EXHIBIT 10.48

                        CONSULTING AGREEMENT

          THIS CONSULTING  AGREEMENT (the  "Agreement") is  made  and
entered into by  and between Daniel  Vapnek (the "Former  Executive")
and Amgen Inc., a Delaware corporation (the "Company").

                         W I T N E S S E T H

          WHEREAS, Former Executive has resigned from his position as
Senior Vice President, Research, and from any and all other positions
he held with the  Company or its affiliates  effective as of  October
31, 1996 (the "Termination Date");

          WHEREAS, the Company  wishes to  retain Former  Executive's
services as  a consultant  for a  period  of twenty-one  (21)  months
commencing on the Termination Date and concluding on July 31, 1998;

          NOW, THEREFORE, in consideration of the mutual promises and
covenants contained herein, it  is hereby agreed  by and between  the
parties hereto as follows:

                          SUMMARY OF TERMS

          1.   Consulting Service.   Under the  general direction  of
the Company's Chief  Executive Officer, Chief  Operating Officer,  or
Sr. Vice  President  of  Research,  Former  Executive  shall  provide
consulting services to the  Company in any area  of his expertise  or
with regard to any matters in which he was involved while employed by
the Company.  These  services will include  scientific advice in  the
areas of new  product discovery,  in-license opportunities,  research
strategy, etc.    Such services  shall  be provided  at  such  times,
locations, and by such means as  reasonably required by the  Company.
The Company also shall, to the  extent consistent with the  Company's
best interests, schedule  Former Executive's  services so  as not  to
interfere with Former Executive's other commitments.  Requests by the
Company for  Former Executive's  Services shall  not exceed,  without
Former Executive's consent, which shall not be unreasonably withheld,
two (2) days per week or nine  (9) days per month.  Former  Executive
shall be compensated for all services to be provided as  specifically
set forth herein.

          2.   Consulting Period. Former Executive  shall serve as  a
consultant to the Company under the terms specified herein commencing
on the  Termination  Date  and terminating  on  July  31,  1998  (the
"Consulting Period").    Former  Executive's  sole  compensation  and
benefits during the Consulting Period shall  be as specified in  this
Agreement.

          3.   Consideration for Consulting Services.

               (a)  Consulting Fee.  The Company agrees to pay Former
Executive the sum of Three Thousand Four Hundred Thirty-eight Dollars
($3,438.00) for each eight hour  day of consulting services  provided
by Former Executive hereunder.

                                    1

               (b)  Stock   Option   Vesting.      Although    Former
Executive's employment  will  have  terminated effective  as  of  the
Termination Date, Amgen will  consider Former Executive a  consultant
through and  including July  31, 1998,  for purposes  of vesting  and
extending the date  through which Former  Executive may exercise  the
below-listed Stock Options (hereinafter referred to as the  "Extended
Stock  Options").    Therefore,  except  as  provided  below,  Former
Executive will have until October 31,  1998 to exercise the  Extended
Stock Options,  unless they  expire sooner.   All  other Amgen  Stock
Options held by the  Former Executive that may  have vested prior  to
Former Executive's Termination Date must also be exercised within the
same three  (3) months  after the  termination of  this Agreement  or
their expiration date,  whichever is sooner.   Former Executive  will
not be entitled to  any reload rights in  connection with either  the
Extended Stock Options or any other Amgen Stock Options that may have
vested prior to Former Executive's Termination Date.  Nothing  herein
shall be deemed to  have altered or extended  the expiration date  of
either the Extended Stock Options or  any Amgen Stock Option  granted
to Former Executive.  In addition, all Amgen Stock Options, including
the Extended  Stock Options,  exercised more  than three  (3)  months
after Former Executive's Termination Date  will no longer qualify  as
Incentive Stock Options.   Former Executive will  be required to  pay
all withholding taxes required by law with respect to the exercise of
all Amgen Stock Options including the Extended Stock Options.

