EXHIBIT 10.45 AMGEN INC. FIRST AMENDMENT TO CREDIT AGREEMENT This FIRST AMENDMENT TO CREDIT AGREEMENT (this "Amendment") is dated as of December 12, 1996 and entered into by and among Amgen Inc., a Delaware corporation (the "Company"), each of the subsidiaries of the Company signatory to the Credit Agreement referred to below (together with the Company, the "Borrowers"), Swiss Bank Corporation, San Francisco Branch and Citicorp USA, Inc., as Co- Documentation Agents, and each other financial institution signatory to the Credit Agreement referred to below (collectively, the "Banks"), Swiss Bank Corporation, New York Branch and ABN AMRO Bank N.V., Los Angeles International Branch, as Issuing Banks, and Swiss Bank Corporation, New York Branch, as Administrative Agent. This Amendment amends the Credit Agreement dated as of June 23, 1995 (the "Credit Agreement") by and among the Borrowers, the Banks, the Issuing Banks and the Administrative Agent. Capitalized terms used herein without definition shall have the same meanings herein as set forth in the Credit Agreement. RECITALS WHEREAS, the parties hereto wish to amend the Credit Agreement to revise the definition of Applicable Percentage as set forth herein. NOW, THEREFORE, in consideration of the premises and the agreements, provisions and covenants herein contained, the parties hereto agree as follows: Article 1 AMENDMENTS TO THE CREDIT AGREEMENT 1.1 Amendments to Section 1.1: Defined Terms. (a) The definition of "Applicable Percentage" set forth in Section 1.1 of the Credit Agreement is hereby amended by deleting it in its entirety and substituting the following therefor: "'Applicable Percentage' means, with respect to Eurodollar Rate Loans, the Commitment Fee and the LC Reimbursement Fee, the per annum percentage corresponding to the tier for the Company's Ratings as specified in the following table: 1 Rate Spread and Fees Tier I Tier II Tier III Tier IV AA- and A- and BBB and BBB- or Aa3 or A3 or Baa2 or Baa3 better better better Eurodollar Rate Spread .200% .250% .375% .550% Commitment Fee .070% .080% .130% .175% LC Reimbursement Fee .200% .250% .375% .550% Ratings indicated are the Company's senior unsecured long- term debt ratings by Standard & Poor's Ratings Group and Moody's Investors Service, Inc., respectively." 1.2 Notice Addresses. For all purposes of the Credit Agreement (including Section 13.6 thereof), the addresses and other contact information of the parties thereto shall be as set forth on the signature pages hereof. Article 2 EFFECTIVENESS OF AMENDMENT This Amendment shall become effective as of December 12, 1996 (the "First Amendment Effective Date"), upon the receipt by the Administrative Agent, on behalf of the Banks, of all of the following, each in form and substance satisfactory to the Administrative Agent: 2.1 Signature and Incumbency Certificates. Signature and incumbency certificates of the officers of each Borrower executing and delivering this Amendment. 2.2 Signature Pages. A counterpart signature page hereof executed by a duly authorized officer of each party listed on the signature pages hereof. Article 3 REPRESENTATIONS AND WARRANTIES In order to induce the Banks, the Issuing Banks and the Administrative Agent to enter into this Amendment and to amend the Credit Agreement in the manner provided herein, each Borrower represents and warrants to each Bank that the following statements are true, correct and complete: 3.1 Corporate Power and Authority. Such Borrower has all requisite corporate power and authority to execute and deliver this Amendment and to perform its Obligations under the Credit Agreement as amended by this Amendment (the "Amended Agreement"). 