EXHIBIT 10.45

                             AMGEN INC.

                           FIRST AMENDMENT
                         TO CREDIT AGREEMENT


          This FIRST AMENDMENT TO CREDIT AGREEMENT (this "Amendment")
is dated as of December 12, 1996 and entered into by and among  Amgen
Inc.,  a   Delaware  corporation   (the  "Company"),   each  of   the
subsidiaries  of  the  Company  signatory  to  the  Credit  Agreement
referred to below (together with the Company, the "Borrowers"), Swiss
Bank Corporation, San Francisco Branch and Citicorp USA, Inc., as Co-
Documentation Agents, and each other financial institution  signatory
to  the  Credit  Agreement  referred  to  below  (collectively,   the
"Banks"), Swiss Bank Corporation, New York  Branch and ABN AMRO  Bank
N.V., Los Angeles International Branch,  as Issuing Banks, and  Swiss
Bank Corporation, New  York Branch,  as Administrative  Agent.   This
Amendment amends the Credit Agreement dated as of June 23, 1995  (the
"Credit Agreement")  by  and  among the  Borrowers,  the  Banks,  the
Issuing Banks and the Administrative  Agent.  Capitalized terms  used
herein without definition shall have the same meanings herein as  set
forth in the Credit Agreement.

RECITALS

          WHEREAS, the  parties  hereto  wish  to  amend  the  Credit
Agreement to revise  the definition of  Applicable Percentage as  set
forth herein.

          NOW, THEREFORE, in  consideration of the  premises and  the
agreements, provisions and  covenants herein  contained, the  parties
hereto agree as follows:

Article 1

AMENDMENTS TO THE CREDIT AGREEMENT

          1.1  Amendments to Section 1.1:  Defined Terms.

               (a)  The definition  of  "Applicable  Percentage"  set
forth in Section  1.1 of the  Credit Agreement is  hereby amended  by
deleting it in its entirety and substituting the following therefor:

          "'Applicable Percentage' means, with respect to  Eurodollar
Rate Loans, the Commitment Fee and the LC Reimbursement Fee, the  per
annum percentage corresponding to the tier for the Company's  Ratings
as specified in the following table:

                                   1

                        Rate Spread and Fees

                          Tier I   Tier II  Tier III  Tier IV

                          AA- and  A- and   BBB and   BBB- or
                          Aa3 or    A3 or   Baa2 or     Baa3
                          better   better    better

 Eurodollar Rate Spread   .200%    .250%    .375%     .550%
 Commitment Fee           .070%    .080%    .130%     .175%
 LC Reimbursement Fee     .200%    .250%    .375%     .550%


          Ratings indicated are the Company's senior unsecured  long-
term debt  ratings by  Standard &  Poor's Ratings  Group and  Moody's
Investors Service, Inc., respectively."

          1.2   Notice Addresses.   For  all purposes  of the  Credit
Agreement (including Section 13.6  thereof), the addresses and  other
contact information of the parties thereto  shall be as set forth  on
the signature pages hereof.

                              Article 2

                     EFFECTIVENESS OF AMENDMENT

          This Amendment shall  become effective as  of December  12,
1996 (the "First Amendment Effective Date"), upon the receipt by  the
Administrative  Agent,  on  behalf  of  the  Banks,  of  all  of  the
following,  each   in  form   and  substance   satisfactory  to   the
Administrative Agent:

          2.1  Signature and Incumbency Certificates.  Signature  and
incumbency certificates of  the officers of  each Borrower  executing
and delivering this Amendment.

          2.2  Signature Pages.  A counterpart signature page  hereof
executed by a  duly authorized officer  of each party  listed on  the
signature pages hereof.

                              Article 3

                   REPRESENTATIONS AND WARRANTIES

          In order to  induce the Banks,  the Issuing  Banks and  the
Administrative Agent to enter  into this Amendment  and to amend  the
Credit  Agreement  in  the  manner  provided  herein,  each  Borrower
represents and warrants  to each Bank  that the following  statements
are true, correct and complete:

          3.1  Corporate Power and Authority.  Such Borrower has  all
requisite corporate power and authority  to execute and deliver  this
Amendment and to perform its  Obligations under the Credit  Agreement
as amended by this Amendment (the "Amended Agreement").

                                     2

          3.2  Authorization;  No  Conflict,  etc.    The  execution,
delivery and performance of this Amendment by such Borrower have been
duly authorized by all necessary corporate action, and do not:

          (a)  Require  any  consent   or  approval  not   heretofore
     obtained of any partner, director, stockholder, security  holder
     or creditor of such Borrower;

          (b)  Result in or require the creation or imposition of any
     Lien upon or with respect to any Property now owned or leased or
     hereafter acquired by such Borrower;

          (c)  Violate, to the best  knowledge of such Borrower,  any
     Requirement of Law applicable to such Borrower;

          (d)  Result (or, with  the giving of  notice or passage  of
     time or both, would result) in a breach of or default under,  or
     cause or permit  the acceleration of  any obligation owed  under
     any Contractual Obligation to which such Borrower is a party  or
     by which  such Borrower  or  any of  its  Property is  bound  or
     affected;

except where failure to receive such consent or approval or  creation
of such Lien or violation of, or default under, any such  Requirement
of Law  or Contractual  Obligation would  not constitute  a  Material
Adverse Effect.

