SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549


                                   FORM 8-K


                                CURRENT REPORT
                      PURSUANT TO SECTION 13 OR 15(D) OF
                      THE SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of Earliest Event Reported) January 24, 2001


                     E. I. du Pont de Nemours and Company
            (Exact Name of Registrant as Specified in Its Charter)


            Delaware                   1-815              51-0014090
    (State or Other Jurisdiction     (Commission       (I.R.S Employer
         of Incorporation)           File Number)     Identification No.)


                              1007 Market Street
                          Wilmington, Delaware  19898
                   (Address of principal executive offices)


      Registrant's telephone number, including area code:  (302) 774-1000














                                      1




Item 5.  Other Events
         ------------
     The Registrant files, pursuant to Regulation FD, its earnings press
release dated January 24, 2001, entitled "DuPont Reports Fourth Quarter And
Full Year 2000 Earnings," a copy of which is below.  This earnings press
release is also filed in connection with Debt and/or Equity Securities that
may be offered on a delayed or continuous basis under Registration Statements
on Form S-3 (No. 33-53327, No. 33-61339, No. 33-60069 and No. 333-86363).

January 24, 2001                       Contact:  Clif Webb
WILMINGTON, Del.                                 302-774-4005
                                                 r-clifton.webb@usa.dupont.com

           DUPONT REPORTS FOURTH QUARTER AND FULL-YEAR 2000 EARNINGS
           ---------------------------------------------------------
Summary
- -------
o  Fourth quarter underlying earnings per share were $.47, bringing full-year
   underlying earnings to $2.73 per share, 6 percent higher than 1999.  For
   the year, six segments had higher sales and five improved earnings.

o  Fourth quarter underlying after-tax operating income (ATOI) was
   $693 million.  ATOI for the quarter was $91 million lower than 1999
   reflecting approximately $250 million in higher after-tax costs for raw
   materials, principally oil, natural gas and their derivatives.

o  Segment sales in the fourth quarter of $7.2 billion decreased 8 percent
   versus 1999.  Volumes, including portfolio changes, declined 5 percent and
   selling prices declined 3 percent.  Two percent volume growth outside the
   United States partly offset an 11 percent U.S. decline.

o  Fourth quarter U.S. dollar selling prices declined 3 percent reflecting the
   impact of a stronger dollar.  Globally, local currency selling prices were
   2 percent higher in the fourth quarter versus the fourth quarter 1999, the
   third consecutive quarter of higher prices versus prior year.

o  Adverse currency effects, principally from the weak euro, reduced fourth
   quarter worldwide sales by 5 percent, the largest quarterly impact in seven
   years.  The full-year impact on earnings was $.15 per share, and $.05 per
   share for the quarter.

o  The company anticipates that the challenging macroeconomic conditions
   experienced in the second half of 2000 will continue into the first half of
   2001.  See the Outlook section of this news release.

                 Earnings Comparisons - Continuing Operations
                 --------------------------------------------
                             ($ per share diluted)

                                                          Including
                                     Underlying        One-Time Items
                                   --------------      ----------------
                                   2000      1999      2000       1999
                                   ----      ----      ----      ------
      4th Quarter                   .47       .55       .25      (1.38)
      Full Year                    2.73      2.58      2.19        .19


                                       2






        DuPont reported earnings from continuing operations, before one-time
items, of $.47 per share for the fourth quarter compared to $.55 per share
earned last year.  For the full year 2000, earnings before one-time items
totaled $2.73 per share versus $2.58 last year.
        "Aggressive pricing initiatives and improved productivity delivered
underlying EPS growth in 2000, in the face of $1.3 billion in higher raw
material costs and negative currency effects," said Charles O. Holliday, Jr.,
DuPont chairman and chief executive officer.  "Our employees worldwide have
done a tremendous job countering some of the worst conditions in our industry
in a decade.  Six segments had higher revenue and five improved earnings
versus last year, a very sold performance."
Global Sales and Income Highlights
- ----------------------------------
        For the full year, consolidated sales totaled $28.3 billion compared
to $26.9 billion in 1999.  Segment sales, including transfers and a pro rata
share of equity affiliates, were $31.8 billion, up 7 percent from
$29.7 billion in 1999.  Including one-time items totaling a net charge of
$564 million after-tax, income from continuing operations was $2,314 million
versus $219 million in 1999, resulting in earnings per share of $2.19 compared
to $.19 last year.  One-time items are described in the notes to the
accompanying financial statements and their earnings impact is summarized in
the table below:







                                       3




                                ONE-TIME ITEMS
                                   $MM Pretax     $MM After-Tax   ($ Per Share)
                                  -------------   --------------  -------------
                                  2000    1999    2000    1999    2000   1999*
                                  -----  -------  -----  -------  -----  ------
1st Quarter - Total               (161)    (171)   (95)    (121)  (.09)   (.11)

2nd Quarter - Total               (418)     (62)  (261)     (40)  (.25)   (.04)

3rd Quarter - Total                 68     (534)    25     (444)   .02    (.42)

4th Quarter
  - WebMD Investment              (342)           (215)           (.20)
  - Nylon-Sabanci J.V.              24              24             .02
  - Restructuring Reserves          25              15             .01
  - Pharmaceuticals Litigation     (45)            (44)           (.04)
  - Pioneer Purchase Accounting    (20)            (13)           (.01)

4th Quarter Total                 (358)  (1,804)  (233)  (2,019)  (.22)  (1.93)

Full Year - Total                 (869)  (2,571)  (564)  (2,624)  (.54)  (2.39)

* Quarterly EPS amounts do not add to the full-year amount due to changes in
  shares outstanding during the year.


