SECURITIES AND EXCHANGE COMMISSION
                       Washington, D.C. 20549
                              FORM 10-K
      [X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
           SECURITIES EXCHANGE ACT OF 1934 [FEE REQUIRED]
                                  
             For the fiscal year ended December 31, 1994
                                  
                     Commission File No. 1-4114
                                  
                      FIRST INTERSTATE BANCORP
        (Exact name of registrant as specified in its charter)
                                  
            DELAWARE                           95-1418530
      (State or other jurisdiction of          (I.R.S. Employer
     incorporation or organization)       Identification Number)
                                  
                           633 WEST FIFTH STREET
         LOS ANGELES, CALIFORNIA                      90071
     (Address of principal executive offices)         (Zip Code)
                                  
                           (213) 614-3001
        (Registrant's telephone number, including area code)
                                  
     SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:

 TITLE OF EACH CLASS                          NAME  OF EACH EXCHANGE
                         ON WHICH REGISTERED
     Common Stock, $2 par value              New York and Pacific
     Stock Exchanges
     Series F Preferred Stock                     New York Stock
     Exchange
     Series G Preferred Stock                     New York Stock
     Exchange

     SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:
               Senior Medium Term Notes, Series A
               Subordinated Medium Term Notes, Series C
               10.5% Notes Due March 1, 1996
               12.75% Subordinated Notes Due May 1, 1997
               Floating Rate Subordinated Notes Due June 1997
               11.0% Notes Due March 5, 1998
               8.625% Subordinated Capital Notes Due April 1, 1999
               9.125% Notes Due February 1, 2004
               9.00% Notes Due November 15, 2004
               8.15% Notes Due March 15, 2002
          
Indicate  by  check mark whether the registrant (1)  has  filed  all
reports  required  to  be  filed by  Section  13  or  15(d)  of  the
Securities Exchange Act of 1934 during the preceeding 12 months  (or
for  such  shorter period that the registrant has been  required  to
file  such  (reports),  and  (2) has been  subject  to  such  filing
requirements for the past 90 days.  Yes  X    No   _

Indicate  by check mark if disclosure of delinquent filers  pursuant
to  Item 405 of Regulation S-K is not contained herein, and will not
be  contained,  to the best of registrant's knowledge, in definitive
proxy  or information statements incorporated by reference  in  Part
III of this Form 10-K or any amendment to this Form 10-K [ ].

    State the aggregate market value of the voting stock held by
                  nonaffiliates of the registrant:

     CLASS                     MARKET VALUE AT FEBRUARY 28, 1995
          Common Stock, $2 par value                 $6,167,071,021
                                  
  Indicate the number of shares outstanding of each of the issuer's
     classes of common stock, as of the latest practicable date:
                                  
      CLASS                   OUTSTANDING AT FEBRUARY 28, 1995
          Common stock, $2 par value                   75,785,819
     shares

                 DOCUMENTS INCORPORATED BY REFERENCE

Portions  of  the Annual Report to Stockholders for the  year  ended
December  31,  1994  are  incorporated by reference  into  Part  II.
Portions  of  the  definitive Proxy Statement for  the  1995  annual
meeting of stockholders are incorporated by reference into Part III.
                             PART  I


ITEM 1.  BUSINESS

The  Corporation was incorporated under the laws of the State  of
Delaware   and   began  operations  in  1958   under   the   name
"Firstamerica Corporation".  The name Western Bancorporation  was
adopted in 1961 and changed to First Interstate Bancorp in 1981.

The  Corporation is a bank holding company registered  under  the
Bank  Holding  Company Act of 1956, as amended.  At December  31,
1994, it owned directly all of the shares of capital stock of  16
banks (the "Subsidiary Banks") which operated approximately 1,100
banking  offices in 13 states.  Ranked according to  assets,  the
Corporation   was  the  fourteenth  largest  commercial   banking
organization  in the United States at December 31,  1994,  having
total  deposits  of  $48.4  billion and  total  assets  of  $55.8
billion.   During December 1994, the average number of  full-time
equivalent   persons   employed  by  the  Corporation   and   its
subsidiaries was 27,394.

The  Subsidiary  Banks accept checking, savings  and  other  time
deposit  accounts  and employ these funds principally  by  making
consumer,  real  estate  and commercial loans  and  investing  in
securities  and  other interest bearing assets.   All  Subsidiary
Banks  are  members of the Federal Deposit Insurance Corporation,
all  but  three exercise trust powers, and the thirteen  national
banks and one of the three state banks are members of the Federal
Reserve System.

The  Corporation also provides banking-related financial services
and  products.   These include asset-based commercial  financing,
asset management and investment counseling, bank card operations,
mortgage  banking, venture capital and investment  products.   It
engages in these activities both through non-bank subsidiaries of
the  Corporation  and  through the  Subsidiary  Banks  and  their
subsidiaries.

