnings per share (5)                           $2.55       $0.97       $1.98       $1.33       $2.13       $2.06

   Weighted average common shares (5)                    12,211      12,110      12,264      12,260      12,273      12,206
   Cash dividends paid per common share                       -           -           -           -           -          -

   Total assets                                        $646,278    $668,862    $367,299    $351,876    $284,925    $285,098
   Long-term debt, net of current maturities           $203,360    $239,211    $ 42,339    $ 38,952    $  6,721     $20,922

   _______________________________________________________________________________________________________________________
    <FN>
   (1) Restated to give effect to current presentation of freight charged to customers as a component of sales in
       compliance with FASB EITF Issue 00-10, Accounting for Shipping and Handling Fees and Costs.
   (2) In 1996, cost of goods sold includes a charge of $2.1 million for a write-down of inventory associated with the
       restructuring costs.
   (3) Extraordinary charge for redemption of subordinated debt:  1996 - $1,176, net of tax effect of $817.
   (4) Cummulative effect on prior years (to 12/31/99) of accounting change per SEC Staff Accounting Bulletin 101, on
       Revenue Recognition.
   (5) Restated to give effect to a stock split in the form of a 50% stock dividend in 1996.
   
                                                                 1
   




   Bio-Rad Laboratories, Inc.
   Consolidated Balance Sheets

   (In thousands)
    
    
   ________________________________________________________________________________________
                                                                    December 31,
   Assets                                                       2000             1999
                                                                        
   Current Assets:
     Cash and cash equivalents                               $ 13,954         $ 17,087
     Accounts receivable, less allowance of $10,255 in 2000
        and $9,582 in 1999                                    182,242          193,898

     Inventories:
       Raw materials                                           32,993           32,398
       Work in process                                         30,071           31,936
       Finished goods                                          69,455           61,943
         Total inventories                                    132,519          126,277

   Deferred tax assets                                         20,770           20,584
   Prepaid expenses and other current assets                   20,183           20,871
         Total current assets                                 369,668          378,717

   Property, Plant and Equipment:
     Land and improvements                                      8,337            8,937
     Buildings and leasehold improvements                      66,039           73,230
     Equipment                                                180,827          168,401
         Total property, plant and equipment                  255,203          250,568
     Accumulated depreciation                                (136,171)        (124,626)
         Net property, plant and equipment                    119,032          125,942

   Goodwill, net of accumulated amortization of
      $13,990 in 2000 and $5,881 in 1999                       90,970          105,350
   Other Assets                                                66,608           58,853

   Total Assets                                              $646,278         $668,862

   ________________________________________________________________________________________
   
   The accompanying notes are an integral part of these statements.



                                                2
  

   Bio-Rad Laboratories, Inc.
   Consolidated Balance Sheets
   (In thousands, except share data)
   
   
   __________________________________________________________________________________________
                                                                          December 31,
   Liabilities and Stockholders' Equity                                2000          1999
                                                                             
   Current Liabilities:
     Accounts payable                                                $ 62,965      $ 64,737
     Accrued payroll and employee benefits                             52,354        59,919
     Notes payable                                                      6,490        11,547
     Current maturities of long-term debt                              11,656        10,413
     Sales, income and other taxes payable                              8,413        14,086
     Other current liabilities                                         47,430        41,819
          Total current liabilities                                   189,308       202,521

   Long-Term Debt, net of current maturities                          203,360       239,211
   Deferred Tax Liabilities                                             8,992         7,016
          Total liabilities                                           401,660       448,748

   Commitments and Contingent Liabilities                                   -             -

   Stockholders' Equity:
     Preferred stock, $1.00 par value, 2,300,000 shares authorized;
       none outstanding                                                     -             -
     Class A common stock, $1.00 par value, 15,000,000 shares
       authorized; outstanding 2000 - 10,042,200;
       1999 - 9,977,862                                                10,042         9,978
     Class B common stock, $1.00 par value, 6,000,000 shares
       authorized; outstanding 2000 - 2,435,928;
       1999 - 2,484,716                                                 2,436         2,485
     Additional paid-in capital                                        19,120        18,830
     Class A treasury stock, 244,499 shares in 2000 and                (5,415)       (7,392)
       335,450 shares in 1999 at cost
     Retained earnings                                                231,821       200,993
     Accumulated other comprehensive income(loss):
       Currency translation and other                                 (13,386)       (4,780)

          Total stockholders' equity                                  244,618       220,114

   Total Liabilities and Stockholders' Equity                        $646,278      $668,862

   __________________________________________________________________________________________
   
   The accompanying notes are an integral part of these statements.
                                                3
   


   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Income
   (In thousands, except per share data)
   
   
   ______________________________________________________________________________________________________________________
                                                                                     Year Ended December 31,
                                                                           2000               1999                1998
                                                                                                       
   Net sales                                                             $725,884           $555,399            $447,863
     Cost of goods sold                                                   343,364            255,223             202,438

   Gross profit                                                           382,520            300,176             245,425
     Selling, general and administrative expense                          247,613            200,367             172,899
     Product research and development expense                              68,140             51,210              41,381
     Purchased in-process research and development expense                      -             15,500                   -

   Income from operations                                                  66,767             33,099              31,145

   Other income (expense):
     Interest expense                                                     (30,612)           (12,741)             (3,731)
     Investment income, net                                                   895                873               8,790
     Other, net                                                             8,393             (4,815)             (1,976)
   Income before taxes and cumulative effect of change
    in accounting principle                                                45,443             16,416              34,228
     Provision for income taxes                                            13,633              4,695               9,926


   Income before cumulative effect of change in
    accounting principle                                                   31,810             11,721              24,302
   Cumulative effect on prior years (to 12/31/99) of
    accounting change, net taxes of $515 (see Note 1)                        (710)                 -                   -
   Net income                                                            $ 31,100           $ 11,721            $ 24,302

   Basic earnings per share:

     Income before cumulative effect of change in
      accounting principle                                                  $2.61              $0.97               $1.98
     Cumulative effect on prior years (to 12/31/99)
      of accounting change                                                  (0.06)                 -                   -

     Net income                                                             $2.55              $0.97               $1.98
     Weighted average common shares                                        12,211             12,110              12,264
   Diluted earnings per share:

     Income before cumulative effect of change in
      accounting principle                                                  $2.59              $0.96               $1.97
     Cumulative effect on prior years (to 12/31/99)
      of accounting change                                                  (0.06)                 -                   -

     Net income                                                             $2.53              $0.96               $1.97
      Weighted average common shares                                       12,284             12,165              12,358
  _______________________________________________________________________________________________________________________
   The accompanying notes are an integral part of these statements.
   
                                                                  4
   


   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Cash Flows
   (In thousands)
   
   
   ________________________________________________________________________________________________________
                                                                          Year Ended December 31,
                                                                       2000         1999        1998
   
   Cash flows from operating activities:                                               
        Cash received from customers                                 $707,046    $527,132    $436,029
        Cash paid to suppliers and employees                         (632,803)   (453,266)   (395,265)
        Interest paid                                                 (27,124)     (9,307)     (3,833)
        Income tax payments                                           (12,294)    (17,237)     (9,370)
        Miscellaneous payments                                        (10,578)     (2,341)       (226)

        Net cash provided by operating activities                      24,247      44,981      27,335

   Cash flows from investing activities:
        Capital expenditures, net                                     (31,406)    (27,275)    (21,176)
        Payments for acquisitions                                           -    (202,828)          -
        Proceeds from divestitures                                     34,118           -           -
        Purchases of marketable securities and investments               (326)     (2,216)    (19,086)
        Sales of marketable securities and investments                    795       6,600      16,367
        Foreign currency hedges, net                                    6,115       2,401      (1,360)

        Net cash provided by (used in) investing activities             9,296    (223,318)    (25,255)

   Cash flows from financing activities:
        Net payments on notes payable                                  (4,325)    (13,493)     (1,365)
        Long-term borrowings                                          438,487     353,108     133,710
        Payments on long-term debt                                   (473,278)   (151,788)   (130,666)
        Arrangement and other fees for
          long-term acquisition financing                              (4,500)     (5,008)          -
        Proceeds from issuance of common stock                            305         343         103
        Purchase of treasury stock                                       (378)     (2,233)     (4,665)
        Reissuance of treasury stock                                    2,083       1,322       1,978

        Net cash provided by (used in) financing activities           (41,606)    182,251        (905)


   Effect of exchange rate changes on cash                              4,930       3,092      (1,937)
   Net increase (decrease) in cash and cash equivalents                (3,133)      7,006        (762)