        The net fourth quarter charge for one-time items principally reflects
a $.20 per share noncash charge to write-down the book value of the company's
investment in WebMD to fair market value and to write-off warrants returned to
WebMD following the company's decision to terminate the 1999 healthcare
collaboration agreement.  (A one-time noncash gain of $.20 per share was
recorded in the fourth quarter of 1999 to establish the value of this invest-
ment after the merger of Healtheon and WebMD.)  Other fourth quarter 2000
one-time items were largely offsetting.
        Fourth quarter consolidated sales were $6.3 billion compared to
$7.1 billion in 1999.  Segment sales were $7.2 billion compared to
$7.8 billion in 1999, down 8 percent.




                                       4




        Fourth quarter income from continuing operations before one-time items
was $494 million, compared to $583 million in the fourth quarter of 1999, down
$89 million or 15 percent.  The earnings decline reflects significantly lower
earnings in the Pharmaceuticals, Nylon and Specialty Fibers segments.
Full-year income from continuing operations before one-time items was
$2,878 million, up 1 percent from 1999.  Higher sales volume and local selling
prices as well as additional earnings from acquisitions and the Polyester
restructuring, more than offset the negative impact of higher raw material
costs, higher interest expense and a stronger U.S. dollar.  Regional segment
sales and related variances for the fourth quarter and full year are
summarized below:
                                FOURTH QUARTER
                     Segment Sales                % Change Due To
                   -----------------   -------------------------------------
                   YR 00   % Change    Local   Currency            Portfolio
 Segment Sales      $B     vs. Yr 99   Price    Effect    Volume    Changes*
- ----------------   -----   ---------   -----   --------   ------   ---------
Worldwide           7.2       (8)        2        (5)       (4)       (1)
U.S.                3.4      (12)        2         0       (11)       (3)
Europe              1.7      (12)        4       (16)        0         0
Asia Pacific        1.3        7         1        (3)        4         5
Canada, Mexico,
  S. America        0.8        2        (2)       (2)        6         0

* Portfolio changes reflect the decreased ownership interest in Photomasks
  and restructuring the Polyester enterprise through formation of joint
  ventures.  The latter increased sales in Asia and decreased sales in the
  United States.
















                                       5






                                   FULL YEAR
                     Segment Sales                % Change Due To
                   -----------------   -------------------------------------
                   YR 00   % Change    Local   Currency            Portfolio
 Segment Sales      $B     vs. Yr 99   Price    Effect    Volume    Changes*
- ----------------   -----   ---------   -----   --------   ------   ---------
Worldwide           31.8       7         2        (3)        2         6
U.S.                16.1       4         1         0        (3)        6
Europe               7.6       3         3       (12)        4         8
Asia Pacific         4.8      20         1         2        13         4
Canada, Mexico,
  S. America         3.3      12         2        (2)        5         7

* Portfolio changes reflect the Herberts and Pioneer acquisitions as well as
  decreased ownership interest in Photomasks and restructuring the Polyester
  Enterprise through formation of joint ventures (which increased sales in
  Asia and decreased sales in the United States).


o  U.S. full-year sales volume declined 3 percent versus 1999, with fourth
   quarter volume 11 percent below a strong fourth quarter 1999.  The latter
   reflects lower volumes of pharmaceuticals, fibers, automotive finishes, and
   TiO2.

o  Asia Pacific full-year sales increased 20 percent reflecting 3 percent
   higher U.S. dollar (USD) prices, 13 percent higher volume and increased
   polyester sales resulting from joint venture growth in the region.
   However, volume growth slowed to 9 percent in the fourth quarter, and
   slowed to 4 percent excluding the impact of polyester structure changes.

o  European full-year sales reflect 4 percent volume growth and an 8 percent
   increase from acquisitions, principally Herberts, partly offset by
   9 percent lower USD prices resulting from the impact of a weak euro.  For
   the fourth quarter, volume was flat versus 1999 reflecting a slowdown in
   automotive finishes, nonwovens and polyester.  Fourth quarter sales were
   down 12 percent reflecting a 16 percent negative currency impact partly
   offset by 4 percent higher local prices.