The   larger  Subsidiary  Banks  provide  international   banking
services on a limited basis through the international departments
of  their  domestic  offices and through a  business  development
agreement  with  Standard  Chartered  PLC.   They  also  maintain
correspondent  relationships  with  major  banks  throughout  the
world.  International banking is subject to special risks such as
fluctuating  exchange  rates,  currency  revaluations   and   the
policies  of  foreign  governments.  United  States  governmental
guarantees  and insurance against political risks  are  sometimes
available  and are used in certain circumstances to minimize  the
impact of such factors.
The  Subsidiary  Banks  are responsible to  the  Corporation  for
achieving  mutually  agreed upon goals under  the  management  of
their  own  officers  and directors.  The Corporation  retains  a
staff  of  specialists  who  provide  assistance  and  advice  to
subsidiaries  in  the  areas of investments, credit,  accounting,
personnel, business development, operations, asset and  liability
management,   budgeting   and  planning,   loan   participations,
protective  controls and compliance with government  regulations.
Internal  audits  and  reviews are  performed  to  determine  the
adequacy  of  internal control systems, compliance  with  general
corporate  policy  and  consistency of  accounting  practices  in
accordance  with  the  Corporation's  accounting  policies.   The
Corporation   monitors  the  Subsidiary  Banks'  credit   policy,
procedures  and  administration by reviewing  portfolio  quality,
balance and mix.

The  Corporation  and the Subsidiary Banks on a continuous  basis
identify and evaluate possible acquisitions of  banks and savings
and  loan associations within the geographic territory served  by
the  Corporation and its Subsidiary Banks.  During 1993 and  1994
the  Corporation  completed five transactions  resulting  in  the
acquisition   of   deposits  from  both  the   Resolution   Trust
Corporation  and  the Federal Deposit Insurance Corporation.   In
addition, the Corporation was party to business combinations with
various  operating entities located within the  territory.  These
transactions  resulted  in the acquisition  of  $8.4  billion  of
deposits and $9.7 billion of assets.  Additional details of these
transactions   are   included  in  the   Consolidated   Financial
Statements and Notes to the Financial Statements attached  as  an
exhibit to this document.

COMPETITION

The   commercial   banking   business  is   highly   competitive.
Subsidiary  Banks compete with other commercial  banks  and  with
other financial and non-financial institutions, including savings
and  loan  associations, finance companies, credit unions,  money
market mutual funds and credit card issuers.


SUPERVISION AND REGULATION

The  Corporation,  as  a  bank holding  company,  is  subject  to
regulation under the Bank Holding Company Act of 1956, as amended
(BHCA) and is registered with the Federal Reserve Board under the
BHCA.   The  acquisition of more than 5% of the voting shares  of
any bank (not already majority owned) requires the prior approval
of  the  Federal  Reserve  Board.  The BHCA  also  prohibits  the
Federal  Reserve Board from approving an application which  would
result  in  the  Corporation or any non-bank  subsidiary  thereof
acquiring all or substantially all the assets or more than 5%  of
the  voting  shares  of  any bank (not  already  majority  owned)
located outside of California unless an acquisition of such  bank
by  a  California-based  bank  holding  company  is  specifically
authorized by the laws of the state in which the bank is located.
The  laws  of several states permit such acquisitions.  The  BHCA
also  prohibits  the Corporation, with certain  exceptions,  from
acquiring direct or indirect ownership or control of more than 5%
of  the voting shares of any company which is not a bank and from
engaging in any business other than that of banking, managing and
controlling banks or furnishing services to its Subsidiary Banks,
except that the Corporation may engage in, and may own shares  of
companies  engaged in, certain businesses found  by  the  Federal
Reserve  Board to be so closely related to banking "as  to  be  a
proper  incident  thereto."  The BHCA does not place  territorial
restrictions on the activities of non-bank subsidiaries  of  bank
holding  companies. The Corporation is required by  the  BHCA  to
file  annual  reports of its operations with the Federal  Reserve
Board and is subject to examination by the Federal Reserve Board.
Under legislation enacted in 1974, the Federal Reserve Board  was
given  jurisdiction to regulate the terms of certain debt  issues
of  bank  holding  companies including the  authority  to  impose
reserve requirements on such debt.

The  Subsidiary Banks, as subsidiaries of the Corporation  within
the  meaning  of  Section  23A of the Federal  Reserve  Act,  are
subject  to  certain restrictions on loans to the Corporation  or
its  non-bank subsidiaries, or investments in the stock or  other
securities of the Corporation or its non-bank subsidiaries and on
advances  to any borrower collateralized by such stock  or  other
securities.   Further, the Subsidiary Banks are also  subject  to
certain  restrictions  on  most types of  transactions  with  the
Corporation  or  its  non-bank subsidiaries, requiring  that  the
terms  of such transactions be substantially equivalent to  terms
of similar transactions with non-affiliated firms.

Each  of  the  16 Subsidiary Banks is either a state or  national
bank.  Three Subsidiary Banks are state-chartered and are subject
to  supervision  and regular examination by the bank  supervisory
authorities of the respective states in which they are chartered.
The  remaining  Subsidiary  Banks  are  national  banks  and  are
subject  to supervision and regular examination by the Office  of
the  Comptroller of the Currency.  Those Subsidiary  Banks  which
are  members  of  the  Federal  Reserve  System  are  subject  to
applicable  provisions  of the Federal  Reserve  Act,  and  First
Interstate  Bank  of  California, the Corporation's  only  state-
chartered   member  bank  subsidiary,  is  subject   to   regular
examination  by  the Federal Reserve Bank of San Francisco.   The
deposit  accounts held by all of the Subsidiary Banks are insured
by  the  FDIC; as such they are subject to the provisions of  the
Federal  Deposit Insurance Act and, in the case of insured  banks
not members of the Federal Reserve System, to regular examination
by  the  FDIC.   The  federal and state laws and  regulations  of
general  application to banks regulate, among other  things,  the
scope  of  their  business,  their  investments,  their  reserves
against  deposits,  the timing of the availability  of  deposited
funds, and numerous other aspects of their business.

