Exhibit 10 (v)


          =================================================================


                               ASSET PURCHASE AGREEMENT

                                        Among

                        COLLABORATIVE CLINICAL RESEARCH, INC.,
                        GFI PHARMACEUTICAL SERVICES, INC., and
                             COLLABORATIVE HOLDINGS, INC.

                                         and

                            THE WEST COMPANY, INCORPORATED



                              DATED:  December 21, 1998


          =================================================================

          



                                             TABLE OF CONTENTS

                                                                 Page No.
          
          
                                                                
          RECITALS  . . . . . . . . . . . . . . . . . . . . . . . . . .   1

          1.   DEFINITIONS; GENERAL PROVISIONS. . . . . . . . . . . . .   1
               1.2   General Provisions; Incorporation of Recitals. . .  10

          2.   PURCHASE AND SALE OF ASSETS; CLOSING . . . . . . . . . .  11
               2.1   Acquired Assets  . . . . . . . . . . . . . . . . .  11
               2.2   Assumption of Liabilities; Excluded Liabilities  .  11
               2.3   Purchase Price Amount; Estimated Purchase Price  .  11
               2.4   Final Closing Date Balance Sheet . . . . . . . . .  12
               2.5   Purchase Price Adjustment for 
                     Uncollected Receivables  . . . . . . . . . . . . .  14
               2.6   Closing Deliveries . . . . . . . . . . . . . . . .  15
               2.7   Closing  . . . . . . . . . . . . . . . . . . . . .  16
               2.8   Allocation of the Purchase Price . . . . . . . . .  16

          3.   REPRESENTATIONS AND WARRANTIES OF SELLERS  . . . . . . .  17
               3.1   Organization and Good Standing . . . . . . . . . .  17
               3.2   Authority; No Conflict . . . . . . . . . . . . . .  17
               3.3   Financial Statements; Accounts Receivable  . . . .  18
               3.4   Books and Records  . . . . . . . . . . . . . . . .  19
               3.5   Title To Assets; Encumbrances  . . . . . . . . . .  19
               3.6   Condition and Sufficiency of Assets  . . . . . . .  20
               3.7   No Undisclosed Liabilities . . . . . . . . . . . .  21
               3.8   Taxes  . . . . . . . . . . . . . . . . . . . . . .  21
               3.9   No Material Adverse Change . . . . . . . . . . . .  22
               3.10  Employee Benefits  . . . . . . . . . . . . . . . .  22
               3.11  Compliance With Legal Requirements; Governmental
                     Authorizations  . .. . . . . . . . . . . . . . . .  22
               3.12  Legal Proceedings; Orders  . . . . . . . . . . . .  23
               3.13  Absence of Certain Changes and Events  . . . . . .  24
               3.14  Contracts; No Defaults . . . . . . . . . . . . . .  25
               3.15  Insurance  . . . . . . . . . . . . . . . . . . . .  27
               3.16  Environmental Matters  . . . . . . . . . . . . . .  28
               3.17  Employees  . . . . . . . . . . . . . . . . . . . .  30
               3.18  Labor Disputes; Compliance . . . . . . . . . . . .  30
               3.19  Intellectual Property  . . . . . . . . . . . . . .  30
               3.20  Relationships With Related Persons . . . . . . . .  31
               3.21  Brokers or Finders . . . . . . . . . . . . . . . .  31
               3.22  Disclosure . . . . . . . . . . . . . . . . . . . .  32

          4.   REPRESENTATIONS AND WARRANTIES OF BUYER  . . . . . . . .  32
               4.1   Organization and Good Standing . . . . . . . . . .  32
               4.2   Authority; No Conflict . . . . . . . . . . . . . .  32
               4.3   Certain Proceedings  . . . . . . . . . . . . . . .  33
               4.4   Brokers or Finders . . . . . . . . . . . . . . . .  33

          5.   COVENANTS OF SELLERS PRIOR TO AND FOLLOWING CLOSING DATE  33
 
            



               5.1   Access and Investigation . . . . . . . . . . . . .  33
               5.2   Operation of the Clinical Business of Sellers.   .  33
               5.3   Negative Covenant  . . . . . . . . . . . . . . . .  34
               5.4   Required Approvals . . . . . . . . . . . . . . . .  34
               5.5   Notification . . . . . . . . . . . . . . . . . . .  34
               5.6   No Negotiation . . . . . . . . . . . . . . . . . .  35
               5.7   Best Efforts . . . . . . . . . . . . . . . . . . .  36
               5.8   HSR Act Filing . . . . . . . . . . . . . . . . . .  36
               5.9   Labor Matters  . . . . . . . . . . . . . . . . . .  36
               5.10  Subsequent Financial Statements  . . . . . . . . .  37
               5.11  Excluded Liabilities . . . . . . . . . . . . . . .  37
               5.12  Voting of Shares . . . . . . . . . . . . . . . . .  38
               5.13  Collaborative Shareholder Approvals  . . . . . . .  38

          6.   COVENANTS OF BUYER PRIOR TO CLOSING DATE . . . . . . . .  38
               6.1   Approvals of Governmental Bodies . . . . . . . . .  38
               6.2   Best Efforts . . . . . . . . . . . . . . . . . . .  38

          7.   CONDITIONS PRECEDENT TO BUYER'S OBLIGATION TO CLOSE  . .  38
               7.1   Accuracy of Representations  . . . . . . . . . . .  39
               7.2   Sellers' Performance . . . . . . . . . . . . . . .  39
               7.3   Consents . . . . . . . . . . . . . . . . . . . . .  39
               7.4   Additional Documents . . . . . . . . . . . . . . .  39
               7.5   No Proceedings . . . . . . . . . . . . . . . . . .  39
               7.6   No Prohibition . . . . . . . . . . . . . . . . . .  40
               7.7   HSR Act  . . . . . . . . . . . . . . . . . . . . .  40
               7.8   Bulk Sales . . . . . . . . . . . . . . . . . . . .  40
               7.9   No Material Adverse Change . . . . . . . . . . . .  40

          8.   CONDITIONS PRECEDENT TO SELLERS' OBLIGATION TO CLOSE . .  40
               8.1   Accuracy of Representations  . . . . . . . . . . .  41
               8.2   Buyer's Performance  . . . . . . . . . . . . . . .  41
               8.3   Consents . . . . . . . . . . . . . . . . . . . . .  41
               8.4   Additional Documents . . . . . . . . . . . . . . .  41
               8.5   Shareholder Approval . . . . . . . . . . . . . . .  41
               8.6   No Injunction  . . . . . . . . . . . . . . . . . .  42

          9.   TERMINATION  . . . . . . . . . . . . . . . . . . . . . .  42
               9.1   Termination Events . . . . . . . . . . . . . . . .  42
               9.2   Effect of Termination  . . . . . . . . . . . . . .  43
               9.3   Termination Fee; Expense Fee . . . . . . . . . . .  43

          10.  INDEMNIFICATION; REMEDIES  . . . . . . . . . . . . . . .  43
               10.1  Survival . . . . . . . . . . . . . . . . . . . . .  43
               10.2  Indemnification and Reimbursement by Sellers . . .  43
               10.3  Indemnification and Reimbursement by Buyer . . . .  44
               10.4  Procedure for Indemnification - Third Party Claims  45
               10.5  Limitation of Claims . . . . . . . . . . . . . . .  46

          11.  GENERAL PROVISIONS . . . . . . . . . . . . . . . . . . .  47
               11.1  Expenses . . . . . . . . . . . . . . . . . . . . .  47
               11.2  Public Announcements . . . . . . . . . . . . . . .  47
               11.3  Confidentiality  . . . . . . . . . . . . . . . . .  47
               11.4  Notices  . . . . . . . . . . . . . . . . . . . . .  47


         


               11.5  Jurisdiction; Service of Process . . . . . . . . .  48
               11.6  Further Assurances . . . . . . . . . . . . . . . .  49
               11.7  Waiver . . . . . . . . . . . . . . . . . . . . . .  49
               11.8  Entire Agreement and Modification  . . . . . . . .  49
               11.9  Schedules  . . . . . . . . . . . . . . . . . . . .  49
               11.10 Assignments, Successors, and No Third-Party Rights  49
               11.11 Severability . . . . . . . . . . . . . . . . . . .  50
               11.12 Section Headings . . . . . . . . . . . . . . . . .  50
               11.13 Time of Essence  . . . . . . . . . . . . . . . . .  50
               11.14 Governing Law  . . . . . . . . . . . . . . . . . .  50
               11.15 Counterparts . . . . . . . . . . . . . . . . . . .  50
               11.16 Use of Name  . . . . . . . . . . . . . . . . . . .  50
               11.17 Records Retention  . . . . . . . . . . . . . . . .  50
               11.18 Joinder by DataTRAK  . . . . . . . . . . . . . . .  51
          







          EXHIBITS
          --------
          
          
                    
          A          -    Acquired Assets
          B          -    Assumed Liabilities
          C          -    Escrow Agreement
          D          -    Intentionally Omitted
          E          -    Excluded Assets
          F          -    Non-Competition Agreement
          G          -    Seller Agreement
          H          -    Sellers' Certificate
          I          -    Assumption Agreement
          J          -    Buyer's Certificate
          K          -    Allocation of Purchase Price
          L          -    Management Letter
          M          -    Opinion of Calfee, Halter & Griswold LLP
          N          -    Opinion of Buyer's Counsel

          SCHEDULES
          ---------
          A          -    Sellers' Management Personnel (for purposes of
                          Knowledge definition)
          2.6(a)(ix) -    Terms of Sublease Agreement
          3.1        -    Jurisdictions of Incorporation
          3.2(b)     -    Conflicts; Consents
          3.3        -    Financial Statements
          3.5(b)     -    Facilities
          3.6        -    Condition of Certain Assets
          3.7        -    Undisclosed Liabilities
          3.8        -    Contested Taxes; Assessments
          3.10       -    Employee Benefit Plans
          3.11(a)    -    Compliance with Legal Requirements, etc.
          3.11(b)    _    Governmental Authorizations
          3.12       -    Proceedings; Orders
          3.13       -    Absence of Certain Changes
          3.14       -    Contracts
          3.15       -    Insurance
          3.16       -    Environmental Matters
          3.17       -    Employees
          3.18       -    Labor Disputes, etc.
          3.19       -    Intellectual Property Assets
          3.20       -    Relationships with Related Persons
          3.22       -    Material Adverse Changes
          5.9(d)     -    Employee Severance Obligations
          

         



                               ASSET PURCHASE AGREEMENT
                              -------------------------

                     THIS ASSET PURCHASE AGREEMENT (the "Agreement") is
          made this 21st day of December, 1998, by and among THE WEST
          COMPANY, INCORPORATED, a Pennsylvania corporation (the "Buyer"),
          and COLLABORATIVE CLINICAL RESEARCH, INC., an Ohio corporation,
          ("Collaborative"), GFI PHARMACEUTICAL SERVICES, INC., an Indiana 
          corporation and a wholly-owned subsidiary of Collaborative
          ("GFI"), and COLLABORATIVE HOLDINGS, INC., an Ohio corporation
          and a wholly-owned subsidiary of Collaborative ("CHI")
          (Collaborative, GFI, and CHI being each sometimes individually
          referred to herein as a "Seller" and being collectively referred 
          to as the "Sellers"; GFI and CHI are sometimes collectively
          referred to herein as the "Selling Subsidiaries").


                                       RECITALS
                                      ---------
               A.   The Sellers are engaged in various businesses,
          including the business of providing clinical research and "over-
          the-counter" drug testing and related services (such business, as
          heretofore conducted by Collaborative and the Selling
          Subsidiaries, being collectively referred to herein as the
          "Clinical Business").  The Sellers also engage in activities
          other than the Clinical Business.


               B.   The Sellers desire to sell, and Buyer desires to
          purchase, substantially all of the assets of the Sellers relating
          to or used in the Clinical Business for the consideration and on 
          the terms set forth in this Agreement.

               C.   Buyer is not assuming any liabilities or obligations of
          or relating to any Seller or the Business except as expressly
          provided in this Agreement, and the parties do not intend in any 
          way to effectuate a merger or consolidation.


                                      AGREEMENT
                                      ----------
               For good and valuable consideration, the receipt and
          sufficiency of which are hereby acknowledged, the parties hereto,
          each intending to be legally bound, hereby agree as follows:


               1.   DEFINITIONS; GENERAL PROVISIONS.
                    --------------------------------
                    1.1   For purposes of this Agreement and the Exhibits
          and Schedules attached hereto, the following terms shall have the
          meanings specified or referred to below in this Section 1:

                    "ACQUIRED ASSETS" - As defined in Exhibit A.

          



                    "ACQUISITION PROPOSAL" - As defined in Section 5.6(a).

                    "ASSIGNED CONTRACT" - Any Contract which is designated 
          as an "Assigned Contract" in Exhibit A and assigned to Buyer by
          Seller.


                    "ASSIGNMENT AND ASSUMPTION AGREEMENT" - As defined in
          Section 2.6(b)(ii)

                    "ASSUMED LIABILITIES" - As defined in Exhibit B.

                    "BASE AMOUNT" - As defined in Section 2.3(a).


                    "BREACH" - A "BREACH" of a representation, warranty,
          covenant, obligation or other provision of this Agreement or any 
          Related Agreement will be deemed to have occurred if there is or 
          has been (a) any inaccuracy in or breach of, or any failure to
          perform or comply with, such representation, warranty, covenant, 
          obligation or other provision, or (b) any claim or other
          occurrence or circumstance that is or was inconsistent with such 
          representation, warranty, covenant, obligation or other
          provision, and the term "Breach" means any such inaccuracy,
          breach, failure, claim, occurrence, or circumstance.

                    "BUYER" - As defined in the heading of this Agreement.


                    "CHI" - As defined in the heading of this Agreement.

                    "CHI FACILITY" - The laboratory and related facilities 
          leased by and operated by the WCE division of CHI and situate at 
          6963 Hillsdale Court, Building 46250, Indianapolis, Indiana
          32796.


                     "CLINICAL BUSINESS" - As defined in Paragraph A of the
          Recitals.

                    "CLOSING" - As defined in Section 2.7.


                    "CLOSING CASH PAYMENT" - As defined as
          Section 2.3(d)(i).

                    "CLOSING DATE" - The date and time as of which the
          Closing actually takes place.


                    "CLOSING DATE NET WORKING CAPITAL" - The Net Working
          Capital as of the Closing Date, as determined by reference to the
          Final Closing Date Balance Sheet.

          



                    "CODE" - The Internal Revenue Code of 1986, as amended,
          or any successor law, and any regulations issued by the IRS
          pursuant to the Internal Revenue Code of 1986, as amended, or any
          successor law.

                    "COLLABORATIVE" - As defined in the heading of this
          Agreement.


                    "COLLABORATIVE BOARD" - The Board of Directors of
          Collaborative.

                    "COLLABORATIVE PREMISES" - Collectively the office
          space leased by Collaborative and situate in the Tower Building, 
          20600 Chagrin Boulevard, Suite 1050, Cleveland, Ohio 44122.

                    "CONFIDENTIALLY AGREEMENT" - The confidentiality
          agreement dated as of July 31, 1998, among the Buyer and the
          Sellers.


                    "CONSENT" - Any approval, consent, ratification,
          waiver, or other authorization (including any Governmental
          Authorization).

                    "CONTEMPLATED TRANSACTIONS" - All of the transactions
          described in this Agreement and each of the Related Agreements.


                    "CONTRACT" - Any agreement, contract, obligation,
          promise, undertaking, letter of intent, or memorandum of
          understanding (whether written or oral and whether express or
          implied) that is legally binding.

                    "CURRENT ASSETS" - At any applicable time, all assets
          included in the Acquired Assets which, in accordance with GAAP,
          should be classified as current assets of Sellers (after
          eliminating inter-company items).


                    "CURRENT LIABILITIES" - At any applicable time, all
          liabilities included in the Assumed Liabilities which, in
          accordance with GAAP, should be classified as current liabilities
          of Sellers.

                    "DAMAGES" - As defined in Section 10.2.


                    "DATATRAK" - DataTRAK, Inc., an Ohio corporation and
          wholly-owned subsidiary of Collaborative.

                    "EMPLOYEE BENEFIT PLANS" - All "Plans" (as defined in
          ERISA  3(3)) of which Seller is or was a "Plan Sponsor" or to

         



          which Seller otherwise contributes or has contributed or in which
          Seller otherwise participates or has participated.

                    "ENCUMBRANCE" - Any charge, claim, community property
          interest, condition, equitable interest, lien, option, pledge,
          security interest, right of first refusal or restriction of any
          kind.


                    "ENVIRONMENTAL, HEALTH AND SAFETY LIABILITIES" - Any
          Damages, Liabilities, or other responsibility arising from or
          under any Environmental Law or Occupational Safety and Health
          Law.