   Cash and cash equivalents at beginning of year                      17,087      10,081      10,843
   Cash and cash equivalents at end of year                          $ 13,954    $ 17,087    $ 10,081
   ________________________________________________________________________________________________________
   
   The accompanying notes are an integral part of these statements.
                                                       5
   


   Bio-Rad Laboratories, Inc.
   Consolidated Statements of Changes in Stockholders' Equity
   (In thousands)
   
   
   ______________________________________________________________________
                                              Year Ended December 31,
                                           2000        1999       1998
   
   Common Stock, $1.00 par value:                         
     Balance at beginning of year         $12,463    $ 12,427   $ 12,421
     Issuance of common stock                  15          36          6
     Balance at end of year                12,478      12,463     12,427

   Additional Paid-In Capital:
     Balance at beginning of year          18,830      18,523     18,426
     Issuance of common stock                 290         307         97
     Balance at end of year                19,120      18,830     18,523

   Treasury Stock:
     Balance at beginning of year          (7,392)     (7,047)    (6,006)
     Purchase of treasury stock              (378)     (2,233)    (4,665)
     Reissuance of treasury stock           2,355       1,888      3,624
     Balance at end of year                (5,415)     (7,392)    (7,047)

   Retained Earnings:
     Balance at beginning of year         200,993     189,838    167,182
     Net income                            31,100      11,721     24,302
     Reissuance of treasury stock at
       less than cost                        (272)       (566)    (1,646)
     Balance at end of year               231,821     200,993    189,838

   Accumulated Other
    Comprehensive Income (Loss):
     Balance at beginning of year          (4,780)        593      4,654
     Other comprehensive loss              (8,606)     (5,373)    (4,061)
     Balance at end of year               (13,386)     (4,780)       593
                                         ________    ________   ________
   Total Stockholders' Equity            $244,618    $220,114   $214,334


   Comprehensive Income:
     Net income                          $ 31,100    $ 11,721   $ 24,302
     Currency translation adjustments      (8,804)     (4,833)     1,241
     Net unrealized holding gains             533          66        819
     Reclassification adjustments for
       gains included in net income          (335)       (606)    (6,121)

   Total Comprehensive Income            $ 22,494    $  6,348   $ 20,241
   _________________________________________________________________________
   

   The accompanying notes are an integral part of these statements.

                                      6
   



        Bio-Rad Laboratories, Inc.

        Notes to Consolidated Financial Statements
        (In thousands of dollars, except share and per share data)
        _________________________________________________________________

        1.  Significant Accounting Policies

        Basis of Presentation

        The consolidated financial statements include the accounts of Bio-Rad
        Laboratories, Inc. and all subsidiaries ("Bio-Rad" or the "Company")
        after elimination of intercompany balances and transactions.  The
        preparation of financial statements in conformity with generally
        accepted accounting principles requires management to make estimates
        and assumptions that affect the amounts reported in the financial
        statements and accompanying notes.  Changes in such estimates may
        affect amounts reported in the future.

        Reclassifications

        Certain prior period amounts have been reclassified to conform with
        the current year presentation.  Pursuant to Financial Accounting
        Standards Board Emerging Issues Task Force Issue No.00-10, "Accounting
        for Shipping and Handling Fees and Costs", the Company has also
        reclassified freight billed to customers from selling, general and
        administrative expenses to net sales.  The amounts reclassified were
        $5,910 and $5,921 for 1999 and 1998, respectively.  Related freight
        costs are included in selling, general and administrative expenses as
        the responsibility for negotiating sales terms rests with the sales
        organization and not manufacturing.

        Cash and Cash Equivalents

        Cash and cash equivalents consist of cash and highly liquid in-
        vestments with original maturities of three months or less which are
        readily convertible into cash.  Cash equivalents are stated at cost,
        which approximates fair market value.

        Concentration of Credit Risk

        Financial instruments that potentially subject the Company to
        concentration of credit risk consist primarily of trade accounts
        receivable.  The Company performs credit evaluation procedures and
        with the exception of certain developing countries, generally does not
        require collateral.  As a result of increased risk in these countries,
        some Bio-Rad sales are subject to collateral letters of credit.
        Credit risk is limited due to the large number of customers and their
        dispersion across many geographic areas.  However, a significant
        amount of trade receivables are with national healthcare systems in
        countries within the European Economic Community.  The Company does
        not currently anticipate a credit risk associated with these receiv-
        ables.



                                           7

        




        Inventory Valuation

        Inventories are valued at the lower of average cost or market and
        include material, labor and overhead costs.

        Property, Plant and Equipment

        Property, plant and equipment are carried at historical cost.
        Depreciation is computed on a straight-line basis over the estimated
        useful lives of the assets ranging from two to thirty years.
        Leasehold improvements are amortized over the lives of the respective
        leases or the lives of the improvements, whichever is shorter.

        Included in property, plant and equipment is reagent rental equipment.
        The Company provides these instruments to its customers for use with
        the Company's reagents.  Depreciation is taken over the useful life of
        the equipment, which does not exceed five years.

        Marketable Securities

        The Company's marketable securities, included in Other Assets, are
        classified as available-for-sale and are recorded at current market
        value.  Unrealized holding gains and losses are included as a separate
        component of stockholders' equity.  Realized gains and losses are
        included in investment income. For the purpose of determining realized
        gains and losses, the cost of securities sold is based upon specific
        identification.

        Goodwill

        Goodwill, representing the excess of the cost over the net tangible
        and identifiable intangible assets of acquired businesses, is stated
        at cost and is amortized on a straight-line basis over the estimated
        future periods to be benefited, typically ten to fifteen years.
        Goodwill, other intangibles and other long-lived assets are
        periodically reviewed for impairment whenever events or changes in
        circumstances indicate that the carrying amount of an asset may not be
        recoverable.

        Revenue Recognition and Warranty

        Bio-Rad recognizes revenues when persuasive evidence of an arrangement
        exists, delivery has occurred, the sales price is fixed or
        determinable and collectibility is probable.  Generally, these
        criteria are met at the time product is shipped.  Provision is made at
        the time the related revenue is recognized for estimated product
        returns and other offerings which may occur under programs the Company
        has with its customers.

        The Company warrants certain equipment against defects in design,
        materials and workmanship, generally for one year.  Upon shipment of
        equipment sold which includes a warranty, the Company establishes, as
        part of cost of goods sold, a provision for the expected costs of such
        warranty.


                                           8

        




        Foreign Currency Translation

        Balance sheet accounts of international subsidiaries are translated at
        the current exchange rate as of the end of the accounting period.
        Income statement items are translated at average exchange rates.  The
        resulting translation adjustment is recorded as a separate component
        of stockholders' equity.

        Forward Exchange Contracts

        The Company does not use derivative financial instruments for
        speculative or trading purposes.  As part of distributing its
        products, the Company regularly enters into intercompany transactions.
        The Company enters into forward foreign exchange contracts to hedge
        against future movements in foreign exchange rates that affect foreign
        currency denominated intercompany receivables and payables.  These
        contracts generally have maturity dates of 60 days or less, relate
        primarily to currencies of industrial countries and are marked to
        market at each balance sheet date.  The resulting gains or losses are
        included in other income and expense and offset exchange losses or
        gains on the related receivables and payables.  Unrealized gains and
        losses are not deferred.  Exchange gains and losses on these contracts
        are net of premiums and discounts which result from interest rate
        differentials between the U.S. and the countries of the currencies
        being traded.  The cash flows related to these contracts are
        classified as cash flows from investing activities in the Statement of
        Cash Flows.

        Stock Compensation Plans

        Stock-based compensation is recognized using the intrinsic value
        method.  For disclosure purposes, pro forma net income and earnings
        per share are provided as if the fair value method had been applied.

        Earnings Per Share

        Basic earnings per share are calculated on the basis of the weighted
        average number of common shares outstanding for each period.  Diluted
        earnings per share are calculated assuming the exercise of certain
        stock options.  Treasury stock is not considered outstanding for
        purposes of calculating weighted average shares.

        Fair Value of Financial Instruments

        The estimated fair value of financial instruments has been determined
        using available market information or other appropriate valuation
        methodologies.  Estimates are not necessarily indicative of the
        amounts that could be realized in a current market exchange as
        considerable judgement is required in interpreting market data used to
        develop estimates of fair value.  The use of different market

                                           9

         





        assumptions or estimation techniques could have a material effect of
        the estimated fair value amounts.

        The estimated fair value of Bio-Rad's financial instruments were as
        follows:

                                           Year Ended December 31,
                                        2000                    1999
                              Carrying         Fair    Carrying       Fair
                               Amount         Value      Amount       Value

        Other assets         $  66,608     $  65,000  $  58,853     $  59,000
        Long-term debt       $ 203,360     $ 212,000  $ 239,211     $ 239,000

        Other Assets include financial instruments (e.g., notes receivable)
        that have fair values based on discounted cash flows, market
        quotations, and other appropriate valuation techniques.  Long-term
        debt has an estimated fair value based on quoted market prices for the
        same or similar issues.