The  Corporation,  as  the holder of common stock  of  Subsidiary
Banks which are national banks, may be subject to assessment  for
the  restoration of impaired capital of such banks, as and to the
extent  provided in Section 5205 of the Revised Statutes  of  the
United States (12 U.S.C. Section 55). Similarly, First Interstate
Bank  of  California  may  be  subject  to  assessment  for   the
restoration of impaired capital, as and to the extent provided in
Section  662  of  the California Financial Code.  These  statutes
provide  for the restoration of impaired capital by the  sale  of
bank   stock,   but  impose  no  personal  liability   upon   the
stockholder.

The Corporation is a legal entity separate and distinct from  the
Subsidiary  Banks.   The principal source  of  the  Corporation's
revenues  is  dividends  received  from  the  Subsidiary   Banks.
Another  source  of  revenue, not presently  utilized,  would  be
charges  to  the  Subsidiary  Banks for  administrative  services
provided by the Corporation.  Various statutory provisions  limit
the amount of dividends the Subsidiary Banks and certain non-bank
subsidiaries  can  pay without regulatory approval,  and  various
regulations also restrict the payment of dividends.

In  1989,  Congress  enacted a law that purports  to  make  banks
liable  to the FDIC for expenses the FDIC incurs in the  case  of
either  its provision of financial assistance to, or the  failure
of,  any  affiliated bank.  Under that law, the Subsidiary  Banks
could  theoretically be held liable to the FDIC in the  event  of
financial  assistance  to, or failure of,  any  other  Subsidiary
Bank,  and  theoretically  that liability  could  be  substantial
enough  to cause the surviving Subsidiary Banks either to require
financial  assistance from the FDIC or to cause  the  failure  of
such Subsidiary Banks.

On  December 19, 1991, comprehensive legislation was enacted that
reforms  the regulation and supervision of banks and bank holding
companies.  Among the more significant aspects of the legislation
is  a  requirement  that federal regulators  prescribe  standards
relating  to  internal  controls, information  systems,  internal
audit  systems, loan documentation, credit underwriting, interest
rate  exposure,  asset growth, employee, director  and  principal
shareholder compensation, fees and benefits, standards specifying
a maximum ratio of classified assets to capital, minimum earnings
sufficient to absorb losses without impairing capital, and to the
extent possible, a minimum ratio of market value to book value of
publicly  traded shares of bank holding companies,  such  as  the
Corporation.  The legislation also provides for a system of early
intervention  by the regulators and prompt corrective  action  at
troubled  banks.  Under that system, a bank may not pay dividends
if  its  capital fails to meet any required minimum and  will  be
expected to submit to its regulator an acceptable plan to restore
its   capital   to   adequate   levels.    While   a   bank    is
undercapitalized, its regulator may preclude its growth,  require
its  recapitalization  through the sale of  shares,  require  its
acquisition or merger, prohibit its parent from paying dividends,
and require divestitures by its parent, including divestiture  of
the bank itself.  Its parent holding company will be expected  to
guarantee  that  the  bank will comply with  the  bank's  capital
restoration  plan until the bank has been adequately capitalized,
on  average, for four consecutive quarters, unless the parent  is
willing  to  accept  loss or closure of the bank  by  regulators.
This guarantee is limited to the lesser of 5% of the bank's total
assets  at  the  time it became undercapitalized  or  the  amount
necessary  to bring the bank into compliance with all  applicable
capital standards.

If  the  bank  does not submit an acceptable capital  restoration
plan  or  if  its parent holding company does not guarantee  such
plan,  the  regulators  will be required  to  take  one  or  more
actions, including requiring recapitalization of the bank through
its  sale  of  securities or forced sale or  merger,  restricting
transactions with affiliates, restricting interest rates paid  on
deposits,  restricting  asset growth,  restructuring  activities,
replacing  management  of  the bank,  prohibiting  deposits  from
correspondent banks, requiring prior approval of dividends by the
holding company, and requiring divestiture.  The law requires the
regulators,  in such cases, to require the sale of securities  by
the  bank  or to force a sale or merger of the bank, to  restrict
affiliate transactions, and to restrict interest rates unless the
regulator  determines that these actions would  not  resolve  the
problems of the bank at the least possible long-term loss to  the
Bank Insurance Fund of the FDIC.  The law also limits advances to
any  undercapitalized bank by any Federal Reserve Bank from being
outstanding  more than 60 days in any 120-day period  unless  the
head  of  the bank regulatory agency certifies that,  giving  due
regard to economic conditions and circumstances in the market  in
which  the bank operates, the bank is not and is not expected  to
become  critically  undercapitalized and is not  expected  to  be
placed   in  conservatorship  or  receivership.   None   of   the
Corporation's Subsidiary  Banks is undercapitalized.

The  foregoing references to applicable statutes and  regulations
are  brief summaries thereof, which do not purport to be complete
and are qualified in their entirety by reference to such statutes
and regulations.

From  time  to  time various bills are introduced in  the  United
States  Congress  which  could result in additional  or  in  less
regulation  of the business of the Corporation and the Subsidiary
Banks.  It cannot be predicted whether any such legislation  will
be  adopted or how such adoption would affect the business of the
Corporation or the Subsidiary Banks.