                    "ENVIRONMENTAL LAWS" - All Legal Requirements
          (including rules, regulations, codes, plans, injunctions,
          judgments, Orders, policies, decrees, rulings and charges
          thereunder) concerning pollution or protection of the
          environment, including laws relating to emissions, discharges,
          Releases, or threatened Releases of pollutants, contaminants, or 
          Hazardous Materials into ambient air, surface water, groundwater,
          or lands or otherwise relating to the manufacture, processing,
          distribution, use, treatment, storage, disposal, transport, or
          handling of Hazardous Materials, including, but not limited to,
          the Comprehensive Environmental Response, Compensation, and
          Liability Act of 1980, 42 U.S.C. '' 9601 et seq., the Emergency
          Planning and Community Right-to-Know Act of 1986, 42 U.S.C.
          '' 1001 et seq., the Resource Conservation and Recovery Act of
          1976, 42 C.S.C. '' 6901 et seq., each as amended from time to
          time.

                    "ERISA" - The Employee Retirement Income Security Act
          of 1974 or any successor law, and regulations and rules issued
          pursuant thereto or to any successor law.


                    "ESCROW AGREEMENT" - The Escrow Agreement among Buyer, 
          Sellers, and Escrow Holder, the form of which is attached hereto 
          as Exhibit C.

                    "ESCROW DEPOSIT" - As defined in Section 2.3(d)(ii).


                    "ESCROW HOLDER" - An independent third party jointly
          selected by the Buyer and the Sellers prior to the Closing Date
          to serve as the escrow holder pursuant to the Escrow Agreement.

                    "ESTIMATED CLOSING DATE NET WORKING CAPITAL" - As
          defined in Section 2.3(b).


                    "ESTIMATED PURCHASE PRICE" - As defined in
          Section 2.3(a).

          



                    "EXCLUDED ASSETS" -  As defined in Exhibit D.

                    "EXCLUDED LIABILITIES" - As defined in Section 2.2.


                    "EXPENSE FEE" - As defined in Section 9.3.

                    "FACILITIES" - Any real property, leaseholds, or other 
          interests currently owned or operated by any Seller and used in
          connection with the Clinical Business, and any buildings, plants,
          structures or equipment currently owned, leased or operated by
          any Sellers and used in connection with the Clinical Business or 
          which otherwise comprise a part of the Clinical Business
          (including, but not limited to, the Leased Properties).

                    "FDA" - The United States Food and Drug Administration,
          together with any department thereof.


                    "FINAL CLOSING DATE STATEMENT" - As defined in
          Section 2.4(a).

                    "FINANCIAL STATEMENTS" - Collectively, the Prior
          Financial Statements and the Interim Financial Statements.


                    "GAAP" - At any particular time, generally accepted
          accounting principles as in effect in the United States at such
          time.

                    "GFI" - As defined in the heading of this Agreement.


                    "GFI FACILITY" - Collectively, the clinical and
          laboratory testing facility leased by GFI and situate in the
          Saint Mary's Medical Center, 800 Saint Mary's Drive, Evansville, 
          Indiana 47714.

                    "GOVERNMENTAL AUTHORIZATION" - Any Consent, license or 
          permit issued, granted or given by or under the authority of any 
          Governmental Body or pursuant to any Legal Requirement.


                    "GOVERNMENTAL BODY" - Any federal, state, local,
          municipal, foreign or other governmental or quasi-governmental
          entity or authority of any nature (including, without limitation,
          the FDA).

                    "HAZARDOUS MATERIALS" - Any pollutants, contaminants,
          toxic or hazardous or extremely hazardous substances, materials, 
          wastes, constituents, compounds, chemicals, natural or man-made
          elements or forces (including, but not limited to, petroleum or
          any byproducts or fractions thereof, any form of natural gas,

         



          Bevill Amendment materials, lead, asbestos, and asbestos-
          containing materials, building construction materials and debris,
          polychlorinated biphenyls ("PCBs") and PCB-containing equipment, 
          radon and other radioactive elements, ionizing radiation,
          electromagnetic field radiation and other non-ionizing radiation,
          sonic forces and other natural forces, infectious, carcinogenic, 
          mutagenic, or etiologic agents, pesticides, defoliants,
          explosives, flammables, corrosives, and urea formaldehyde foam
          insulation) that is now or has heretofore been regulated by or
          may now form the basis for Liabilities under, any Environmental
          Laws, whether or not listed or classified in any Environmental
          Laws.

                    "HSR ACT" - The Hart-Scott-Rodino Antitrust
          Improvements Act of 1976, as amended.


                    "INDEMNIFIED PERSONS" - As defined in Section 10.2.

                    "INTELLECTUAL PROPERTY ASSETS" - As defined in
          Section 3.19.

                    "INTERIM BALANCE SHEET" - As defined in Section 3.5(a).


                    "INTERIM FINANCIAL STATEMENTS" - As defined in
          Section 3.3(a)(ii).

                    "IRS" - The Internal Revenue Service.


                    "KNOWLEDGE" - An individual will be deemed to have
          "Knowledge" of a particular fact or matter if:

                          (a)  such individual is aware of such fact or
               other matter; or


                          (b)  a prudent individual could be expected to
               discover or otherwise become aware of such fact or other
               matter in the course of conducting a reasonably
               comprehensive investigation concerning the existence of such
               fact or other matter.

          A Seller will be deemed to have "Knowledge" of a particular fact 
          or other matter if any of the following Persons has, or at any
          time had, Knowledge of such fact or other matter: (1) any
          individual who, as of the date hereof and during any period
          hereafter through and including the Closing Date, is serving as a
          director or officer of any Seller; or (2) any member of Sellers' 
          management identified on Schedule A hereto.


                    "LAB SERVICE CONTRACT" - Any Contract to which any

           



          Seller is a party relating to laboratory and related services
          utilized in connection with clinical research studies conducted.

                    "LEASED PROPERTIES" and "LEASED PROPERTY" -
          Collectively or individually, as appropriate, the Collaborative
          Premises, the GFI Facility, and the CHI Facility.


                    "LEASES" and "LEASE" - Collectively or individually, as
          appropriate, the leases relating to the Leased Properties and
          more particularly described in EXHIBIT A.  

                    "LEGAL REQUIREMENT" - Any federal, state, local,
          municipal, foreign, international, multi-national, or other law, 
          ordinance, regulation, statute or treaty (including, without
          limitation, rules and regulations promulgated by the FDA).

                    "LIABILITIES" - Any debts, obligations, or liabilities 
          of any nature (including, but not limited to, any unknown,
          undisclosed, unaccrued, unasserted, contingent, or conditional
          debt, obligation, or liability), regardless of whether such
          debts, obligations, or liabilities would be required to be
          disclosed on a balance sheet prepared in accordance with GAAP.


                    "MARKS" - As defined in Section 3.19(a).

                    "MATERIAL ADVERSE EFFECT" - A material adverse effect
          upon the financial condition of any Seller or the Clinical
          Business.


                    "NET WORKING CAPITAL" - As at any applicable time,
          (i) Current Assets minus (ii) Current Liabilities.

                    "NON-COMPETITION AGREEMENT" - As defined in
          Section 2.6(a)(i).


                    "OCCUPATIONAL SAFETY AND HEALTH LAW" - Any Legal
          Requirement designed to provide safe and healthful working
          conditions, and to reduce occupational safety and health hazards,
          and any program, whether governmental or private, designed to
          provide safe and healthful working conditions.

                    "ORDER" - Any award, decision, injunction, judgment,
          order, ruling, subpoena, or verdict entered, issued, made, or
          rendered by any court, administrative agency, or other
          Governmental Body or by any arbitrator.


                    "ORDINARY COURSE OF CLINICAL BUSINESS" - An action
          taken by a Person will be deemed to have been taken in the
          "Ordinary Course of Clinical Business" only if:

         



                          (a)  such action is consistent with the past
               practices of such Person and is taken in the ordinary course
               of the normal operations of such Person;

                          (b)  such action is not required to be authorized
               by the board of directors of such Person (or by any Person
               or group of Persons exercising similar authority), and does 
               not require any other separate or special authorization; and


                          (c)  such action is similar in nature and
               magnitude to actions customarily taken, without any separate
               or special authorization, in the ordinary course of the
               operations of other Persons that are engaged in the same
               type or line of business as such Person.

                    "PATENTS" - As defined in Section 3.19(a)(ii).

                    "PERSON" - Any individual, corporation, general or
          limited partnership, limited liability company, joint venture,
          estate, trust, association, organization, or other entity or
          Governmental Body.


                    "PRIOR FINANCIAL STATEMENTS" - As defined in
          Section 3.3(a)(i).

                    "PROCEEDING" - Any action, arbitration, audit, hearing,
          investigation, litigation, or suit (whether civil, criminal,
          administrative, investigative or informal) commenced, brought,
          conducted, or heard by or before, or otherwise involving, any
          Governmental Body or arbitrator.


                    "PURCHASE PRICE" - As defined in Section 2.3(a).

                    "RELATED AGREEMENTS" - All agreements, documents,
          certificates and instruments to be delivered pursuant to this
          Agreement or the Contemplated Transactions, including, without
          limitation, the Assignment and Assumption Agreement, the Escrow
          Agreement, the Non-Competition Agreement, the Sublease Agreement,
          and the Seller Agreements.


                    "RELATED PERSON" - With respect to a particular
          individual shall mean:

                          (a)  each other member of such individual's
               family;


                          (b)  any Person that is directly or indirectly
               controlled by any one or more members of such individual's
               family;

          



                          (c)  any Person in which members of such
               individual's family hold (individually or in the aggregate) 
               a material interest; and

                          (d)  any Person with respect to which one or more
               members of such individual's family serves as a director,
               officer, partner, or trustee (or in a similar capacity).


          With respect to a specified Person other than an individual shall
          mean:

                          (a)  any Person that directly or indirectly
               controls, is directly or indirectly controlled by, or is
               directly or indirectly under common control with such
               specified Person;

                          (b)  each Person that serves as a director,
               officer, partner, or trustee of such specified Person (or in
               a similar capacity); and


                          (c)  any Person in which specified Person holds a
               material interest.

                    "RELEASE" - Any spilling, leaking, pumping, pouring,
          emitting, emptying, discharging, ejecting, escaping, dumping or
          other dissemination.


                    "REPRESENTATIVE" - With respect to a particular Person,
          any director, officer, employee, agent, consultant, advisor, or
          other representative of such Person, including legal counsel,
          accountants and financial advisors.

                    "SEC" - The Securities Exchange Commission, or any
          successor agency.


                    "SELLERS" and "SELLER" - As defined in the heading of
          this Agreement.


                    "SELLER AGREEMENTS" - As defined in Section 2.6(a)(ii).



                    "SELLING SUBSIDIARIES" - As defined in the heading of
          this Agreement.



                    "SITE CONTRACTS" - Collectively, any Contract to which 
            




          any Seller is a party with hospitals, physicians, clinics, and
          other sites, pursuant to which such sites conduct clinical
          studies for and on behalf of such Seller.

                    "SPONSOR" - Collectively, each pharmaceutical company, 
          biotechnology company, and contract research organization which
          is a party to the Sponsor Contracts.


                    "SPONSOR CONTRACTS" - Collectively, any Contract to
          which any Seller is a party with a pharmaceutical company,
          biotechnology company, and contract research organization,
          pursuant to which such Seller has agreed to provide, or cause to 
          be provided, clinical studies for and on behalf of such company
          or organization.

                    "SUBLEASE AGREEMENT" - As defined in Section
          2.6(a)(ix).

                    "SUPERIOR PROPOSAL" - As defined in Section 5.6(b).


                    "SUPPLEMENTAL CLOSING" - As defined in Section 2.4(c).

                    "TAX" - Any tax, levy, assessment, tariff, duty,
          deficiency or other fee, and any related charge or amount
          imposed, assessed or collected by or under the authority of any
          Governmental Body.


                    "TAX ALLOCATION" - The manner in which the Purchase
          Price is allocated among the Acquired Assets pursuant to
          Section 2.7.

                    "TAX RETURN" - Any return, report, form or other
          document or information filed with or submitted to, or required
          to be filed with or submitted to, any Governmental Body in
          connection with the determination, assessment, collection, or
          payment of any Tax.


                    "TERMINATION FEE" - As defined in Section 9.3.

                    "THREATENED" - A Proceeding, claim, dispute or other
          matter will be deemed to have been "Threatened" if any demand or 
          statement has been made (orally or in writing) or any notice has 
          been given (orally or in writing), or if any other event has
          occurred or any other circumstances exist, which could reasonably
          be expected to result in such a Proceeding, claim, dispute or
          other matter.  


                    "34 ACT" - The Securities Exchange Act of 1934, as
          amended, and all rules and regulations promulgated thereunder.

          



                    "THRESHOLD AMOUNT" - As defined in Section 10.5(b).

                    "UNCOLLECTED RECEIVABLES" - As defined in Section 2.5.


                    "WARN" - The Worker Adjustment and Retraining
          Notification Act (29 U.S.C. '' 2101 et seq.) and the regulations 
          adopted pursuant thereto.

                    1.2   General Provisions; Incorporation of Recitals.

                          (a)  Unless expressly provided otherwise in this 
          Agreement or the Related Agreements, or unless the context
          requires otherwise:


                               (i)  all capitalized terms used in the
               Related Agreements that are defined in this Agreement shall 
               have the respective meanings assigned to them herein;

                               (ii)  all accounting terms used in this
               Agreement and in the Related Agreements shall have the
               meanings given to them in accordance with GAAP;


                               (iii)  the singular shall mean the plural,
               the plural shall mean the singular, and the use of any
               gender shall include all genders; and all references to any 
               particular party defined herein shall be deemed to refer to 
               each and every Person defined herein as such party
               individually, and to all of them, collectively, jointly and 
               severally, as though each were named wherever the applicable
               defined term is used;

                               (iv)  all references to "Sections" shall be 
               deemed to refer to the provision of this Agreement and all
               references to "Schedules" and "Exhibits" shall be deemed to 
               refer to the schedules and exhibits annexed to this
               Agreement, as appropriate;


                               (v)  all references to time herein shall
               mean Eastern Standard Time or Eastern Daylight Time, as then
               in effect; and 

                               (vi)  all references to sections,
               subsections, paragraphs or other provisions of any Legal
               Requirement that consists of a law, ordinance, regulation,
               statute or treaty, shall be deemed to include successor,
               amended, renumbered and replacement provisions thereof.


                               (vii)  the word "including" shall not limit 
               the preceding words or terms.

                 



                          (b)  The recitals set forth above (including,
          without limitation, the defined terms set forth therein) are
          hereby incorporated by reference into this Agreement and made a
          part hereof as if set forth in their entirety in this
          Section 1.2(b).

               2.   PURCHASE AND SALE OF ASSETS; CLOSING


                    2.1   Acquired Assets.  On and subject to the terms and
          conditions of this Agreement, Buyer agrees to purchase from
          Sellers, and Sellers agree to sell, transfer, convey and deliver 
          to Buyer, all of the Acquired Assets at the Closing for the
          consideration specified in Section 2.3 and also in consideration 
          of the covenants of Buyer set forth herein.  Sellers shall
          specifically retain, and the Acquired Assets shall not include,
          any of the Excluded Assets.

                    2.2   Assumption of Liabilities; Excluded Liabilities. 
           On and subject to the terms and conditions of this Agreement,
          Buyer agrees to assume and become responsible for all of the
          Assumed Liabilities at the Closing.  Notwithstanding anything in 
          this Agreement or any of the Exhibits or Schedules attached
          hereto to the contrary, Buyer will not assume or have any
          responsibility for or with respect to, or purchase the Acquired
          Assets subject to, any Liabilities of any nature whatsoever
          (collectively, the "Excluded Liabilities") which are not
          expressly included within the definition of "Assumed
          Liabilities."  

                    2.3   Purchase Price Amount; Estimated Purchase Price.


                          (a)  Subject to adjustment as provided in
          Section 2.5 and the other provisions of this Section 2.3, the
          purchase price for the Acquired Assets shall be an amount equal
          to (i) Fifteen Million Dollars ($15,000,000) (the "Base Amount")
          PLUS (ii) the Closing Date Net Working Capital (if positive)
          MINUS (iii) the Closing Date Net Working Capital (if negative)
          (the amount calculated pursuant to the foregoing being referred
          to herein as the "Purchase Price").

                          (b)  The parties hereto recognize and acknowledge
          that they will be unable to calculate the Closing Date Net
          Working Capital until after the Closing in accordance with the
          provisions of Section 2.4.  Accordingly, the parties hereto have 
          agreed to calculate the Purchase Price on the Closing Date based 
          upon an estimate of the Closing Date Net Working Capital (the
          "Estimated Closing Date Net Working Capital").  The parties
          hereto shall mutually agree upon the Estimated Closing Date Net
          Working Capital within fifteen (15) days prior to the Closing
          Date based upon and determined by reference to the financial
          statements of the Sellers as of the date on which the Estimated


           


          Closing Date Net Working Capital is determined, and such other
          information which Buyer may require in connection therewith.  The
          parties hereto shall set forth their agreement with respect to
          the Estimated Closing Date Net Working Capital in a written
          instrument signed by them and which shall be attached to and
          become a part of this Agreement.