Six Sigma
- ---------
        Six Sigma implementation continues to gain momentum.  At the end of
the year 2000, there were about 1,100 trained Black Belts and over 3,400
active projects.  The potential pretax benefit from active projects was
$700 million.  The actual annualized pretax benefit of completed projects at




                                       6




the end of the year 2000 was $370 million.  By comparison, the company
reported in the third quarter that annualized pretax benefits from Six Sigma
implementation were estimated at $500 million in potential benefit for active
projects and $260 million for completed projects.
Business Segment Performance
- ----------------------------
        Segment ATOI before one-time items for the fourth quarter and the
full-year 2000 was $693 million and $3,684 million, respectively, compared to
$784 million in the fourth quarter 1999, and $3,474 million for the year 1999.
In the year 2000, six segments had higher revenue and five had improved
earnings versus last year.  Comments regarding fourth quarter and full-year
2000 results for individual segments are summarized below.
o  Performance Coatings & Polymers - Full-year sales and earnings increased in
   all three business units - Performance Coatings, Engineering Polymers and
   Elastomers.  Segment volume growth and higher local prices more than offset
   a significant adverse currency impact.  In addition, lower fixed costs
   driven by ongoing Herberts integration activities contributed to increased
   earnings.  Fourth quarter sales were 10 percent lower than 1999 reflecting
   lower vehicle builds in the United States and a weak euro.

o  Specialty Fibers - Fourth quarter sales and earnings were 8 percent and
   24 percent lower, respectively.  Improvement from "Kevlar" and "Nomex"
   aramid fibers partially offset lower "Lycra" elastane earnings, which were
   adversely affected by currency, higher raw material costs, and continued
   price competition from generic elastane.

o  Specialty Polymers - Fourth quarter and full-year earnings increases in
   "Corian", Fluoropolymers, and iTechnologies offset a significant decline in
   Packaging & Industrial Polymers earnings resulting from higher ethane
   costs.  Fourth quarter segment earnings increased 10 percent on slightly
   lower sales, with full-year earnings up 7 percent.

o  Pigments & Chemicals - Full-year earnings increased 13 percent reflecting
   7 percent higher sales and lower fixed costs.  Sales increased in all
   business units with higher average prices and improved volumes principally
   outside the United States.  Fourth quarter sales were flat, due to lower
   volumes in the United States.








                                       7






o  Polyester Enterprise - Full-year segment earnings were $69 million versus a
   loss of $39 million last year.  The improvement principally reflects a sub-
   stantial reduction in fixed costs achieved through productivity measures
   and restructuring.  Fourth quarter sales were 14 percent lower, reflecting
   depressed conditions in worldwide fibers markets.  Margins continue being
   squeezed by higher raw material and energy costs.

o  Nylon Enterprise - Full-year segment sales increased 1 percent and earnings
   declined 23 percent, principally reflecting the impact of higher raw
   material costs.  Fourth quarter sales were down 3 percent due to lower
   flooring and apparel volumes, particularly in the United States.  Forty-six
   percent lower earnings in the quarter reflect lower volumes and negative
   currency impact, in addition to significantly higher raw material costs.

o  Agriculture & Nutrition - Full-year segment earnings were down 7 percent on
   3 percent lower sales, lower variable margins in Crop Protection and higher
   natural gas costs, and planned higher marketing costs in Nutrition &
   Health.  Volumes were essentially flat for the year while lower USD prices
   reduced sales by 3 percent.  Fourth quarter earnings were up 13 percent
   versus 1999 despite lower sales due to lower fixed costs in both business
   units.

o  Pioneer - Pioneer results for the year reflect strong performance in a
   difficult agricultural economy.  Corn and soybean seed revenues increased
   6 and 12 percent, respectively, over 1999 on a comparable basis.  Higher
   net selling prices more than offset a slight decline in corn unit volumes.
   Soybean units and prices were both up as flyphosate tolerant acreage
   continued to expand.

o  Pharmaceuticals - A fourth quarter loss of $13 million was primarily due to
   lower sales, as product in the distribution channel began to be reduced.
   As planned, R&D and marketing expenses increased.  "Cardiolite" cardiac
   imaging agent sales and earnings benefited from customer purchases prior to
   a year-end price increase.  In the quarter, DuPont announced plans to
   separate the Pharma business.  Major product sales are shown below:

           ($ in millions)        4Q 2000   YR 2000   4Q 1999   YR 1999
       ------------------------   -------   -------   -------   -------
       "Coumadin"                     7       256        89       464
       SustivaTM                     50       386        87       211
       "Sinemet Brand"               35       170        95       331
       "Cardiolite"/MiralumaTM       93       272        68       210

Outlook
- -------
        The company anticipates that the challenging economic condition
experienced in the second half of 2000 will continue into the first half of
2001 and is accelerating efforts to manage costs in line with the difficult


                                       8




business environment.  In assessing the outlook for the first half of 2001, it
is important to consider the varying impact of economic factors across the
DuPont portfolio of businesses.
o  The Pharmaceuticals segment revenues and earnings will significantly
   decline in the first half of 2001, as product in the distribution channel
   returns to normal levels and the business increases investment in R&D and
   marketing to support a promising R&D pipeline.  Accordingly, the company
   expects Pharmaceuticals to continue to show losses in the first half of
   2001, weighted toward the first quarter.  First quarter losses are expected
   to be several times greater than those of the fourth quarter.  This outlook
   includes the impact of accounting for "Cozaar" losartan potassium payments
   on an equalized basis, beginning Feb. 1, 2001.  The company expects the
   Pharmaceuticals business to return to profitability during the second half
   of 2001.