          3.3  Governmental Consents.  Subject to the  representation
of the  Banks  contained in  Section  13.8 of  the  Agreement,  which
representation is  hereby  remade  by the  Banks,  no  authorization,
consent,  approval,  order,  license  or  permit  from,  or   filing,
registration  or  qualification  with,  any  Governmental  Agency  is
required to authorize or permit under applicable Laws the  execution,
delivery and performance of this Amendment by such Borrower.

          3.4  Binding Obligation.    The Amendment  Agreement  will,
when this  Amendment  is executed  and  delivered by  such  Borrower,
constitute the legal, valid and binding obligation of such  Borrower,
enforceable against  such  Borrower  in accordance  with  its  terms,
except as  enforcement  may  be limited  by  Debtor  Relief  Laws  or
equitable principles relating to the granting of specific performance
and other equitable remedies as a matter of judicial discretion.

          3.5  Incorporation of Representations  and Warranties  From
Credit Agreement.   The representations and  warranties contained  in
Article 4 of the Credit Agreement are  and will be true, correct  and
complete in all material  respects on and as  of the First  Amendment
Effective Date to the same  extent as though made  on and as of  that
date, except  to  the  extent  such  representations  and  warranties
specifically relate to an earlier date, in which case they were true,
correct and  complete in  all material  respects on  and as  of  such
earlier date.

                                     3

          3.6  Absence of  Default.   No event  has occurred  and  is
continuing (or will result from the consummation of the  transactions
contemplated by  this  Amendment)  that is  a  Default  or  Event  of
Default.

                              Article 4

                            MISCELLANEOUS

          4.1  Reference to  and Effect on  the Credit Agreement  and
the Other Loan Documents.

               (a)  On and after the First Amendment Effective  Date,
each  reference  in  the   Credit  Agreement  to  "this   Agreement",
"hereunder", "hereof", "herein" or words of like import referring  to
the Credit Agreement, and each reference in the other Loan  Documents
to the "Credit Agreement", "thereunder",  "thereof" or words of  like
import referring  to  the  Credit  Agreement  shall  mean  and  be  a
reference to the Credit Agreement as amended by this Amendment.

               (b)  Except as specifically amended by this Amendment,
the Credit Agreement  and the other  Loan Documents  shall remain  in
full force and effect and are hereby ratified and confirmed.

               (c)  The execution, delivery  and performance of  this
Amendment shall not, except as expressly provided herein,  constitute
a waiver of any provision  of, or operate as  a waiver of any  right,
power or remedy of the Administrative Agent, any Bank or any  Issuing
Bank under, the Credit Agreement or any of the other Loan Documents.

          4.2  Headings.   Section  and subsection  headings in  this
Amendment are included herein for  convenience of reference only  and
shall not constitute a part of  this Amendment for any other  purpose
or be given any substantive effect.

          4.3  Applicable Law.  THIS AMENDMENT SHALL BE GOVERNED  BY,
AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE  INTERNAL
LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO CONFLICTS OF  LAWS
PRINCIPLES.

          4.4  Counterparts.  This Amendment  may be executed in  any
number of counterparts  and by different  parties hereto in  separate
counterparts, each of which when so  executed and delivered shall  be
deemed  an  original,  but  all  such  counterparts  together   shall
constitute but one and the same instrument.

                                     4

          IN WITNESS  WHEREOF, the  parties hereto  have caused  this
Amendment to  be  duly executed  and  delivered by  their  respective
officers thereunto  duly  authorized as  of  the date  first  written
above.

                         THE COMPANY:

                         AMGEN INC.

                         By:       /s/ Kathryn E. Falberg
                         Title:    Vice President, Treasurer

                         Address:
                         Amgen Inc.
                         Amgen Center
                         1840 DeHavilland Drive
                         Thousand Oaks, California  91320-1789

                         Attn:     Treasurer
                         cc:       Secretary

                         Telecopier: (805) 499-8011
                         Telephone:  (805) 447-1000


                         BORROWING SUBSIDIARY:

                         AMGEN MANUFACTURING, INC.

                         By:       /s/ Katherine E. Falberg
                         Title:    Vice President, Treasurer

                         Address:
                         Amgen Inc.
                         Amgen Center
                         1840 DeHavilland Drive
                         Thousand Oaks, California  91320-1789

                         Attn:     Treasurer
                         cc:       Secretary

                         Telecopier:  (805) 499-8011
                         Telephone:   (805) 447-1000

                                      5

                         THE ADMINISTRATIVE AGENT AND
                         CO-DOCUMENTATION AGENT:

                         SWISS BANK CORPORATION,
                         NEW YORK BRANCH

                         By:       /s/ James J. Diaz
                         Title:    Director
                                   Banking Finance Support, N.A.