                          (c)  At the Closing and for purposes thereof, the
          Purchase Price shall be estimated in an amount equal to (i) the
          Base Amount PLUS (ii) the Estimated Closing Date Net Working
          Capital (if positive) MINUS (iii) the Estimated Closing Date Net 
          Working Capital (if negative) (the amount calculated pursuant to 
          the foregoing being referred to herein as the "Estimated Purchase
          Price").


                          (d)  The Estimated Purchase Price shall be
          payable as follows:

                               (i)  an amount equal to the Estimated
               Purchase Price LESS the Escrow Deposit (the "Closing Cash
               Payment") shall be paid by the Buyer to the Sellers at the
               Closing by means of wire transfer of immediately available
               funds to an account or accounts designated by the Sellers,
               in writing, at least three (3) business days prior to the
               Closing Date.

                               (ii) the sum of One Million Dollars
               ($1,000,000) (the "Escrow Deposit") shall be paid by the
               Buyer to the Escrow Holder at the Closing by means of wire
               transfer of immediately available funds to an account
               designed by the Escrow Agent, in writing, at least three (3)
               business days prior to the Closing Date, to be held in
               escrow by the Escrow Holder pursuant to the Escrow Agreement
               for (A) the payment of any sums due to the Buyer under
               Sections 2.4(c)(ii) and 2.5 hereof, and (B) the payment and 
               satisfaction of indemnity claims of the Buyer hereunder
               after the Closing, all in accordance with and subject to the
               provisions of the Escrow Agreement.


                    2.4   Final Closing Date Balance Sheet; Calculation of 
          Closing Date Net Working Capital.

                          (a)  As soon as practicable, but in no event
          later than sixty (60) days after the Closing Date, Buyer will
          prepare and deliver to Sellers a statement of Acquired Assets and
          Assumed Liabilities as of the Closing Date setting forth Buyer's 
          calculation of the Closing Date Net Working Capital by reference 
          thereto (such statement of Acquired Assets and Assumed
          Liabilities, including Buyer's calculation of Closing Date Net
          Working Capital, being referred to as the "Final Closing Date
          Statement").  The Final Closing Date Statement shall be prepared 

            



          in a manner consistent with the preparation of the Financial
          Statement (provided that the Financial Statements have been
          prepared in accordance with GAAP consistently applied).

                          (b)  Upon the completion of the Final Closing
          Date Statement, a copy thereof shall be delivered to Sellers. 
          Sellers shall have the right, for a period of fifteen (15) days
          following their receipt thereof, to review the Final Closing Date
          Statement to determine whether the Final Closing Date Statement
          was prepared in accordance with the provisions hereof.  If,
          following such review, Sellers determine that the Final Closing
          Date Statement was not prepared in accordance with the provisions
          hereof and that Buyer's calculation of Closing Date Net Working
          Capital is in error as a result thereof, Sellers shall so notify 
          Buyer.  For a period of fifteen (15) days following the receipt
          of such notice, Buyer and Sellers shall attempt to resolve any
          such dispute with respect to the Final Closing Date Statement. 
          If, at the expiration of such fifteen (15) day period, Buyer and 
          Sellers are not able to resolve such dispute, within the three
          (3) day period immediately following the expiration of such
          fifteen (15) day period, the Buyer and Sellers shall promptly
          submit to the Pittsburgh, Pennsylvania office of any "big five"
          firm of independent, certified public accountants recommended by 
          the Pennsylvania Institute of Certified Public Accountants
          (provided that such accountants do not then serve as accountants 
          to Buyer or Seller), which firm shall resolve all matters in
          dispute with respect to the Final Closing Date Balance Sheet
          within the fifteen (15) day period immediately following such
          submission and whose determination shall be final, binding and
          conclusive upon Buyer and Sellers.  The fees of any such
          independent, certified public accounting firm shall be borne
          equally by Buyer and Sellers.


                          (c)  At a supplemental closing to be held within 
          the later of ninety (90) days after the Closing Date or ten (10) 
          days after the final determination of the Final Closing Date
          Statement and calculation of the Closing Date Net Working Capital
          pursuant to Section 2.4(b) (the "Supplemental Closing"), payment 
          shall be made from Buyer to Sellers or Sellers to Buyer, as
          appropriate, to take into account any difference between the
          Estimated Purchase Price (based upon the Estimated Closing Date
          Net Working Capital) and the Purchase Price (based upon the
          actual Closing Date Net Working Capital).  Such difference, if
          any, will be paid as follows:

                                    (i)  If the Purchase Price EXCEEDS the 
               Estimated Purchase Price, at the Supplemental Closing,
               Sellers will be entitled to receive from Buyer an amount
               equal to such excess, which shall be paid by Buyer by means 
               of wire transfer of immediately available funds to an
               account or accounts designated by Seller in writing.  




         
                                    (ii) If the Estimated Purchase Price
               EXCEEDS the Purchase Price, Buyer will be entitled to
               receive from the Escrow Holder funds from the Escrow Deposit
               in an amount equal to such excess, which amount shall be
               paid by Escrow Holder pursuant to the terms of the Escrow
               Agreement at the Supplemental Closing by means of wire
               transfer of immediately available funds to an account or
               accounts designated by Buyer in writing.  If the amount by
               which the Estimated Purchase Price EXCEEDS the Purchase
               Price is greater than the Escrow Deposit, Sellers will pay
               to Buyer an amount equal to such excess which shall be paid 
               by Sellers at the Supplemental Closing by means of wire
               transfer of immediately available funds to an account or
               accounts designated by Buyer in writing.

                    2.5   Purchase Price Adjustment for Uncollected
          Receivables.  Notwithstanding anything contained herein to the
          contrary, to the extent that all or any portion of the accounts
          receivable of Sellers included in the Acquired Assets (net of any
          reserve therefor reflected in the Final Closing Date Balance
          Sheet), including both billed and unbilled accounts receivable,
          are not collected in full and in cash by the Buyer in the
          ordinary course of its business and using the Buyer's customary
          collection practices (without resort to legal proceedings),
          within one hundred eighty (180) days after the Closing Date
          (collectively, the "Uncollected Receivables") there shall be a
          dollar-for-dollar reduction in the Purchase Price in an amount
          equal to the aggregate amount of the Uncollected Receivables. 
          Any adjustment to the Purchase Price pursuant to this Section 2.5
          shall be paid in the manner provided by Section 2.4(c)(ii). 
          Following the satisfaction by the Sellers of all of their
          obligations under this Section 2.5, the Buyer shall, if requested
          by the Sellers, assign and transfer (without recourse,
          representation, or warranty) to Sellers all of Buyer's right,
          title, and interest in, to, and under the Uncollected
          Receivables, pursuant to a written instrument of assignment
          reasonably satisfactory to Buyer and Sellers; PROVIDED, HOWEVER, 
          Sellers shall not disrupt the Clinical Business conducted by
          Buyer in connection with any effort by Sellers to collect the
          Uncollected Receivables following such assignment and transfer
          thereof.  The parties further agree that if the Buyer collects in
          cash an aggregate amount in respect of billed and unbilled
          accounts receivable of the Sellers included in the Acquired
          Assets (net of any reserve therefor reflected in the Final
          Closing Date Balance Sheet) which is in excess of such billed and
          unbilled accounts receivable reflected in the Final Closing Date 
          Balance Sheet (net of the aforesaid reserve) as of the date which
          is one hundred eighty (180) days after the Closing Date, the
          Purchase Price shall be increased, dollar-for-dollar, by an
          amount equal to such excess (such Purchase Price increase to be
          paid in the manner provided by the provisions of Section
          2.4(c)(i)).

          



                    2.6   Closing Deliveries.  At the Closing:

                          (a)  Sellers will deliver, or cause to be
          delivered, to Buyer:


                               (i)  a non-competition agreement(s) in the
               form of EXHIBIT F executed by each Seller, DataTRAK and
               Dr. Jeffrey A. Green (the "Non-Competition Agreement");

                               (ii)  The agreements in the form of
               EXHIBITS G1 and G2 executed by Collaborative and DataTRAK,
               respectively (the "Seller Agreements");

                               (iii)  any other Related Agreements to which
               any Seller is a party;


                               (iv)  a bill of sale and such assignments
               and other instruments of sale, transfer, conveyance and
               assignment (including certificates of title and an
               assignment to Buyer of all of Seller's rights in, to and
               under the Lease) regarding the Acquired Assets as Buyer and 
               its counsel may request;

                               (v)  a certificate executed by Sellers to
               the effect that each of Sellers' representations and
               warranties in this Agreement and in each Related Agreement
               to which Sellers (or any of them) are parties was accurate
               in all respects as of the date of this Agreement and is
               accurate in all respects as of the Closing Date as if made
               on the Closing Date, which certificate shall be in the form 
               of EXHIBIT H hereto;


                               (vi)  estoppel certificates from the
               landlord under each Lease, in form and substance
               satisfactory to Buyer;

                               (vii)  for each Leased Property subject to
               Encumbrance against any of the Landlord's interest therein, 
               satisfactory evidence that the Lease pertaining thereto is
               subject to a non-disturbance and attornment agreement in
               favor of the applicable Seller thereunder (and any assignee 
               of such Seller), which non-disturbance and attornment
               agreement shall be satisfactory, in form and substance, to
               Buyer;


                               (viii)  the Assignment and Assumption
               executed by Sellers;

                               (ix)  a sublease agreement (the "Sublease


                 


               Agreement") executed by Collaborative, pursuant to which
               Collaborative shall sublease that portion of the
               Collaborative Premises which Collaborative and the Buyer
               deem reasonably necessary in order for the Buyer to conduct 
               the Clinical Business thereat, which Sublease Agreement
               shall be satisfactory, in form and substance, to
               Collaborative and the Buyer and shall incorporate those
               terms set forth on SCHEDULE 2.6(a)(ix); and 

                               (x)  all other certificates, instruments and
               documents to be delivered by Sellers (or any of them)
               pursuant to this Agreement or any of the Related Agreements.


                          (b)  Buyer will deliver, or cause to be
          delivered, to Sellers:

                               (i)  the Closing Cash Payment;

                               (ii)  an assignment, delegation and
               assumption agreement (the "Assumption Agreement") in the
               form of EXHIBIT I hereto;


                               (iii)  the Non-Competition Agreement
               executed on behalf of Buyer;

                               (iv)  the Services Agreement executed on
               behalf of Buyer;


                               (v)  the Sublease Agreement; and

                               (vi)  a certificate executed by Buyer to the
               effect that each of Buyer's representations and warranties
               in this Agreement and in each Related Agreement to which
               Buyer is a party was accurate in all respects as of the date
               of this Agreement and is accurate in all respects as of the 
               Closing Date as if made on the Closing Date, which
               certificate shall be in the form of EXHIBIT J hereto.


                    2.7   Closing.  The purchase and sale (the "Closing")
          provided for in this Agreement will take place at the offices of 
          Stevens & Lee, One Glenhardie Corporate Center, 1275 Drummers
          Lane, Wayne, Pennsylvania 19087, at 10:00 A.M., within five (5)
          business days after the conditions set forth in Sections 7.7 and 
          8.5 have been satisfied, on or at such other earlier time and
          place as the parties may mutually agree upon in writing.

                    2.8   Allocation of the Purchase Price.  The Purchase
          Price shall be allocated among the Acquired Assets and the
          Assumed Liabilities in accordance with EXHIBIT K attached hereto. 


           


          As soon as practicable after the Supplemental Closing, but in any
          event not later than thirty (30) days after the Supplemental
          Closing, the Sellers and Buyer shall make any and all appropriate
          adjustments to the Tax Allocation by reason of any adjustment to 
          the Purchase Price under Section 2.4(c).  It is understood and
          agreed that the Tax Allocation shall be prepared pursuant to and 
          an in accordance with the provisions of Section 1060 of the Code 
          and Buyer shall prepare Form 8594 under Section 1060 of the Code 
          relating to the Contemplated Transactions based upon the final
          Tax Allocation prepared pursuant hereto.  The Tax Allocation
          shall, for tax purposes, be binding on Sellers and Buyer, and
          Sellers and Buyer shall file their respective Tax Returns in
          accordance with such Tax Allocation and shall not take any
          position inconsistent with the Tax Allocation.

               3.   REPRESENTATIONS AND WARRANTIES OF SELLERS


                    Sellers hereby jointly and severally represent and
          warrant to Buyer as follows:

                    3.1   Organization and Good Standing.  Each Seller is a
          corporation duly organized, validly existing, and in good
          standing under the laws of its jurisdiction of incorporation (as 
          set forth on SCHEDULE 3.1), with full corporate power and
          authority to conduct the Clinical Business as it is now being
          conducted, to own or use the properties and assets that it
          purports to own or use, and to perform all its obligations under 
          all Assigned Contracts.  Each Seller is duly qualified to do
          business as a foreign corporation and is in good standing under
          the laws of each state or other jurisdiction in which the failure
          to be so qualified and in good standing could reasonably be
          expected to have a Material Adverse Effect.

                    3.2   Authority; No Conflict.


                          (a)  Subject to approval by the shareholders of
          Collaborative contemplated by Section 8.5, this Agreement
          constitutes the legal, valid, and binding obligation of Sellers, 
          enforceable against Sellers in accordance with its terms. 
          Subject to approval by the shareholders of Collaborative
          contemplated by Section 8.5, upon the execution and delivery by
          Sellers of the Related Agreements to which Sellers (or any of
          them) are parties, the Related Agreements will constitute the
          legal, valid, and binding obligations of Sellers, enforceable
          against Sellers in accordance with their respective terms. 
          Sellers have the requisite right, power, authority, and capacity 
          to execute and deliver this Agreement and such Related Agreements
          and to perform their obligations under this Agreement and such
          Related Agreements.

                          (b)  Except for those Consents set forth in

          



          SCHEDULE 3.2(b), neither the execution and delivery of this
          Agreement or the Related Agreements to which Sellers (or any of
          them) are parties nor the consummation or performance of any of
          the Contemplated Transactions will, directly or indirectly (with 
          or without notice or lapse of time):

                               (i)  contravene, conflict with, or result in
               a violation of any provision of the articles of
               incorporation, code of regulations, or other organizational 
               documents of Sellers; 


                               (ii)  contravene, conflict with, or result
               in a violation of, or give any Governmental Body or other
               Person the right to challenge any of the Contemplated
               Transactions or to exercise any remedy or obtain any relief 
               under, any Legal Requirement or any Order to which Sellers
               or any of the Acquired Assets may be subject;

                               (iii)  contravene, conflict with, or result 
               in a violation of any of the terms or requirements of, or
               give any Governmental Body the right to revoke, withdraw,
               suspend, cancel, terminate, or modify, any Governmental
               Authorization that is held by any Seller or that otherwise
               relates to the Clinical Business or any of the Acquired
               Assets or the Leased Property;

                               (iv)  cause any of the Acquired Assets to be
               reassessed or revalued by any taxing authority or other
               Governmental Body;


                               (v)  contravene, conflict with, or result in
               a violation or breach of any provision of, or give any
               Person the right to declare a default or exercise any remedy
               under, or to accelerate the maturity or performance of, or
               to cancel, terminate, or modify, any Assigned Contract; or

                               (vi)  except pursuant to any Contract to
               which the Buyer is a party, result in the imposition or
               creation of any Encumbrance upon or with respect to any of
               the Acquired Assets.


          Except for those Consents set forth in SCHEDULE 3.2(b), Seller is
          not, and will not be, required to give any notice to or obtain
          any Consent from any Person (including parties to the Assigned
          Contracts) in connection with the execution and delivery of this 
          Agreement or any of the Related Agreements or the consummation or
          performance of any of the Contemplated Transactions.
                    3.3   Financial Statements; Accounts Receivable.  


                          (a)  SCHEDULE 3.3 includes the following:
          




                               (i)  Audited consolidated and consolidating 
               balance sheets of Collaborative and its subsidiaries
               (including the Selling Subsidiaries) as at the close of each
               of the years December 31, 1995, December 31, 1996, and
               December 31, 1997, inclusive, and the related consolidated
               and consolidating statements of income, changes in
               stockholders' equity, and cash flow of collaborative and its
               subsidiaries (including the Selling Subsidiaries) for each
               of the fiscal years then ended, all on a comparative basis, 
               together with the notes thereto and the report thereon of
               Seller's Accountant (the "Prior Financial Statements"); and

                               (ii)  a consolidated and consolidating
               balance sheet of Collaborative and its subsidiaries as at
               September 30, 1998, and the related internally prepared
               consolidated and consolidating statements of income, changes
               in stockholders' equity and cash flow for the nine (9) month
               period then ended (which, together with any financial
               statements delivered pursuant to Section 5.11, shall be
               collectively referred to as the "Interim Financial
               Statements").


