EXHIBIT 10.49

May 30, 1995


Mr. George A. Vandeman
1600 Waverly Road
San Marino, California  91108

Dear George:

I am pleased  to offer  you the  position of  Senior Vice  President,
General Counsel and Corporate Secretary.  In the next meeting of  the
Board of Directors the Board will elect you as an officer of Amgen.

Your monthly salary will be $27,100.  Amgen is prepared to offer  you
a five year adjustable  rate loan up to  $1.7 million, which will  be
secured by residential  real estate.   The 1995 rate  on the loan  is
4.9%.  The rate  is adjusted January  1st of each  year based on  the
average "Introduction  Rates"  on  adjustable  loans  as  offered  by
California banks and savings & loans.   The most the rate will change
each year is 1% with a cap of 3%  over the life of the initial  loan.
You will be required to make annual interest-only payments, with  the
principal amount due on  or before the end  of the five-year  period.
At the end of  this period you  may discuss with  Amgen an option  to
convert to a fully  amortized loan payable  over an additional  five-
year  period  with  terms  agreed  upon  at  that  time.    Following
commencement of employment, you will be  entitled to a signing  bonus
of $500,000.   We  will agree  to pay  this in  installments of  your
choosing, payable in no more than  three years with deferred  amounts
increased by a present value factor of 8% annual rate calculated on a
360 day  basis.   This signing  bonus is  subject to  withholding  as
required by law.  In addition, you will be eligible to participate in
the Amgen Management Incentive Plan (MIP) with a  target award of 61%
of your base pay.   During 1995  and 1996, you  will be guaranteed  a
minimum MIP payment of  $200,000 annual rate,  prorated in 1995  from
the start of your  employment at Amgen until  December 31, 1995,  and
for the full year in 1996.  This  plan is an annual plan with  awards
paid following the close of the year, usually by the end of February.

In addition,  you will  be granted  the  option to  purchase  100,000
shares of Amgen common stock.  All  shares will be priced at 100%  of
the fair market value at the close of the stock market on your  start
date.  The shares will be granted as Incentive Stock Options  (ISO's)
to the extent permitted by law, with the balance being issued as Non-
Qualified (NQ's) stock options.   If you choose,  all of the  options
can be issued as NQ's.  The options  will have a seven year term  and
will vest  over five  years in  equal annual  installments of  20,000
shares commencing with your first anniversary.  Amgen will  guarantee
that, calculated as if you had not sold any of the underlying  stock,
the then vested portion of the 100,000 share options will  appreciate
in value by at least $2,500,000 on at least one day on or before  the
fifth anniversary of  your start  date.   Of course,  Amgen will  not
guarantee that you will  actually realize this profit  if you do  not
sell all of the vested option shares on that date.

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You  will  also   have  the   opportunity  to   participate  in   our
comprehensive benefits program.   Materials  describing the  benefits
programs and other conditions  which are applicable  to our offer  of
employment are enclosed.  Please  note particularly the home  selling
and relocation benefits.

You  have  made  an  excellent  impression  on  all  of  us.    I  am
enthusiastic about the contributions you can  make to our efforts  to
build upon  the success  of Amgen,    and I  believe that  Amgen  can
provide you with  attractive opportunities  for personal  achievement
and growth.

Assuming your acceptance, please return a signed copy of this  letter
to Ed Garnett.  I will review a  draft of the press release with  you
before it is issued.

Sincerely yours,


/s/  Gordon M. Binder
Gordon M. Binder
Chairman and Chief Executive Officer


Accepted:


/s/  George A. Vandeman       June 1, 1995   July, 1995
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George A. Vandeman            Date           Anticipated State Date


cc:  Ed Garnett

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