                         By:       /s/ Thomas Eggenschwiler
                         Title:    Executive Director
                                   Credit Risk Management

                         Address:
                         222 Broadway
                         New York, New York  10038

                         Attn:  Banking Finance Support

                         Telecopier:  (212) 574-3888
                         Telephone:   (212) 574-3043


                         THE ISSUING BANKS:

                         SWISS BANK CORPORATION,
                         NEW YORK BRANCH

                         By:       /s/ James J. Diaz
                         Title:    Director
                                   Banking Finance Support, N.A.

                         By:       /s/ Thomas Eggenschwiler
                         Title:    Executive Director
                                   Credit Risk Management

                         Address:
                         Swiss Bank Tower
                         10 East 50th Street
                         New York, New York  10022

                         Attn:  Letter of Credit Department

                         Telecopier:  (212) 574-4634
                         Telephone:   (212) 574-4643
 
                                      6

                         ABN AMRO BANK N.V., LOS ANGELES
                         INTERNATIONAL BRANCH

                         By:       /s/ Ellen M. Coleman
                         Title:    Vice President/Director

                         By:       /s/ Paul K. Stimpfl
                                   Vice President/Director

                         Address:
                         300 South Grand Avenue
                         Suite 1115
                         Los Angeles, California  90071

                         Attn:  Letter of Credit Department

                         Telecopier:  (213) 687-2061
                         Telephone:   (213) 687-2306


                         THE CO-DOCUMENTATION AGENT:

                         CITICORP USA, INC.

                         By:       /s/ Marjorie Futornick
                         Title:    Vice President

                         Address:
                         725 South Figueroa Street
                         Los Angeles, California  90017

                         Attn:  Deborah Ironson/Banker

                         Telecopier:  (213) 623-3592
                         Telephone:   (213) 239-1424

                                        7

                         THE BANKS:

                         SWISS BANK CORPORATION,
                         SAN FRANCISCO BRANCH

                         By:       /s/ Hans-Ueli Surber
                         Title:    Executive Director
                                   Merchant Banking

                         By:       /s/ Nang S. Peechaphand
                         Title:    Associate Director
                                   Accounting

                         Address:
                         101 California Street
                         Suite 1700
                         San Francisco, California  94111

                         Attn:  Hans-Ueli Surber

                         Telecopier:  (213) 989-7570
                         Telephone:   (213) 774-3336


                         CITICORP USA, INC.

                         By:       /s/ Marjorie Futornick
                         Title:    Vice President

                         Address:
                         725 South Figueroa Street
                         Los Angeles, California  90017

                         Attn:  Deborah Ironson/Banker
                         Telecopier:  (213) 623-3592
                         Telephone:   (213) 239-1424

                                    8

                         ABN AMRO BANK N.V., LOS ANGELES
                         INTERNATIONAL BRANCH

                         By:       /s/ Ellen M. Coleman
                         Title:    Vice President/Director

                         By:       /s/ Paul K. Stimpfl
                         Title:    Vice President/Director

                         Address:
                         300 South Grand Avenue
                         Suite 1115
                         Los Angeles, California  90071

                         Attn:  Ellen Coleman, John Miller

                         Telecopier:  (213) 687-2061
                         Telephone:   (213) 687-2306


                         BANCA COMMERCIALE ITALIANA,
                         LOS ANGELES FOREIGN BRANCH

                         By:       /s/ E. Bombieri
                         Title:    Vice President and Manager

                         By:       /s/ J. Wityak
                         Title:    Vice President

                         Address:
                         555 South Flower Street
                         43rd Floor
                         Los Angeles, California  90071

                         Attn:  Jack Wityak

                         Telecopier:  (213) 624-0457
                         Telephone:   (213) 624-0440


                         BANK OF MONTREAL

                         By:       /s/ Beverly Blucher
                         Title:    Senior Vice President

                         Address:
                         601 South Figueroa Street
                         Los Angeles, California  90017

                         Attn:  Craig Ingram
                         Telecopier:  (213) 239-0680
                         Telephone:   (213) 239-0614

                                     9

                         THE SANWA BANK, LIMITED,
                         LOS ANGELES BRANCH

                         By:       Gill Realon
                         Title:    Vice President

                         Address:
                         601 South Figueroa Street
                         5th Floor
                         Los Angeles, California  90017

                         Attn:  Gill Realon
                         U.S. Banking Department

                         Telecopier:(213) 623-4912
                         Telephone:(213) 896-7494

                         NATIONSBANK OF TEXAS, N.A.

                         By:       Chas A. McDonell
                         Title:    Vice President

                         Address:
                         444 South Flower Street
                         Suite 4100
                         Los Angeles, California  90071

                         Attn:  Michael Shea

                         Telecopier:  (213) 624-5815
                         Telephone:   (213) 236-4915

                         WELLS FARGO BANK, N.A.

                         By:       /s/ Guity Javid
                         Title:    Senior Vice President

                         By:       Edith R. Lim
                         Title:    Vice President

                         Address:
                         707 Wilshire Boulevard MAC2818-163
                         Los Angeles, California  90071

                         Attn:  Guity Javid/Edith Lim

                         Telecopier:  (213) 614-2569
                         Telephone:   (213) 614-3572/5686

                                      10