The  Federal  Reserve  Board has established  risk-based  capital
guidelines  for  bank holding companies.  The  guidelines  define
Tier  1  Capital and Total Capital.  Tier 1 Capital  consists  of
common  and  qualifying  preferred shareholders'  equity,  before
unrealized gains and losses on available-for-sale debt securities
and   minority  interests  in  equity  accounts  of  consolidated
subsidiaries,  less  goodwill, other  nonqualifying  intangibles,
excess   deferred   tax  assets  and  50%   of   investments   in
unconsolidated  subsidiaries.   Total  Capital  consists  of,  in
addition to Tier 1 Capital, mandatory convertible debt, preferred
stock  not  qualifying as Tier 1 Capital, subordinated and  other
qualifying  term  debt and a portion of the  allowance  for  loan
losses  less  the remaining 50% of investments in  unconsolidated
subsidiaries.  The Tier 1 component must comprise at least 50% of
qualifying   Total  Capital.   Risk-based  capital   ratios   are
calculated with reference to risk-weighted assets, as outlined by
bank  supervisory  authorities, which include both  on  and  off-
balance  sheet exposures.  The minimum required qualifying  Total
Capital ratio is 8%, of which at least 4% must consist of Tier  1
Capital.   As  of  December 31, 1994, the  Corporation's  Tier  1
Capital   and  Total  Capital  ratios  were  7.20%  and   10.22%,
respectively.

The  Federal Reserve Board has adopted a "minimum leverage ratio"
which  requires bank holding companies to maintain Tier 1 Capital
of at least 3% of adjusted quarterly average assets, although the
Federal  Reserve Board may require a higher ratio depending  upon
the  rating of the bank holding company and its expected  growth.
Regulations  issued by the FDIC to implement the 1991 legislation
referred  to  above  establish five levels of capitalization  for
banks;  any bank with a Tier 1 Capital ratio of 6%, Total Capital
ratio of 10% and a leverage ratio of 5% is considered to be "well
capitalized."    As  of  December  31,  1994,  the  Corporation's
leverage  ratio  was 5.35%, and all of the Subsidiary  Banks  had
leverage ratios exceeding 5.50%.


MONETARY POLICY AND ECONOMIC CONDITIONS

The  earnings of the Corporation are affected by the policies  of
regulatory  authorities,  including the Federal  Reserve  System.
Federal  Reserve monetary policies have had a significant  effect
on  the operating results of commercial banks in the past and are
expected  to  continue to do so in the future.   Interest  rates,
credit  availability  and  deposit  levels  may  change  due   to
circumstances  beyond  the  control of  the  Corporation  or  the
Subsidiary Banks because of changing conditions in  national  and
international economies and in the money markets, as a result  of
actions by monetary and fiscal authorities.






ITEM 2. PROPERTIES

The Corporation and its Subsidiaries occupied, as of December 31,
1994,  1,192  premises  in  13 western  states,  which  consisted
primarily  of  bank buildings.  On that date, 584  premises  were
owned,  456 premises were leased, and the remaining 152  premises
were  owned  in  part  and  leased in  part.   In  addition,  the
Subsidiary  Banks  have 1,633 ATM locations.   The  Corporation's
headquarters are in Los Angeles, California.


ITEM 3. LEGAL PROCEEDINGS

There  are presently pending against the Corporation and  certain
of  its Subsidiaries a number of legal proceedings.  While it  is
not  possible to predict the outcome of these proceedings, it  is
the  opinion  of management, after consulting with counsel,  that
the  ultimate disposition of potential or existing suits will not
have  a  material  adverse effect on the Corporation's  financial
position, results of operations or liquidity.


ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

No  matters were submitted to security holders during the  fourth
quarter of the year ended December 31, 1994.
EXECUTIVE OFFICERS OF THE REGISTRANT

Shown  below  are names and ages of all executive  officers  with
indication  of  all positions and offices with  the  Corporation.
There  were no family relationships among the executive  officers
of the Corporation.


NAME                  AGE     OFFICE


Edward M. Carson      65      Chairman of the Board

William E. B. Siart   48      President and Chief Executive Officer

William S. Randall    54      Chief Operating Officer

James J. Curran       55      Chief Executive Officer - Northwest Region
                      
Linnet F. Deily       49      Chief Executive Officer - Texas Region

John S. Lewis         40      Chief Executive Officer - Southwest Region

Bruce G. Willison     46      Chief Executive Officer - California Region

David S. Belles       57      Executive Vice President and Controller

William J. Bogaard    56      Executive Vice President and 
                              General Counsel

Theodore F. Craver    43      Executive Vice President and Treasurer

Gary S. Gertz         50      Executive Vice President and 
                              General Auditor

Lillian R. Gorman     41      Executive Vice President and 
                              Human Resources Director

Robert E. Greene      53      Executive Vice President and 
                              Chief Credit Officer

Thomas P. Marrie      56      Executive Vice President and 
                              Chief Financial Officer

Richard W. Tappey     54      Executive Vice President and
                              Administration Director

David K. Wilson       40      Executive Vice President and 
                              Manager of Credit Review


Mr. Carson was elected Chairman of the Board on June 1, 1990.  He
was  Chief Executive Officer from June, 1990 to December 31, 1994
and  President from  January, 1985 to May 31, 1990.

Mr. Siart was elected Chief Executive Officer  effective  January 
1,  1995  and  President of First Interstate Bancorp on  June  1,
1990.  He was Chairman, President and Chief Executive Officer  of
First  Interstate  Bank  of California  from  December,  1985  to
January, 1991.

Mr. Randall was elected Chief Operating Officer effective January
1,  1995.  He served as Chief Executive Officer of the  Southwest
Region  from September, 1991 to December, 1994.  He was Chairman,
President and Chief Executive Officer of First Interstate Bank of
Arizona,  N.A. from January 11, 1990 to December, 1994.   He  was
previously  Chairman,  President and Chief Executive  Officer  of
First Interstate Bank of Washington, N.A. between July, 1985  and
January, 1990.