                          (b)  The Financial Statements fairly present, in 
          all material respects, the financial condition and the results of
          operations, changes in stockholders' equity, and cash flow of
          Collaborative and its subsidiaries as at the respective dates of 
          and for the periods referred to in such Financial Statements, all
          in accordance with GAAP, subject, in the case of interim
          financial statements, to normal year-end adjustments (the effect
          of which will not, individually or in the aggregate, be
          materially adverse), and the Financial Statements reflect the
          consistent application of such accounting principles throughout
          the periods involved.  Except to the extent provided otherwise in
          such Financial Statements, (i) adequate provision was made in the
          Financial Statements for doubtful accounts or other receivables; 
          (ii) sales were stated in the Financial Statements net of
          discounts, returns and allowances; and (iii) all Taxes due or
          paid were timely reflected in the Financial Statements and all
          Taxes not yet due and payable were accrued or otherwise provided 
          for therein.  At the respective dates of each of the Financial
          Statements, Sellers had no Liability required to be reflected or 
          disclosed in the Financial Statements under GAAP which was not so
          reflected or disclosed.  No provision in the Financial Statements
          as of and for the periods covered by such Financial Statements
          was necessary, under GAAP, for Liability on account of warranties
          or with respect to the Clinical Business.  Any significant items 
          of income or expense which were unusual or of a nonrecurring
          nature were separately disclosed in the Financial Statements.  

                          (c)  All of the Accounts Receivable of Sellers
          included in the Acquired Assets represent amounts receivable for 
          services actually provided, have arisen from bona-fide
       
          



          transactions in the Ordinary Course of Business, are not subject 
          to any counterclaims or offsets, and have been billed or are
          billable, as appropriate, in accordance with the terms of the
          Assigned Contract applicable thereto.  

                    3.4   Books and Records.  The books of account, minute 
          books, stock record books, and other records of each Seller, all 
          of which have been made available to Buyer, are complete and
          correct in all material respects.


                    3.5   Title To Assets; Encumbrances.

                          (a)  Sellers have or will have and convey to
          Buyer at the Closing, good and merchantable title to, or a valid 
          leasehold interest in, all of the properties and assets (other
          than the Excluded Assets) used or usable by Sellers in the
          Clinical Business or shown on the balance sheet of Sellers dated 
          as of September 30, 1998, which comprises a portion of the
          Interim Financial Statements (the "INTERIM BALANCE SHEET"), or
          acquired after the date thereof, free and clear of all
          Encumbrances, except for (i) the Assumed Liabilities, and (ii)
          properties and assets disposed of in the Ordinary Course of
          Clinical Business since the date of the Interim Balance Sheet. 
          Without limiting the generality of the foregoing, Sellers have,
          and will convey to Buyer at the Closing, good and merchantable
          title to all of the Acquired Assets, free and clear of any
          Encumbrance or restriction on transfer of any nature, other than 
          the Assumed Liabilities.

                          (b)  SCHEDULE 3.5(b) contains a complete and
          accurate list of all Facilities at which any Seller currently
          conducts the Clinical Business.  To the best of the Sellers'
          Knowledge, all Facilities currently used by Sellers lie wholly
          within the boundaries of the real property owned or leased by
          Seller and do not encroach upon the property of, or otherwise
          conflict with the property rights of, any other Person.  The use 
          and operation of such Facilities are in compliance with all
          applicable Legal Requirements, Orders, Consents and Governmental 
          Authorizations.  To the best of the Sellers' Knowledge, there are
          no existing, pending, or Threatened (i) requests, applications or
          proceedings to alter or restrict the zoning or other use
          restrictions applicable to any such Facilities, (ii) condemnation
          proceedings that would affect any of such Facilities in any way, 
          or (iii) public improvements that would result in any charge or
          Taxes being levied or assessed against, or would result in the
          creation of any Encumbrance upon, any of such Facilities.


                          (c)  DataTRAK has no right, title or interest in 
          any of the Acquired Assets.

                    3.6   Condition and Sufficiency of Assets.  

           



                          (a)  Except as set forth in SCHEDULE 3.6, (i) the
          machinery, equipment, tools, supplies and other tangible personal
          property included in the Acquired Assets are in good operating
          condition and repair, ordinary wear and tear excepted and (ii)
          none of such machinery, equipment, tools, supplies and other
          tangible personal property included in the Acquired Assets is in 
          need of maintenance or repairs except for ordinary, routine
          maintenance and repairs that are not material in nature or cost.

                          (b)  To the best of the Sellers' Knowledge, all
          buildings, structures and other improvements and fixtures which
          comprise the Facilities (i) are free of any structural or
          engineering defects, (ii) are in good repair and condition,
          ordinary wear and tear excepted, and (iii) are free from any
          latent defects and (iv) suitable for their intended use.


                    3.7   No Undisclosed Liabilities.  Except as set forth 
          in SCHEDULE 3.7 or any other SCHEDULE hereto, Sellers have no
          Liabilities of any nature with respect to the Clinical Business
          except for Liabilities reflected or reserved against in the
          Interim Balance Sheet and current Liabilities incurred in the
          Ordinary Course of Business since the date thereof; provided,
          however, notwithstanding the foregoing or the meaning ascribed to
          the term Liability herein, Liabilities of the Sellers which are
          expressly described in or expressly covered by the provisions of 
          any other representation and warranty contained in this Section 3
          or as otherwise disclosed in the applicable Schedule thereto, or 
          which are not required to be disclosed in such other
          representation or warranty (or the applicable Schedule thereto)
          by reason of materiality qualifiers therein, need not be
          disclosed in SCHEDULE 3.7 solely by reason of the representation 
          and warranty in this Section 3.7.

                    3.8   Taxes.

                          (a)  Sellers have filed or caused to be filed on 
          a timely basis all Tax Returns that are or were required to be
          filed by or with respect to Sellers, either separately or as a
          member of a group of corporations, pursuant to applicable Legal
          Requirements for all periods prior to the Closing Date.  Sellers 
          have paid, or made provision for the payment of, all Taxes that
          have or may have become due pursuant to those Tax Returns or
          otherwise, or pursuant to any assessment received by Sellers,
          except such Taxes, if any, as are listed in SCHEDULE 3.8 and are 
          being contested in good faith and as to which adequate reserves
          (determined in accordance with GAAP) have been provided in the
          Interim Balance Sheet.


                          (b)  The charges, accruals, and reserves with
          respect to Taxes on the books of Sellers are adequate (determined
          in accordance with GAAP) and are at least equal to Sellers


         


          liability for Taxes.  There exists no proposed tax assessment
          against Seller to Seller Knowledge except as disclosed in
          SCHEDULE 3.8.  All Taxes that Seller is or was required by Legal 
          Requirements to withhold or collect have been duly withheld or
          collected and, to the extent required, have been paid to the
          proper Governmental Body or other Person.

                          (c)  All Tax Returns filed by Sellers (or that
          include Sellers on a consolidated basis) are true, correct, and
          complete in all material respects.


                          (d)  No audit or examination by any Tax authority
          is pending with respect to or relating to any Taxes and no Seller
          has received any notice from any Tax authority of (i) any pending
          or Threatened claim for any Tax deficiency, (ii) intention to
          examine or audit any Tax Return for any period, or
          (iii) intention to reassess any of the Acquired Assets for Tax
          purposes.

                    3.9   No Material Adverse Change.  Since the date of
          the Interim Balance Sheet, there has not been any material
          adverse change in the operations, properties, assets,
          Liabilities, or financial condition of Sellers relating to the
          Clinical Business or any material adverse change in the Clinical 
          Business taken as a whole, and no event, condition or
          circumstance exists that could reasonably be expected to result
          in such a material adverse change.

                    3.10  Employee Benefits.


                          (a)  SCHEDULE 3.10 lists each Employee Benefit
          Plan that any Seller maintains or to which any Seller contributes
          with respect to any employee of the Clinical Business.  All
          contributions (including all employer contributions and employee 
          salary reduction contributions) which are due have been paid to
          each such Employee Benefit Plan and all contributions for any
          period ending on or before the Closing Date which are not yet due
          have been paid to each such Employee Benefit Plan or accrued in
          accordance with the past custom and practice of Seller.

                          (b)  Sellers do not contribute to, never have
          contributed to, and never has been required to contribute to any 
          Multiemployer Plan (as defined in ERISA ' 3(37)(A)) or have any
          Liability (including withdrawal Liability) under any
          Multiemployer Plan.


                          (c)  Except as set forth on SCHEDULE 3.10, no
          Seller maintains or contributes to any bonus, deferred
          compensation, incentive, severance, termination, or other
          compensation plan or arrangement, for the benefit of any employee

          



          of Seller.

                    3.11  Compliance With Legal Requirements; Governmental
          Authorizations.


                          (a)  Except as set forth in SCHEDULE 3.11(a):

                               (i)  Each Seller is, and at all times since 
               December 31, 1995 has been, in full compliance with each
               Legal Requirement that is or was applicable to it or to the 
               conduct or operation of its Clinical Business or the
               ownership or use of any of the Acquired Assets or the
               Facilities;

                               (ii)  no event has occurred or circumstance 
               exists that (with or without notice or lapse of time)
               (A) may constitute or result in a violation by Seller of, or
               a failure on the part of any Seller to comply with, any
               Legal Requirement, or (B) may give rise to any obligation on
               the part of Seller to undertake, or to bear all or any
               portion of the cost of, any remedial action of any nature;


                               (iii)  Sellers have not received, at any
               time since December 31, 1995, any notice or other
               communication (whether oral or written) from any
               Governmental Body or any other Person regarding (A) any
               actual, alleged, or potential violation of, or failure to
               comply with, any Legal Requirement, or (B) any actual,
               alleged, or potential obligation on the part of Seller to
               undertake, or to bear all or any portion of the cost of, any
               remedial action of any nature; and

                               (iv)  Sellers have timely filed any and all 
               reports, forms, and documents required to be filed by them
               under and pursuant to the 34 Act.


                          (b)  SCHEDULE 3.11(b) contains a complete and
          accurate list of each Governmental Authorization that is held by 
          any Seller or that otherwise relates to the Clinical Business, or
          to any of the Acquired Assets or the Facilities.  Each
          Governmental Authorization listed or required to be listed in
          Schedule 3.12 is valid and in full force and effect.  Except as
          set forth in SCHEDULE 3.11(b):

                               (i)  each Seller is, and at all times has
               been, in full compliance with all of the terms and
               requirements of each Governmental Authorization identified
               or required to be identified in SCHEDULE 3.11(b); and

          



                               (ii)  no event has occurred or circumstance 
               exists that may (with or without notice or lapse of time)
               (A) constitute or result directly or indirectly in a
               violation of or a failure to comply with any term or
               requirement of any Governmental Authorizations listed or
               required to be listed in SCHEDULE 3.11(b), or (B) result
               directly or indirectly in the revocation, withdrawal,
               suspension, cancellation, or termination of, or any
               modification to, any Governmental Authorization listed or
               required to be listed in SCHEDULE 3.11(b).

          The Governmental Authorizations listed in SCHEDULE 3.11(b)
          collectively constitute all of the Governmental Authorizations
          necessary to permit Sellers to lawfully conduct and operate the
          Clinical Business in the manner it currently conducts and
          operates such Clinical Business and to permit Sellers to own and 
          use the Acquired Assets and to use the Facilities in the manner
          in which they currently own and use such assets.


                    3.12  Legal Proceedings; Orders.

                          (a)  Except as set forth in SCHEDULE 3.12, there 
          is no pending Proceeding:

                               (i)  that has been commenced by or against
               Seller or that otherwise relates to or may affect the
               Clinical Business or any of the Acquired Assets or the
               Facilities; or


                               (ii)  that challenges, or that may have the 
               effect of preventing, delaying, making illegal, or otherwise
               interfering with, any of the Contemplated Transactions or
               the Related Transactions.

          To the Knowledge of Sellers, (1) no such Proceeding has been
          Threatened, and (2) no event has occurred or circumstance exists 
          that could reasonably be expected to give rise to or serve as a
          basis for the commencement of any such Proceeding.  The
          Proceedings listed in SCHEDULE 3.12 will not have a material
          adverse effect on the Clinical Business of any Seller or the
          Acquired Assets or the Facilities.


                          (b)  Except as set forth in SCHEDULE 3.12:

                               (i)  there is no Order to which any of the
               Sellers, or any of the Acquired Assets or the Facilities is 
               subject; and


                               (ii)  each Seller is in full compliance with

              



               all of the terms and requirements of each Order set forth in
               SCHEDULE 3.12.

                          (c)  SCHEDULE 3.12 sets forth a complete and
          accurate summary and current status of all pending and Threatened
          workers' compensation claims by any current or former employees
          of Seller.


                    3.13  Absence of Certain Changes and Events.  Since the
          date of the Interim Balance Sheet, each Seller has conducted the 
          Clinical Business only in the Ordinary Course of Business. 
          Without limiting the generality of the foregoing sentence, since 
          the date of the Interim Balance Sheet, there has not been, with
          respect to the Clinical Business, any of the following except as 
          set forth on Schedule 3.13 (or any supplement thereto delivered
          pursuant to Section 7.10):

                               (i)  amendment to the certificate of
               incorporation, bylaws or other organizational documents of
               Seller;

                               (ii)  payment or increase by any Seller of
               any bonuses, salaries, or other compensation to any
               director, officer, or (except in the Ordinary Course of
               Clinical Business) employee or entry into any employment,
               severance, or similar Contract with any director, officer,
               or employee;


                               (iii)  payment by Seller of the personal
               expenses of any shareholder, director, officer or employee;

                               (iv)  adoption of, or increase in the
               payments to or benefits under, any Employee Benefit Plan for
               or with any employees of any Seller;


                               (v)  damage to or destruction or loss of any
               asset or property of any Seller, whether or not covered by
               insurance, materially and adversely affecting the
               properties, assets, Clinical Business or financial condition
               of Seller, taken as a whole;

                               (vi) ^ termination of, or receipt of notice 
               of termination of (i) any license, distributorship, sales
               representative, joint venture, credit, or similar agreement,
               or (ii) any Contract or transaction which are individually
               or in the aggregate material to the Clinical Business;


                               (vii)  sale, lease, or other disposition of 
               any asset or property of Seller or mortgage, pledge, or





               imposition of any Encumbrance on any of the Acquired Assets,
               including the sale, lease, or other disposition of any of
               the Intellectual Property Assets;

                               (viii)  cancellation or waiver of any claims
               or rights material to the conduct of the Clinical Business
               or any cancellation or waiver of any debts or claims
               affecting the Clinical Business;


                               (ix)  material change in the accounting
               methods used by any Seller; or

                               (x)  agreement, whether oral or written, by 
               Seller to do any of the foregoing.

                    3.14  Contracts; No Defaults.


                          (a)  SCHEDULE 3.14 contains (except as provided
          in clause (iii) below) a complete and accurate list, and Sellers
          have made available to Buyer true and complete copies, of all
          Contracts in effect as of the date hereof with respect to the
          Clinical Business or the Acquired Assets including the following:

                               (i)  each Lab Service Contract;


                               (ii)  each Sponsor Contract;

                               (iii)  a list of all Site Contracts (to be
               delivered no later than five (5) business days before
               Closing);


                               (iv)  to the extent not included under
               clauses (i) through (iii) above, each Contract that involves
               performance of services or delivery of goods or materials by
               Seller relating to the Clinical Business;

                               (v)  to the extent not included under
               clauses (i) through (iii) above, each Contract that involves
               performance of services or delivery of goods or materials to
               Seller relating to the Clinical Business; 


                               (vi)  each Contract relating to the Clinical
               Business that was not entered into in the Ordinary Course of
               Business and that involves expenditures or receipts of
               Seller;

                               (vii)  each lease, rental or occupancy
               agreement, license, installment and conditional sale

              



               agreement, and other Contract affecting the ownership of,
               leasing of, title to, use of, or any leasehold or other
               interest in, any real or personal property (including the
               Leases);

                               (viii)  each joint venture, partnership, and
               other Contract (however named) involving a sharing of
               profits, losses, costs, or liabilities by Seller with any
               other Person;


                               (ix)  each Contract containing covenants
               that in any way purport to restrict Seller's business
               activity or limit the freedom of Seller to engage in any
               line of business or to compete with any Person;

                               (x)  each Contract entered into other than
               in the Ordinary Course of Business that contains or provides
               for an express undertaking by Seller to be responsible for
               consequential damages;

                               (xi)  each Contract for capital expenditures
               in excess of Five Thousand Dollars ($5,000);


                               (xii)  each written warranty, guaranty, and 
               or other similar undertaking extended by Seller other than
               in the Ordinary Course of Business; and

                               (xiii)  each amendment, supplement, and
               modification (whether oral or written) in respect of any of 
               the foregoing.