        No. of Option      Grant No.     Date of Vesting
        Shares

        3,200              884633        June 22, 1997
        316                910684        September 1, 1997
        3,434              910685        September 1, 1997
        2                  914247        July 1, 1997
        5,188              914248        July 1, 1997
        1,034              914268        July 1, 1997
        9,200              918034        July 1, 1997
        10,000             921197        July 3, 1997
        5,190              914247        July 1, 1998
        384                914267        July 1, 1998
        650                914268        July 1, 1998
        9,200              918034        July 1, 1998
        10,000             921197        July 3, 1998

               (c)  Health Coverage.  Should Former Executive  and/or
Former Executive's  eligible dependents  elect to  continue  coverage
under Amgen's  group health  plan(s) under  the Consolidated  Omnibus
Budget Reconciliation Act ("COBRA")  continuation rights, and  Former
Executive and/or Former Executive's eligible dependents timely submit
to Amgen  the documents  necessary to  initiate such  coverage,  then
Amgen will pay the cost of COBRA coverage for Former Executive and/or
Former Executive's eligible dependents until the earlier of April 30,
1998, or until  Former Executive and/or  Former Executive's  eligible
dependents no longer qualify for COBRA continuation rights or, in the
case of  Former  Executive's  dependents,  the  date  on  which  such
dependents cease to be eligible dependents under Amgen's group health
insurance plan(s), which

                                   2

ever  shall  first  occur.     If  Former  Executive  and/or   Former
Executive's eligible  dependents qualify  for  COBRA benefits  as  of
April 30,  1998,  then  Former Executive  and/or  Former  Executive's
eligible dependents will have the option of continuing coverage under
Amgen's group health plan(s), under  COBRA and at Former  Executive's
own expense,  for  the  remainder of  the  period  for  which  Former
Executive is entitled  to receive COBRA  benefits, generally no  more
than eighteen (18) months from the date of the termination of  Former
Executive's employment, provided that Former Executive and/or  Former
Executive's eligible dependents  meet the qualification  requirements
under COBRA and under Amgen's group  health plan(s).  For a  complete
description of the  rights and responsibilities  of Former  Executive
and  Former  Executive's  eligible  dependents  under  COBRA,  Former
Executive must refer  to the  COBRA documents  that will  be sent  to
Former Executive by the  Company after Former Executive's  employment
terminates.

               (d)  Financial Advice.   Company  agrees to  reimburse
Former Executive for  financial, tax and  estate planning  assistance
incurred during 1996 in  a sum not to  exceed Three Thousand  Dollars
($3,000.00).   Former Executive  agrees to  provide Company  invoices
covering the cost  of such  assistance upon  which Company's  payment
will be made.

               (e)  Expenses.    Former  Executive  shall  incur   no
expenses on behalf of the Company without the Company's prior written
approval.  The Company will  reimburse Former Executive, pursuant  to
Company policy  and regular  business  practice, for  all  reasonable
business  expenses  he  incurs   during  the  Consulting  Period   in
furtherance of his obligations hereunder upon prior written  approval
by the  Company.   For  purposes  of this  subparagraph,  "reasonable
business  expense"   shall  include,   without  limitation,   travel,
telephone, hotel and meal expenses.

               (f)  Management Incentive Plan.  Except as provided in
this  paragraph,  all   other  benefits  provided   by  the   Company
(including, but  not limited  to participant  elected  contributions,
matching payments,  profit  sharing contributions,  and  other  Amgen
contributions made under the Amgen  Retirement and Savings Plan,  and
all stock purchase  plan rights, and  life and disability  insurance)
will cease as of the Termination Date.  Company and Former  Executive
acknowledge that Former Executive will be entitled to receive a bonus
under the Company's  Management Incentive  Plan (the  "MIP") for  the
calendar year  ending December  31, 1996,  which MIP  bonus shall  be
prorated based upon the Company's 1996 results through September  30,
1996, and which MIP  bonus shall be paid  to Former Executive on  the
same date  in early  1997 as  such MIP  bonuses are  paid to  current
members of Amgen's  management.  Former  Executive also  acknowledges
and agrees that Former Executive will not be entitled to  participate
in any MIP  benefits after 1996.   Former Executive  agrees that  the
Former Executive  is not  entitled to  receive,  will not  claim  and
expressly waives any entitlement to rights, benefits or  compensation
other than as expressly set forth in this Agreement.