Mr. Curran was appointed Chief Executive Officer of the Northwest
Region  in  September, 1991. He was elected  Chairman  and  Chief
Executive  Officer of First Interstate Bank of  Oregon,  N.A.  on
February  1,  1991  and President on October 22,  1991.   He  was
elected    President  and  Chief  Executive  Officer   of   First
Interstate  Bank  of  Washington, N.A. on October  16,  1991  and
served  as Chairman from October 16, 1991 to March 30, 1994.   He
was  elected  President  and  Chief Executive  Officer  of  First
Interstate  Bank  of  Idaho, N.A. and First  Interstate  Bank  of
Montana,  N.A.  on December 17, 1991 and served as Chairman  from
December  17, 1991 to March 15, 1994.  He was previously Chairman
and  Chief Executive Officer of First Interstate Bank of  Denver,
N.A.  between March, 1990 and February, 1991, and he was Chairman
and  Chief  Executive Officer of First Interstate Bank of  Idaho,
N.A. between July, 1984 and March, 1990.

Ms.  Deily  was appointed Chief Executive Officer  of  the  Texas
Region  in  September, 1991. She was elected  Chairman  of  First
Interstate  Bank  of  Texas, N.A. in  November,  1991.   She  was
elected  President and Chief Executive Officer January  1,  1991,
having  served  as  President and Chief Operating  Officer  since
November, 1988.

Mr.  Lewis was appointed Chairman and Chief Executive Officer  of
the  Southwest Region in December, 1994 at which time he was also
elected Chairman and  Chief Executive Officer of First Interstate
Bank  of  Arizona, N.A.  He has served as Chief Operating Officer
of the Southwest Region since April, 1994 and as Chairman of both
First  Interstate  Bank of New Mexico, N.A. and First  Interstate
Bank of Utah, N. A.  since 1993.

Mr.  Willison  was  appointed  Chief  Executive  Officer  of  the
California  Region in September, 1991.  He was elected  Chairman,
President,  and Chief Executive Officer of First Interstate  Bank
of California on February 1, 1991 and previously was Chairman and
Chief Executive Officer of First Interstate Bank of Oregon,  N.A.
between January, 1986 and February, 1991.

Mr.  Belles  was elected Executive Vice President and  Controller
effective September, 1994 having assumed responsibility  for  the
management of the Corporate Controller's Group in June, 1994.  He
previously  served as Chief Financial Officer  of  the  Northwest
Region.

Mr.  Bogaard  was  elected Executive Vice President  and  General
Counsel in September, 1982.

Mr. Craver was elected Executive Vice President and Treasurer  in
September,  1991.   He was elected Executive Vice  President  and
Chief  Financial Officer of First Interstate Bank, Ltd. in  June,
1988

Mr.  Gertz  was  elected  Executive Vice  President  and  General
Auditor in April, 1991.  Between August, 1986 and April, 1991  he
held  various managerial positions with First Interstate Bank  of
California,  including General Auditor, Chief  Financial  Officer
and Division Manager.

Ms. Gorman was elected Executive Vice President in January, 1994.
She  has served as Human Resources Director since October,  1990.
She  was  named Director of First Interstate Bank of California's
Human  Resources  Division  in 1986  and  became  a  Senior  Vice
President  in  1987.  Between 1985 and 1989, she was  Manager  of
Human Resources Strategic Planning at First Interstate Bancorp.

Mr.  Greene was elected Executive Vice President and Chief Credit
Officer in October, 1987.

Mr.  Marrie  was  elected  Executive  Vice  President  and  Chief
Financial Officer in December, 1988.

Mr.  Tappey  was elected Executive Vice President in July,  1991.
He  was  Executive Vice President and head of the Banking Service
Group of First Interstate Bank of California from July 1990,  and
previously   held   various  management  positions   with   First
Interstate Bank of California since joining the bank in  January,
1961.

Mr.  Wilson  was elected Executive Vice President and Manager  of
Credit  Review  effective March, 1995. He  previously  served  as
Senior  Vice  President  and Manager of  Credit  Review  for  the
Northwest Region.

                             PART II


ITEM 5. MARKET FOR REGISTRANT'S COMMON STOCK AND RELATED SECURITY
HOLDER MATTERS

(a)  $2 par value Common Stock

The  below  listed information contained in the Annual Report  to
Shareholders  for the year ended December 31, 1994, with  respect
to  the  Corporation's $2 par value Common Stock is  incorporated
herein by reference:

                                            Page
               Principal Market              60
               Sales Prices                  33
               Dividends Paid                33

As  of  February 28, 1995, there were 24,976 holders of record of
the Corporation's $2 par value Common Stock.


ITEM 6. SELECTED FINANCIAL DATA

Consolidated  Balance  Sheets  and  Consolidated  Statements   of
Operations  on  pages  56  and  57  of  the  Annual   Report   to
Shareholders   for  the  year  ended  December   31,   1994   are
incorporated herein by reference.


ITEM   7.  MANAGEMENT'S  DISCUSSION  AND  ANALYSIS  OF  FINANCIAL
CONDITION AND RESULTS OF OPERATIONS

Management's  Discussion  & Analysis 1992  -  1994  on  pages  11
through  33  of the Annual Report to Shareholders  for  the  year
ended December 31, 1994 is incorporated herein by reference.