          SCHEDULE 3.14 also sets forth the details concerning such
          Contracts which are specified in such SCHEDULE 3.14, including
          the parties to the Contracts and the amount of the remaining
          commitment of Seller under the Contracts.

                          (b)  Except as set forth in SCHEDULE 3.14:


                               (i)  Sellers do not have and cannot acquire 
               any rights under, and Sellers do not have and cannot become 
               subject to any Liability under, any Contract that relates to
               the Clinical Business or any of the Acquired Assets;

                               (ii)  each Contract identified or required
               to be identified in SCHEDULE 3.14 is in full force and
               effect and is valid and enforceable against such Seller in
               accordance with its terms;


                               (iii)  to the best of the Sellers'


             


               Knowledge, each Contract identified or required to be
               identified in SCHEDULE 3.14 is enforceable against the other
               party thereto in accordance with its terms;

                               (iv)  each Seller is and at all times has
               been in full compliance with all applicable terms and
               requirements of each Contract under which Seller has or had 
               any Liability or by which Seller or any of the Acquired
               Assets is or was bound;


                               (v)  each other Person that has or had any
               Liability under any Contract under which any Seller has or
               had any rights is, and at all times has been, in full
               compliance with all applicable terms and requirements of
               such Contract; and

                               (vi)  no event has occurred or circumstance 
               exists that (with or without notice or lapse of time) may
               contravene, conflict with, or result in a violation or
               breach of, or give any Seller or other Person the right to
               declare a default or exercise any remedy under, or to
               accelerate the maturity or performance of, or to cancel,
               terminate, or modify, any Contract involving any Seller or
               the Clinical Business or any of the Acquired Assets.

                    3.15  Insurance.


                          (a)  Sellers have made available to Buyer:

                               (i)  true and complete copies of all current
               policies of insurance to which Seller is a party or under
               which any Seller is or has been covered at any time within
               the three (3) years preceding the date of this Agreement
               relating to the Clinical Business or the Acquired Assets;
               and


                               (ii)  true and complete copies of all
               pending applications for policies of insurance relating to
               the Clinical Business or the Acquired Assets.

                          (b)  SCHEDULE 3.15 describes:


                               (i)  any self-insurance arrangement by or
               affecting any Seller, including any reserves established
               thereunder;

                               (ii)  any Contract or arrangement, other
               than a policy of insurance, for the transfer or sharing of
               any risk by any Seller; and

                



                               (iii)  all obligations of any Seller to
               provide coverage to third parties (for example, under leases
               or service agreements).

                          (c)  Except as set forth in SCHEDULE 3.15:


                               (i)  All policies to which any Seller is a
               party or that provide coverage to any Seller:

                                    (A)  are valid, outstanding,
                    enforceable, and are in full force and effort;

                                    (B)  taken together, to the best of the
                    Sellers' Knowledge, provide adequate insurance coverage
                    for the assets and the operations of any Seller for all
                    risks normally insured against by a Person carrying on 
                    the same business or businesses as the Sellers; and


                                    (C)  are sufficient for compliance with
                    all Legal Requirements and Contracts to which any
                    Sellers are a party or by which any Seller is bound.

                    3.16  Environmental Matters.  Except as set forth in
          SCHEDULE 3.16:


                          (a)  Each Seller is, and at all times prior to
          the date hereof has been, in compliance in all material aspects
          with, and has not been and is not in violation of or liable
          under, any applicable Environmental Law.  No Seller has any
          reasonable basis to expect, nor has any Seller received, any
          actual or Threatened order, notice, or other communication from
          (i) any Governmental Body or other Person, or (ii) the current or
          prior owner or operator of any Facilities, of any actual or
          potential violation or failure to comply with in any material
          respect any Environmental Law, or of any actual or Threatened
          obligation to undertake or bear the cost of any Environmental,
          Health, and Safety Liabilities with respect to any of the
          Facilities or any Acquired Assets, or with respect to any
          property or Facility at or to which Hazardous Materials were
          generated, manufactured, refined, transferred, imported, used, or
          processed by any Seller, or any other Person for whose conduct
          any Seller is or may be held responsible, or from which Hazardous
          Materials have been transported, treated, stored, handled,
          transferred, disposed, recycled, or received.

                          (b)  There are no pending or, to the Knowledge of
          Sellers, Threatened claims or Encumbrances resulting from any
          Environmental, Health, and Safety Liabilities or arising under or
          pursuant to any Environmental Law, with respect to or affecting
          any of the Facilities or any Acquired Asset.


         


                          (c)  No Seller has Knowledge of any basis to
          expect, nor has any of them received, any Order, notice,
          communication, inquiry, warning, citation, summons, directive, or
          any other indication that relates to any alleged, actual, or
          potential violation or failure by any Seller to comply in any
          material respect with any Environmental Law, or of any alleged,
          actual, or potential obligation of any Seller to undertake or
          bear the cost of any Environmental, Health, and Safety
          Liabilities with respect to any of the Facilities or any of the
          Acquired Assets, or with respect to any property or facility to
          which Hazardous Materials generated, manufactured, refined,
          transferred, imported, used, or processed by any Seller, or any
          other Person for whose conduct any Seller is or may be held
          responsible, have been transported, treated, stored, handled,
          transferred, disposed, recycled, or received.

                          (d)  To the best of the Sellers' Knowledge, no
          Seller nor any other Person for whose conduct any Seller is or
          may be held responsible, has any Environmental, Health, and
          Safety Liabilities with respect to the Facilities or any of the
          Acquired Assets, at any property geologically or hydrologically
          adjoining the Facilities.


                          (e)  There are no Hazardous Materials present on 
          or in the Facilities in violation of any applicable Environmental
          Law, including any Hazardous Materials contained in barrels,
          above or underground storage tanks, landfills, land deposits,
          dumps, equipment (whether moveable or fixed) or other containers,
          either temporary or permanent, and deposited or located in land, 
          water, swamps, or any other part of the Facilities or such
          adjoining property, or incorporated into any structure therein or
          thereon.  No Seller, nor any other Person for whose conduct any
          Seller is or may be held responsible, or to the Knowledge of any 
          Seller, any other Person, has permitted or conducted, or is aware
          of, any hazardous activity conducted with respect to Hazardous
          Materials at the Facilities or any of the Acquired Assets, except
          in full compliance with all applicable Environmental Laws.

                          (f)  There has been no Release or, to the
          Knowledge of any Seller, threat of Release, of any Hazardous
          Materials at or from the Facilities or, to the best of Sellers'
          Knowledge at any other locations where any Hazardous Materials
          were generated, manufactured, refined, transferred, produced,
          imported, used, or processed from or by the Facilities, or from
          or by any of the Acquired Assets, or to the Knowledge of Sellers 
          any geologically or hydrologically adjoining property, whether by
          any Seller or any other Person.

                          (g)  Each Seller has made available to Buyer true
          and complete copies and results of any reports, studies,
          analyses, tests, or monitoring possessed or initiated by such
          Seller pertaining to Hazardous Materials or hazardous activities 

             



          in, on, or under the Facilities, or concerning compliance by such
          Seller or any other Person for whose conduct such Seller is or
          may be held responsible with Environmental Laws.

                    3.17  Employees.


                          (a)  SCHEDULE 3.17 contains a complete and
          accurate list of the following information for each employee of
          Sellers engaged in the Clinical Business, including each employee
          on leave of absence or layoff status: employer; name; job title; 
          current compensation paid or payable and any change in
          compensation since the date of the Interim Balance Sheet;
          vacation accrued; and service credited for purposes of vesting
          and eligibility to participate under any Employee Benefit Plan.

                          (b)  To the best of the Sellers' Knowledge, no
          Seller has received any verbal or written indication that any
          director, officer, or other employee of any Seller engaged in the 
          Clinical Business will terminate his or her employment with such
          Seller prior to the Closing (whether as a result of the
          Contemplated Transactions or otherwise).

                    3.18  Labor Disputes; Compliance.  Except as disclosed 
          in SCHEDULE 3.18, none of the Sellers is a party to any
          collective bargaining or other labor Contract, and there has not 
          been, there is not presently pending or existing, and to Sellers'
          Knowledge there is not Threatened any strike, slowdown,
          picketing, work stoppage, labor arbitration or proceeding in
          respect of the grievance of any employee, application or
          complaint filed by an employee or union with the National Labor
          Relations Board or any comparable Governmental Body,
          organizational activity, or other labor dispute against or
          affecting any Seller with respect to the Clinical Business, and
          no application for certification of a collective bargaining agent
          is pending or to any Sellers' Knowledge is Threatened; to any
          Sellers' Knowledge, no event has occurred or circumstance exist
          that could provide the basis for any work stoppage or other labor
          dispute.  Except as disclosed in SCHEDULE 3.18, each Seller has
          complied in all respects with all Legal Requirements relating to 
          employment, equal employment opportunity, nondiscrimination,
          immigration, wages, hours, benefits, collective bargaining, the
          payment of social security and similar taxes, occupational safety
          and health, and plant closing (including WARN).  No Seller is
          liable for the payment of any Taxes, fines, penalties, or other
          amounts, however designated, for failure to comply with any of
          the foregoing Legal Requirements.


                    3.19  Intellectual Property.

                          (a)  Intellectual Property Assets - The term
          "Intellectual Property Assets" includes:

         



                               (i)  corporate names (and any derivation
               thereof), fictitious business names, trade names, registered
               and unregistered trademarks, service marks, and applications
               (collectively, "Marks");

                               (ii)  all patents and patent applications
               (collectively, "Patents"); and


                               (iii)  all know-how, trade secrets,
               confidential information, software, technical information,
               processes, technology, plans, drawings, and blue prints
               (collectively, "Trade Secrets");

          owned or used by any Seller, or licensed by any Seller as
          licensee or licensor, and, in any case, used in the Clinical
          Business.

                          (b)  AGREEMENTS - SCHEDULE 3.19 contains a
          complete and accurate list and summary description of all
          Intellectual Property Assets pertaining to the Clinical Business 
          and any Contracts relating to such Intellectual Property Assets
          to which any Seller is a party or by which any Seller is bound.  
          There are no outstanding and, to Sellers' Knowledge, no
          Threatened disputes or disagreements with respect to any such
          Contract.


                          (c)  Know-How Necessary for the Clinical Business
          - The Intellectual Property Assets described in SCHEDULE 3.19 are
          all Intellectual Property Assets necessary for the operation of
          the Clinical Business as currently conducted.  Sellers are the
          owner of all right, title, and interest in and to each of the
          Intellectual Property Assets, free and clear of all Encumbrances,
          and has the right to use without payment to a third party all of 
          the Intellectual Property Assets.

                    3.20  Relationships With Related Persons.  No Related
          Person of Seller has any interest in the Clinical Business or any
          of the Assigned Contracts or any of the other Acquired Assets. 
          Except as described in SCHEDULE 3.20, to the best of the Sellers'
          Knowledge, no Related Person of Seller owns of record or as a
          beneficial owner, an equity interest or any other financial or
          profit interest in any Person that has (a) business dealings or a
          material financial interest in any transaction with any Seller,
          or (b) engages in competition with Sellers with respect to the
          Clinical Business in any market presently served by Seller. 
          Except as set forth in SCHEDULE 3.20, no Related Person of any
          Seller is a party to any Contract with, or has any claim or right
          against, Seller.


                    3.21  Brokers or Finders.  Sellers and their agents

              



          have incurred no obligation or Liability, contingent or
          otherwise, for brokerage or finders' fees or agents' commissions 
          or other similar payment in connection with this Agreement or the
          Contemplated Transactions for which Buyer will have any
          Liability.

                    3.22  Disclosure.


                          (a)  No representation or warranty of Sellers in 
          this Agreement or any Related Agreement and no statement in any
          of the Schedules omits to state a material fact necessary to make
          the statements herein or therein, in light of the circumstances
          in which they were made, not misleading.

                          (b)  Except as described on SCHEDULE 3.22, there 
          is no fact known to Sellers that has specific application to
          Sellers (other than general economic or industry conditions) and 
          that materially adversely affects or, as far as Sellers can
          reasonably foresee, materially threatens, the Clinical Business
          or the Acquired Assets, or the financial condition, or results of
          operations or prospects relating to the Clinical Business or the 
          Acquired Assets that has not been set forth in this Agreement or 
          the Schedules to this Agreement.

               4.   REPRESENTATIONS AND WARRANTIES OF BUYER


                    Buyer represents and warrants to Sellers as follows:

                    4.1   Organization and Good Standing.  Buyer is a
          corporation duly organized, validly existing, and in good
          standing under the laws of the Commonwealth of Pennsylvania.


                    4.2   Authority; No Conflict.

                          (a)  This Agreement constitutes the legal, valid,
          and binding obligation of Buyer, enforceable against Buyer in
          accordance with its terms.  Upon the execution and delivery by
          Buyer of the Related Agreements to which Buyer is a party, the
          Related Agreements to which Buyer is a party will constitute the 
          legal, valid, and binding obligations of Buyer, enforceable
          against Buyer in accordance with their respective terms.  Buyer
          has the absolute and unrestricted right, power, and authority to 
          execute and deliver this Agreement and the Related Agreements to 
          which Buyer is a party and to perform its obligations under this 
          Agreement and the Related Agreements to which Buyer is a party.


                          (b)  Neither the execution and delivery by Buyer 
          of this Agreement or the Related Agreements to which Buyer is a
          party nor the consummation or performance of any of the

         



          Contemplated Transactions by Buyer will give any Person the right
          to prevent, delay, or otherwise interfere with any of the
          Contemplated Transactions pursuant to:

                               (i)  any provision of Buyer's certificate of
               incorporation, bylaws or other organizational documents;


                               (ii)  any Legal Requirement or order to
               which Buyer may be subject; or

                               (iii)  any Contract to which Buyer is a
               party or by which Buyer may be bound.

          Except for the Consents identified in Section 7, Buyer is not and
          will not be required to obtain any Consent from any Person in
          connection with the execution and delivery of this Agreement or
          the Related Agreements to which Buyer is a party or the
          consummation or performance of any of the Contemplated
          Transactions.


                    4.3   Certain Proceedings.  There is no pending
          Proceeding that has been commenced against Buyer and that
          challenges, or may have the effect of preventing, delaying,
          making illegal, or otherwise interfering with, any of the
          Contemplated Transactions.  To Buyer's Knowledge, no such
          Proceeding has been Threatened.

                    4.4   Brokers or Finders.  Buyer and its officers and
          agents have incurred no obligation or liability, contingent or
          otherwise, for brokerage or finders' fees or agents' commissions 
          or other similar payment in connection with this Agreement or any
          of the Contemplated Transactions for which Sellers will have any 
          Liability.


               5.   COVENANTS OF SELLERS PRIOR TO AND FOLLOWING CLOSING
          DATE

                    5.1   Access and Investigation.  Between the date of
          this Agreement and the Closing Date, Sellers will, and will cause
          their Representatives to, (a) afford to Buyer and its
          Representatives full and free access (subject to reasonable
          advance notice from Buyer to authorized personnel designated by
          the Sellers from time to time, which may be verbal) to
          Collaborative's senior executive management, Seller's Accountant 
          and counsel, as well as access to Sellers' properties, Contracts,
          books and records, and other documents and data, (b) furnish
          Buyer and Buyer's Representatives with copies of all such
          Contracts (other than Site Contracts), books and records, and
          other existing documents and data as Buyer may reasonably
          request, (c) provide the Buyer and Buyer's Representatives with

           



          access to all Site Contracts, and (d) furnish Buyer and Buyer's
          Representatives with such additional financial, operating, and
          other data and information as Buyer may reasonably request;
          provided, however, that Buyer and its Representative will, in
          connection with the performance of such investigation, use
          commercially reasonable efforts to avoid materially interfering
          with the day-to-day operations of the Clinical Business.  Any and
          all information furnished by the Sellers to or otherwise obtained
          by the Buyer pursuant to this Section 5.1 shall, pending the
          closing, remain subject to the provisions of the Confidentiality 
          Agreement and the provisions of Section 11.3.

                     5.2  Operation of the Clinical Business of Sellers. 
          Between the date of this Agreement and the Closing Date, unless
          otherwise agreed in writing by Buyer, Sellers will:


                               (i)  conduct the Clinical Business only in
               the Ordinary Course of Business;

                               (ii)  use commercially reasonable efforts to
               preserve intact the current business organization of Sellers
               with respect to the Clinical Business, keep available the
               services of the current officers, employees, and agents of
               Sellers, and maintain the relations and good will with
               suppliers, customers, landlords, creditors, employees,
               agents, and others having business relationships with
               Sellers; 

                               (iii)  cooperate with Buyer on all
               transitional matters, and in communications and dealings
               with third parties be supportive of Buyer and the
               Contemplated Transactions;


                               (iv)  confer with Buyer from time to time as
               reasonably requested by the Buyer concerning operational
               matters of a material nature; and

                               (v)  as and when reasonably requested by the
               Buyer from time to time, otherwise report periodically to
               Buyer concerning the status and operation of the Clinical
               Business.