        For certain of the Company's financial instruments, including cash and
        cash equivalents, accounts receivable, marketable securities, notes
        payable, accounts payable, and forward exchange contracts, the
        carrying amounts approximate fair value.

        Accounting Change

        During the fourth quarter of 2000, the Company modified its revenue
        recognition policies to comply with guidelines outlined by the SEC in
        Staff Accounting Bulletin 101.  The effects of the change in revenue
        recognition policies, as of January 1, 2000, are reported as the
        cumulative effect of an accounting change in the fourth quarter of
        2000.  This change did not have a significant effect on previously
        reported quarterly or prior years' income.

        2.  Acquisitions and Dispositions

        In July 2000, Accent Semiconductor Technology, Inc. ("ASTI") acquired
        the assets and certain liabilities of the Company's semiconductor and
        optoelectronic metrology business.  The proceeds of approximately
        $36,000 represent $27,000 in cash, an $8,000 note receivable due in
        five years and an 18% passive equity interest in ASTI.  The Company
        used $17,000 of the cash proceeds to reduce borrowings on the term
        loan portion of the Senior Credit facility.  The equity interest in
        ASTI will be held as a long-term investment on the cost method.

        In October 1999, the Company acquired Pasteur Sanofi Diagnostic S.A.,
        a French corporation ("PSD"), from its shareholders, Sanofi-Synthelabo
        S.A. and Institut Pasteur. PSD was founded by the Institut Pasteur and
        operates in the HIV and infectious disease diagnostic product market.

                                          10
        




        The Company paid $202,828 for all of the capital stock of PSD (and
        certain ancillary assets and assumed liabilities related to PSD).
        The purchase of PSD was financed with the proceeds from a $200,000
        Senior Credit Agreement and a $100,000 Senior Subordinated Credit
        Agreement (see Note 5).  The acquisition was accounted for using the
        purchase method of accounting.  The 1999 operating results of PSD have
        been included in the Consolidated Statement of Income from the date of
        acquisition.

        As a result of the acquisition, the Company recorded $88,630 of
        goodwill.  Goodwill reflects the excess of the purchase price,
        purchase liabilities and liabilities assumed over the fair value of
        net identifiable assets and in-process research and development
        projects acquired.  Acquired in-process research and development of
        $15,500 was charged to expense in the fourth quarter of 1999 in
        accordance with generally accepted accounting principles.  Purchase
        liabilities recorded included approximately $14,000 for severance and
        other employee costs and $4,000 for the consolidation and closure of
        certain leased facilities.  The closure of facilities identified by
        the Company were completed in fiscal 2000, with lease payments, net of
        sublease revenues, continuing until all contractual obligations are
        met.  As of December 31, 2000, expenses charged against these reserves
        were approximately $12,400 for severance and other employee costs and
        $1,600 for facilities and asset related write-offs.

        As the Company's 1999 financial statements include only three months
        of operations of PSD, the following selected unaudited pro forma
        information is being provided to present a summary of the combined
        results of Bio-Rad and PSD as if the acquisition had occurred as of
        January 1, 1998, giving effect to purchase accounting adjustments and
        actual costs of financing.  The pro forma data is for informational
        purposes only and may not necessarily reflect the results of
        operations of Bio-Rad had PSD operated as part of the Company for the
        years ended December 31, 1999 and 1998.

                                                Unaudited Pro Forma
                                               Year Ended December 31,
                                                 1999            1998

             Sales                             $727,900        $675,700
             Net income (loss)                  $ 6,300         $(5,000)
             Basic earnings (loss)per share       $0.52          $(0.41)

        The pro forma amounts reflect the results of operations for Bio-Rad
        and PSD and the following purchase accounting adjustments for the
        periods presented:

             Amortization of intangible assets and goodwill was based on the
             purchase price allocation for the period presented.

             Amortization of debt financing fees and expenses over the
             relative term of the following debt: Senior Credit
             Agreement,  Senior Subordinated Credit Facility and Senior
             Subordinated Notes.


                                          11
             




             The additional interest expense on debt incurred to finance
             the acquisition was offset by a reduction of historical interest
             resulting from the elimination of PSD's debt.

             The estimated income tax effect on the pro forma
             adjustments, including a limitation on the deductibility of
             goodwill amortization.

             The pro forma statements do not include the $15,500 write-
             off of in-process research and development.  This charge is
             included in the Consolidated Statements of Operations of the
             Company for 1999.

        3. Investment Income

        Investment income in 1998 included $8,620 of net realized gains from
        the sales of marketable securities.  The majority of the Company's
        marketable securities portfolio was sold in 1999 in preparation for
        the purchase of PSD.

        4.  Investment in Affiliates

        In December 1997, Bio-Rad began investing in Instrumentation
        Laboratory, S.p.A. (IL), an Italian based clinical diagnostics
        company.  At December 31, 2000, Bio-Rad held approximately 28% of the
        outstanding stock of IL.  A privately held company based in Spain
        controls over 51% of the outstanding stock of IL.  The investment in
        IL is reviewed as published financial statements are made available to
        the Company.  The most recently published financial statements for IL
        are as of November 1999.

        Given the limited availability of financial information, that no
        organized market exists for the shares to be traded and that Bio-Rad
        does not have the ability to significantly influence the operating and
        financial policies of IL, the investment has been recorded at its cost
        of $18,809 and is included in Other Assets.

        5.  Notes Payable and Long-Term Debt

        Notes payable include local credit lines maintained by the Company's
        subsidiaries aggregating approximately $25,611, of which $19,121 was
        unused at December 31, 2000.  At December 31, 1999 these lines
        aggregated approximately $32,742, of which $21,195 was unused.  The
        weighted average interest rate on these lines was 7.29% and 5.76% at
        December 31, 2000 and 1999, respectively.  The Company guarantees most
        of these credit lines.






                                          12
         




        The principal components of Long-Term Debt are as follows:

                                              Year Ended December 31,
                                                2000            1999
        Senior Subordinated Credit
          Agreement                         $      -         $100,000
        Senior Credit Agreement:
          Term loan                           63,000          100,000
          Revolving credit agreement           1,750           49,000
        Senior Subordinated Notes            148,467                -
        Capitalized leases                     1,799              624
                                             215,016          249,624
        Less current maturities               11,656           10,413
        Long-Term Debt                      $203,360         $239,211

        In September 1999, the Company entered into a $200,000 Senior Credit
        Agreement and a $100,000 Senior Subordinated Credit Agreement to
        finance the acquisition of PSD and certain related assets and to
        provide funds for working capital needs.  The Senior Credit Agreement
        included a term loan and revolving facility, each in the amount of
        $100,000.  The term loan has since been reduced through permanent
        repayments to $63,000.  1999 debt issue costs related to these
        financings were $8,600.

        The Company entered into a $100,000 Senior Subordinated Credit
        Agreement dated January 31, 2000.  This agreement had a one-year term
        and provided for an automatic rollover for an additional term maturing
        in September 2005.  The proceeds of this transaction were used to
        replace the Senior Subordinated Credit Agreement dated September 30,
        1999.  Fees paid in January 2000 to replace and initiate the Senior
        Subordinated Credit Agreements were $4,000.  This loan was repaid in
        February 2000.

        The Company sold $150,000 aggregate principal amount of Senior
        Subordinated Notes due in 2007 under an indenture dated February 17,
        2000.  The notes were offered at 98.832% of par and pay a fixed rate
        of interest of 11.625% per year.  The notes are redeemable at the
        Company's option prior to the due date under certain terms and
        conditions.  The Company's obligations under the notes are not secured
        and rank junior to all the Company's existing and future senior debt.
        The proceeds from this transaction were used (1) to repay the $100,000
        Senior Subordinated Credit Agreement dated January 31, 2000, (2) to
        permanently retire $20,000 of the $100,000 term loan, and (3) to repay
        a portion of the outstanding borrowings under the revolving facility.

        The term loan and revolving facility are secured by an interest in the
        Company's assets through September 2004.  Interest on both loans is
        based upon either the Eurodollar, the Federal Funds effective or
        corporate based (prime) rate.  The term loan interest rate was 8.14%
        at December 31, 2000.  The interest rate on the revolving facility at
        December 31, 2000 was 9.50%.  A commitment fee ranging from .25% to
        .50% annually is charged on the daily unused portion of the revolving
        credit agreement.