o  The agriculture related segments are expected to continue to operate in a
   difficult farm economy and experience negative currency impacts during the
   first half of 2001.  In addition, the company expects that, as high U.S.
   natural gas prices drive up nitrogen fertilizer costs, North American
   planting decisions may be affected, tending to decrease total acreage
   planted and shift the crop mix away from corn.  High natural gas costs will
   continue to pressure Protein Technologies International, whose manufactur-
   ing processes are natural gas energy intensive.  Taking these factors into
   account, the company expects a moderately negative operating outlook for
   these segments versus 2000.

o  DuPont chemicals and materials businesses will continue to be adversely
   affected by high raw materials costs and the current economic slow down.
   The company expects further weakening in apparel, automotive and housing
   markets - which are end-use markets for over 40 percent of DuPont sales.
   In aggregate, these segments will see significantly lower first half sales
   and ATOI, compared to a strong first half in 2000.

o  While the company currently expects adverse macroeconomic conditions at
   least through the first half of 2001, these are expected to have the
   greatest impact in the first quarter of 2001 - when declines in demand,
   increases in energy and raw materials prices and negative currency impacts
   are anticipated to be the most pronounced.

o  In addition to these business-related factors, preliminary indications are
   that the impact of changes in assumptions used to measure accruals for
   pension and other post-retirement employee benefits (OPEBs) could result in
   increased cost in the range of $.01 - $.03 per share, per quarter, versus
   2000.








                                       9






o  DuPont has accelerated operational initiatives begun last year to manage
   costs in line with the business environment.  Actions have been taken to
   streamline logistics, production scheduling, purchasing and other processes
   through Six Sigma; improve pricing and product mix; reduce working capital
   and capital expenditures; and strengthen focus on the customer.  Through
   aggressive and integrated management of these performance levers, the
   company expects to mitigate some of the impact of macroeconomic factors
   while strengthening its businesses.

        "We share the concerns voiced throughout our industry over the
economic uncertainties for 2001 and the volatility of the business environment
we are facing," Holliday said.  "We are addressing these concerns by staying
focused on the fundamentals and will bring spending in line with a tough
environment, while staying alert to opportunities for targeted growth
investment.  We will be poised to capitalize on a recovery when it occurs."

Forward-Looking Statements:  This news release contains forward-looking
statements based on management's current expectations, estimates and
projections.  All statements that address expectations or projections about
the future, including statements about the company's strategy for growth,
product development, market position, expected expenditures and financial
results are forward-looking statements.  Some of the forward-looking state-
ments may be identified by words like "expects," "anticipates," "plans,"
"intends," "projects," "indicates," and similar expressions.  These state-
ments are not guarantees of future performance and involve a number of risks,
uncertainties and assumptions.  Many factors, including those discussed more
fully elsewhere in this release and in DuPont's filings with the Securities
and Exchange Commission,  particularly its latest annual report on Form 10-K,
as well as others, could cause results to differ materially from those stated.
These factors include, but are not limited to changes in the laws, regula-
tions, policies and economic conditions of countries in which the company does
business; competitive pressures; successful integration of structural changes,
including restructuring plans, acquisitions, divestitures and alliances;
research and development of new products, including regulatory approval and
market acceptance, seasonality of sales of agricultural products.


                                      ###

1/24/01









                                      10







E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES



                                                                 Three Months Ended          Year Ended
CONSOLIDATED INCOME STATEMENT                                       December 31              December 31
- -------------------------------------------------------------------------------------------------------------
(Dollars in millions, except per share)                           2000       1999         2000         1999
- -------------------------------------------------------------------------------------------------------------
                                                                                         
SALES .......................................................   $6,316     $ 7,140      $28,268      $26,918
Other Income<Fa> ............................................      (52)        562          934          974
                                                                ------     -------      -------      -------
  Total .....................................................    6,264       7,702       29,202       27,892
                                                                ------     -------      -------      -------
Cost of Goods Sold and Other Operating Charges<Fb> ..........    4,188       4,681       18,207       16,991
Selling, General and Administrative Expenses ................      765         811        3,041        2,595
Depreciation ................................................      360         363        1,415        1,444
Amortization of Goodwill and Other Intangible Assets<Fc> ....      116         110          445          246
Research and Development Expense ............................      453         478        1,776        1,617
Interest and Debt Expense ...................................      194         202          810          535
Purchased In-Process Research and Development<Fd> ...........      -         2,210          (11)       2,250
Employee Separation Costs and Write-Down of Assets<Fe> ......      (25)        (72)         101          524
Gain on Issuance of Stock by Affiliates - Nonoperating<Ff> ..      -           -            (29)         -
                                                                ------     -------      -------      -------
  Total .....................................................    6,051       8,783       25,755       26,202
                                                                ------     -------      -------      -------
INCOME (LOSS) FROM CONTINUING OPERATIONS BEFORE INCOME TAXES
  AND MINORITY INTERESTS ....................................      213      (1,081)       3,447        1,690
Provision for Income Taxes ..................................      (61)        344        1,072        1,410
Minority Interests in Earnings of Consolidated Subsidiaries .       13          11           61           61
                                                                ------     -------      -------      -------
INCOME (LOSS) FROM CONTINUING OPERATIONS ....................      261      (1,436)       2,314          219
DISCONTINUED OPERATIONS
  Gain on Disposal of Discontinued Business,
    Net of Income Taxes<Fg> .................................      -            16          -          7,471
                                                                ------     -------      -------      -------
NET INCOME (LOSS) ...........................................   $  261     $(1,420)     $ 2,314      $ 7,690
                                                                ======     =======      =======      =======
=============================================================================================================