                    5.3   Negative Covenant.  Except as otherwise expressly
          permitted by this Agreement, between the date of this Agreement
          and the Closing Date, Sellers will not, without the prior written
          consent of Buyer, take any affirmative action, or fail to take
          any reasonable action within their control, as a result of which 
          any of the changes or events listed in Section 3.13 is likely to 
          occur.

           



                    5.4   Required Approvals.  As promptly as practicable
          after the date of this Agreement, Sellers will make all filings
          required by Legal Requirements to be made by them in order to
          consummate the Contemplated Transactions.  Between the date of
          this Agreement and the Closing Date, Sellers will reasonably
          (a) cooperate with Buyer with respect to all filings that Buyer
          elects to make or is required by Legal Requirements to make in
          connection with the Contemplated Transactions (including any
          filing under the HSR Act), and (b) cooperate with Buyer in
          obtaining all Consents that may be required to complete the
          Contemplated Transactions.

                    5.5   Notification.  Between the date of this Agreement
          and the Closing Date, Sellers will promptly notify Buyer in
          writing if Sellers become aware of any fact or condition that
          causes or constitutes a Breach of any of Sellers' representations
          and warranties in any material respect as of the date of this
          Agreement, or if Sellers become aware of the occurrence after the
          date of this Agreement of any fact or condition that would
          (except as expressly contemplated by this Agreement) cause or
          constitute a Breach of any such representation or warranty in any
          material respect had such representation or warranty been made as
          of the time of occurrence or discovery of such fact or condition. 
          Should any fact or condition require any change in the Schedules
          to this Agreement if the Schedules were dated the date of the
          occurrence or discovery of any such fact or condition, Sellers
          will promptly deliver to Buyer a supplement to the appropriate
          Schedule specifying such change.  During the same period, Sellers
          will promptly notify Buyer of the occurrence of any Breach of any
          covenants of Sellers in this Agreement or of the occurrence of
          any event that may reasonably make the satisfaction of the
          conditions in Section 7 impossible or unlikely.  Delivery of such
          notification or supplement will be for information purposes only 
          and will not modify in any respect any representation, warranty, 
          covenant, obligation or condition or other provision contained in
          this Agreement or in any Related Agreement.


                    5.6   No Negotiation.

                          (a)  From the date hereof until the Closing Date 
          or the earlier termination of this Agreement pursuant to
          Section 9, Sellers will not, nor will they cause or permit any of
          their respective Representatives to, directly or indirectly
          solicit, initiate, or encourage any inquiries or proposals from, 
          discuss or negotiate with, provide any nonpublic information to, 
          or consider the merits of any inquiries or proposals from, any
          Person (other than Buyer) relating to any transaction involving
          the sale of the Clinical Business or the Acquired Assets (an
          "Acquisition Proposal"); provided, however, that nothing
          contained in this Section 5.6 or any other provision hereof shall
          prohibit Collaborative or the Collaborative Board from engaging
          in negotiations or soliciting proposals concerning a possible

         



          transaction involving DataTRAK or the Excluded Assets, including 
          a possible sale, merger or other transaction not involving the
          Clinical Business or the Acquired Assets; provided further that
          nothing contained in this Section 5.6 or any other provision
          hereof shall prohibit Collaborative or the Collaborative Board
          from (i) taking and disclosing to Collaborative's shareholders a 
          position with respect to a tender or exchange offer by a third
          party pursuant to Rules 14d-9 and 14e-2 promulgated under the 34 
          Act, or (ii) making such disclosure to Collaborative's
          shareholders as, in the good faith judgment of the Collaborative 
          Board, after receiving advice from outside counsel, is required
          under applicable law, provided that Collaborative may not, except
          as permitted by Section 5.6(b), withdraw or modify, or propose to
          withdraw or modify, its position with respect to the Contemplated
          Transactions or approve or recommend, or propose to approve or
          recommend any Acquisition Proposal, or enter into any agreement
          with respect to any Acquisition Proposal.  Collaborative will
          immediately cease any existing activities, discussions or
          negotiations with any parties conducted heretofore with respect
          to any Acquisition Proposal.

                          (b)  Notwithstanding the foregoing, prior to the 
          Closing Date, Collaborative may respond to an unsolicited request
          for information concerning Collaborative from any corporation,
          partnership, person or other entity or group pursuant to
          appropriate confidentiality agreements, and may negotiate and
          participate in discussions and negotiations with such entity or
          group concerning an Acquisition Proposal if such entity or group 
          has submitted a bona fide written proposal to Collaborative
          relating to any such transaction which the Collaborative Board
          determines in good faith, after receiving advice from its legal
          counsel and consulting with its financial advisors, represents a 
          superior transaction to the Contemplated Transaction (a "Superior
          Proposal").  Collaborative will promptly notify Buyer of the
          existence of any proposal or inquiry received by Collaborative,
          the identity of the party making such proposal or inquiry, and
          the terms (both initial and modified) of any such proposal or
          inquiry (an will disclose any written materials delivered in
          connection therewith) and Collaborative will keep Buyer
          reasonably informed of the status (including amendments or
          proposed amendments) of any such proposal or inquiry. 
          Collaborative will promptly provide to Buyer any material non-
          public information regarding Collaborative provided to any other 
          party which was not previously provided to Buyer.  At any time
          following notification to Buyer of Collaborative's intent to do
          so (which notification shall include the identity of the bidder
          and the material terms and conditions of the proposal) and if
          Collaborative has otherwise complied with the terms of this
          Section 5.6(b), the Collaborative Board may withdraw or modify
          its approval or recommendation of the Contemplated Transactions
          and may enter into an agreement with respect to a Superior
          Proposal, provided it shall concurrently with entering into such 
          agreement pay or cause to be paid to Buyer the Termination Fee

          



          and the Expense Fee.  If Collaborative shall have notified Buyer 
          of its intent to enter into an agreement with respect to a
          Superior Proposal in compliance with the preceding sentence and
          has otherwise complied with such sentence, Collaborative may
          enter into an agreement with respect to such Superior Proposal.

                    5.7   Best Efforts.  Between the date of this Agreement
          and the Closing Date, Sellers will use their reasonable best
          efforts to cause the conditions in Sections 7 and 8 to be
          satisfied.


                    5.8   HSR Act Filing.  Seller agrees to pay one-half
          (1/2) of the filing fees associated with any filings made by
          Buyer under the HSR Act in connection with the Contemplated
          Transactions.

                    5.9   Labor Matters.

                          (a)  Sellers shall terminate all of their
          employees (other than employees who are parties to employment
          agreements included in the Assigned Contracts) as of the Closing 
          Date and shall take all actions which are necessary or
          appropriate in connection therewith.  Without limiting the
          generality of the foregoing, Sellers shall provide appropriate
          and compliant advance notices of termination pursuant to and in
          accordance with all provisions of (i) WARN and all other state
          and local plant closing laws (if and to the extent applicable),
          and (ii) all other Legal Requirements.  In this regard, Sellers
          will identify all such notification requirements to Buyer and
          coordinate the content and timing of such notices with Buyer.


                          (b)  Except as otherwise provided in Section
          5.9(d), Sellers shall liquidate and pay or make adequate
          provision for all Liabilities accrued through the Closing Date
          for compensation, including salary, wages, bonuses, overtime
          premiums, and vacation benefits, with respect to employees of
          Sellers, provided that payments to such employees for accrued
          vacation benefits shall be paid directly to such employees at or 
          prior to Closing.

                          (c)  Sellers shall make available to the Buyer
          all personnel information to allow Buyer to evaluate Sellers'
          employees engaged in the Clinical Business in connection with
          Buyer's decision of which employees of Sellers are to be hired as
          Buyer's employees following the Closing.


                          (d)  Subject to Buyer's satisfactory review of
          the employees identified on SCHEDULE 5.9(d), pursuant to and in
          accordance with the Buyer's standard and customary pre-employment
          review and screening practices, the Buyer covenants and agrees to
 
           



          (i) offer employment to those employees of Sellers identified on
          SCHEDULE 5.9(d) immediately after the Closing and (ii) assume (as
          part of the Assumed Liabilities) those severance obligations of
          such employees described on Schedule 5.9(d) in connection
          therewith. The Sellers shall provide the Buyer with reasonable
          assurances prior to the Closing that such employees will accept
          Buyer's offer of employment herein described.

                    5.10  Subsequent Financial Statements.  As soon as
          practicable after the end of each month during the period from
          the date of this Agreement until the Closing Date, and in no
          event later than twenty-five (25) days after the end of each such
          month, Sellers will prepare and promptly deliver to Buyer copies 
          of an unaudited balance sheet and related unaudited income and
          cash flow statements for Sellers relating to the Clinical
          Business, the Acquired Assets, and the Assumed Liabilities for
          the month then ended.  All financial statements delivered
          pursuant to this Section 5.10 will, when delivered, comply in all
          respects with, and otherwise be subject to, the representations
          and warranties set forth herein including those set forth in
          Section 3.3.


                    5.11  Excluded Liabilities.  Sellers shall pay, perform
          or discharge, or cause to be paid, performed or discharged, when 
          due all Excluded Liabilities in the Ordinary Course of Business.

                    5.12  Voting of Shares.  Concurrently with the
          execution and delivery of this Agreement, the Sellers shall cause
          all members of the Collaborative Board and Collaborative's
          executive management who own shares of Collaborative common stock
          to deliver a letter to the Buyer in the form of EXHIBIT L
          attached hereto.

                    5.13  Collaborative Shareholder Approvals. 
          Collaborative agrees to take, in accordance with applicable law, 
          applicable stock exchange rules, its Articles of Incorporation
          and its Code of Regulations, all action necessary to convene, and
          shall hold, an appropriate meeting of shareholders of
          Collaborative to consider and vote upon the approval of the
          Contemplated Transactions and any other matters required to be
          approved by Collaborative's shareholders for consummation of the 
          Contemplated Transactions as promptly as practicable after this
          Agreement is executed.  Unless the Collaborative Board, after
          having consulted with and considered the written advice of
          outside counsel, has determined in good faith that it is
          otherwise required in order to discharge properly the directors' 
          fiduciary duties in accordance with the Ohio General Corporation
          law, the Collaborative Board shall recommend such approval, and
          Collaborative shall take all reasonable lawful action to solicit 
          such approval by its shareholders.


           


               6.   COVENANTS OF BUYER PRIOR TO CLOSING DATE

                    6.1   Approvals of Governmental Bodies.  As promptly as
          practicable after the date of this Agreement, Buyer will, and
          will cause each of its Related Persons to, make all filings
          required by Legal Requirements to be made by them to consummate
          the Contemplated Transactions.  Between the date of this
          Agreement and the Closing Date, Buyer will, and will cause each
          Related Person of Buyer to, (a) cooperate with Sellers with
          respect to all filings that Sellers are required by Legal
          Requirements to make in connection with the Contemplated
          Transactions, and (b) cooperate with Sellers in obtaining all
          Consents identified in SCHEDULE 3.2(b); provided that Buyer shall
          in no event be required to dispose of or make any change in any
          portion of its business or to incur any other significant burden 
          to obtain a Governmental Authorization.


                    6.2   Best Efforts.  Except as set forth in the proviso
          to Section 6.1, between the date of this Agreement and the
          Closing Date, Buyer shall use its best efforts to cause the
          conditions in Sections 8.1, 8.2, 8.4 and 8.5 to be satisfied.
           
               7.   CONDITIONS PRECEDENT TO BUYER'S OBLIGATION TO CLOSE

                    Buyer's obligation to purchase the Acquired Assets and 
          assume the Assumed Liabilities and to take the other actions
          required to be taken by Buyer at the Closing is subject to the
          satisfaction, at or prior to the Closing, of each of the
          following conditions (any of which may be waived by Buyer, in
          whole or in part):


                    7.1   Accuracy of Representations.  All of Sellers'
          representations and warranties in this Agreement and any Related 
          Agreement (considered collectively), and each of these
          representations and warranties (considered individually), must
          have been accurate in all material respects as of the date of
          this Agreement, and must be accurate in all material respects as 
          of the Closing Date as if made on the Closing Date, without
          giving effect to any supplement to any Schedule made after the
          date of this Agreement.

                    7.2   Sellers' Performance.


                          (a)  All of the covenants and obligations that
          Sellers are required to perform or to comply with pursuant to
          this Agreement at or prior to the Closing (considered
          collectively), and each of these covenants and obligations
          (considered individually), must have been duly performed and
          complied with in all material respects.

          



                          (b)  Sellers must have delivered, or caused to be
          delivered, each of the documents required to be delivered
          pursuant to Section 2.6 and each of the other covenants and
          obligations in Sections 5.4, 5.6 and 5.7 must have been performed
          and complied with in all respects.

                    7.3   Consents. Each of the Consents identified in
          SCHEDULE  3.2(b) must have been obtained and must be in full
          force and effect (including the consents of the lessors to
          Sellers' assignment of the Leases to Buyer hereunder).


                    7.4   ADDITIONAL DOCUMENTS.  Sellers shall have caused 
          the following documents to be delivered to Buyer:

                          (a)  an opinion of Calfee, Halter $Griswold LLP, 
          addressed to Buyer and dated the Closing Date, in the form of
          EXHIBIT M hereto; and

                          (b)  such other documents as Buyer may reasonably
          request for the purpose of (i) enabling its counsel to provide
          the opinion referred to in Section 8.4(a), (ii) evidencing the
          accuracy of any of Sellers' representations and warranties, (iii)
          evidencing the performance by Sellers of, or the compliance by
          Sellers with, any covenant or obligation required to be performed
          or complied with by Sellers, (iv) evidencing the satisfaction of
          any condition referred to in this Section 7, or (v) otherwise
          facilitating the consummation or performance of any of the
          Contemplated Transactions.


                    7.5   No Proceedings.  Since the date of this
          Agreement, there must not have been commenced or Threatened
          against Buyer, or against any Person affiliated with Buyer, any
          Proceeding (a) involving any challenge to, or seeking damages or 
          other relief in connection with, any of the Contemplated
          Transactions, or (b) that may have the effect of preventing,
          delaying, making illegal, or otherwise interfering with any of
          the Contemplated Transactions.

                    7.6   No Prohibition.  Neither the consummation nor the
          performance of any of the Contemplated Transactions will,
          directly or indirectly (with or without notice or lapse of time),
          contravene, or conflict with, or result in a violation of, or
          cause Buyer or any Person affiliated with Buyer to suffer any
          adverse consequence under, any applicable Legal Requirement or
          Order.


                    7.7   HSR Act.  Any waiting period applicable to the
          Contemplated Transactions under the HSR Act shall have been
          terminated or shall have expired.

          



                    7.8   Bulk Sales.  Sellers shall have furnished to
          Buyer satisfactory evidence that Sellers have complied with all
          bulk sales, bulk clearance, and related Legal Requirements in
          connection with the sale of the Acquired Assets.

                    7.9  No Material Adverse Change.  Since the date of
          this Agreement, there shall have been no material adverse change 
          in the operations, properties, assets, Liabilities, or financial 
          condition of the Sellers relating to the Clinical Business or any
          material adverse change in the Clinical Business taken as a
          whole, and no event, condition or circumstance shall exist that
          could reasonably be expected to result in such a material adverse
          change.


                    7.10  Supplement to Schedule 3.13.  Because the parties
          anticipate changes will be necessary to SCHEDULE 3.13 by reason
          of clause (vi) of Section 3.13 and the operation of the Clinical 
          Business pending the Closing, the Sellers shall have delivered to
          the Buyer prior to the Closing a supplement to SCHEDULE 3.13 to
          reflect matters required to be disclosed to the Buyer under
          clause (vi) of Section 3.13 by reason of the Sellers' operation
          of the Clinical Business pending the Closing, as aforesaid. 

                    7.11  Delivery of Site Contracts.  Not less than five
          (5) business days prior to the Closing Date, the Sellers shall
          have delivered to the Buyer true, correct and complete copies of 
          all Site Contract then in effect, which shall be subject to the
          review and approval of the Buyer.

               8.   CONDITIONS PRECEDENT TO SELLERS' OBLIGATION TO CLOSE


                    Sellers' obligation to sell the Acquired Assets and to 
          take the other actions required to be taken by Sellers at the
          Closing is subject to the satisfaction, at or prior to the
          Closing, of each of the following conditions (any of which may be
          waived by Sellers, in whole or in part):

                    8.1   Accuracy of Representations.  All of Buyer's
          representations and warranties in this Agreement (considered
          collectively), and each of those representations and warranties
          (considered individually), must have been accurate in all
          material respects as of the date of this Agreement and must be
          accurate in all material respects as of the Closing Date as if
          made on the Closing Date.