2 3.2 Authorization; No Conflict, etc. The execution, delivery and performance of this Amendment by such Borrower have been duly authorized by all necessary corporate action, and do not: (a) Require any consent or approval not heretofore obtained of any partner, director, stockholder, security holder or creditor of such Borrower; (b) Result in or require the creation or imposition of any Lien upon or with respect to any Property now owned or leased or hereafter acquired by such Borrower; (c) Violate, to the best knowledge of such Borrower, any Requirement of Law applicable to such Borrower; (d) Result (or, with the giving of notice or passage of time or both, would result) in a breach of or default under, or cause or permit the acceleration of any obligation owed under any Contractual Obligation to which such Borrower is a party or by which such Borrower or any of its Property is bound or affected; except where failure to receive such consent or approval or creation of such Lien or violation of, or default under, any such Requirement of Law or Contractual Obligation would not constitute a Material Adverse Effect. 3.3 Governmental Consents. Subject to the representation of the Banks contained in Section 13.8 of the Agreement, which representation is hereby remade by the Banks, no authorization, consent, approval, order, license or permit from, or filing, registration or qualification with, any Governmental Agency is required to authorize or permit under applicable Laws the execution, delivery and performance of this Amendment by such Borrower. 3.4 Binding Obligation. The Amendment Agreement will, when this Amendment is executed and delivered by such Borrower, constitute the legal, valid and binding obligation of such Borrower, enforceable against such Borrower in accordance with its terms, except as enforcement may be limited by Debtor Relief Laws or equitable principles relating to the granting of specific performance and other equitable remedies as a matter of judicial discretion. 3.5 Incorporation of Representations and Warranties From Credit Agreement. The representations and warranties contained in Article 4 of the Credit Agreement are and will be true, correct and complete in all material respects on and as of the First Amendment Effective Date to the same extent as though made on and as of that date, except to the extent such representations and warranties specifically relate to an earlier date, in which case they were true, correct and complete in all material respects on and as of such earlier date. 3 3.6 Absence of Default. No event has occurred and is continuing (or will result from the consummation of the transactions contemplated by this Amendment) that is a Default or Event of Default. Article 4 MISCELLANEOUS 4.1 Reference to and Effect on the Credit Agreement and the Other Loan Documents. (a) On and after the First Amendment Effective Date, each reference in the Credit Agreement to "this Agreement", "hereunder", "hereof", "herein" or words of like import referring to the Credit Agreement, and each reference in the other Loan Documents to the "Credit Agreement", "thereunder", "thereof" or words of like import referring to the Credit Agreement shall mean and be a reference to the Credit Agreement as amended by this Amendment. (b) Except as specifically amended by this Amendment, the Credit Agreement and the other Loan Documents shall remain in full force and effect and are hereby ratified and confirmed. (c) The execution, delivery and performance of this Amendment shall not, except as expressly provided herein, constitute a waiver of any provision of, or operate as a waiver of any right, power or remedy of the Administrative Agent, any Bank or any Issuing Bank under, the Credit Agreement or any of the other Loan Documents. 4.2 Headings. Section and subsection headings in this Amendment are included herein for convenience of reference only and shall not constitute a part of this Amendment for any other purpose or be given any substantive effect. 4.3 Applicable Law. THIS AMENDMENT SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO CONFLICTS OF LAWS PRINCIPLES. 4.4 Counterparts. This Amendment may be executed in any number of counterparts and by different parties hereto in separate counterparts, each of which when so executed and delivered shall be deemed an original, but all such counterparts together shall constitute but one and the same instrument. 