BASIC EARNINGS (LOSS) PER SHARE OF COMMON STOCK<Fh><Fi>
  Continuing Operations .....................................   $  .25     $ (1.38)     $  2.21      $   .19
  Discontinued Operations ...................................      -           .02         -            6.89
                                                                ------     -------      -------      -------
  Net Income (Loss) .........................................   $  .25     $ (1.36)     $  2.21      $  7.08
                                                                ======     =======      =======      =======
DILUTED EARNINGS PER SHARE OF COMMON STOCK<Fh><Fi>
  Continuing Operations .....................................   $  .25     $ (1.38)     $  2.19      $   .19
  Discontinued Operations ...................................      -           .02         -            6.80
                                                                ------     -------      -------      -------
  Net Income (Loss) .........................................   $  .25     $ (1.36)     $  2.19      $  6.99
                                                                ======     =======      =======      =======
DIVIDENDS PER SHARE OF COMMON STOCK .........................   $  .35     $   .35      $  1.40      $  1.40
                                                                ======     =======      =======      =======



                                                      11





[FN]
FOOTNOTES TO CONSOLIDATED INCOME STATEMENT
- ------------------------------------------
<Fa> Fourth quarter 2000 includes a noncash charge of $342 to write down the
     Company's investment in WebMD to estimated fair market value and to
     write off warrants returned to WebMD in connection with terminating the
     Company's 1999 healthcare collaboration agreement with WebMD.  Fourth
     quarter 2000 also includes a $24 gain related to formation of a global
     50/50 joint venture with Sabanci Holding for industrial nylon.

     In addition, total year 2000 includes the following gains:  $94 result-
     ing from the sale of stock that reduced the Company's ownership interest
     in DuPont Photomasks, $23 resulting from the sale of the Company's
     interest in a Mexican affiliate, and $176 resulting from the sale by
     Pioneer of certain equity securities classified as available for sale.

     Fourth quarter 1999 includes a noncash $336 gain associated with
     exchanging the Company's investment in WebMD for Healtheon/WebMD, an $80
     benefit related to recalculation of interest on federal tax refunds and
     liabilities, and a $55 loss related to the formation of a 50/50 joint
     venture for the polyester films business.  In addition, total year 1999
     includes an exchange loss of $131 on forward exchange contracts pur-
     chased in 1998 to lock in the U.S. dollar cost of the acquisition of
     Herberts.

<Fb> In accordance with purchase accounting rules applied to the acquisition
     of the remaining 80 percent ownership interest in Pioneer on October 1,
     1999, Pioneer inventory was increased to fair value.  This inventory
     step-up generates noncash charges to cost of goods sold as the inventory
     on hand at the acquisition date is sold.  Fourth quarter and total year
     2000 charges were $20 and $609, respectively.  Fourth quarter 2000 also
     includes a charge of $45 to establish a litigation reserve within the
     Pharmaceuticals segment.

     Total year 2000 also includes a charge of $29 for accrued post-employ-
     ment costs for Pioneer employees and a charge of $100 to increase the
     Company's reserve for "Benlate" 50 DF fungicide litigation.

<Fc> Includes amortization expense associated with the March 1999 acquisition
     of Herberts and the October 1999 acquisition of the remaining 80 percent
     ownership in Pioneer.  Prior to October 1, 1999, Pioneer's results
     (including amortization expense associated with the Company's 20 percent
     ownership interest) were reported as Other Income.

<Fd> Total year 2000 includes a credit of $11 that was recorded based on
     revisions of preliminary purchase price allocations associated with the
     October 1, 1999 purchase of the remaining 80 percent ownership interest
     in Pioneer.

     During the fourth quarter 1999, a charge of $2,186 was recorded in con-
     nection with the purchase of Pioneer based on preliminary allocations of
     purchase price.  In addition, a fourth quarter charge of $24 was




                                      12




[FN]
FOOTNOTES TO CONSOLIDATED INCOME STATEMENT - (CONT'D)
- -----------------------------------------------------
     recorded on revisions of preliminary purchase price allocations asso-
     ciated with the purchase of Herberts.  Total year 1999 also includes an
     estimated charge of $40 that was initially recorded in conjunction with
     the purchase of Herberts based on preliminary allocations of purchase
     price.

<Fe> During the fourth quarter 2000, a net benefit of $25 was recorded to
     reflect changes in estimates related to restructuring activities.  Total
     year 2000 includes restructuring charges of $126 resulting from the
     activities within Pigments & Chemicals and Performance Coatings &
     Polymers, partly offset by the $25 fourth quarter changes in estimates
     as discussed above.  The charge for Pigments & Chemicals totaled a $28
     and included termination payments to about 65 employees and the shutdown
     of various operating facilities at the Chambers Works site.  The
     Performance Coatings & Polymers charges totaled $98 and included
     termination payments to about 1,000 employees and the shutdown of
     manufacturing facilities associated with the continued restructuring of
     the performance coatings business.