                                          13
        




        The Senior Credit Agreement (including amendments) and the Senior
        Subordinated Notes require the Company, among other things, to comply
        with certain financial ratios and covenants.  The Company was in
        compliance with all financial ratios as of December 31, 2000. These
        agreements also contain certain other restrictions, including
        limitations on payments of cash dividends, sales of assets, incurrence
        of indebtedness, the creation of liens, making certain investments and
        engaging in sale/leaseback transactions.

        Maturities of long-term debt at December 31, 2000, are as follows:
        2001 - $11,656; 2002 - $14,566; 2003 - $17,540; 2004 - $21,036;
        2005 - $0; thereafter - $150,218.

        6.  Income Taxes

        The U.S. and international components of income before taxes are
        as follows:
                                           Year Ended December 31,
                                         2000       1999        1998

        U.S.                           $  6,429   $ 15,176    $ 24,173
        International                    39,014      1,240      10,055

        Income before taxes and
        cumulative effect of change
        in accounting principle        $ 45,443   $ 16,416    $ 34,228

        The provision for income taxes consists of:

                                           Year Ended December 31,
                                         2000       1999        1998
        Current:
          U.S. Federal                 $ (4,576)  $  4,583    $  8,564
          International                  15,284      8,323       4,974
          U.S. State                        585        853         374
                                         11,293     13,759      13,912
        Deferred                          2,340     (9,064)     (3,986)

        Provision for income taxes     $ 13,633   $  4,695    $  9,926




                                        14
        





        The Company's income tax provision differs from the amount
        computed by applying the U.S. federal statutory rate to income
        before taxes as follows:

                                            Year Ended December 31,
                                          2000      1999        1998

        U.S. statutory tax rate           35%        35%         35%
        State taxes, net of
          federal income tax benefit       2          2          (1)
        Foreign Sales Corporation
          tax benefit                     (3)       (10)         (5)
        Research and development
          tax credit                      (2)        (1)         (1)
        Difference between U.S. and
          foreign tax rates (net of
          foreign tax credits)            (1)        12           -
        Loss carryforwards utilized        0         (5)         (1)
        Amortization of goodwill           1          4           -
        Foreign losses not benefited       4         31           -
        Favorable resolution of U.S.
          income tax disputes             (1)       (40)          -
        Foreign exchange gain/(loss)
          recognized                      (6)         -           -
        Other                              1          1           2
        Provision for income taxes        30%        29%         29%

        Deferred income taxes reflect the net tax effect of temporary
        differences between the carrying amounts of assets and
        liabilities for financial reporting purposes and the amounts used
        for income tax purposes.  Significant components of deferred tax
        assets and liabilities are as follows:

                                               Year Ended December 31,
                                                2000            1999
        Deferred Tax Assets:
          Reserves for obsolete inventory,
            warranty and bad debts            $ 11,845        $ 12,622
          Eliminated intercompany profit         3,823           3,661
          Tax benefit of foreign loss
            carryforwards                       12,629          16,457
          Other                                  9,493          11,975
                                                37,790          44,715
          Valuation allowance                  (17,020)        (24,131)
          Deferred Tax Assets                 $ 20,770        $ 20,584
        Deferred Tax Liabilities:
          Deferred gain on condemnation       $  3,444        $  3,522
          Depreciation                           1,325           1,567
          Development cost of Hercules
            facility                             1,483           1,385
          Other                                  2,740             542
          Deferred Tax Liabilities            $  8,992        $  7,016



                                        15
          





        The valuation allowance is needed to reduce the deferred tax
        assets to an amount that is more likely than not to be realized.
        The net change in the valuation allowance in 2000 was a decrease
        of $7,111, primarily resulting from a utilization of tax loss
        carryforwards.  Carryforwards resulting from the acquisition of
        PSD, which were not valued at the acquisition date, adjusted the
        recorded goodwill by approximately $5,800.  The net change in
        1999 was an increase of $18,789 primarily resulting from an
        increase in tax loss carryforwards.

        At December 31, 2000, Bio-Rad's international subsidiaries had
        combined net operating loss carryforwards of $31,759.  A portion
        of these loss carryforwards will expire in the following years:
        2002 - $629; 2003 - $145; 2004 - $172; and 2005 - $1,582.  The
        remainder of these loss carryforwards have no expiration date.
        The utilization of these carryforwards is limited to the separate
        taxable income of each individual subsidiary.

        Bio-Rad does not provide for taxes which would be payable if the
        cumulative undistributed earnings of its international subsidiaries,
        approximately $55,666 at December 31, 2000, were remitted to the U.S.
        parent company.  Unless it becomes advantageous for tax or foreign
        exchange reasons to remit a subsidiary's earnings, such earnings are
        indefinitely reinvested in subsidiary operations.  The withholding tax
        and U.S. federal income taxes on these earnings, if remitted, would in
        large part be offset by tax credits.

        7.  Stockholders' Equity

        Stock Classification

        The Company's outstanding stock consists of Class A Common Stock
        (Class A) and Class B Common Stock (Class B).  Each share of Class A
        and Class B participates equally in the earnings of Bio-Rad, and is
        identical in most respects except that Class A has limited voting
        rights.  Each share of Class A is entitled to one-tenth of a vote on
        most matters, and each share of Class B is entitled to one vote.
        Additionally, Class A stockholders are entitled to elect 25% of the
        Board of Directors and Class B stockholders are entitled to elect the
        balance of the directors.  Cash dividends may be paid on Class A
        shares without paying a cash dividend on Class B shares but no cash
        dividend may be paid on Class B shares unless at least an equal cash
        dividend is paid on Class A shares.  Class B shares are convertible at
        any time into Class A shares on a one-for-one basis at the option of
        the stockholder.

        Stock Option Plans

        Bio-Rad maintains incentive and non-qualified stock option plans for
        officers and certain other key employees.  Under the Amended 1994
        Stock Option Plan (the Plan), the Company may grant options to its
        employees for up to 1,175,000 shares of common stock provided that no
        option shall be granted after March 1, 2004.  Under the plans, Class A
        and Class B options are granted at prices not less than fair market
        value on the date of grant, are exercisable on a cumulative basis at a

                                          16
        




        rate not greater than 25% per annum commencing one year after the date
        of grant. Under an amendment to the Plan effective September 19, 2000,
        options expire ten years after the grant date with the exception of
        options granted in 1999 which expire five years after the grant date.

        The Company has made no charge to income with respect to any stock
        options.  At the time options are exercised, the par value of the
        shares is credited to common stock and the excess is credited to
        additional paid-in capital.  The Company may receive income tax
        benefits from the exercise of non-qualified stock options and from
        certain dispositions of stock received by employees under qualified or
        incentive stock options.  The fair value of each option granted since
        January 1, 1995, was estimated on the date of the grant using the
        Black-Scholes option-pricing model with the following assumptions for
        grants in 2000, 1999 and 1998, respectively:  no dividend yield for
        all periods; weighted average expected lives of 4.1 years in 2000,
        3.9 in 1999 and 3.8 years in 1998; expected volatility of 30%, 34% and
        35%; and risk-free interest rates of 6.71%, 4.79% and 5.44% for 2000,
        1999 and 1998, respectively.






                                        17
         
         
        Activity under the plans is summarized below (amounts reported in the Price columns
        represent the weighted average exercise price):
         
                                                                      Year Ended December 31,
                                                     2000                         1999                       1998
                                             Shares         Price        Shares          Price       Shares         Price
                                                                                                 
          Outstanding at beginning of year  645,115        $24.18        561,047        $23.73       517,018       $21.40

          Granted                           530,945         22.52        166,080         19.89       150,653        23.54

          Exercised                         (65,250)        18.95        (60,914)         8.47       (89,625)       10.09

          Forfeited                        (111,338)        24.61        (19,712)        25.10       (14,677)       25.07

          Expired                           (38,583)        18.21         (1,386)         7.37        (2,322)        9.46

          Outstanding at end of year        960,889        $23.80        645,115        $24.18       561,047       $23.73


          Options exercisable at year-end   272,048        $26.92        280,825        $24.72       222,539       $19.86


          Weighted average fair value of
            options granted during the year   $6.91                        $6.46                       $7.62

          
          
          The following summarizes information about stock options outstanding at December 31, 2000:
          
                                                 Options Outstanding                        Options Exercisable

                                  Number        Weighted Average                         Number
                Range of        Outstanding         Remaining       Weighted Average  Exercisable    Weighted Average
             Exercise Prices    at 12/31/00     Contractual Life     Exercise Price   at 12/31/00     Exercise Price
                                                                                          
             $19.69 - $19.88      120,281          3.1 years            $19.74           27,668          $19.73
             $21.50 - $21.50      295,865          9.7                   21.50                0               0
             $21.86 - $23.88      280,566          8.4                   23.43           43,173           22.99
             $23.94 - $35.89      264,177          6.1                   28.63          201,207           28.75
             $19.69 - $35.89      960,889          7.5                   23.80          272,048           26.92

             


                                                                  18

             




        Employee Stock Purchase Plan

        Under the Amended and Restated 1988 Employee Stock Purchase Plan (the
        Plan), the Company has authorized the sale of 745,000 shares of Class
        A to eligible employees.  The purchase price of the shares under the
        Plan is the lesser of 85% of the fair market value on the first day of
        each calendar quarter, or 85% of the fair market value on the last day
        of each calendar quarter.  Employees may designate up to 10% of their
        compensation for the purchase of stock.  Under the Plan, the Company
        sold 57,101 shares for $1,136, 58,762 shares for $1,098 and 51,446
        shares for $1,129 to employees in 2000, 1999 and 1998, respectively.
        At December 31, 2000, 48,263 shares remained authorized under the
        Plan.