Subsequent Events:

On  March 15, 1995, the Corporation issued $100 million of  8.15%
Subordinated Notes Due March 15, 2002.  Interest on the Notes  is
payable semi-annually on March 15 and September 15 of each  year,
commencing September 15, 1995.  The Notes are redeemable  at  the
option  of  the  Corporation, upon not less than  30  days  prior
written notice, in whole on any interest payment date on or after
March  15,  1998,  at a redemption price equal  to  100%  of  the
principal  amount  of  the  Notes to be  redeemed  plus  interest
accrued  and  unpaid  to  the redemption  date.   The  Notes  are
subordinate  to  all  present  and  future  Senior  Debt  of  the
Corporation. In addition these Notes are considered to  be  Total
Capital, but not Tier 1 Capital, for regulatory purposes.


ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The following consolidated financial statements of the Registrant
included in the Annual Report to Shareholders for the year  ended
December 31, 1994 are incorporated herein by reference:

Consolidated Financial Statements of First Interstate Bancorp and
Subsidiaries:
  Consolidated Balance Sheet - December 31, 1994 and 1993
  Consolidated Statement of Operations - Years Ended December 31,
     1994, 1993 and 1992
  Consolidated Statement of Cash Flows - Years Ended December 31,
     1994, 1993 and 1992
  Statement of Shareholders' Equity - Years Ended December 31,
     1994, 1993 and 1992
  Notes to Financial Statements
  Report of Ernst & Young LLP, Independent Auditors

Summary  of Quarterly Results on page 33 of the Annual Report  to
Shareholders for the year ended December 31, 1994 is incorporated
herein by reference.

The below listed financial data contained in the Annual Report to
Shareholders for the year ended December 31, 1994 is incorporated
herein by reference:

                                                             Page

Distribution of Assets, Liabilities and Shareholders'
Equity;  
  Interest Rates and Interest Differential:
    Average balance sheets and net interest earnings        58-59
    Change in interest income and expense                      14
Investment Portfolio:
  Investment types                                             40
  Maturities and yields                                    16, 24
  Investment concentrations                                 26-27
Loan Portfolio:
  Loan types                                                   41
  Maturities and sensitivity                                   25
Risk Elements:
  Nonaccrual, past due and restructured loans               30-31
  Potential problem loans                                   30-31
  Foreign outstandings                                         28
  Loan concentrations                                          27
Summary of Credit Loss Experience:
  Credit loss experience                                    28-29
  Allocation of allowance                                      29
Deposits:
  Average deposits                                          58-59
  Maturities of time certificates of deposit                   19
Return on Equity and Assets                                    55
Short Term Borrowings                                          41





ITEM  9.   CHANGES  IN  AND  DISAGREEMENTS  WITH  ACCOUNTANTS  ON
ACCOUNTING AND FINANCIAL DISCLOSURE

None.
                             PART III



ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

Information required under this item relating to Directors of the
Registrant is contained in the Registrant's 1994 Proxy  Statement
("1994  Proxy Statement") with respect to the Registrant's Annual
Meeting of Shareholders to take place on April 28, 1995, pursuant
to  Regulation  14A of the Securities Exchange Act  of  1934,  as
amended,  and  is incorporated herein by reference.   Information
required  under  this item related to Executive Officers  of  the
Registrant  is  contained  in Part I of  this  report  under  the
caption "Executive Officers of the Registrant."


ITEM 11. EXECUTIVE COMPENSATION

Information  required  under  this  item  is  contained  in   the
Registrant's  1994 Proxy Statement, pursuant to  Regulation  14A,
and is incorporated herein by reference.


ITEM  12.  SECURITY  OWNERSHIP OF CERTAIN BENEFICIAL  OWNERS  AND
MANAGEMENT

Information  required  under  this  item  is  contained  in   the
Registrant's  1994 Proxy Statement, pursuant to  Regulation  14A,
and is incorporated herein by reference.


ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

Information  required  under  this  item  is  contained  in   the
Registrant's  1994 Proxy Statement, pursuant to  Regulation  14A,
and is incorporated herein by reference.
                             PART IV


ITEM  14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS  ON
FORM 8-K

(a) 1 - Financial Statements

The following consolidated financial statements of the Registrant
included in the Annual Report to Shareholders for the year  ended
December 31, 1994 are incorporated herein by reference in Item 8:

Consolidated Financial Statements of First Interstate Bancorp and
Subsidiaries:
  Consolidated Balance Sheet - December 31, 1994 and 1993
  Consolidated Statement of Operations - Years Ended December 31,
     1994, 1993 and 1992
  Consolidated Statement of Cash Flows - Years Ended December 31,
     1994, 1993 and 1992
  Statement of Shareholders' Equity - Years Ended December 31,
     1994, 1993 and 1992
  Notes to Financial Statements
  Report of  Ernst & Young LLP, Independent Auditors

(a) 2 - Other Schedules

All  other schedules to the consolidated financial statements  of
the  Registrant required by Article 9 of Regulation S-X  are  not
required  under the related instructions or are inapplicable  and
therefore have been omitted.