     During the fourth quarter 1999, a net benefit of $72 was recorded to
     reflect changes in estimates related to restructuring and divestiture
     activities.  Total year 1999 includes charges of $596 resulting from the
     implementation of restructuring activities within Agriculture &
     Nutrition, the Nylon Enterprise and the Polyester Enterprise, partly
     offset by the $72 fourth quarter changes in estimates as discussed
     above.

<Ff> Represents an increase in the Company's equity investment in DuPont
     Photomasks that resulted from the issuance by DuPont Photomasks of
     additional shares to unrelated parties at a price in excess of book
     value.

<Fg> Reflects income from Conoco's operations through August 6, 1999 and
     includes the gain of $7,306 realized by the Company from the completion
     of the Conoco exchange offer.

<Fh> Earnings per share are calculated on the basis of the following average
     number of common shares:
                 Three Months Ended                  Year Ended
                     December 31                     December 31
            -----------------------------   -----------------------------
                Basic          Diluted          Basic          Diluted
            -------------   -------------   -------------   -------------
     2000   1,039,337,687   1,045,723,893   1,043,358,416   1,051,042,524
     1999   1,045,195,827   1,045,195,827   1,084,537,228   1,097,970,329

<Fi> Year-to-date earnings per share do not equal the sum of quarterly
     earnings per share due to changes in average share calculations.






                                      13







E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES



SEGMENT INFORMATION -                                 Three Months Ended                 Year Ended
CONTINUING OPERATIONS<Fa><Fb>                            December 31                     December 31
- -------------------------------------------------------------------------------------------------------------
(Dollars in millions)                                2000          1999              2000           1999
- -------------------------------------------------------------------------------------------------------------
                                                                                      
SEGMENT SALES<Fc>
- -------------
Agriculture & Nutrition ......................      $  588        $   622          $ 2,511        $ 2,592
Nylon Enterprise .............................       1,109          1,138            4,554          4,487
Performance Coatings & Polymers ..............       1,544          1,713            6,485          6,111
Pharmaceuticals ..............................         315            457            1,487          1,630
Pigments & Chemicals .........................         935            933            3,907          3,660
Pioneer ......................................          85             64            1,938            427
Polyester Enterprise .........................         611            714            2,533          2,649
Specialty Fibers .............................         807            876            3,452          3,448
Specialty Polymers ...........................       1,142          1,152            4,508          4,255
Other ........................................          76            129              456            481
                                                    ------        -------          -------        -------
  Total Segment Sales ........................       7,212          7,798           31,831         29,740

Elimination of Intersegment Transfers ........        (141)          (191)            (642)          (733)
Elimination of Equity Affiliate Sales ........        (755)          (468)          (2,927)        (2,092)
Miscellaneous ................................         -                1                6              3
                                                    ------        -------          -------        -------
  CONSOLIDATED SALES .........................      $6,316        $ 7,140          $28,268        $26,918
                                                    ======        =======          =======        =======
AFTER-TAX OPERATING INCOME (LOSS)<Fd><Fe>
- ---------------------------------
Agriculture & Nutrition<Ff> ..................      $   40        $    32          $   189        $   159
Nylon Enterprise<Fg> .........................          79            107              328             63
Performance Coatings & Polymers<Fh> ..........         196            167              674            582
Pharmaceuticals<Fi> ..........................         (57)            48               89            230
Pigments & Chemicals<Fj> .....................         196            168              714            634
Pioneer<Fk> ..................................        (126)        (2,339)            (195)        (2,313)
Polyester Enterprise<Fl> .....................          34            (37)              73           (119)
Specialty Fibers .............................         147            194              690            732
Specialty Polymers ...........................         190            174              713            668
Other<Fm> ....................................        (239)           202             (174)           246
                                                    ------        -------          -------        -------
  Total Segment ATOI .........................         460         (1,284)           3,101            882

Interest & Exchange Gains and Losses<FN> .....        (112)           (70)            (493)          (362)
Corporate Expenses<Fo> .......................         (87)           (82)            (294)          (301)
                                                    ------        -------          -------        -------
  INCOME (LOSS) FROM CONTINUING OPERATIONS ...      $  261        $(1,436)         $ 2,314        $   219
                                                    ======        =======          =======        =======
=============================================================================================================





                                                     14





[FN]
NOTES TO SEGMENT INFORMATION - CONTINUING OPERATIONS
- ----------------------------------------------------
<Fa> In September 1997, the Company acquired a 20 percent interest in Pioneer
     and on October 1, 1999, the Company acquired the remaining 80 percent
     ownership interest.  A new segment has been added to separately report
     Pioneer results; amounts previously reported in the Agriculture &
     Nutrition segment have been reclassified.

<Fb> Certain reclassifications of segment data have been made to reflect
     changes in organizational structure.

<Fc> Includes pro rata equity affiliate sales and intersegment transfers.

<Fd> Fourth quarter 2000 includes a net benefit of $15 resulting from changes
     in estimates related to restructuring activities as follows: Agriculture
     & Nutrition - $6; Nylon Enterprise - $3; Performance Coatings & Polymers
     - $2; and Polyester Enterprise - $4.