                    8.2   Buyer's Performance.

                          (a)  All of the covenants and obligations that
          Buyer is required to perform or to comply with pursuant to this
          Agreement at or prior to the Closing (considered collectively),



         

          and each of these covenants and obligations (considered
          individually), must have been performed and complied with in all 
          material respects.

                          (b)  Buyer must have delivered each of the
          documents required to be delivered by Buyer pursuant to Section
           2.6 and must have made, or caused to have been made, the Closing
          Cash Payments.


                    8.3   Consents. Each of the Consents identified in
          SCHEDULE 3.2(b) must have been obtained and must be in full force
          and effect.

                    8.4   Additional Documents.  Buyer must have caused the
          following documents to be delivered to Sellers:

                          (a)  an opinion of in-house counsel to Buyer,
          dated the Closing Date, in the form of EXHIBIT M; and


                          (b)  such other documents as Sellers may
          reasonably request for the purpose of (i) enabling their counsel 
          to provide the opinion referred to in Section 7.4(a), (ii)
          evidencing the accuracy of any representation or warranty of
          Buyer, (iii) evidencing the performance by Buyer of, or the
          compliance by Buyer with, any covenant or obligation required to 
          be performed or complied with by Buyer, (iv) evidencing the
          satisfaction of any condition referred to in this Section 8, or
          (v) otherwise facilitating the consummation of any of the
          Contemplated Transactions.

                    8.5   Shareholder Approval.  This Agreement and the
          Contemplated Transactions shall have been approved by the
          affirmative vote of the shareholders of Collaborative in
          accordance with applicable law.  The Sellers may terminate and
          cancel this Agreement without liability to the Buyer if such
          shareholder approval is not obtained and the Sellers have not
          otherwise breached any provision of this Agreement by providing
          written notice thereof to the Buyer by no later than April 30,
          1999.  Failure by the Sellers to furnish any such written notice 
          to the Buyer pursuant to this Section 8.5 shall constitute a
          waiver by the Sellers of the condition contained herein.


                    8.6   No Injunction.  There must not be in effect any
          Legal Requirement or any injunction or other Order that prohibits
          the sale of the Acquired Assets by Sellers to Buyer.

               9.   TERMINATION


                    9.1   Termination Events.  This Agreement may, by


               


          notice given prior to or at the Closing, be terminated:

                          (a)  by either Buyer or Sellers if a material
          Breach of any provision of this Agreement has been committed by
          the other party and such Breach has not been waived or cured to
          the reasonable satisfaction of the non-breaching party within
          fifteen (15) days following the breaching party's receipt of
          written notice of such Breach from the non-breaching party;


                          (b)  by Buyer if any of the conditions in
          Section 7 has not been satisfied as of the Closing Date or if
          satisfaction of such a condition is or becomes impossible (other 
          than through the failure of Buyer to comply with its obligations 
          under this Agreement) and Buyer has not waived such condition on 
          or before the Closing Date;

                          (c)  by Sellers, if any of the conditions in
          Section 8 has not been satisfied as of the Closing Date or if
          satisfaction of such a condition is or becomes impossible (other 
          than through the failure of Sellers to comply with their
          obligations under this Agreement) and Sellers have not waived
          such condition on or before the Closing Date;

                          (d)  by mutual consent of Buyer and Sellers; 


                          (e)  by the Sellers if a Superior Proposal is
          accepted in accordance with Section 5.6(b); provided that, the
          Sellers shall not be permitted to terminate this Agreement
          pursuant to this Section 9.1(e) unless the Sellers have provided
          the Buyer with written notification thereof that includes the
          identity of the Person making such Acquisition Proposal and a
          description of the material terms of such Acquisition Proposal in
          accordance with Section 5.6 and the Sellers' intent to so
          terminate this Agreement; provided, further, such right of
          termination shall be expressly conditioned upon payment by the
          Sellers to the Buyer of the Termination Fee and Expense Fee in
          the manner provided by Section 9.3; or

                          (f)  by either Buyer or Sellers if the Closing
          has not occurred (other than through the failure of any party
          seeking to terminate this Agreement to comply fully with its
          obligations under this Agreement) on or before April 30, 1999, or
          such later date as the parties may agree upon.


                    9.2   Effect of Termination.  Each party's right of
          termination under Section 9.1 is in addition to any other rights 
          it may have under this Agreement or otherwise, and the exercise
          of a right of termination will not be an election of remedies or 
          relieve any party hereto of liability for any Breach of this
          Agreement.  Subject to the provisions of the immediately


          


          preceding sentence, if this Agreement is terminated pursuant to
          Section 9.1, all further obligations of the parties under this
          Agreement will terminate, except that the obligations in Sections
          9.3, 11.1 and 11.3 will survive.

                    9.3   Termination Fee; Expense Fee.  Notwithstanding
          anything contained herein to the contrary, if this Agreement is
          terminated by the Sellers pursuant to the provisions of Section
          9.1(e), the Sellers shall promptly, but in no event later than
          one (1) business day after the date on which such right to
          terminate is exercised, pay to Buyer a fee of One Million Dollars
          ($1,000,000) (the "Termination Fee") and shall also reimburse
          Buyer for all reasonable out-of-pocket expenses and fees payable 
          by it or its affiliates up to the maximum aggregate amount of Two
          Hundred Thousand Dollars ($200,000) (collectively, the
          "Expenses") (including, without limitation, fees and expenses of 
          all counsel, printers, banks, accountants, and investment banking
          firms, and their respective agents) (the "Expense Fee") related
          to the Contemplated Transactions, such amount to be paid in cash 
          in the immediately available funds by wire transfer to an account
          designated by Buyer.


               10.  INDEMNIFICATION; REMEDIES

                    10.1  Survival.  Subject to the limitations set forth
          in Section 10.5, all representations, warranties, covenants, and 
          obligations in this Agreement, the Schedules to this Agreement,
          and the Related Agreement will survive the Closing.  The right to
          indemnification, reimbursement, or other remedy based on such
          representations, warranties, covenants, and obligations will not 
          be affected by any investigation conducted with respect to, or
          any Knowledge acquired (or capable of being acquired) about the
          accuracy or inaccuracy of or compliance with, any such
          representation, warranty, covenant, or obligation.  The waiver of
          any condition based on the accuracy of any representation or
          warranty, or on the performance of or compliance with any
          covenant or obligation, will not affect the right to
          indemnification, reimbursement, or other remedy based on such
          representations, warranties, covenants, and obligations.

                    10.2  Indemnification and Reimbursement by Sellers. 
          Sellers, jointly and severally, shall indemnify and hold harmless
          Buyer and its Representatives, stockholders, controlling persons,
          and affiliates (collectively, the "Indemnified Persons"), and
          will reimburse the Indemnified Persons, for any loss, Liability, 
          claim, damage and expense (including costs of investigation and
          defense and reasonable attorneys' fees), whether or not involving
          a third-party claim (collectively, "Damages"), arising from or in
          connection with any of the following:


                          (a)  any Breach of any representation or warranty

            



          made by Sellers in this Agreement, the Schedules to this
          Agreement, the certificate delivered pursuant to
          Section 2.6(a)(v), or any other Related Agreements delivered by
          Sellers pursuant to or in connection with this Agreement;

                          (b)  any Breach by any Seller of any covenant or 
          obligation of any Seller in this Agreement or any Related
          Agreement;


                          (c)  the Excluded Liabilities;

                          (d)  any Environmental, Health and Safety
          Liabilities arising out of or relating to (i) the ownership,
          operation or condition at any time on or prior to the Closing
          Date of any of the Facilities or any other properties or assets
          in which any Seller has or had an interest; (ii) any Hazardous
          Materials or other contaminants that were present at such
          Facilities or such other properties or assets at any time on or
          prior to the Closing Date; (iii) any Hazardous Materials or other
          contaminants, wherever located, that were, or were allegedly,
          generated, transported, stored, treated, Released or otherwise
          handled or any hazardous activities that were, or were allegedly,
          conducted by any Seller or by any other Person for whose conduct 
          they are or may be held responsible; and (iv) any bodily injury
          (including illness, disability and death), personal injury, and
          property damage or other damage of or to any Person, in any way
          arising from or allegedly arising from any hazardous activity
          conducted or allegedly conducted with respect to such Facilities 
          or the operations of any Seller prior to the Closing Date or from
          Hazardous Material that was present on or before the Closing Date
          on or at such Facilities or that was Released or allegedly
          Released at any time on or prior to the Closing Date by any
          Seller or its predecessors; 

                          (e)  any claim by any Person for brokerage or
          finder's fees or commissions or similar payments based upon any
          agreement or understanding alleged to have been made by any such 
          Person with any Seller (or any Person acting on such Seller's
          behalf) in connection with any of the Contemplated Transactions; 
          or


                          (f)  without limiting the generality of
          Section 10.2(c), any failure by the Sellers to comply with all
          bulk sales, bulk clearance, and related legal requirements in
          connection with the sale of the Acquired Assets or the
          Contemplated Transactions.

                    10.3  Indemnification and Reimbursement by Buyer. 
          Buyer shall indemnify and hold harmless Sellers, and will
          reimburse Sellers, for any Damages arising from or in connection 
          with any of the following:

            



                          (a)  any Breach of any representation or warranty
          made by Buyer in this Agreement or in any Related Agreement
          delivered by Buyer pursuant to or in connection with this
          Agreement;

                          (b)  any Breach by Buyer of any covenant or
          obligation of Buyer in this Agreement or any Related Agreement;
          or


                          (c)  any claim by any Person for brokerage or
          finder's fees or commissions or similar payments based upon any
          agreement or understanding alleged to have been made by such
          Person with Buyer (or any Person acting on its behalf) in
          connection with any of the Contemplated Transactions.

                    10.4  Procedure for Indemnification - Third Party
          Claims.

                          (a)  Promptly after receipt by an indemnified
          party under Section 10.2 or 10.3 of notice of the commencement of
          any Proceeding against it, such indemnified party shall, if a
          claim is to be made against an indemnifying party under such
          Section, give notice to the indemnifying party of the
          commencement of such claim, but the failure to notify the
          indemnifying party will not relieve the indemnifying party of any
          liability that it may have to any indemnified party, except to
          the extent that the indemnifying party demonstrates that the
          defense of such action is materially prejudiced by the
          indemnifying party's failure to give such notice.


                          (b)  If any Proceeding referred to in
          Section 10.4(a) is brought against an indemnified party and it
          gives notice to the indemnifying party of the commencement of
          such Proceeding, the indemnifying party shall be entitled to
          participate in such Proceeding and, if (i) the indemnifying party
          acknowledges in writing to the indemnified party, without
          qualification or limitation, its obligation to indemnify the
          indemnified party for all Damages arising from such Proceeding
          and (ii) provides the indemnified party with satisfactory
          assurances that it has the financial ability to fully indemnify
          the indemnified party for such Damages, the indemnifying party
          shall assume the defense of such Proceeding with counsel
          reasonably satisfactory to the indemnified party.  If notice is
          given to an indemnifying party of the commencement of any
          Proceeding and the indemnifying party does not, within ten days
          after the indemnified party's notice is given, give notice to the
          indemnified party of its election to assume the defense of such
          Proceeding, the indemnifying party will be bound by any
          determination made in such Proceeding or any compromise or
          settlement effected by the indemnified party.

          



                          (c)  Notwithstanding the foregoing, if an
          indemnified party determines in good faith that there is a
          reasonable probability that a Proceeding may adversely affect it 
          or its Related Persons other than as a result of monetary damages
          for which it would be entitled to indemnification under this
          Agreement, or if an indemnified party reasonably believes that it
          may not receive the indemnification to which it may be entitled
          from the indemnifying party, the indemnified party may, by notice
          to the indemnifying party, assume the exclusive right to defend, 
          compromise, or settle such Proceeding, but the indemnifying party
          will not be bound by any determination of a Proceeding so
          defended or any compromise or settlement effected without its
          consent (which may not be unreasonably withheld).

                    10.5  Limitation of Claims.  


                          (a)  Except as set forth below, there shall be no
          liability under or with respect to any of the warranties or
          representations of Sellers or Buyer in or under this Agreement or
          in any Schedule hereto, unless a claim for indemnity is given by 
          the party seeking indemnification within the six (6) month period
          immediately following the Closing Date, except for Damages
          arising as a result of, or in connection with, or with respect to
          the following, with respect to which there shall be no limitation
          as to the time period within which an indemnity claim must be
          made by Buyer hereunder:  (i) the Excluded Liabilities; or (ii)
          the Breach of any agreements or covenants of any Seller
          hereunder.  

                          (b)  The maximum aggregate amount recoverable by 
          Buyer from Sellers pursuant to this Section 10 arising by reason 
          or Breach of a representation or warranty of Sellers hereunder
          shall be limited to the sum of One Million Dollars ($1,000,000); 
          provided, however, (i) the Buyer shall be entitled to
          indemnification hereunder only when the aggregate of all such
          claims exceeds One Hundred Thousand Dollars ($100,000) (the
          "Threshold Amount"), and (ii) all such claims shall be
          recoverable by the Buyer after the Threshold Amount of claims has
          been reached.

                          (c)  The maximum amount recoverable by Sellers
          from Buyer pursuant to this Section 10 arising by reason or
          Breach of a representation or warranty of Buyer hereunder shall
          be limited to the sum of One Million Dollars ($1,000,000);
          provided, however, (i) the Sellers shall be entitled to
          indemnification hereunder only when the aggregate of all such
          claims exceed the Threshold Amount, and (ii) all such claims
          shall be recoverable by the Sellers after the Threshold Amount
          has been reached.


                          (d)  Anything to the contrary set forth in this

          



          Section 10 notwithstanding, the provisions of this Section 10
          shall not apply to any Damages relating to, or arising out of, or
          in connection with, the fraud of any party hereto.

                    11.   GENERAL PROVISIONS


                    11.1  Expenses. Except as otherwise expressly provided 
          in this Agreement, each party to this Agreement will bear its
          respective expenses incurred in connection with the preparation, 
          execution, and performance of this Agreement and the Contemplated
          Transactions, including all fees and expenses of agents,
          representatives, counsel, and accountants.

                    11.2  Public Announcements.  Any public announcement or
          similar publicity with respect to this Agreement or the
          Contemplated Transactions will be issued, if at all, at such time
          and in such manner as Buyer and Sellers mutually determine. 
          Unless consented to by Buyer in advance or required by Legal
          Requirements, prior to the Closing the Sellers shall keep this
          Agreement strictly confidential and may not make any disclosure
          of this Agreement to any Person.  Sellers and Buyer will consult 
          with each other concerning the means by which Seller's employees,
          customers, and suppliers and others having dealings with Seller
          will be informed of the Contemplated Transactions, and both the
          Sellers and the Buyer will have the right to be present for any
          such communication.  The Buyer acknowledges that the Sellers
          intend to issue a press release with respect to the Contemplated 
          Transactions following the execution of this Agreement and that
          the form of such press release will be subject to the prior
          approval of the Buyer.

                    11.3  Confidentiality.  Between the date of this
          Agreement and the Closing Date, Buyer and Sellers will maintain
          in confidence, and will cause the Related Persons and
          Representatives of Buyer and Sellers to maintain in confidence
          any confidential or proprietary written, oral, or other
          information obtained from the other party or such parties'
          Related Persons or Representatives in connection with this
          Agreement or the Contemplated Transactions, unless (a) such
          information is already known to such party or to others not bound
          by a duty of confidentiality or such information becomes publicly
          available through no fault of such party, (b) the use of such
          information is necessary or appropriate in making any filing or
          obtaining any consent or approval required for the consummation
          of the Contemplated Transactions, or (c) the furnishing or use of
          such information is required by or necessary or appropriate in
          connection with a Legal Requirement or Proceeding.  Without
          limiting the generality of the foregoing, if the Contemplated
          Transactions are not completed, the Buyer agrees to make no use
          whatsoever of any of the confidential information made available 
          to it by the Sellers including, without limitation, customer
          lists, Sponsor Contracts, or Site Contracts and each party will

            



          return or destroy as much of such written information as the
          other party may reasonably request.