                                    3

               (g)  Reimbursement.    Former  Executive  will  submit
written detailed invoices  on a regular  basis covering his  retained
time (nine days per month) plus any additional days in excess of  the
nine days and  all expense incurred  under this Consulting  Agreement
for reimbursement by Company.  Such  invoices are to be submitted  to
Edward Garnett, Vice  President, Human Resources.   Former  Executive
shall incur  no  expenses  on  behalf  of  the  Company  without  the
Company's prior written approval.  The Company will reimburse  Former
Executive pursuant to Company  policy and regular business  practice,
for all  reasonable business  expenses he  incurs during  the  period
covered by this Agreement in furtherance of his obligations hereunder
upon prior written  approval by the  Company.  For  purposes of  this
subparagraph, "reasonable business  expenses" shall include,  without
limitation, travel, telephone, hotel and meal expenses.

          4.   Independent Contractor.   Former Executive shall  have
no responsibilities  as a  consultant to  the Company  other than  as
provided for herein and shall not  represent or purport to  represent
the Company in  any manner  whatsoever to  any third  party.   Former
Executive is being engaged by Amgen as an independent contractor  and
not an employee and Former Executive  will be solely responsible  for
making appropriate  filings  and  payments to  the  Internal  Revenue
Service and state taxing authorities, including payments of all taxes
due on compensation received under this Agreement.

          5.   Inventions.  Former  Executive hereby  assigns to  the
Company his entire right, title and interest in and to all Inventions
(and all  proprietary rights  with respect  thereto) whether  or  not
patentable or registrable under  copyright or similar statutes,  made
or  conceived  of  or  reduced  to  practice  or  learned  by  Former
Executive, either alone or  jointly with others,  during the term  of
the Consulting Period in the course  of or as a result of  performing
consulting services hereunder.  Former Executive agrees that all such
inventions are the sole property of the Company.

          6.   Noncompetition.  Former  Executive hereby agrees  that
during the Consulting Period he will not, without first obtaining the
Company's prior written  approval, directly or  indirectly engage  or
prepare to engage in any activities  in competition with the  Company
or accept employment or establish a business relationship or accept a
position on a Board of Directors  with any company.  For purposes  of
this paragraph, the  holding of  less than  one percent  (1%) of  the
outstanding voting securities of any firm or business organization in
competition with  the  Company  shall not  constitute  activities  or
services precluded by this Agreement.

          7.   Termination.   This  Agreement may  be  terminated  by
either party by 30  days advance written notice.   In the event  that
this Agreement is terminated prior to July 31, 1998, then only  those
extended stock options  which have already  vested by  the date  this
Agreement terminates  shall vest.   In  addition,  in the  event  the
Agreement terminates prior to July 31, 1998, then Former Executive

                                     4

shall have until three months from the date this Agreement terminates
or the  expiration  date of  the  options, whichever  is  sooner,  to
exercise any  options  that  have  vested  prior  to  the  date  this
Agreement terminates.

          8.   Proprietary Information Obligations.  Former Executive
hereby acknowledges  his responsibilities  under  the terms  of  that
certain Proprietary Information and Inventions Agreement between  the
Company  and  Former   Executive,  dated  February   26,  1982   (the
"Proprietary Information Agreement"),  attached hereto as  Exhibit A,
and Former Executive  agrees to continue  to be bound  by all of  the
terms and conditions thereof.