<Fe> Fourth quarter 1999 includes a net benefit of $47 resulting from changes
     in estimates related to restructuring and divestiture activities as
     follows:  Agriculture & Nutrition - $2; Nylon Enterprise - $11;
     Performance Coatings & Polymers - $1; Pharmaceuticals - $3; Pigments &
     Chemicals - $1; Polyester Enterprise - $10; Specialty Fibers - $1,;
     Specialty Polymers - $2; and Other - $16.

<Ff> Total year 2000 includes a charge of $62 to increase the Company's
     reserve for "Benlate" 50 DF fungicide litigation.

     Total year 1999 includes a charge of $107 attributable to separation
     costs for about 800 employees, shutdown of various manufacturing
     facilities and the write-off of an intangible asset resulting from
     the loss of exclusive product marketing rights.

<Fg> Fourth quarter and total year 2000 includes a $24 gain related to
     formation of a global 50/50 joint venture with Sabanci Holding for
     industrial nylon.

     Total year 1999 includes a $337 charge, of which $247 represents an
     impairment charge for the write-down of an adipic acid plant in
     Singapore that continues to operate.  Other costs are principally due to
     the write-down of manufacturing assets in India pursuant to a sales
     agreement and the liquidation of a joint venture in China.

<Fh> Total year 2000 includes a charge of $61 related to employee separation
     costs for about 1,000 employees within Performance Coatings, the
     shutdown of related manufacturing facilities, and other exit costs.








                                      15





[FN]
NOTES TO SEGMENT INFORMATION - CONTINUING OPERATIONS - (CONT'D)
- ---------------------------------------------------------------
     Fourth quarter 1999 includes a charge of $24 to increase the preliminary
     purchase price allocation to purchased in-process research and develop-
     ment in conjunction with the acquisition of Herberts.  Total year 1999
     includes a charge of $64 attributable to purchased in-process research
     and development associated with the acquisition of Herberts.

<Fi> Fourth quarter and total year 2000 includes a charge of $44 to establish
     a litigation reserve.

     Fourth quarter and total year 1999 includes a charge of $36 resulting
     from finalization of the tax basis related to the assets acquired and
     liabilities assumed in connection with the purchase of Merck's 50
     percent interest in The DuPont Merck Pharmaceutical Company.

<Fj> Total year 2000 includes a charge of $17 resulting from restructuring
     manufacturing operations at the Chambers Works site, offset by a gain of
     $16 attributable to the sale of the Company's interest in a Mexican
     affiliate.

<Fk> Fourth quarter 2000 includes a noncash charge of $13 resulting from the
     sale of acquired Pioneer inventories which, in accordance with purchase
     accounting rules, were recorded at fair value on October 1, 1999.  Total
     year 2000 includes charges of $379 resulting from the sale of acquired
     Pioneer inventories and a charge of $42 for accrued post-employment
     costs for Pioneer employees, partly offset by a $109 gain resulting from
     the sale by Pioneer of certain equity securities classified as available
     for sale and a credit of $11 to reduce the preliminary purchase price
     allocated to purchased in-process research and development.

     Fourth quarter and total year 1999 include a net charge of $2,213, of
     which $2,186 is an estimated charge to write off the purchase price
     allocated to in-process research and development based on preliminary
     purchase price allocations in conjunction with the acquisition of the
     remaining 80 percent interest in Pioneer.

<Fl> Fourth quarter 1999 includes a charge of $50 resulting from a loss on
     formation of a 50/50 global joint venture with Teijin for the polyester
     films business.  Total year 1999 also includes a charge of $40 related
     to employee separation costs for about 850 employees.

<Fm> Fourth quarter 2000 includes a noncash charge of $215 to write down the
     Company's investment in WebMD to estimated fair market value and to
     write off warrants returned to WebMD in connection with terminating the
     Company's 1999 healthcare collaboration agreement with WebMD.  Total
     year 2000 includes this fourth quarter charge, partly offset by a gain
     of $62 resulting from the sale of stock that reduced the Company's
     ownership interest in DuPont Photomasks.






                                      16





[FN]
NOTES TO SEGMENT INFORMATION - CONTINUING OPERATIONS - (CONT'D)
- ---------------------------------------------------------------
     Fourth quarter and total year 1999 includes a noncash $208 gain
     associated with exchanging the Company's investment in WebMD for
     Healtheon/WebMD.

[FN] Fourth quarter 1999 includes a benefit of $49 related to recalculation
     of interest on federal tax refunds and liabilities.  Total year 1999
     includes this fourth quarter gain, which was offset by an exchange loss
     of $81 on forward exchange contracts purchased in 1998 to lock in the
     U.S. dollar cost of the acquisition of Herberts.  The purchase price for
     Herberts was negotiated in German marks.

<Fo> Total year 2000 includes a nonoperating gain of $19 on issuance of stock
     by affiliates.  This represents the increase in the Company's equity
     investment in DuPont Photomasks that resulted from the issuance by
     DuPont Photomasks of additional shares to unrelated parties at a price
     in excess of book value.