(a) 3 - Exhibits:

        (1)     Dealer agreement  dated  as  of  December 9, 1994 
                among Registrant and various dealers named there-  
                in incorporated by reference to the  Registrant's    
                Form 8-K dated March 24, 1995)

        (3.1)   Composite Certificate of Incorporation of  Regis- 
                trant incorporating all amendments filed prior to
                January 30,  1988   (incorporated by reference to  
                the Registrant's Form 10-K filed in  March, 1990)

        (3.2)   By laws of Registrant  incorporating  all  amend-
                ments  through  July  20, 1993  (incorporated  by
                reference to the Registrant's Form 10-K  filed in 
                March, 1994)

        (4.1)   Terms of Series F Preferred  Stock  (incorporated 
                by  reference  to  Registrant's  Form S-3  Regis- 
                tration Statement No. 33-42889)

        (4.2)   Terms of Series G Preferred  Stock  (incorporated
                by reference  to  Registrant's  Form  S-3  Regis- 
                tration Statement No. 33-47174

        (4.3)   Registrant  has  outstanding  certain  long  term    
                debt.  See Note F  of  "Notes to Financial State-   
                ments"  at Page  42  of the  1994  Annual  Report    
                to  shareholders.  Such  long term  debt does not    
                exceed 10%  of the  total  assets  of  Registrant 
                and  its  consolidated  subsidiaries;  therefore,    
                copies of constituent  instruments  defining  the     
                rights of holders of such long term debt are  not    
                included  as  exhibits.    Registrant  agrees  to    
                furnish   copies  of  such  instruments  to   the  
                Securities and Exchange Commission upon request.

        (10.1)  1983  Performance Stock  Plan   (incorporated  by
                reference to Registrant's  Form S-8  Registration 
                Statement No.2-82812)

        (10.2)  1988 Performance Stock   Plan   (incorporated  by 
                reference to Registrant's  Form S-8  Registration 
                Statement No. 33-23404)

        (10.3)  First Interstate Bancorp  1991  Performance Stock
                Plan (incorporated by reference  to  Registrant's 
                Form S-8 Registration Statement No. 33-38903)

        (10.4)  First Interstate Bancorp  1995  Performance Stock 
                Plan

        (10.5)  First Interstate Bancorp  1991   Director  Option 
                Plan (incorporated by reference to   Registrant's
                Form S-8 Registration Statement No. 33-37299)

        (10.6)  First Interstate Bancorp  1995 Regional Executive
                Incentive Plan

        (10.7)  First  Interstate  Bancorp  Corporate   Executive 
                Incentive Plan

        (10.8)  First Interstate Bancorp  1995 Management Incent-
                ive Plan

        (10.9)  1989  Restatement  of the  Supplemental  Employee  
                Savings  Plan  of  Registrant   (incorporated  by 
                reference to the Registrant's Form 10-K  filed in 
                March 1990)

        (10.10) 1992  Restatement of  the Supplemental  Executive 
                Retirement Plan of Registrant  (incorporated   by 
                reference  to  Registrant's  Form 10-K  filed  in 
                March 1992)

        (10.11) 1989  Restatement  of  First  Interstate  Bancorp    
                Benefit Retirement Plan  (incorporated by  refer-
                ence to Registrant's  Form  10-K  filed in  March 
                1990)

        (10.12) Retirement Plan  for  Directors,  amended and re-  
                stated (incorporated by reference to Registrant's 
                Form 10-K filed in March, 1994)

        (10.13) Dividend Reinvestment and Stock Purchase Plan, as 
                amended(incorporated by reference to Registrant's 
                Form S-3 Registration Statement No. 33-50054)

        (10.14) Form of Employment Agreement between   Registrant
                and Edward M. Carson  (incorporated by  reference 
                to Registrant's Form 10-K filed in March 1990)

        (10.15) Form of Employment Agreement between   Registrant
                and   William  E. B. Siart,   William S. Randall, 
                Bruce G. Willison and James J. Curran

        (10.16) Form of  Split-Dollar  Life  Insurance  Agreement 
                between Registrant and Edward M. Carson,  William
                E.B. Siart, William S. Randall, Bruce G. Willison
                and James J. Curran  (incorporated  by  reference
                to Registrant's Form 10-K filed in March 1992)

        (10.17) Form of  Split-Dollar Insurance Agreement between 
                Registrant and Registrant's Directors  (incorpor-  
                ated by reference to Registrant's Form 10-K filed 
                in March 1992)

        (10.18) $500,000,000 Credit Agreement dated as of May 31,  
                1994 among First Interstate Bancorp  and  certain 
                banks (incorporated by  reference to Registrant's  
                Form 10-Q  for  the quarter ending  June 30, 1994  
                filed in August 1994)

        (10.19) Other Agreements  (1)  (incorporated by reference
                to Registrant's Form 10-K filed in March 1993) 
                
        (11)    Computation  of Earnings Per Share
               
        (12)    Computation of Ratio of Earnings to Fixed Charges
               
        (13)    Annual Report to Shareholders for the year  ended 
                December 31, 1994

        (21)    Subsidiaries  of the Registrant
               
        (23)    Consent of Ernst & Young LLP, Independent Auditors

        (27)    Financial Data Schedule


(b) - Reports on Form 8-K

      A report on  Form 8-K dated  January 19, 1994 announced the 
      Corporation's  1993 fourth quarter and annual results;  the 
      date, time and place of  its  1994 Annual Meeting of Stock-
      holders;  and a  repurchase  program for  up  to  1,500,000 
      shares of Common  Stock.   Copies of related documents were
      included in such filing.

      A report on  Form 8-K  dated  March 22, 1994  announced the  
      Corporation's next phase of its ongoing strategic plan. Key
      elements include  reduction  in  the expense/revenue ratio,
      improved  capital   management,  internal  revenue  growth, 
      appropriate  acquisition  growth and  earnings improvement.
      Copies of related documents were included in such filing.
      
      A report on  Form 8-K  dated  April 20, 1994  announced the
      Corporation's 1994 first quarter results and the repurchase
      of up to  6,500,000  shares  of  Common  Stock.   Copies of 
      related documents were included in such filing.
      
      A report on  Form 8-K  dated  July 20, 1994  announced  the 
      Corporation's  1994  second  quarter  results and purchases 
      under  the  previously  announced repurchase program for up
      to 6,500,000  shares of Common Stock, as well as completion 
      of the repurchase program  for 1,500,000 shares.  Copies of
      related documents were included in such filing.
      
      A report on Form 8-K dated September 21, 1994 announced the
      adoption of a restructuring plan  to  better  position  the 
      Corporation for the introduction of full  interstate  bank-
      ing, purchases under  the  previously announced 1.5 million
      and 6.5 million  share repurchase programs and the approval 
      by the Board of Directors  of a plan to repurchase up to an  
      additional  1.2  million  shares  in  connection  with  the 
      proposed acquisition of  Levy Bancorp.  Copies  of  related  
      documents were included in such filing.
      
      A  report on Form 8-K dated October 25, 1994 announced that
      President William E. B. Siart will succeed Edward M. Carson
      as  Chief Executive Officer of the Corporation,  William S.
      Randall,  head of the Corporation's Southwest Region,  will 
      become Executive Vice President and Chief Operating Officer
      of the  Corporation,  effective  January 1, 1995,  and  Mr.
      Carson will remain  Chairman  of the Corporation  until his
      retirement  on  May  1,  1995.  Copies of related documents
      were included in such filing.

      A  report on Form 8-K dated February 17, 1995 announced the
      date, time and place of  its  1995 Annual Meeting of Stock-
      holders.  Copies of related documents were included in such 
      filing.
      
      A report on  Form 8-K  dated  March 24, 1995 announced that 
      Registrant has entered into a  Dealer Agreement dated as of
      December 9, 1994 among Registrant and various dealers named
      therein.  Copies of related documents were included in such
      filing.


                           SIGNATURES

Pursuant  to  the  requirements of Section 13  or  15(d)  of  the
Securities  Exchange Act of 1934, the registrant has duly  caused
this  report  to  be  signed on its behalf  by  the  undersigned,
thereunto duly authorized, this 24th day of March, 1995.

                    FIRST INTERSTATE BANCORP
                        Registrant

                           By    /s/   Edward S. Garlock
                                        Edward S. Garlock
                                        Secretary

POWER OF ATTORNEY

KNOW  ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints David S. Belles and Edward
S.  Garlock,  and  each of them, as his or her  true  and  lawful
attorney-in-fact and agent, with full power of substitution,  for
him  or  her and in his or her name, place and stead, in any  and
all  capacities, to sign any or all amendments to this report and
to  file the same, with all exhibits thereto, and other documents
in   connection  therewith,  with  the  Securities  and  Exchange
Commission,  granting unto said attorney-in-fact and agent,  full
power  and  authority to do and perform each and  every  act  and
thing  requisite  and  necessary to be  done  in  and  about  the
premises, as fully to all intents and purposes as he or she might
or  could do in person, hereby ratifying and confirming all  that
said  attorney-in-fact and agent, or his or  her  substitute  may
lawfully do or cause to be done by virtue hereof.

Pursuant  to the requirements of the Securities Exchange  Act  of
1934,  this report has been signed below by the following persons
on  behalf  of the registrant and in the capacities  and  on  the
dates indicated.


          Signature                      Title                       Date
        

 /s/   E. M. Carson
                                   Chairman of the Board           03/24/95
        E. M. Carson
                                   Director


 /s/   William E. B. Siart         President and
                                   Chief Executive Officer         03/24/95
        William E. B. Siart
                                   Director

       
 /s/   William S. Randall                                
                                   Chief Operating Officer         03/24/95
        William S. Randall
                                  (Principal Financial Officer)



          Signature                      Title                       Date


 /s/   David S. Belles
                                   Executive Vice President        03/24/95
        David S. Belles
                                  (Principal Accounting Officer)


 /s/   John E. Bryson
        John E. Bryson
                                   Director                        03/24/95


 /s/   Jewel Plummer Cobb
        Jewel Plummer Cobb
                                   Director                        03/24/95


 /s/   Ralph P. Davidson
        Ralph P. Davidson
                                   Director                        03/24/95

 /s/   Myron Du Bain
        Myron Du Bain
                                   Director                        03/24/95

 /s/   Don C. Frisbee
        Don C. Frisbee
                                   Director                        03/24/95


 /s/   George M. Keller
        George M. Keller
                                   Director                        03/24/95


 /s/   W. F. Kieschnick
        W. F. Kieschnick
                                   Director                        03/24/95


 /s/   William F. Miller
        William F. Miller
                                   Director                        03/24/95


 /s/   J. J. Pinola
        J. J. Pinola
                                   Director                        03/24/95


 /s/   Thomas L. Lee
        Thomas L. Lee
                                   Director                        03/24/95



        

          Signature                      Title                       Date


 /s/   Steven B. Sample
        Steven B. Sample
                                   Director                        03/24/95


 /s/   Forrest N. Shumway
        Forrest N. Shumway
                                   Director                        03/24/95


 /s/   Richard J. Stegemeier
        Richard J. Stegemeier
                                   Director                        03/24/95


 /s/   Daniel M. Tellep
        Daniel M. Tellep
                                   Director                        03/24/95