        The fair value of the employees' purchase rights since 1995 was
        estimated using the Black-Scholes model with the following assumptions
        for 2000, 1999 and 1998, respectively:  no dividend yield for all
        periods; an expected life of three months for all periods; expected
        volatility ranging from 28% to 43%, from 22% to 35% and from 28% to
        38%; and risk-free interest rates ranging from 5.45% to 6.46%, from
        4.28% to 4.88% and from 4.27% to 5.23%.  The weighted average fair
        value of those purchase rights granted in 2000, 1999 and 1998 was
        $5.10, $4.74 and $5.55, respectively.

        Pro Forma Disclosures

        If compensation cost for the Company's stock-based compensation plans
        had been determined based upon the fair value at grant dates for
        awards under those plans, the Company's net income and earnings per
        share would have been reduced to the pro forma amounts indicated
        below:

                                                 Year Ended December 31,
                                               2000       1999        1998

        Net income             As reported    $31,100    $11,721    $24,302
                               Pro forma      $29,874    $10,469    $23,026

        Diluted earnings per   As reported      $2.53      $0.96      $1.97
          share                Pro forma        $2.45      $0.86      $1.86

        Since employee stock options vest over several years, and
        additional grants are likely to be made in the future, the
        disclosures may not be representative of the effects on reported
        pro forma net income or earnings per share in future years.




                                        19
        





        8. Earnings Per Share

        Weighted average shares used for diluted earnings per share
        include the dilutive effect of outstanding stock options of
        73,000, 55,000 and 94,000 shares, for the years ended
        December 31, 2000, 1999 and 1998, respectively.

        Options to purchase 201,000, 261,000 and 229,000 shares of common
        stock were outstanding during 2000, 1999 and 1998, respectively,
        but were excluded from the computation of diluted earnings per
        share because the exercise price of the options was greater than
        the average market price of the common shares.  The options were
        still outstanding at the end of 2000.

        9.  Other Income and Expense

        Other, net includes the following income and (expense)
        components:
                                              Year Ended December 31,
                                           2000        1999       1998

        Amortization of goodwill         $(8,109)    $(3,813)   $(2,068)
        Exchange gains (losses)             (420)       (886)        22
        Other non-operating litigation
          costs, net                      (3,339)         73        117
        Gain on sale of fixed assets       5,155           -          -
        Gain on sale of semiconductor
          division                        16,690           -          -
        Miscellaneous other items         (1,584)       (189)       (47)
        Other, net                       $ 8,393     $(4,815)   $(1,976)

        Non-operating litigation costs represent fees incurred to
        litigate intellectual property issues.  Management does not
        believe that the outcome of these actions would have a material
        adverse effect on the future results of operations or the
        financial position of the Company.  The Company will continue to
        incur costs relating to these issues.

        Exchange gains (losses) include premiums and discounts on forward
        foreign exchange contracts.




                                        20

       




   10.  Supplemental Cash Flow Information

   The reconciliation of net income to net cash provided by operating
   activities is as follows:

                                                     Year Ended December 31,
                                                     2000      1999      1998

   Net income                                      $31,100   $11,721   $24,302
   Adjustments to reconcile net income to
    net cash provided by operating activities:
     Depreciation                                   33,722    23,090    18,510
     Amortization                                    9,587     4,405     2,465
     Foreign currency hedge transactions, net       (6,115)   (2,401)    1,360
     Gains on dispositions of marketable securities   (479)     (850)   (8,620)
     Increase in accounts receivable, net             (329)  (16,082)   (5,739)
     (Increase) decrease in inventories            (18,915)    4,095      (166)
     Decrease in other current assets                  914     5,609     4,629
     Increase (decrease) in accounts payable and
      other current liabilities                       (586)   26,153    (4,808)
     Increase (decrease) in income taxes payable    (4,599)    4,804     1,040
     Increase (decrease) in deferred taxes           3,383   (16,946)   (5,292)
     Gain on sale of semiconductor division
      and fixed assets                             (21,845)        -         -
     Other                                          (1,591)    1,383      (346)
   Net cash provided by operating activities       $24,247   $44,981   $27,335

        11.  Commitments and Contingent Liabilities

        Rents and Leases

        Net rental expense under operating leases was $12,953 in 2000,
        $13,607 in 1999 and $12,622 in 1998.  Leases are principally
        for facilities and automobiles.

        Annual future minimum lease payments at December 31, 2000, under
        operating leases are as follows:  2001 - $13,373; 2002 - $9,012; 2003 -
        $6,601; 2004 - $4,605; 2005 - $3,992; subsequent to 2005 - $7,214.

        Deferred Profit Sharing Retirement Plan

        The Company has a profit sharing plan covering substantially all U.S.
        employees.  Contributions are made at the discretion of the Board of
        Directors.  Bio-Rad has no liability other than for the current year's
        contribution.  Contributions charged to income were $4,815, $4,030 and
        $3,566 in 2000, 1999 and 1998, respectively.

        Foreign Exchange Contracts

        The Company enters into forward foreign exchange contracts as a hedge
        against foreign currency denominated intercompany receivables and
        payables.  At December 31, 2000, the Company had contracts maturing in
        January 2001 to sell foreign currency with a market value of $46,700
        and to purchase foreign currency with a market value of $11,827.  At

                                           21

         




        December 31, 1999, the Company had contracts maturing in January 2000
        to sell foreign currency with a market value of $64,390 and to purchase
        foreign currency with a market value of $6,339.

        Letters of Credit

        In the ordinary course of business, the Company is at times required to
        post letters of credit.  These letters of credit are required by
        certain insurance companies to ensure payments of certain charges.  The
        Company was contingently liable for approximately $763 of standby
        letters of credit with a bank as of December 31, 2000.

        12. Legal Proceedings

        The Company is a party to various claims, legal actions and complaints
        arising in the ordinary course of business.  In the opinion of
        management, the outcome of these claims, legal actions and complaints
        would not have a material adverse effect on the future results of
        operations or the financial position of the Company.


        13.  Segment Information

        Bio-Rad is a multinational manufacturer and worldwide distributor of
        life science research products, clinical diagnostics and analytical
        instruments.  Bio-Rad has three reportable segments:  Life Science,
        Clinical Diagnostics and Analytical Instruments.  These reportable
        segments are strategic business lines that offer different products and
        services and require different marketing strategies.

        The Life Science segment develops, manufactures, sells and services
        liquid chromatography, electrophoresis, gene amplification and
        transformation, imaging and image analysis, and nucleic acid sample
        preparation products.  These products are sold to university and
        medical school laboratories, pharmaceutical and biotechnology
        companies, and government and industrial research facilities.

        The Clinical Diagnostics segment develops, manufactures, sells and
        services automated test systems, informatics systems, test kits and
        specialized quality controls for the healthcare market.  These products
        are sold to reference laboratories, hospital laboratories, state
        newborn screening facilities, physicians office laboratories, and
        insurance and forensic testing laboratories.

        The Analytical Instruments segment develops, manufactures, sells and
        services FT-IR spectroscopy systems, semiconductor test and
        manufacturing instruments, spectral reference publications and
        software.  These products are sold to industrial companies, government
        institutions, academia and forensic analysis laboratories.  The
        Company's semiconductor business was sold in 2000 (see Note 2).






                                           22
         




        The accounting policies of the segments are the same as those described
        in Significant Accounting Policies (see Note 1).  Segment profit or
        loss used for corporate management purposes includes an allocation of
        corporate expense based upon sales and an allocation of interest
        expense based upon accounts receivable and inventories.  Segments are
        expected to manage only assets completely under their control.
        Accordingly, segment assets include primarily accounts receivable,
        inventories and gross machinery and equipment.