          9.   Nonsolicitation of Employees.  Former Executive agrees
not to entice, induce or encourage any of the Company's employees  to
engage in any activity which, were it done by Former Executive, would
violate any  provision  of  the  Proprietary  Information  Agreement.
Former Executive  further  agrees that  for  a period  of  two  years
following the end of the term of this Agreement, he will not directly
or indirectly solicit, entice, induce  or encourage employees of  the
Company to leave the Company to accept other employment or to provide
services to Former Executive or any other person or entity.

          10.  No Other Authority.   Former Executive  shall have  no
responsibilities or duties to the Company other than as provided  for
above and shall not represent or purport to represent the Company  in
any manner whatsoever to  any third party, unless  required to do  so
pursuant to this  Agreement or by  specific written authorization  of
the Company's Chief Executive Officer or Chief Operating Officer.

          11.  Entire  Agreement.    This  Agreement,  including  the
Exhibits  attached  hereto,  represents  the  final,  complete,   and
exclusive  embodiment  of  the  entire  agreement  and  understanding
between  the   Company  and   Former  Executive   concerning   Former
Executive's consulting services  to the Company,  and supersedes  and
replaces any and all  prior agreements and understandings  concerning
Former Executive's relationship with the Company and his compensation
by the  Company.    It  is expressly  understood  that  there  is  no
agreement or understanding between the parties about or pertaining to
Former Executive's employment with or Retirement from the Company  or
any matter addressed in  this Agreement except what  is set forth  in
this Agreement (including the Exhibits  hereto).  This Agreement  may
only be amended in a writing signed by Former Executive and the Chief
Executive Officer of the Company.

          12.  Severability.  If any  provision of this Agreement  is
determined to be invalid or unenforceable, in whole or in part,  this
determination will not affect any other provision of this Agreement.

          13.  Notices.   All notices  required  or permitted  to  be
given under this Agreement must be in writing and may be given by any
method of delivery which provides evidence or confirmation of receipt
including but not limited to personal delivery, express courier (such

                                  5

as Federal Express)  and prepaid  certified or  registered mail  with
return receipt requested.  Notices shall be deemed to have been given
and received  on the  date of  actual receipt  or, if  either of  the
following dates is applicable  and is earlier,  then on such  earlier
date: one  (1) business day  after sending,  if  sent by  or  express
courier; or three (3) business days after  deposit in the U.S.  mail,
if sent by  certified or  registered mail.   Notices  shall be  given
and/or  addressed  to  the   respective  parties  at  the   following
addresses:

               To the Company:          Amgen Inc.
                                   Attn.: General Counsel
                                   Amgen Center
                                   1840 DeHavilland Drive
                                   Thousand Oaks, CA  91320-1789

               To Former Executive:     Daniel Vapnek
                                   414 Plaza Rubio
                                   Santa Barbara, CA 93103

Any party may change its address for the purpose of this paragraph by
giving written notice of such change to the other party in the manner
herein provided.

          14.  Applicable Law.   This  Agreement shall  be  construed
according to  the laws  of  the State  of  California as  applied  to
contracts entered into within such state by residents thereof.

          15.  Binding  Effect.     Except  as  otherwise   expressly
provided herein, the provisions hereof shall inure to the benefit of,
and be binding  upon, the successors,  assigns, heirs, executors  and
administrators of the parties hereto; notwithstanding the  foregoing,
Former Executive shall not delegate any of his duties hereunder.

          16.  Counterparts.  This Agreement  may be executed in  two
counterparts, each of which shall be deemed an original, all of which
together shall constitute one and the same instrument.

                                     6

          IN WITNESS WHEREOF, the  parties hereto have executed  this
Agreement as of the respective dates written below.


CONSULTANT:



/s/ Daniel Vapnek
- -----------------
Daniel Vapnek

Date:          November 15, 1996



AMGEN INC.



By:  /s/ Gordon M. Binder
     -----------------------------
     Gordon M. Binder
     Chairman of the Board and CEO

Date:          November 12, 1996

                                         7