4 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and delivered by their respective officers thereunto duly authorized as of the date first written above. THE COMPANY: AMGEN INC. By: /s/ Kathryn E. Falberg Title: Vice President, Treasurer Address: Amgen Inc. Amgen Center 1840 DeHavilland Drive Thousand Oaks, California 91320-1789 Attn: Treasurer cc: Secretary Telecopier: (805) 499-8011 Telephone: (805) 447-1000 BORROWING SUBSIDIARY: AMGEN MANUFACTURING, INC. By: /s/ Katherine E. Falberg Title: Vice President, Treasurer Address: Amgen Inc. Amgen Center 1840 DeHavilland Drive Thousand Oaks, California 91320-1789 Attn: Treasurer cc: Secretary Telecopier: (805) 499-8011 Telephone: (805) 447-1000 5 THE ADMINISTRATIVE AGENT AND CO-DOCUMENTATION AGENT: SWISS BANK CORPORATION, NEW YORK BRANCH By: /s/ James J. Diaz Title: Director Banking Finance Support, N.A. By: /s/ Thomas Eggenschwiler Title: Executive Director Credit Risk Management Address: 222 Broadway New York, New York 10038 Attn: Banking Finance Support Telecopier: (212) 574-3888 Telephone: (212) 574-3043 THE ISSUING BANKS: SWISS BANK CORPORATION, NEW YORK BRANCH By: /s/ James J. Diaz Title: Director Banking Finance Support, N.A. By: /s/ Thomas Eggenschwiler Title: Executive Director Credit Risk Management Address: Swiss Bank Tower 10 East 50th Street New York, New York 10022 Attn: Letter of Credit Department Telecopier: (212) 574-4634 Telephone: (212) 574-4643 6 ABN AMRO BANK N.V., LOS ANGELES INTERNATIONAL BRANCH By: /s/ Ellen M. Coleman Title: Vice President/Director By: /s/ Paul K. Stimpfl Vice President/Director Address: 300 South Grand Avenue Suite 1115 Los Angeles, California 90071 Attn: Letter of Credit Department Telecopier: (213) 687-2061 Telephone: (213) 687-2306 THE CO-DOCUMENTATION AGENT: CITICORP USA, INC. By: /s/ Marjorie Futornick Title: Vice President Address: 725 South Figueroa Street Los Angeles, California 90017 Attn: Deborah Ironson/Banker Telecopier: (213) 623-3592 Telephone: (213) 239-1424 7 THE BANKS: SWISS BANK CORPORATION, SAN FRANCISCO BRANCH By: /s/ Hans-Ueli Surber Title: Executive Director Merchant Banking By: /s/ Nang S. Peechaphand Title: Associate Director Accounting Address: 101 California Street Suite 1700 San Francisco, California 94111 Attn: Hans-Ueli Surber Telecopier: (213) 989-7570 Telephone: (213) 774-3336 CITICORP USA, INC. By: /s/ Marjorie Futornick Title: Vice President Address: 725 South Figueroa Street Los Angeles, California 90017 Attn: Deborah Ironson/Banker Telecopier: (213) 623-3592 Telephone: (213) 239-1424 8 ABN AMRO BANK N.V., LOS ANGELES INTERNATIONAL BRANCH By: /s/ Ellen M. Coleman Title: Vice President/Director By: /s/ Paul K. Stimpfl Title: Vice President/Director Address: 300 South Grand Avenue Suite 1115 Los Angeles, California 90071 Attn: Ellen Coleman, John Miller Telecopier: (213) 687-2061 Telephone: (213) 687-2306 BANCA COMMERCIALE ITALIANA, LOS ANGELES FOREIGN BRANCH By: /s/ E. Bombieri Title: Vice President and Manager By: /s/ J. Wityak Title: Vice President Address: 555 South Flower Street 43rd Floor Los Angeles, California 90071 Attn: Jack Wityak Telecopier: (213) 624-0457 Telephone: (213) 624-0440 BANK OF MONTREAL By: /s/ Beverly Blucher Title: Senior Vice President Address: 601 South Figueroa Street Los Angeles, California 90017 Attn: Craig Ingram Telecopier: (213) 239-0680 Telephone: (213) 239-0614 9 THE SANWA BANK, LIMITED, LOS ANGELES BRANCH By: Gill Realon Title: Vice President Address: 601 South Figueroa Street 5th Floor Los Angeles, California 90017 Attn: Gill Realon U.S. Banking Department Telecopier:(213) 623-4912 Telephone:(213) 896-7494 NATIONSBANK OF TEXAS, N.A. By: Chas A. McDonell Title: Vice President Address: 444 South Flower Street Suite 4100 Los Angeles, California 90071 Attn: Michael Shea Telecopier: (213) 624-5815 Telephone: (213) 236-4915 WELLS FARGO BANK, N.A. By: /s/ Guity Javid Title: Senior Vice President By: Edith R. Lim Title: Vice President Address: 707 Wilshire Boulevard MAC2818-163 Los Angeles, California 90071 Attn: Guity Javid/Edith Lim Telecopier: (213) 614-2569 Telephone: (213) 614-3572/5686 10