EXHIBIT

                       FIRST AMENDMENT TO THE
                  AMGEN RETIREMENT AND SAVINGS PLAN
           AS AMENDED AND RESTATED EFFECTIVE APRIL 1, 1996


     The Amgen Retirement and Savings Plan (as amended and restated
effective April 1, 1996) (the "Plan") is hereby amended, effective as
of October 22, 1996, in the following respects:

1.   Section 6.9 of the Plan is amended to read in its entirety as 
     follows:

          6.9  Transfers Among Investment Funds.  A Participant may
     elect to reapportion the values of his or her Accounts among
     Investment Funds by properly following procedures prescribed by
     the Company.  The Company's procedures by which a Participant
     may elect to transfer amounts into or out of the Company Stock
     Fund shall be drafted to provide notice to Participants if such
     an election would cause a Participant to have a purchase or sale
     of Company Stock which is not exempt from potential short-swing
     trading profits liability under Section 16(b) of the Exchange
     Act by virtue of the application of Rule 16b-3 (promulgated
     under Section 16 of the Exchange Act) as in effect from time to
     time.  As of the effective date of this amended and restated
     Plan, such liability may arise if such election is made by a
     Participant (or successor in interest) who is an officer,
     director, or greater than 10% stockholder of the Company (within
     the meaning of Section 16 of the Exchange Act and the rules
     promulgated thereunder) within six months following the date of
     the most recent election made under any employee benefit plan
     sponsored by the Company or an Affiliate if (a) both elections
     involved either an intra-plan transfer involving a fund invested
     in the Company's equity securities or a cash distribution from
     the employee benefit plan to the Participant (or successor in
     interest) funded by a volitional disposition of the Company's
     equity securities, (b) the prior election involved an
     acquisition of the Company's equity securities if the current
     election involves a disposition of the Company's equity
     securities, or vice versa, and (c) both elections are made at
     the volition of the Participant (or successor in interest) not
     in connection with the Participant's death, disability,
     retirement, termination of employment, or an election which is
     required to be made available under a provision of the Code.
     Such a volitional election (considering without regard as to
     whether or not any similar elections have occurred within six
     months of such an election) shall be described as a
     "Discretionary Transaction."  Prior to July 1, 1996,
     Participants may not elect to transfer amounts to the Company
     Stock Fund.  On and after July 1, 1996, transfers into the
     Company Stock Fund shall be limited so that, after any such
     transfer, no more than 50% of the value of the Participant's
     aggregate Account is invested in the Company Stock Fund.  For
     purposes of carrying out Investment Fund transfers, the value of
     the Accounts shall be determined as of the Valuation Date
     immediately preceding the Participant's transfer election.

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2.   Section 8.6(d) of the Plan is amended to read in its entirety as
     follows:

               (d)  The Company shall establish procedures to notify
     a Participant (or successor in interest) if any election
     regarding the form or timing of distribution of benefits from
     the Plan involving the Company Stock Fund constitutes a
     Discretionary Transaction (as defined in Section 6.9) which may
     trigger short-swing trading profits liability for the
     Participant (or successor in interest) under Section 16(b) of
     the Exchange Act.  In such an event, the person making the
     election shall be provided with a reasonable opportunity to
     modify, delay, or revoke such an election.

3.   Section 10.4 of the Plan is amended to read in its entirety as
     follows:

          10.4 Source of Loans.  If a Participant requests and is
     granted a loan, a Loan Account shall be established for the
     Participant.  The Loan Account shall be held by the Trustee as
     part of the Loan Fund.  The amount of the loan shall be
     transferred to the Participant's Loan Account from the
     Participant's other Accounts and shall be disbursed from the
     Loan Account. Transfers from the Company Stock Fund shall be
     made in accordance with the requirements for exemption under
     Section 16(b) of the Exchange Act if such a transfer would cause
     the Participant to incur short-swing trading profits liability
     under Section 16(b) of the Exchange Act.  The promissory note
     executed by the Participant shall be held by the Trustee (or by
     the Company as agent of the Trustee) and the promissory note
     shall be treated as an investment of the Participant's Loan
     Account.

4.   Section 11.6 of the Plan is amended to read in its entirety as
     follows:

          11.6 Source of Withdrawals.  Withdrawals shall be paid from
     the affected Accounts.  If more than one Account is available to
     pay the withdrawal because the Participant elected to invest in
     more than one Investment Fund, the withdrawal shall be made from
     the subaccount(s) designated by the Participant, subject to such
     ordering and timing restrictions as the Company may adopt.

5.   Section 11.8 of the Plan is amended to read in its entirety as
     follows:

          11.8 Limitations on Withdrawals.  A Participant shall not
     be permitted to make more than one withdrawal under this Article
     in any period of six consecutive months; provided, however, that
     withdrawals made at the same time shall be considered a single
     withdrawal.  The timing of withdrawals from the Company Stock
     Fund shall be limited when necessary to avoid liability from the
     short-swing trading profits provisions of Section 16(b) of the
     Exchange Act.

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To record this First Amendment to the Plan as set forth herein, the
Company has caused its authorized officer to execute this document
this 22nd of October , 1996.


                                   AMGEN INC.


                              By:       /s/ George A. Vandeman


                              Title:    Senior Vice President,
                                        General Counsel and
                                        Secretary

                                   

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