        Information regarding industry segments at December 31, 2000, 1999 and
        1998 and for the years then ended is as follows:

                                             Life     Clinical    Analytical
                                            Science  Diagnostics Instruments

        Segment net sales            2000  $269,805    $409,004    $ 53,101
                                     1999   238,007     251,842      67,974
                                     1998   213,570     172,008      66,100


        Allocated interest expense   2000  $  9,322    $ 19,370    $  1,909
                                     1999     3,761       7,775       1,206
                                     1998     1,501       1,464         571

        Depreciation and             2000  $  6,380    $ 25,655    $    858
          amortization               1999     8,003      15,466       1,335
                                     1998     7,328      11,242       1,652

        Segment profit (loss)        2000  $ 15,342    $ 25,337    $ (2,395)
                                     1999    16,643      18,749       2,928
                                     1998    12,649      20,228      (2,166)

        Segment assets               2000   $152,179    $308,437   $ 14,441
                                     1999    131,689     320,419     35,387
                                     1998    124,219     129,089     38,607

        Capital expenditures         2000   $  6,763    $ 27,508   $    755
                                     1999     10,673      13,388      1,378
                                     1998      6,487      15,213      1,912

        Inter-segment sales are primarily from Life Science to Clinical
        Diagnostics and are priced to give Life Science a market
        representative gross margin.  This represents the difference
        between total segment net sales and consolidated net sales.  The
        difference between total segment allocated interest expense,
        depreciation and amortization, and capital expenditures and the
        corresponding consolidated amounts is attributable to the
        Company's corporate headquarters.





                                        23
        



        The following reconciles total segment profit to consolidated
        income before taxes and cumulative effect of change in accounting
        principle:

                                                Year Ended December 31,
                                               2000       1999       1998

        Total segment profit                 $38,284    $38,320    $30,711
        Gross profit on inter-segment sales   (1,755)    (1,204)    (1,925)
        Net corporate operating, interest
          and other income and expense
          not allocated to segments           (8,671)    (6,073)    (3,348)
        Gain on sale of Semiconductor
          Division                            16,690          -          -
        Purchased in-process research and
          development                              -    (15,500)         -
        Investment income, net                   895        873      8,790

        Consolidated income before taxes
          and cumulative effect of change
          in accounting principle            $45,443    $16,416    $34,228

        The following reconciles total segment assets to consolidated total
        assets:
                                                     December 31,
                                               2000       1999       1998

        Total segment assets                $475,057   $487,495   $291,915
        Cash and other current assets         54,907     58,542     36,968
        Net property, plant and
          equipment excluding segment
          specific gross machinery and
          equipment                          (41,264)   (41,378)   (11,364)
        Other long-term assets               157,578    164,203     49,780

        Total assets                        $646,278   $668,862   $367,299


        The following presents sales to external customers by geographic area
        based primarily on the location of the use of the product or service:

                                                 Year Ended December 31,
                                               2000       1999       1998

        Europe                              $275,062   $188,969   $141,004
        Pacific Rim                          128,311    110,729     88,917
        United States                        274,541    231,705    201,230
        Other (primarily Canada
          and Latin America)                  47,970     23,996     16,712

        Total net sales                     $725,884   $555,399   $447,863





                                          24
         




        The following presents long-lived assets by geographic area based
        upon the location of the asset:

                                                Year Ended December 31,
                                               2000       1999       1998

        Europe                              $ 26,663   $ 34,129   $  7,860
        Pacific Rim                            6,550      6,954      4,933
        United States                        239,817    247,293    118,628
        Other (primarily Canada
          and Latin America)                   3,580      1,769        489

        Total long-lived assets             $276,610   $290,145   $131,910

   14.  Quarterly Financial Data - (unaudited)

   Summarized quarterly financial data for 2000 and 1999 are as follows:

                                     First      Second       Third    Fourth
                                    Quarter     Quarter     Quarter   Quarter
      2000

   Net sales                       $185,463    $186,826    $175,761  $177,834
   Gross profit                      98,743      99,633      91,671    92,473
   Net income                         2,955       5,074      13,919     9,152
   Basic earnings
     per share                        $0.24       $0.42       $1.14     $0.75
   Diluted earnings
     per share                        $0.24       $0.41       $1.14     $0.74

      1999

   Net sales                       $127,378    $117,284    $115,066  $195,671
   Gross profit                      71,822      66,731      63,167    98,456
   Net income (loss)                 10,802       7,881       4,253   (11,215)
   Basic earnings (loss)
     per share                        $0.89       $0.65       $0.35    $(0.92)
   Diluted earnings (loss)
     per share                        $0.89       $0.65       $0.35    $(0.92)








                                        25
         




        15.  Information Concerning Common Stock - (unaudited)

        The Company's Class A and Class B Common Stock are listed on the
        American Stock Exchange with the symbols BIO.A and BIO.B,
        respectively.  The following sets forth, for the periods indicated,
        the high and low prices for the Company's Class A and Class B Common
        Stock.

                                     Class A              Class B
                                  High      Low        High      Low
             2000

        First Quarter            33        21.25      33.25     22.63
        Second Quarter           27.25     21         28.25     21.50
        Third Quarter            25        21         24.25     21.50
        Fourth Quarter           34        22.20      33.50     23.88

             1999

        First Quarter            21.75     18.88      21.38     19.38
        Second Quarter           29        20.38      27.50     23.38
        Third Quarter            28        25.63      27        25.88
        Fourth Quarter           27.50     22.50      27.13     23.13


        On February 28, 2001 the Company had 963 holders of record of
        Class A Common Stock and 250 holders of record of Class B Common
        Stock.  Bio-Rad has never paid a cash dividend and has no present
        plans to pay cash dividends.





                                            26
     


      REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

      To the Stockholders and Board of Directors of
        Bio-Rad Laboratories, Inc.:

      We have audited the accompanying consolidated balance sheets of
      Bio-Rad Laboratories, Inc. (a Delaware Corporation) and
      subsidiaries as of December 31, 2000 and 1999, and the related
      consolidated statements of income, cash flows and changes in
      stockholders' equity for each of the three years in the period
      ended December 31, 2000.  These financial statements are the
      responsibility of the Company's management.  Our responsibility is
      to express an opinion on these financial statements based on our
      audits.

      We conducted our audits in accordance with auditing standards
      generally accepted in the United States.  Those standards require
      that we plan and perform the audit to obtain reasonable assurance
      about whether the financial statements are free of material
      misstatement.  An audit includes examining, on a test basis,
      evidence supporting the amounts and disclosures in the financial
      statements.  An audit also includes assessing the accounting
      principles used and significant estimates made by management, as
      well as evaluating the overall financial statement presentation.
      We believe that our audits provide a reasonable basis for our
      opinion.

      In our opinion, the consolidated financial statements referred to
      above present fairly, in all material respects, the financial
      position of Bio-Rad Laboratories, Inc. and subsidiaries as of
      December 31, 2000 and 1999, and the results of their operations and
      their cash flows for each of the three years in the period ended
      December 31, 2000 in conformity with accounting principles
      generally accepted in the United States.







                                                  ARTHUR ANDERSEN LLP




      San Francisco, California
      February 6, 2001





                                           27
     


      Bio-Rad Laboratories, Inc.

      Management's Discussion and Analysis
      ________________________________________________________________

      MANAGEMENT'S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS AND

                             FINANCIAL CONDITION

      This discussion should be read in conjunction with the
      information contained in the Company's Consolidated Financial
      Statements and the accompanying notes which are an integral part
      of the statements.  References are to the Notes to Consolidated
      Financial Statements.

      The following shows operating income and expense items as a
      percentage of net sales:
                                               Year Ended December 31,
                                                2000    1999    1998
      Net sales                                100.0   100.0   100.0
        Cost of goods sold                      47.3    46.0    45.2
      Gross profit                              52.7    54.0    54.8
        Selling, general and
          administrative expense                34.1    36.0    38.6
        Product research and
          development expense                    9.4     9.2     9.2
        Purchased in-process
          research and development                 -     2.8       -

      Income from operations                     9.2     6.0     7.0
                                               =====   =====   =====
      Net income                                 4.3     2.1     5.4
                                               =====   =====   =====

      The year 2000 operations of Bio-Rad Laboratories include a full
      year's operations of Pasteur Sanofi Diagnostics, S.A. (PSD).  The
      acquisition of PSD was made in October 1999 with the potential
      benefits of complementary product lines, increased geographic
      reach and the opportunity to achieve increased operational
      efficiencies.  During the first half of the year 2000, Bio-Rad
      consolidated selling, marketing and general and administrative
      operations in Europe and North America.  Reductions in both
      employees and facilities were completed in compliance with legal
      guidelines in Europe to improve profitability.  On August 1,
      2000, the Company sold its semiconductor equipment test and
      manufacturing product line for cash and a note receivable.  The
      cash was used to pay down debt under the senior credit facility.