                                      17






E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES



SEGMENT SALES<Fa>
(4TH QUARTER 2000 VS 4TH QUARTER 1999)
- ------------------------------------------------------------------------------------------------------------------
                                                                  Segment Sales
                                                               Three Months Ended
                                                                  December 31         Percentage Change Due to:
                                                               ------------------    ----------------------------
                                                                                     U.S.$
                                                                  $      Change      Price     Volume    Other<Fb>
                                                               ------    ------      ------    ------    --------
                                                                                          
Agriculture & Nutrition ...................................    $  588      (5)%       (4)%      (1)%
Nylon Enterprise ..........................................     1,109      (3)         0        (3)
Performance Coatings & Polymers ...........................     1,544     (10)        (3)       (7)
Pharmaceuticals ...........................................       315     (31)        N/M       N/M
Pigments & Chemicals ......................................       935       -          3        (3)
Pioneer ...................................................        85      33          0        33
Polyester Enterprise ......................................       611     (14)         0        (9)        (5)%
Specialty Fibers ..........................................       807      (8)        (8)        0
Specialty Polymers ........................................     1,142      (1)        (2)        1
Other .....................................................        76     (41)         -         -        (41)
                                                               ------
  Total                                                        $7,212      (8)%       (3)%      (4)%       (1)%

<FN>                                                               ======
- --------------
<Fa> Includes transfers and pro rata share of equity affiliate sales.
<Fb> Includes sales increase/(decrease) due to acquisitions and divestitures.



SEGMENT INFORMATION EXCLUDING
IMPACT OF ONE-TIME ITEMS -                                      Three Months Ended             Year Ended
CONTINUING OPERATIONS                                              December 31                 December 31
- -----------------------------------------------------------------------------------------------------------------
(Dollars in millions)                                          2000     1999    % Chg.    2000     1999    % Chg.
- -----------------------------------------------------------------------------------------------------------------
                                                                                         
AFTER-TAX OPERATING INCOME
- --------------------------
Agriculture & Nutrition ...................................   $  34    $  30      13%    $  245   $  264     (7)%
Nylon Enterprise ..........................................      52       96     (46)       301      389    (23)
Performance Coatings & Polymers ...........................     194      190       2        733      645     14
Pharmaceuticals ...........................................     (13)      81     N/M        133      263    (49)
Pigments & Chemicals ......................................     196      167      17        715      633     13
Pioneer ...................................................    (113)    (126)    N/M        106     (100)   N/M
Polyester Enterprise ......................................      30        3     N/M         69      (39)   N/M
Specialty Fibers ..........................................     147      193     (24)       690      731     (6)
Specialty Polymers ........................................     190      172      10        713      666      7
Other .....................................................     (24)     (22)    N/M        (21)      22    N/M
                                                              -----    -----             ------   ------
  Total Segment ATOI ......................................     693      784     (12)     3,684    3,474      6

Interest & Exchange Gains and Losses ......................    (112)    (119)              (493)    (330)
Corporate Expenses ........................................     (87)     (82)              (313)    (301)
                                                              -----    -----             ------   ------
  INCOME FROM CONTINUING OPERATIONS .......................   $ 494    $ 583     (15)%   $2,878   $2,843      1%
                                                              =====    =====             ======   ======


                                                       18







FINANCIAL SUMMARY - CONTINUING OPERATIONS
- -----------------------------------------
(Dollars in millions, except per share)



                                                         Three Months Ended                 Year Ended
                                                            December 31                     December 31
                                                     --------------------------      --------------------------
                                                      2000      1999     % Chg.       2000      1999     % Chg.
                                                     ------    ------    ------      ------    ------    ------
                                                                                       
Selected Income Statement Data -
Excluding Impact of One-Time Items
- ----------------------------------
Consolidated Sales .............................     $6,316    $7,140    (12)%       $28,268   $26,918     5%
Segment Sales ..................................      7,212     7,798     (8)         31,831    29,740     7
Segment ATOI ...................................        693       784    (12)          3,684     3,474     6
EBIT ...........................................        782       941    (17)          5,189     4,858     7
EBITDA .........................................      1,258     1,414    (11)          7,049     6,548     8
Income From Continuing Operations ..............        494       583    (15)          2,878     2,843     1
EPS - Diluted ..................................       0.47      0.55    (15)           2.73      2.58     6





                                                     4th Quarter 2000 Vs.            Year 2000 Vs.
                                                     4th Quarter 1999                Year 1999
                                                     --------------------            -------------
                                                                               
Segment ATOI Variance Analysis -
Excluding Impact of One-Time Items
- ----------------------------------
Prices .........................................            $ 124                       $ 349
Volume .........................................             (127)                        258
Costs ..........................................             (152)                       (664)
Other ..........................................               66                           3
Currency .......................................              (50)                       (149)
Portfolio Change ...............................               48                         413
                                                            -----                       -----
  Total ........................................            $ (91)                      $ 210
                                                            =====                       =====






                                                       19









                                  SIGNATURE



          Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.





                                 E. I. DU PONT DE NEMOURS AND COMPANY
                                             (Registrant)




                                          /s/ D. B. Smith
                                 ------------------------------------
                                             D. B. Smith
                                         Assistant Controller




January 24, 2001









                                      20