AMGEN INC. Exhibit 21 SUBSIDIARY STATE OF INCORPORATION (Name under which OR subsidiary does business) ORGANIZATION Amgen AB Sweden Amgen Australia Pty Limited Australia Amgen-Bio-Farmaceutica, Lda. Portugal Amgen Boulder Development Colorado Corporation Amgen Boulder Production Colorado Corporation Amgen B.V. The Netherlands Amgen Cambridge Real Estate Delaware Holdings Inc. Amgen Canada Inc. Canada Amgen Caribe Corporation Puerto Rico Amgen (Europe) AG Switzerland Amgen Europe B.V. The Netherlands Amgen GmbH Austria Amgen GmbH Germany Amgen Greater China, Ltd. Hong Kong Amgen Holding, Inc. California Amgen International Inc. Delaware Amgen Kabushiki Kaisha Japan Amgen Limited United Kingdom Amgen N.V. Belgium Amgen Puerto Rico, Inc. Delaware 1 SUBSIDIARY STATE OF INCORPORATION (Name under which OR subsidiary does business) ORGANIZATION Amgen Sales Corporation Barbados Amgen S.A. France Amgen S.A. Spain Amgen S.p.A. Italy Kirin-Amgen, Inc. Delaware Synergen B.V. The Netherlands Synergen Europe, Inc. Colorado 2