Exhibit 4.1.3



                    AMENDMENT NO. 3 TO CREDIT AGREEMENT

          This Amendment No. 3 (this "Amendment") is entered into as
     of August 9, 2002 by and among BIO-RAD LABORATORIES, INC., a
     Delaware corporation (the "Borrower"), the undersigned lenders
     (collectively, the "Lenders") and BANK ONE, NA, having its
     principal office in Chicago, Illinois, as one of the Lenders and
     in its capacity as contractual representative (the "Agent") on
     behalf of itself and the other Lenders.

                                 RECITALS:

          WHEREAS, the Borrower, the Lenders and the Agent have
     entered into that certain Credit Agreement dated as of September
     30, 1999, as amended (the "Credit Agreement");

          WHEREAS, the Borrower seeks to amend the Credit Agreement,
     among other things, to permit the repurchase by the Borrower of
     certain subordinated debt; and

          WHEREAS, the Lenders and the Agent are willing to amend the
     Credit Agreement on the terms and conditions herein set forth;

          NOW, THEREFORE, for good and valuable consideration, the
     receipt and sufficiency of which are hereby acknowledged, the
     parties hereto hereby agree as follows:

          1.   Defined Terms.   Capitalized terms used  herein and not
     otherwise defined  herein shall  have the meanings  attributed to
     such terms in the Credit Agreement.

          2.   Amendments to Credit Agreement. Upon  the effectiveness
     of  this Amendment in accordance with the provisions of Section 3
     below,  the Credit  Agreement  is hereby  amended  by adding  the
     following sentence at the end of Section 6.21:

          Notwithstanding the foregoing, so long as no Default or
          Unmatured Default shall have occurred and be continuing or
          would result, or would be reasonably likely to result,
          therefrom, the Borrower may repurchase its Senior
          Subordinated Notes due 2007, provided that (i) the aggregate
          purchase price for such Subordinated Indebtedness on a
          cumulative basis shall not exceed $50,000,000 and (ii) such
          repurchased Subordinated Indebtedness shall be cancelled and
          not reissued.

          3.   Conditions of Effectiveness.  This Amendment shall
     become effective and be deemed effective as of the date hereof
     (the "Effective Date") if, and only if, the Agent shall have
     received duly executed originals of this Amendment from the
     Borrower and the Required Lenders.

          4.   Representations and Warranties of the Borrower.  The
     Borrower represents and warrants to the Lenders that, as of the
     Effective Date and giving effect to this Amendment:


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               (a)  there exists no Default or Unmatured Default; and

               (b)  the representations and warranties contained in
          Article V of the Credit Agreement are true and correct as of
          the Effective Date except to the extent any such
          representation or warranty is stated to relate solely to an
          earlier date, in which case such representation or warranty
          was true and correct on and as of such earlier date.

          5.   Reference to and Effect on the Credit Agreement.

          5.1  Upon the effectiveness of this Amendment pursuant to
     Section 3 hereof, on and after the Effective Date each reference
     in the Credit Agreement to "this Agreement," "hereunder,"hereof,"
     "herein" or words of like import and each reference to the Credit
     Agreement in each Loan Document shall mean and be a reference to
     the Credit Agreement as modified hereby.

          5.2  Except as specifically waived or amended herein, all of
     the terms, conditions and covenants of the Credit Agreement and
     the other Loan Documents shall remain in full force and effect
     and are hereby ratified and confirmed.

          5.3  The execution, delivery and effectiveness of this
     Amendment shall not, except as expressly provided herein, operate
     as a waiver of (a) any right, power or remedy of any Lender or
     the Agent under the Credit Agreement or any of the Loan
     Documents, or (b) any Default or Unmatured Default under the
     Credit Agreement.

          6.   CHOICE OF LAW.  THIS AMENDMENT SHALL BE CONSTRUED IN
     ACCORDANCE WITH THE INTERNAL LAWS (INCLUDING 735 ILCS 105/5-1 ET
     SEQ. BUT OTHERWISE WITHOUT REGARD TO THE CONFLICT OF LAWS
     PROVISIONS) OF THE STATE OF ILLINOIS, BUT GIVING EFFECT TO
     FEDERAL LAWS APPLICABLE TO NATIONAL BANKS.

          7.   Counterparts.  This Amendment may be executed in any
     number of counterparts, each of which when so executed shall be
     deemed an original and all of which taken together shall
     constitute one and the same agreement.

          8.   Headings.  Section headings in this Amendment are
     included herein for convenience of reference only and shall not
     constitute a part of this Amendment for any other purpose.

     [Signature Pages Follow]


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                             Amendment No. 3 to
                         Bio-Rad Laboratories, Inc.
                              Credit Agreement



          IN WITNESS WHEREOF, the Borrower, the Agent and the Lenders
     have executed this Amendment No. 3 as of the date first above
     written.

                              BIO-RAD LABORATORIES, INC.
                              By: /s/ Ronald W. Hutton
                                    Name:  Ronald W. Hutton
                                    Title: Treasurer


                              BANK ONE, NA, as a Lender and as Agent
                              By: /s/ Kandis A. Jaffrey
                                    Name: Kandis A. Jaffrey
                                    Title: Director


                              ABN AMRO BANK N.V., as a Lender
                              By: /s/ Todd J. Miller
                                     Name: Todd J. Miller
                                     Title: Assistant Vice President

                              By: /s/ Craig Trautwein
                                     Name: Craig Trautwein
                                     Title: Vice President


                              UNION BANK OF CALIFORNIA, N.A.,
                                as a Lender
                              By: /s/ Mark Reardon
                                     Name: Mark Reardon
                                     Title: Vice President


                              THE BANK OF NOVA SCOTIA,
                                as a Lender
                              By: /s/ R. P. Reynolds
                                     Name: R. P. Reynolds
                                     Title: Director


                              BNP PARIBAS,
                                 as a Lender
                              By: /s/ Sandy Bertram
                                   Name: Sandy Bertram
                                   Title: Vice President
                              By: /s/ Joseph Mack
                                   Name: Joseph Mack
                                   Title: Associate
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                              WELLS FARGO BANK,
                                as a Lender
                              By: /s/ Nuzha Bukhari
                                    Name: Nuzha Bukhari
                                    Title: Vice President


                              COMERICA BANK,
                                 as a Lender
                              By: /s/ John Bonifacio
                                   Name: John Bonifacio
                                   Title: Vice President


                              CREDIT LYONNAIS NEW YORK BRANCH,
                                as a Lender
                              By:/s/ Dianne M. Scott
                                    Name: Diane M. Scott
                                    Title: Senior Vice President


                              LLOYDS TSB BANK PLC,
                                as a Lender
                              By: /s/ Matthew A. L. Packham
                                   Name: Matthew A. L. Packham
                                   Title: Assistant Director
                                     Acquisition Finance P-002
                              By: /s/ Nicholas J. Bruce
                                    Name: Nicholas J. Bruce
                                    Title: Vice President
                                            Credit Services B-499


                              THE NORTHERN TRUST COMPANY,
                                as a Lender
                              By: /s/ Patricia A. Williams
                                    Name: Patricia A. Williams
                                    Title: Vice President


                              U.S. BANK, NATIONAL ASSOCIATION,
                                as a Lender
                              By:/s/ Scott T. Smith
                                   Name: Scott T. Smith
                                   Title: Vice President
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