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      Corporate Results -- Sales, Margins and Expenses

      Bio-Rad's net sales for 2000 were $725.9 million, an increase of
      30.7% over the prior year.  The year 2000 was positively impacted
      by the inclusion of twelve months sales of PSD versus 1999 which
      included sales for the fourth quarter only.  The year 2000 was
      negatively impacted by a strengthening U.S. dollar, the
      divestiture of the semiconductor product line and expiration of a
      distribution agreement.  Adjusting for the above significant
      items, sales growth would have been 8.4% using the 1999
      proforma/acquisition sales of $727.9 million and adjusting for
      currency changes and divested product lines.

      The Diagnostic segment had growth of 5.4% adjusted for currency,
      the acquisition of PSD and product line divestitures.  Product
      lines contributing to this growth were Bio-Rad's quality control
      business, genetic tests and improved penetration for the PSD
      product line in North America and Asia.  The Life Science segment
      had growth of 17.9% adjusted for currency.  The increase reflects
      increases in the sales of laboratory devices and consumables.
      Analytical Instrument sales decreased on the divestiture of the
      semiconductor business as well as a decline in the Company's
      spectroscopy product lines.

      Bio-Rad's net sales (sales) in 1999 were $555.4 million, an
      increase of 24.0% over 1998 sales.  Included in the 1999 fourth
      quarter sales was $60.2 million from the PSD operations (see Note
      2).  Excluding this amount, Bio-Rad's sales grew by 10.6% over
      the year 1998.  For the year 1999, the impact from currency
      translation on sales was less than $1.0 million.  Excluding any
      impact from currency for 1999, the Life Science and Clinical
      Diagnostics segments (excluding the PSD acquisition) grew by
      12.2% and 11.6%, respectively.  The growth in the Life Science
      segment is attributable to laboratory products and scientific
      imaging equipment.  The Clinical Diagnostics segment growth was a
      result of the continuing demand for the Company's diabetes
      monitoring and quality control systems.

      Consolidated gross margins in 2000 were 52.7% compared to 54.0%
      for the year 1999.  The inclusion of a full year's operations of
      the PSD product lines further reduced the Company's margins as
      these products have overall lower margins than the Company's
      other Diagnostic products.  Excluding PSD, the products of this
      segment had a decline of 1% on higher manufacturing and service
      costs.  The Life Science segment had no change in gross margin as
      favorable manufacturing overhead absorption was offset by the
      negative impact from declining margins on foreign sales.

      Consolidated gross margins were 54.0% for 1999 compared to 54.8%
      in the prior year.  After adjusting for the acquisition of PSD,
      gross margins for the businesses operated for full year were

                                      29

      



      55.9%, an improvement over the 54.8% recorded in 1998.  The Life
      Science segment's gross margin improved as sales growth provided
      the opportunity to lower fixed factory overhead and new product
      pricing remained firm.  The Clinical Diagnostics segment's gross
      margin experienced no change as pricing pressure in the
      healthcare industry remained a considerable factor and the cost
      of foreign sourced products rose as the Yen strengthened when
      compared to the dollar.  The Analytical Instruments segment's
      gross margin improved as demand increased and pricing improved
      for the Company's semiconductor test and manufacturing equipment.

      Consolidated selling, general and administrative expense (SG&A)
      decreased to 34.1% of sales from 36.0%.  For the year 2000, the
      Company implemented Financial Accounting Standards Board Emerging
      Issues Task Force Issue 00-10 related to the standardized method
      for recording shipping and handling charges billed separately to
      customers.  All prior periods presented have been adjusted to
      consistently apply the gross method.  There is no impact on
      either income from operations or net income in any period
      presented, only increased sales and increased selling expense.

      Both the Life Science and Diagnostics segments grew SG&A expense
      at a rate lower than sales growth.  The Analytical Instruments
      segment had slightly higher SG&A expense on a reduced sales base
      as declining spectroscopy sales and the divestiture of the
      semiconductor business did not permit proportional reductions in
      SG&A without jeopardizing the ongoing business which would
      further diminish the potential to find suitable strategic
      options.  The Company continues to make the efficient use of SG&A
      expense a priority.  The acquisition of PSD should allow the
      Company to further leverage this expense in a larger sales
      environment through the elimination of duplicate facilities and
      more efficient operations.

      Consolidated SG&A decreased to 36.0% of sales in 1999 when
      compared to 38.6% for 1998.  After adjustment for the PSD
      acquisition, SG&A expense for the Company was 36.9%, a decline of
      1.7% of sales from the prior year.  For the Company excluding
      PSD, total SG&A grew by less than 60% of sales growth.  In
      absolute dollars, the largest increase in SG&A expense was in the
      Life Science segment as the Clinical Diagnostics segment grew
      only slightly and the Analytical Instruments segment declined.

      Product research and development expense (R&D) increased by 33.1%
      or $16.9 million, which includes for 2000 a full year's expense
      associated with the acquired PSD business.  As a percentage of
      sales R&D expense rose to 9.4% of sales from 9.2% in the prior
      year as both the Life Science and Diagnostics segments have large
      long term projects with opportunity for substantial future sales
      and current opportunities including improvements to the existing
      industrial diagnostic testing product line related to the
      increased demand for BSE (Bovine Spongiform Encephalopathy or Mad

                                      30

      



      Cow Disease) tests.  Expenditure levels as a percentage of sales
      could rise in 2001 as the longer term projects will not be
      completed until after 2001.

      R&D increased by 23.7% in 1999 to $51.2 million including the
      operations of PSD compared to $41.4 million for the year 1998.
      Both Life Science and Clinical Diagnostics segments (excluding
      PSD) increased R&D spending at a rate higher than sales growth as
      the Company was focusing on R&D programs to increase sales
      through new product development complementing recent
      acquisitions.  Included in income from operations is the write-
      off of $15.5 million of "purchased in-process research and
      development expense" related to the PSD acquisition (IPR&D).
      IPR&D represents the value assigned in a purchase business
      combination to research and development projects of the acquired
      business that have been commenced but not completed at
      acquisition in accordance with SFAS No. 2, "Accounting for
      Research and Development Costs".

      Corporate Results -- Non-Operating Items

      Interest expense increased substantially for the year 2000
      reflecting a full year's cost of borrowed funds to purchase PSD.
      The Company, in early 2000, replaced the interim $100.0 million
      Senior Subordinated Credit Facility with a $150.0 million
      aggregate principal amount of Senior Subordinated Notes due in
      2007.  The additional capacity was used to reduce the $200.0
      million Senior Credit Facility.  The Company used a significant
      portion of the proceeds from the sale of the semiconductor
      product line to further reduce borrowing under the Senior Credit
      Facility.  At December 31, 2000, the debt to equity ratio was 91%
      compared to 119% at year end 1999.  At this time, no significant
      asset sales are being considered that would further materially
      reduce net borrowings and interest expense.  Average borrowings
      for the year 2000 and 1999 were $251.3 and $97.8 million,
      respectively.

      Net other income and expense for 2000 includes the gain on sale
      of assets, amortization of goodwill, non-operating legal costs
      and settlement costs related to cancelling a financing
      arrangement (see Note 9).  Net other income and expense for 1999
      is comprised principally of amortization of goodwill.  All years
      include exchange gains and losses from nonspeculative forward
      foreign exchange contracts which hedged the exposure of
      intercompany receivables and payables.  The net exchange gain or
      loss results from the estimating inherent in projecting
      intercompany balances and transaction charges.

      Bio-Rad's consolidated effective tax rate was 30%, 29% and 29% in
      2000, 1999 and 1998, respectively.  The tax rate for all years
      reflects the utilization of loss carryforwards, foreign sales
      corporation benefits and foreign tax credits.  The effective tax

                                      31
      




      rate in future periods is expected to rise as the deductibility
      of goodwill amortization and interest expenses, as well as the
      utilization of loss carryforwards are dependent on the source and
      amount of income generated by the Company.

      Financial Condition

      The Company became substantially leveraged as it entered into
      expanded credit facilities to acquire PSD.  As a result of the
      debt service obligations undertaken, the Company has a risk of
      limited liquidity and capital resources.

      The Company has a Senior Credit Facility of $163.0 million
      consisting of a $100.0 million revolving facility and a $63.0
      million term loan (reduced from $100.0 million initially),
      allowing for borrowings on a secured basis to September 2004.
      Additionally, in February 2000, the Company completed the sale of
      $150.0 million aggregate principal amount of Senior Subordinated
      Notes due 2007.

      The lenders have placed restrictions on the Company's ability to:
      borrow further, service this and other debt, make expenditures
      for capital improvements, pay dividends, repurchase the Company's
      own stock and/or make strategic and tactical investments in
      support of operating the business.  The Company is also required
      to comply with certain financial ratios.  The amount of debt
      undertaken in connection with this acquisition could materially
      impact the financial condition of the Company should management's
      plan for operating the new entity not be successful.

      At December 31, 2000, the Company had available $14.0 million in
      cash and cash equivalents, $19.1 million under its international
      lines of credit, and $98.3 million under its principal revolving
      credit agreement (see Note 5).  Management believes that this
      availability, together with cash flow from operations, will be
      adequate to meet the Company's current objectives for operations,
      research and development and investment in our systems and
      equipment.

      Net cash provided by operations was $24.2 million, $45.0 million
      and $27.3 million in 2000, 1999 and 1998, respectively.  The
      largest contributing factor to the decline in net cash provided
      is increased interest expense on borrowings to purchase PSD.

      Consolidated net accounts receivable decreased approximately
      $11.7 million in 2000 when compared to 1999.  This decrease is
      attributable in part to weakening foreign currencies causing a
      decline in the value of foreign receivables.  This decline was
      offset by increased domestic receivables due to sales increases,
      the inclusion of PSD ancillary asset sites after January 1, 2000
      in Brazil and the Czech Republic, and increased representation in
      countries with slower payment expectations.  Bio-Rad's management

                                      32

       




      regularly reviews the allowance for uncollectible receivables and
      believes net receivables are fully realizable.

      For the year ended December 2000, consolidated inventories rose
      $6.2 million to $132.5 million.  The Diagnostic segment had
      inventory increases related to equipment orders which at year-end
      1999 were unfilled due to a short-term supplier problem.
      Additionally, the inclusion after January 1, 2000 of the
      ancillary asset sites in Brazil and the Czech Republic added to
      Diagnostics inventories.  The Life Science segment had inventory
      increases in line with sales activity.  The component of
      inventory at international locations declined as weakened local
      currencies caused the value of foreign manufactured goods to
      decline in U.S. dollar terms.  Management regularly reviews the
      impact of obsolescence on current inventory caused by the
      introduction of new products.  Management will continue its focus
      on inventory control to moderate capital requirements.

      A valuation reserve is necessary for deferred tax assets (see
      Note 6) primarily because realization of tax benefits
      attributable to foreign loss carryforwards is uncertain.

      Net capital expenditures in 2000 totaled $31.4 million compared
      to $27.3 million and $21.2 million in 1999 and 1998,
      respectively.  Expenditures in all years include clinical
      diagnostic equipment placed with customers to be used with the
      Company's diagnostic reagents.  Management regularly approves
      capital spending in the normal course of business.

      The Board of Directors authorized the Company to repurchase up to
      $18 million of the Company's common stock over an indefinite
      period of time.  Through December 2000, the Company has
      repurchased 583,636 shares of Class A Common Stock and 30,000
      shares of Class B Common Stock for a total of $14.5 million.  The
      Company's credit agreements restrict the Company's ability to
      repurchase its own stock.  Share repurchases made during 2000
      amounted to $0.4 million.  The repurchase is designed to improve
      shareholder value and to satisfy the Company's obligations under
      the employee stock purchase and stock option plans.

      Euro - A New European Currency

      On January 1, 1999, certain member countries of the European
      Union entered a three-year transition phase during which the euro
      was introduced as a common currency in participating countries.
      The euro is currently used for wholesale financial transactions
      and will replace the legacy currencies that will be withdrawn
      between January 1, 2002 and July 1, 2002.

      This transition will have business implications including the
      need to adjust internal systems to accommodate the euro and
      cross-border price transparency.  A group of Corporate and

                                      33

      




      European managers have been assigned the task of preparing and
      accommodating the changes required to continue to do business in
      the European Union.  The Company does not presently expect that
      the efforts involved will have a material impact on operations,
      financial position or liquidity.  There will be increased
      competitive pressures, and marketing strategies will need to be
      continuously evaluated until the transition is complete.  As a
      result of competitive forces and emerging government regulations,
      the Company cannot guarantee that all problems will be foreseen
      and remediated, and that no material disruption will occur.

      Year 2000

      From December 31, 1999 continuing through the year 2000, the
      Company monitored its information centers and operations for
      transition issues related to the Year 2000.  No material problems
      were reported in any of the Company's facilities or operations
      during the year.  The Company did not experience any material
      Year 2000 problems with its systems or products, nor did the
      Company experience any material problems with any of its key
      customers or suppliers.

      Financial Risk Management

      Bio-Rad uses derivative financial instruments to reduce the
      Company's exposure to fluctuations in foreign exchange rates and,
      on occasion interest rates.  No derivative financial instruments
      are entered into for the purpose of speculating or trading.
      Company policy limits all derivative positions exclusively to
      reducing risk by hedging an underlying economic exposure.  In
      most material cases, derivative investments do not qualify for
      hedge accounting treatment under Statement of Financial
      Accounting Standards No. 133, "Accounting for Derivative
      Instruments and Hedging Activities" ("SFAS 133").  Derivative
      instruments used in these transactions will be valued at fair
      value and changes in fair value will be consequently classified
      into earnings.

      Bio-Rad operates and conducts business in many foreign countries
      and is exposed to movements in foreign currency exchange rates.
      Additionally, Bio-Rad's consolidated net equity is impacted by
      the conversion of the net assets of international subsidiaries
      for which the functional currency is not the U.S. dollar.
      Foreign currency exposures are managed on a centralized basis by
      the Company's Treasury Department.  This allows for the netting
      of natural offsets and lowers transaction costs and exposures.
      Bio-Rad currently makes more than 50% of its sales outside the
      United States and weakening in one currency can often be offset
      by strengthening in another.

      Bio-Rad typically enters into forward exchange contracts to sell
      its foreign currency.  Contracts are entered into typically for

                                      34

      




      30 to 60 days, primarily in British Sterling, Japanese Yen, and
      euros or related currencies.  The costs are recognized in income
      monthly and generally are the reciprocal of the change in
      underlying assets.  Bio-Rad does not hold any derivative
      contracts that hedge its foreign currency denominated net asset
      exposures.

      Bio-Rad uses sensitivity analysis to assess the market risk
      associated with its foreign currency exchange risk.  Market risk
      is the potential change in fair value of derivative positions
      from an adverse movement in currency exchange rates.  The forward
      foreign exchange contracts at December 31, 2000 had a net fair
      value of $34.9 million.  A 10% adverse loss on quoted foreign
      currency exchange rates would result in a $3.5 million loss.
      This impact of a change in exchange rates, excludes from the
      analysis the offset derived from the change in the Company's
      underlying assets and liabilities, which could reduce the effect
      to zero.

      The Company's long-term debt consists mostly of fixed rate
      instruments in order to minimize earnings volatility related to
      interest expense.  While the Company has used derivative
      instruments in the past, it did not hold any interest rate
      derivative contracts at December 31, 2000.  The current policy is
      to manage interest costs using a mix of fixed and variable debt.

      New Financial Accounting Standards

      In June 1998, the Financial Accounting Standards Board issued
      SFAS 133.  Implementation was then delayed to fiscal years
      beginning after June 15, 2000.  This statement establishes
      accounting and reporting standards requiring companies to record
      all derivatives on the balance sheet as either assets or
      liabilities and measure those instruments at fair value.  The
      manner in which companies are to record gains or losses resulting
      from changes in the values of those derivatives depends on the
      use of the derivative and whether it qualifies for hedge
      accounting.  The Company adopted SFAS 133 and subsequent
      amendments as of the first day of fiscal year 2001 and will
      currently not seek hedge accounting treatment, instead recording
      the value adjustment to derivative instruments through earnings.

      Forward Looking Statements

      Other than statements of historical fact, statements made in this
      Annual Report include forward looking statements, such as
      statements with respect to the Company's future financial
      performance, operating results, plans and objectives.  We have
      based these forward looking statements on our current
      expectations and projections about future events.  However,
      actual results may differ materially from those currently
      anticipated depending on a variety of risk factors including

                                      35
      




      among other things: our ability to successfully integrate with
      PSD; our substantial leverage and ability to service our debt;
      our ability to successfully develop and market new products; our
      reliance on and access to necessary intellectual property;
      competition in and government regulation of the industries in
      which we operate; and the monetary policies of various countries.
      We undertake no obligation to publicly update or revise any
      forward looking statements, whether as a result of new
      information, future events, or otherwise.





                                          36