EXHIBIT 10.16

                             AMGEN INC.

       AMENDED AND RESTATED 1987 DIRECTORS' STOCK OPTION PLAN


1.   PURPOSE
    (a)  The purpose of the  1987 Directors' Stock Option Plan  (the
"Plan") is to provide  a means by which  each director of AMGEN  INC.
(the "Company") and its Affiliates, as defined in subparagraph  1(b),
who is not  otherwise an  employee of  the Company  or any  Affiliate
(each such  person being  hereafter referred  to as  a  "Non-Employee
Director") may  be given  an opportunity  to  purchase stock  of  the
Company.
    (b)  The word "Affiliate" as  used in the Plan means any  parent
corporation or subsidiary corporation of  the Company as those  terms
are defined in Sections 424(e) and (f), respectively, of the Internal
Revenue Code of 1986, as amended (the "Code").
    (c)  The  Compan y, by means  of the  Plan, seeks to  retain the
services of  persons now  serving as  Non-Employee Directors  of  the
Company, to  secure and  retain the  services of  persons capable  of
serving in such capacity, and to provide incentives for such  persons
to exert maximum efforts for the success of the Company.
    (d)  The Company intends that the options issued under  the Plan
not be incentive stock options as that term is used in Section 422 of
the Code.

2.   ADMINISTRATION
    (a)  The Plan  shall be administered by  the  Board of  Directors
(the "Board") of  the Company unless  and until  the Board  delegates
administration to a committee, as provided in subparagraph 2(c).
    (b)  The Board shall have the power, subject to, and  within the
limitations of, the express provisions of the Plan:
         (1)  To construe and interpret the Plan and options granted
under it, and to  establish, amend and  revoke rules and  regulations
for its administration.   The Board, in the  exercise of this  power,
may correct any defect, omission or  inconsistency in the Plan or  in
any option agreement,  in a manner  and to the  extent it shall  deem
necessary or expedient to make the Plan fully effective.
         (2)  To amend the Plan as provided in paragraph 11.
         (3)  Generally, to exercise such powers and to perform such
acts as the Board  deems necessary or expedient  to promote the  best
interests of the Company.    (c)       The   Board    may   delegate
administration of the Plan to a committee composed of not fewer  than
three (3) members of the Board (the "Committee"), all of the  members
of which Committee shall be persons who in the opinion of counsel  to
the Company are  "disinterested persons" within  the meaning of  Rule
16b-3 under the Securities Exchange Act  of 1934.  If  administration
is delegated to a Committee, the Committee shall have, in  connection
with the administration of the Plan, the powers theretofore possessed
by the Board, subject, however, to such resolutions, not inconsistent
with the provisions of the Plan, as may be adopted from time to time

by the Board.  The  Board may abolish the  Committee at any time  and
revest in the Board the administration of the Plan.

3.   SHARES SUBJECT TO THE PLAN
    (a)   Subject to  the provisions  of  paragraph 10  relating  to
adjustments upon  changes  in  stock, the  stock  that  may  be  sold
pursuant to options granted  under the Plan shall  not exceed in  the
aggregate one million  eight hundred thousand  (1,800,000) shares  of
the Company's common  stock.  If  any option granted  under the  Plan
shall for any  reason expire  or otherwise  terminate without  having
been exercised in  full, the stock  not purchased  under such  option
shall again become available for the Plan.
    (b)  The  stock subject to  the Plan may  be unissued shares  or
reacquired shares, bought on the market or otherwise.

4.   ELIGIBILITY
    Options shall be granted only  to Non-Employee Directors of  the
Company, or an affiliate of such Non-Employee Directors.

5.   NON-DISCRETIONARY GRANTS
    (a)  On  January 27 of  each year commencing  January 27,  1992,
each person  who is  at  that time  a  Non-Employee Director  of  the
Company,  or  an  affiliate  of  such  Non-Employee  Director,  shall
automatically be granted  under the Plan,  without further action  by
the Company, the Board, or the  Company's stockholders, an option  to
purchase three thousand five hundred  (3,500) shares of common  stock
of the Company  on the terms  and conditions set  forth herein.   The
number of shares  to be granted  hereunder shall not  be adjusted  as
provided for in subparagraph 10(a),  but, however, shall be  adjusted
by multiplying by a fraction, the numerator of which is forty dollars
($40.00) per share and  the denominator of which  is the fair  market
value of the common stock of the Company  on the date of grant.   The
number of shares granted pursuant to this subparagraph 5(a) shall  be
rounded to the nearest  one hundred (100) shares  (rounding up if  50
shares); notwithstanding the foregoing, the number  of shares that
shall be granted pursuant to this subparagraph 5(a) shall not be less
than two thousand  (2,000) nor shall it exceed five thousand (5,000)
shares.  The option shall be on the terms and conditions set forth 
herein and should the date of grant set forth above be a Saturday,
Sunday or legal holiday, such grant shall be made on the next business
day.
    (b)  Each person  who, after January 27  of any year  commencing
January 27, 1991 and prior to November 1 of any year, becomes a  Non-
Employee Director,  or an  affiliate of  such Non-Employee  Director,
shall, upon  the date  he or  such affiliate  becomes a  Non-Employee
Director, automatically be  granted under the  Plan, without  further
action by the Company, the Board,  or the Company's stockholders,  an
option to  purchase three  thousand five  hundred (3,500)  shares  of
common stock of  the Company on  the terms and  conditions set  forth
herein.  The number  of shares to be  granted hereunder shall not  be
adjusted as provided for in  subparagraph 10(a), but, however,  shall
be adjusted by multiplying by a  fraction, the numerator of which  is
forty dollars ($40.00) per share and the denominator of which is  the
fair market value of the common stock  of the Company on the date  of
grant.

The number of shares granted pursuant to this subparagraph 5(b) shall
be rounded to the nearest one hundred (100) shares (rounding up if 50
shares); notwithstanding  the foregoing,  the number  of shares  that
shall be granted pursuant to this subparagraph 5(b) shall not be less
than two thousand (2,000) nor shall  it exceed five thousand  (5,000)
shares.  The option  shall be on the  terms and conditions set  forth
herein and should the  date of grant set  forth above be a  Saturday,
Sunday or  legal  holiday, such  grant  shall  be made  on  the  next
business day.

6.   OPTION PROVISIONS
    Each option shall be in such  form and shall contain such  terms
and conditions as the Board or the Committee shall deem  appropriate.
The provisions of separate  options need not  be identical, but  each
option shall include (through  incorporation of provisions hereof  by
reference in the option  or otherwise) the substance  of each of  the
following provisions:
    (a)  The term of  each  option shall be  ten (10) years from  the
date it was granted.
    (b)  The  exercise price  of each  option shall  be one  hundred
percent (100%) of the fair market value of the stock subject to  such
option on the date such option is granted.
    (c)  The purchase price of stock acquired pursuant to  an option
shall be paid,  to the extent  permitted by  applicable statutes  and
regulations, either (i) in cash
at the  time the  option is  exercised  or (ii)  by delivery  to  the
Company of shares of common stock that have been held for the  period
required to avoid  a charge to  the Company's  reported earnings  and
valued at their fair market value  on the date of exercise.   Options
granted under the Plan that are  outstanding on April 2, 1991,  shall
be amended to include the right to exercise with common stock of  the
Company as provided for in this subparagraph 6(c).
    (d)  An option granted to a natural person shall  be exercisable
during the lifetime of such person only by such person, provided that
such person during such person's lifetime may designate an  affiliate
of such person to  be such person's beneficiary  with respect to  the
Option, and such beneficiary shall, after the death of the person  to
whom the Option was granted, have all of the rights that such  person
had while living, including the right to exercise the Option.  In the
absence of such designation,  after the death of  the person to  whom
the Option is granted, the Option shall be exercisable by the  person
or persons to whom  the optionee's rights under  such Option pass  by
will or by the laws of descent and distribution.
    (e)  An option shall not vest with respect to each  optionee (i)
unless the optionee, or the affiliate  of such optionee, as the  case
may be, has, at the date of grant, provided three (3) years of  prior
continuous service as a Non-Employee Director, or (ii) until the date
upon which such optionee  or the affiliate of  such optionee, as  the
case may be, has  provided one year of  continuous service as a  Non-
Employee Director  following  the  date  of  grant  of  such  option,
whereupon such option  shall become fully  exercisable in  accordance
with its terms, provided that, if the optionee, or the affiliate of such
optionee, as the case may  be, has, at the date of grant, provided
three (3) years of prior continuous service as a Non-Employee

Director, such option shall not become exercisable for six (6) months
after the  date of  grant (even  though such  option shall  be  fully
vested as of the date of grant).
    (f)  The Company may require any optionee, or any person to whom
an option is transferred under subparagraph  6(d), as a condition  of
exercising  any  such  option:    (1)  to  give  written   assurances
satisfactory to  the  Company  as to  the  optionee's  knowledge  and
experience in financial and business matters; and (2) to give written
assurances satisfactory to  the Company stating  that such person  is
acquiring the  stock subject  to the  option  for such  person's  own
account and not with  any present intention  of selling or  otherwise
distributing the stock.  These requirements, and any assurances given
pursuant to  such  requirements,  shall be  inoperative  if  (i)  the
issuance of  the shares  upon the  exercise of  the option  has  been
registered under a  then currently  effective registration  statement
under the Securities Act of 1933, as amended (the "Securities  Act"),
or (ii), as to any particular requirement, a determination is made by
counsel for the Company that such requirement need not be met in  the
circumstances under the then applicable securities laws.
    (g)  Subject to  the last  sentence of  this  subparagraph 6(g),
each option granted after April 2, 1991, under the Plan shall include
and all outstanding options under the Plan on April 2, 1991 shall  be
amended to include a  provision entitling the  optionee to a  further
option (a "Reload Option")  in the event  the optionee exercises  the
option evidenced  by  the option  grant,  in  whole or  in  part,  by
surrendering  other  shares  of  common  stock  of  the  Company   in
accordance with the Plan and the terms of the option grant.  Any such
Reload Option (i) shall be for a number of shares equal to the number
of shares surrendered  as part or  all of the  exercise price of  the
original option; (ii) shall have an expiration date which is the same
as the expiration date of the  original option; and (iii) shall  have
an exercise price which is equal to one hundred percent (100%) of the
fair market value of the common stock subject to the Reload Option on
the date of exercise of the original option.  Any such Reload  Option
shall be  subject  to the  availability  of sufficient  shares  under
subparagraph 3(a).   There  shall be  no Reload  Option on  a  Reload
Option.  The provisions  of this subparagraph  6(g) shall not  become
effective and shall be void unless  and until receipt by the  Company
of an interpretive letter from the Securities and Exchange Commission
or an opinion of counsel reasonably acceptable to the Company to  the
effect that the Plan will be a "formula plan" as defined in Rule 16b-
3(c)(2)(ii)  if  Reload   Options  are  granted   pursuant  to   this
subparagraph 6(g).

7.   COVENANTS OF THE COMPANY
    (a)  During the terms of the options granted under the Plan, the
Company shall keep  available at all  times the number  of shares  of
stock required to satisfy such options.
    (b)   The Company  shall seek  to  obtain from  each  regulatory
commission or agency having jurisdiction over the Plan such authority
as may be required to issue and sell shares of stock upon exercise of
the options  granted under  the Plan;  provided, however,  that  this
undertaking shall  not  require the  Company  to register  under  the
Securities Act either the Plan, any option granted under the Plan, or

any stock issued  or issuable pursuant  to any such  option.  If  the
Company is unable to  obtain from any  such regulatory commission  or
agency the authority  which counsel for  the Company deems  necessary
for the lawful issuance and sale of stock under the Plan, the Company
shall be relieved from  any liability for failure  to issue and  sell
stock upon exercise of such options  unless and until such  authority
is obtained.

8.   USE OF PROCEEDS FROM STOCK
    Proceeds from  the sale  of stock  pursuant  to options  granted
under the Plan shall constitute general funds of the Company.

9.   MISCELLANEOUS
    (a)  Neither  an optionee nor  any person to  whom an option  is
transferred under subparagraph 6(d) shall be deemed to be the  holder
of, or to have  any of the rights  of a holder  with respect to,  any
shares subject  to  such option  unless  and until  such  person  has
satisfied all requirements for exercise of the option pursuant to its
terms.
    (b)  Throughout the te rm of any option granted  pursuant to the
Plan, the Company shall make available to the holder of such  option,
not later than one hundred twenty (120) days after the close of  each
of the Company's fiscal years during  the option term, upon  request,
such  financial  and  other  information  regarding  the  Company  as
comprises the  annual  report  to the  stockholders  of  the  Company
provided for in the by-laws of the Company and such other information
regarding the Company  as the holder  of such  option may  reasonably
request.

10.  ADJUSTMENTS UPON CHANGES IN STOCK
    (a)  If any change is made in the stock subject to  the Plan, or
subject to  any  option  granted  under  the  Plan  (through  merger,
consolidation,  reorganization,  recapitalization,  stock   dividend,
dividend in  property  other  than  cash,  stock  split,  liquidating
dividend, combination  of  shares,  exchange  of  shares,  change  in
corporate structure or otherwise),  the Plan and outstanding  options
will be appropriately adjusted in the class(es) and maximum number of
shares subject to the Plan and the class(es) and number of shares and
price per share  of stock subject  to outstanding options;  provided,
that the minimum and maximum number  of shares of common stock to  be
granted as provided for in subparagraphs  5(a) and 5(b) shall not  be
adjusted for any stock split, combination  of shares or common  stock
dividend.
     (b)  Notwithstanding anything to the  contrary in this Plan,  in
the event of a Change in  Control (as hereinafter defined), then,  to
the extent permitted by  applicable law:  (i)  the time during  which
options become vested shall automatically be accelerated so that  the
unvested portions of all options shall be vested prior to the  Change
in Control  and  (ii)  the  time during  which  the  options  may  be
exercised shall automatically be accelerated  to prior to the  Change
of Control.   Upon  or  after the  acceleration  of the  vesting  and
exercise periods, at the election of the holders of the options,  the
options may be:   (x)  exercised or,  if the  surviving or  acquiring
corporation agrees  to  assume  the  options  or  substitute  similar
options, (y) assumed; or (z) replace with substitute options.  Options

not exercised, substituted or assumed prior to or upon the Change in
Control  shall  be terminated.
          (c)  For purposes of the Plan, a "Change of Control"  shall
be deemed to have occurred at any of the following times:
               (i)  Upon  the  acquisition   (other  than  from   the
Company) by  any person,  entity or  "group," within  the meaning  of
Section 13(d) (3) or 14(d) (2) of the Securities Exchange Act of 1934
as amended (the  "Exchange Act")  (excluding, for  this purpose,  the
Company or  its  affiliates, or  any  employee benefit  plan  of  the
Company or  its affiliates  which  acquires beneficial  ownership  of
voting securities of  the Company), of  beneficial ownership  (within
the meaning  of Rule  13d-3 promulgated  under the  Exchange Act)  of
fifty percent (50%) or more of either the then outstanding shares  of
Common Stock  or the  combined voting  power  of the  Company's  then
outstanding voting  securities  entitled  to vote  generally  in  the
election of directors; or
               (ii) At the  time individuals who,  as of October  23,
1995, constitute the Board (the "Incumbent
Board") cease for any reason to constitute at least a majority of the
Board, provided that  any person  becoming a  director subsequent  to
October 23, 1995, whose election, or  nomination for election by  the
Company's stockholders, was approved by a vote of at least a majority
of the directors then comprising the  Incumbent Board (other than  an
election or nomination of an  individual whose initial assumption  of
office is in connection with an actual or threatened election contest
relating to the  election of the  Directors of the  Company, as  such
terms are used in Rule 14A-11 of Regulation 14A promulgated under the
Exchange Act)  shall be,  for purposes  of  the Plan,  considered  as
though such person were a member of the Incumbent Board; or
              (iii) Immediately  prior to  the  consummation by  the
Company of a  reorganization, merger, consolidation,  (in each  case,
with respect  to  which persons  who  were the  stockholders  of  the
Company  immediately  prior   to  such   reorganization,  merger   or
consolidation do  not, immediately  thereafter, own  more than  fifty
percent (50%) of the combined voting power entitled to vote generally
in  the  election  of  directors   of  the  reorganized,  merged   or
consolidated company's  then  outstanding  voting  securities)  or  a
liquidation or dissolution of  the Company or of  the sale of all  or
substantially all of the assets of the Company.

11.  AMENDMENT OF THE PLAN
    (a)  The Board at any time, and from time to time, may amend the
Plan; provided, however, that the Board shall not amend the Plan more
than once every six months with respect to the provisions of the Plan
relating to the amount,  price, and timing of  grants, other than  to
comply with  changes  in the  Code,  the Employee  Retirement  Income
Security Act of 1974, as amended, or the regulations thereunder.
    (b)   Rights and  obligations under  any  option granted  before
amendment of  the  Plan shall  not  be  altered or  impaired  by  any
amendment of the Plan, except with the consent of the person to  whom
the option was granted.

12.  TERMINATION OR SUSPENSION OF THE PLAN

    (a)  The Board  may suspend or terminate  the Plan at any  time.
Unless sooner terminated, the Plan shall terminate ten (10) years from

the date the Plan is adopted by the Board.  No options may be granted
under the Plan while the Plan is suspended or after it is terminated.
    (b)  Rights and obligations under  any option granted while  the
Plan is in effect shall not  be altered or impaired by suspension  or
termination of the  Plan, except with  the consent of  the person  to
whom the option was granted.

13.  EFFECTIVE DATE OF PLAN
    The Plan became effective  as of January 27,  1987.  No  options
granted under the Plan  as the result of  the amendments on July  24,
1990 and April  2, 1991 shall  be exercisable unless  and until  said
amendment is approved by the stockholders of the Company, and to  the
extent required or necessary under applicable law, amendments made on
April  2,  1991  shall  not  be  effective  until  approved  by   the
stockholders of the Company.