                    11.4  Notices.  All notices, consents, waivers, and
          other communications under this Agreement must be in writing and 
          will be deemed to have been duly given when (a) delivered by hand
          (with written confirmation of receipt), (b) sent by telecopier
          (with written confirmation of receipt), provided that a copy is
          also mailed to such party, or (c) when received by the addressee,
          if sent by a nationally recognized overnight delivery service
          (receipt requested) or by mailing, certified mail (return receipt
          requested), in each case to the appropriate addresses and
          telecopier numbers set forth below (or to such other addresses
          and telecopier numbers as a party may designate by notice to the 
          other parties):


               Sellers:             Collaborative Clinical Research, Inc.
                                    20600 Chagrin Boulevard, Suite 1050
                                    Cleveland, Ohio  44122

                                    Attn:  Mr. Jeffrey A. Green, Chief

                                           Executive Officer
                                    Telecopy No.:  (216) 491-3888

               with a copy to:      Calfee, Halter & Griswold LLP

                                    1400 McDonald Investment Center
                                    800 Superior Avenue
                                    Cleveland, Ohio  44114-2688


                                    Attn:  Thomas F. McKee, Esquire
                                    Telecopy No.:  (216) 241-0816

               Buyer:               The West Company, Incorporated
                                    101 Gordon Drive

                                    Lionville, Pennsylvania  19341-0645

                                    Attn:  Mr. Michael A. Anderson, Vice
                                           President, Strategic Planning &

                                           New Clinical Business
                                           Development
                                    Telecopy No.: (610) 594-3010


                


               with a copy to:      The West Company, Incorporated
                                    101 Gordon Drive
                                    Lionville, Pennsylvania  19341-0645


                                    Attn:  John R. Gailey, III, Esquire
                                    Telecopy No.:  (610) 594-3013

                    11.5  Jurisdiction; Service of Process.  Any action or 
          proceeding seeking to enforce any provision of, or based on any
          right arising out of, this Agreement may be brought against any
          of the parties in the courts of the Commonwealth of Pennsylvania,
          County of Philadelphia, or, if it has or can acquire
          jurisdiction, in the United States District Court for the Eastern
          District of Pennsylvania, and each of the parties consents to the
          jurisdiction of such courts (and of the appropriate appellate
          courts) in any such action or proceeding and waives any objection
          to venue laid therein.


                    11.6  Further Assurances.  The parties agree (a) to
          furnish upon request to each other such further information, (b)
          to execute and deliver to each other such other documents, and
          (c) to do such other acts and things, all as the other party may
          reasonably request for the purpose of carrying out the intent of
          this Agreement and the Related Agreements and the documents
          referred to in this Agreement and the Related Agreements. 
          Without limiting the foregoing, Sellers shall assist Buyer in
          obtaining all permits, licenses, approvals and other Governmental
          Authorizations which may be necessary or appropriate in
          connection with the Contemplated Transactions.

                    11.7  Waiver.  The rights and remedies of the parties
          to this Agreement are cumulative and not alternative.  Neither
          the failure nor any delay by any party in exercising any right,
          power, or privilege under this Agreement or the documents
          referred to in this Agreement will operate as a waiver of such
          right, power, or privilege, and no single or partial exercise of 
          any such right, power, or privilege will preclude any other or
          further exercise of such right, power, or privilege or the
          exercise of any other right, power, or privilege.


                    11.8  Entire Agreement and Modification.  Except as
          otherwise provided by the last sentence of Section 5.1, this
          Agreement supersedes all prior agreements between the parties
          with respect to its subject matter and constitutes (along with
          the Related Agreements) a complete and exclusive statement of the
          terms of the agreement between the parties with respect to its
          and their subject matter.  This Agreement may not be amended
          except by a written agreement executed by the party to be charged
          with the amendment.

          



                    11.9  Schedules.

                          (a)  The disclosures in the Schedules to this
          Agreement, and those in any supplements thereto, relate only to
          the representations and warranties in the Section of the
          Agreement to which they expressly relate and not to any other
          representation or warranty in this Agreement.


                          (b)  In the event of any inconsistency between
          the statements in the body of this Agreement and those in the
          Schedules (other than an exception expressly set forth in a
          Schedule with respect to a specifically identified representation
          or warranty), the statements in the body of this Agreement will
          control.

                    11.10 Assignments, Successors, and No Third-Party
          Rights.  Neither party may assign any of its rights under this
          Agreement without the prior consent of the other parties, except 
          that Buyer (a) may assign any of its rights under this Agreement 
          to any affiliate of Buyer (but such assignment will not relieve
          Buyer of any of its obligations under this Agreement), (b) shall 
          have the right to require Sellers to transfer and convey at the
          Closing any of the Acquired Assets specified by Buyer to one or
          more affiliates of Buyer, and (c) assign or pledge all of its
          rights hereunder to the financial institutions providing
          financing to Buyer, as security for Buyer's obligations to such
          institutions.  Subject to the preceding sentence, this Agreement 
          will apply to, be binding in all respects upon, and inure to the 
          benefit of the successors and permitted assigns of the parties.  
          Nothing expressed or referred to in this Agreement will be
          construed to give any Person other than the parties to this
          Agreement any legal or equitable right, remedy, or claim under or
          with respect to this Agreement or any provision of this
          Agreement.  This Agreement and all of its provisions and
          conditions are for the sole and exclusive benefit of the parties 
          to this Agreement and their successors and assigns.

                    11.11 Severability. If any provision of this Agreement 
          is held invalid or unenforceable by any court of competent
          jurisdiction, the other provisions of this Agreement will remain 
          in full force and effect.  Any provision of this Agreement held
          invalid or unenforceable only in part or degree will remain in
          full force and effect to the extent not held invalid or
          unenforceable.


                    11.12 Section Headings.  The headings of Sections in
          this Agreement are provided for convenience only and will not
          affect its construction or interpretation.

                    11.13 Time of Essence.  With regard to all dates and
          time periods set forth or referred to in this Agreement, time is 

         



          of the essence.

                    11.14 Governing Law.  This Agreement will be governed
          by and construed under the laws of the Commonwealth of
          Pennsylvania without regard to conflicts of laws principles.


                    11.15 Counterparts. This Agreement may be executed in
          one or more counterparts, each of which will be deemed to be an
          original copy of this Agreement and all of which, when taken
          together, will be deemed to constitute one and the same
          agreement.

                    11.16 Use of Name.  Buyer will acquire all rights to
          each corporate name and tradename of each Seller, and any
          variations and derivations thereof.  Accordingly, each Seller
          will change its name and cause all of their Related Persons, if
          any, which are not individuals to change their names immediately 
          after the Closing to names that are not similar to such Seller's 
          corporate name, tradename, or any derivation thereof.

                    11.17 Records Retention.  For a period of two (2) years
          after the Closing Date or until the sale, merger, or liquidation 
          (at least forty-five (45) days' advance written notice of which
          shall have been furnished by the Sellers to the Buyer), whichever
          first occurs, Sellers shall afford Buyer access to, and Sellers
          shall retain and shall not destroy, all of its books, records,
          Government Authorizations, reports, data, materials, and
          documents which are not included in the Acquired Assets but which
          relate to the Clinical Business as conducted prior to the Closing
          Date.


                    11.18  Joinder by DataTRAK.  Except as otherwise
          expressly permitted under and pursuant to the Non-Competition
          Agreement to which DataTRAK is a party, DataTRAK has also
          executed and delivered this Agreement at the request of
          Collaborative for the purpose of joining in the provisions of
          this Agreement to evidence its agreement to transfer and convey
          to the Buyer, at the Closing, any right, title or interest that
          DataTRAK may have in or to any of the Acquired Assets and to
          execute and deliver any and all agreements, documents and
          instruments reasonably requested by the Buyer in connection
          therewith.

                    IN WITNESS WHEREOF, the parties have executed this
          Agreement as of the date first written above.


                                         COLLABORATIVE CLINICAL RESEARCH,
                                         INC., an Ohio corporation

                                         By________________________________


                


                                                  Name:
                                                  Title:

                                         Attest:___________________________

                                                  Name:
                                                  Title:


                                         GFI PHARMACEUTICAL SERVICES, INC.,
                                         an Indiana corporation


                                         By________________________________
                                                  Name:
                                                  Title:


                                         Attest:___________________________
                                                  Name:
                                                  Title:



          (SIGNATURE LINES CONTINUED ON NEXT PAGE)

        



                                         CHI COLLABORATIVE HOLDINGS, an
                                         Ohio corporation

                                         By________________________________
                                                  Name:

                                                  Title:

                                         Attest:___________________________
                                                  Name:
                                                  Title:



                                         DATATRAK, INC., an Ohio
                                         corporation


                                         By________________________________
                                                  Name:
                                                  Title:


                                         Attest:___________________________
                                                  Name:
                                                  Title:

                                                       ("Sellers")



                                         THE WEST COMPANY, INCORPORATED, a 
                                         Pennsylvania corporation


                                         By________________________________
                                                  Name:
                                                  Title:

                                         Attest:___________________________

                                                  Name:
                                                  Title:

                                                  ("Buyer")

         



                                                                  EXHIBIT A


                                 THE ACQUIRED ASSETS


                    The "ACQUIRED ASSETS" to be purchased by Buyer and
          sold, conveyed, assigned, transferred and delivered on the
          Closing Date to Buyer by Sellers shall include all right, title
          and interest in and to all of the assets, rights, privileges, and
          interests of Sellers used by the Sellers in connection with the
          Clinical Business, of whatever nature and wherever located, other
          than the "EXCLUDED ASSETS", including without limitation all of
          the following:

                    1.    Account Receivable.  All accounts receivable and 
          other amounts owed or otherwise payable to any Seller that exist 
          as of the Closing Date.


                    2.    Tangible Personal Property.  All items of
          machinery, equipment, trade fixtures, furnishings, motor
          vehicles, furniture, and other tangible personal property,
          including such items as are referred to on EXHIBIT A-2 (but with 
          such additions thereto and deletions therefrom in the Ordinary
          Course of Clinical Business as may be contemplated or permitted
          by this Agreement).

                    3.    Assigned Contracts.  All of Sellers' rights and
          interests as of the Closing Date under or relating to the
          "ASSIGNED CONTRACTS" (as defined below).


                    4.    Claims, Prepayments, Deposits, Etc.  All claims, 
          deposits, prepayments, prepaid expenses, refunds, causes of
          action, chooses in action, rights of recovery, rights of setoff
          and rights of recoupment.

                    5.    Books and Records.  All books, records, ledgers, 
          files, documents, correspondence, lists (including, without
          limitation, sponsor lists, provider lists, site lists, and
          prospect lists), plats, architectural plans, drawings,
          specifications, studies, reports, computer software, systems,
          procedures manuals, and related materials used in the Acquired
          Assets.


                    6.    Advertising.  All advertising and promotional
          materials, market research, business plans and projections,
          artwork, masters, tapes, mats and other similar items pertaining 
          to the Acquired Assets.

                    7.    Permits and Licenses.  All transferable

           



          approvals, permits, licenses, orders, registrations,
          certificates, variances and other Governmental Authorizations.

                    8.    Intellectual Property Assets.  Intellectual
          Property Assets pertaining to the Clinical Business (including,
          without limitation, the names "Collaborative Clinical Research," 
          GFI Pharmaceutical Services," and "[CHI/WCE] Clinical
          Evaluations" and any derivations thereof).


                    The "Assigned Contracts" shall be comprised of the
          agreements and other instruments identified on SCHEDULE A
          attached to this EXHIBIT A; PROVIDED, HOWEVER, that if the
          Consent of any Person is required in order to permit the
          assignment to Buyer of any such agreement or other instrument,
          and if such Consent is not obtained on or before the Closing
          Date, then Buyer may elect, on the Closing Date, either (i) to
          include such agreement or other instrument among the "Assigned
          Contracts," or (ii) to exclude such agreement or other instrument
          from the "Assigned Contracts."

         



                                      SCHEDULE A

                    [This SCHEDULE A shall be prepared by Sellers and
          include, among other things, Employment Agreements being assigned
          to Buyer (Richard J. Kasmer, William Stigelman, Wade Lange,
          Gregory A. Folz, Herbert L. Hugill, and David Hirsch), the
          Leases, the Lab Testing Contracts, the Site Contracts, and the
          Sponsor Contracts.]

         



                                                                  EXHIBIT B


                                 ASSUMED LIABILITIES


                    The liabilities to be assumed by Buyer pursuant to the 
          Agreement or otherwise in connection with the transactions
          described therein shall consist only of the following Liabilities
          (the "Assumed Liabilities") in connection with the operation of
          the Clinical Business:

                    1.    Assigned Contracts.  All obligations of Seller
          under the Assigned Contracts which are to be performed after, and
          relate to the period after, the Closing Date (to the extent that 
          the existence of such obligations is ascertainable solely by
          reference to the written provisions of the Assigned Contracts as 
          disclosed to Buyer before the Closing Date or the descriptions of
          any oral Assigned Contracts set forth in SCHEDULE 3.14), but
          specifically excluding any obligations to be performed prior to
          the Closing and any obligations relating to breaches, defaults or
          non-performance under any of the Assigned Contracts occurring or 
          commencing prior to the Closing Date.


                    2.    Accrued Expenses; Trade Payables.  All accrued
          expenses and accounts payable of Sellers as of the Closing Date
          that were incurred in the Ordinary Course of Clinical Business, a
          list and description (including amounts) of which is attached as
          EXHIBIT B-2 hereof.

                    3.    Scheduled Severance Obligations.  Those severance
          obligations described on SCHEDULE 5.9(d) for and with respect to 
          those employees of Sellers hired by the Buyer pursuant to
          Section 5.9(d).

         



                                                                  EXHIBIT E


                                   EXCLUDED ASSETS


                    The Acquired Assets shall not include, and Sellers
          shall specifically retain, all of the following (the "Excluded
          Assets"):

                    1.    Cash; Cash Equivalents.  All cash and cash
          equivalents (including marketable equity services and short-term 
          investments) of Sellers as of the Closing Date.


                    2.    Corporate Charters, Etc.  The corporate charter, 
          qualifications to conduct business as foreign corporations,
          arrangements with registered agents relating to foreign
          qualifications, taxpayer and other identification numbers, seals,
          minute books, stock transfer books and other documents relating
          to the organization, maintenance and existence of Seller as a
          corporation.

                    3.    Rights Under This Agreement.  All of the rights
          of the Sellers under this Agreement or under any Related
          Agreement between Sellers on the one hand and the Buyer on the
          other hand entered into on or after the date of this Agreement.


                    4.    Non-Clinical Business Assets.  All of the assets,
          rights, privileges, and interests of Sellers not used in
          connection with the Clinical Business.

                    5.    DataTRAK.  The capital stock of DataTRAK owned by
          Collaborative.


                    6.    Tax Records.  The Sellers' tax returns and
          related corporate records.

                    7.    Privileged Information.  All information
          protected by the Sellers' attorney-client or attorney work
          product privilege.

                    8.    Third-Party Claims.  Claims and similar rights of
          any Seller against third parties which are not related to the
          Clinical Business.


                    9.    Shared Assets.  [TO BE COVERED IN SELLER
          AGREEMENTS].

         



                                     EXHIBIT G-1

                    The Sellers and the Buyer shall in good faith use their
          joint best efforts to negotiate a mutually satisfactory Services 
          Agreement prior to the Closing, pursuant to which the parties
          shall share with one another certain assets and/or services which
          relate to both the Clinical Business and other businesses of the 
          Sellers and DataTRAK (including, by way of example but not
          limitation, accounting, payroll and telephone systems). The
          execution and delivery of the Services Agreement shall be a
          condition precedent to the parties' obligation to complete the
          Contemplated Transactions. 

         



                                    Exhibit G-2

          Seller Agreement required by EXHIBIT G-2 shall be in             
                substantially the following form.



                                  December 21, 1998

          The West Company, Incorporated

          101 Gordon Drive
          Lionville, Pennsylvania  19341

          Attention: Mr. Michael Anderson


          Dear Mr. Anderson:

               On December 21, 1998, The West Company, Incorporated
          ("Buyer"), Collaborative Clinical Research, Inc.
          ("Collaborative"), GFI Pharmaceutical Services, Inc. ("GFI"), and
          Collaborative Holdings, Inc. ("CHI") (Collaborative, GFI and CHI
          being collectively referred to herein as the "Sellers") entered
          into an Asset Purchase Agreement (the "Purchase Agreement").
          Pursuant to the terms of the Purchase Agreement, the Sellers
          agreed to sell and the Buyer agreed to purchase substantially all
          of the assets of the Sellers relating to the Clinical Business
          (as defined in the Purchase Agreement). DataTRAK, Inc.
          ("DataTRAK") is engaged in, among other things, the business of
          developing and providing software, technology and related
          electronic data handling services (as more fully described on
          Exhibit "A" on the Non-Competition Agreement to be executed by
          the Sellers and DataTRAK pursuant to the Purchase Agreement).


               In connection with the transactions described in the
          Purchase Agreement and as a material inducement for the Buyer to 
          complete such transactions, DataTRAK covenants and agrees to make
          the services and the products of DataTRAK's electronic data
          capture business available to the Buyer on royalty, fee and other
          material terms which are no less favorable than those terms
          offered to other non-affiliated customers (excluding, however,

          







          arrangements made by DataTRAK with any members of any Consortium 
          described in Section 1(c) of the above mentioned Non-Competition 
          Agreement.


               DataTRAK has executed this letter intending to be legally
          bound.

                                        DATATRAK, INC.


                                        By_________________________________
                                             Name:
                                             Title: