EXHIBIT

                           PROMISSORY NOTE

$700,000.00


1.  Promise to Pay.

    For value received, I, George A. Vandeman ("Staff Member"), a
    married man, and I, Winifred M. Vandeman, wife of Staff Member,
    promise to pay to the order of Amgen Inc., a Delaware corporation
    ("Payee"), at its office at Amgen Center, Thousand Oaks, CA
    91320-1789, the sum of Seven Hundred Thousand Dollars
    ($700,000.00) (the "Principal"), payable in full on the earlier
    of five (5) years from date of execution of this Note or thirty
    (30) days from the date on which Staff Member ceases to be an
    employee of Payee, whichever first occurs, together with interest
    on the Principal from the date of this Note until such date as
    the Note is paid in full.

    Interest shall be payable annually commencing December 31, 1996;
    and each successive year thereafter until the Principal is
    repaid.  Interest on this Note shall be computed as set forth
    below.  The interest rate for the period from the date of this
    Note through December 31, 1995 (the "initial rate") is 4.9% per
    annum on the unpaid Principal.  After December 31, 1995 the
    interest rate on this Note shall change as set forth below.

2.  Adjustable Interest Rate.

    The interest rate shall be adjusted annually on January 1 of each
    year (the "Change Date") so as to equal the average interest rate
    designated as the "Introduction Rates" on adjustable rate loans
    as publicly offered by the 32 largest banks and savings and loans
    in California as published by the Los Angeles Times in its
    Saturday edition.  The rate shall be set using the rates
    published in the Los Angeles Times on the Saturday immediately
    preceding the Change Date.  In the event that the "Introduction
    Rates" list is not published in the Los Angeles Times for any
    reason, then, in such event, the Payee shall establish the
    interest rate based on a survey by it of the introductory
    interest rates on adjustable loans offered by no fewer than five
    banking institutions located in Southern California that the
    Payee, in its sole discretion, deems representative of banking
    institutions in the

    Ventura and Los Angeles County areas.  Payee shall give Staff
    Member notice if the interest rate shall be determined using this
    alternative method.  Notwithstanding the foregoing, the interest
    rate shall never be increased or decreased on any single Change
    Date by more than one percentage point from the interest rate for
    the preceding 12 months.  At no time during the term of this Note
    shall the annual interest rate exceed 7.9% per annum.

    Payee shall deliver or mail to Staff Member a notice of any
    changes in the adjustable interest rate on this Note and the
    amount of the Staff Member's semi-monthly payroll deductions
    before the effective date of any change.  The notice shall
    include information required by law to be given to Staff Member
    and also the title and telephone number of a person who shall
    answer any questions Staff Member may have regarding the notice.

3.  Option to Convert.

    At the end of the term of this Note, Staff Member shall have the
    option to seek to convert this loan to a loan amortized over an
    additional five-year period by executing a new Promissory Note at
    terms to be mutually agreed upon by Staff Member and Payee.  In
    the event that Staff Member and Payee are unable to reach
    agreement on such terms, this Note shall become immediately due
    and payable.

4.  Prepayment.

    Staff Member may prepay without penalty this Note in whole or in
    part at any time.  Any and all payments or prepayments under this
    Note may be made by Staff Member to Payee at the following
    address (or such other address as it designates in writing to
    Staff Member):

               AMGEN INC.
               Amgen Center
               Thousand Oaks, California 91320-1789

               Attention:  Accounting Manager

5.  Attorneys' Fees.

    Staff Member agrees to pay all costs and expenses, including,
    without limitation, collection agency fees and expenses,
    reasonable attorneys' fees, costs of suit and costs of appeal,
    which Payee may incur

    in the exercise, preservation or enforcement of its right, powers
    and remedies hereunder, or under any documents or instruments
    securing this Note, or under law.

6.  Modification of Terms.

    Payee may, with or without notice to Staff Member, cause
    additional parties to be added to this Note, or release any party
    to this Note, or revise, extend, or renew the Note, or extend the
    time for making any installment provided for by this Note, or
    accept any installment in advance, all without affecting the
    liability of Staff Member.  Staff Member may not assign or
    transfer in any manner whatsoever this Note or any of Staff
    Member's obligations under this Note.

7.  Security Interest.

    The purpose of this loan is to purchase a personal residence.
    Staff Member shall secure this loan by executing and causing to
    be filed, immediately upon close of escrow, a trust deed on this
    residence, commonly known as 1652 Aldercreek Place, Westlake
    Village, California 91361 whose property description is as
    follows:

     Lot 20 of Tract No. 3917, in the City of Thousand Oaks, County of
     Ventura, State of California, as per Map recorded in Book 102,
     Pages 54 to 59, inclusive, of Maps, in the office of the County
     Recorder of said County.

8.  Acceleration.

    A) In the event Staff Member fails to pay when due any sums under
    this Note, then:

      (1) the entire unpaid balance of this Note shall, at the option
      of the Payee hereof, immediately become due and payable in full
      and unpaid Principal thereafter shall bear interest at the
      lesser of the maximum rate permitted by law or at the rate of
      7.9% per annum; and

      (2) Staff Member authorizes Payee to deduct any sums due to
      Payee under this Note from any monies, including any wages due,
      otherwise owing to Staff Member.


    B) If Staff Member sells the residence which is purchased with
    the funds herein provided, this Note shall immediately become due
    and payable upon the sale of such residence.

9.  Waiver of Rights by Staff Member.

    Staff Member waives (1) presentment, demand, protest, notice of
    dishonor and/or protest and notice of non-payment; (2) the right,
    if any, to the benefit of, or to direct the application of, any
    security hypothecated to Payee until all indebtedness of Staff
    Member to Payee, however arising, has been paid; and (3) the
    right to require the Payee to proceed against any party to this
    Note, or to pursue any other remedy in Payee's power.  Payee may
    proceed against Staff Member directly and independently of any
    other party to this Note, and the cessation of the liability of
    any other party for any reason other than full payment, or any
    revision, renewal, extension, forbearance, change of rate of
    interest, or acceptance, release or substitution of security, or
    any impairment or suspension of Payee's remedies or rights
    against any other party, shall not in any way affect the
    liability of Staff Member.

10. Obligations of Persons Under this Note.

    If more than one person signs this Note, each person is fully and
    personally obligated to keep all of the promises made in this
    Note, including the promise to pay the full amount owed.  Any
    person who is a guarantor, surety, or endorser of this Note is
    also obligated to do these things.  Any person who takes over
    these obligations, including the obligations of a guarantor,
    surety or endorser of this Note, is also obligated to keep all of
    the promises made in this Note.  Payee may enforce its rights
    under this Note against each person individually or against all
    of the signatories to this Note.  This means that any one of the
    signatories to this Note may be required to pay all of the
    amounts owed under this Note.

11. Governing Law.

    This Note and the obligations under this Note of Staff Member or
    any other signatory to this Note shall be governed by and
    interpreted and determined in accordance with the laws of the
    State of California as applied to contracts between

    California residents entered into and to be performed entirely
    within said State.

IN WITNESS WHEREOF, the undersigned have executed and delivered this
Note as of the 15th day of
December, 1995.


                    /s/ George A. Vandeman
                    _______________________                           
                        GEORGE A. VANDEMAN


                    /s/ Winifred M. Vandeman
                    _________________________                         
                        WINIFRED M. VANDEMAN