EXHIBIT 10.18

                                AMGEN INC.
                       SUPPLEMENTAL RETIREMENT PLAN
            (As Amended and Restated Effective January 1, 1998)



                                 ARTICLE I
                       INTRODUCTION AND PLAN PURPOSE

  The Amgen Supplemental Retirement Plan (the "Plan") was established by
  Amgen Inc. (the "Company") effective as of January 1, 1993 and was
  amended and restated effective January 1, 1998. The purpose of this
  Plan is to provide benefits to employees of the Company and certain of
  its affiliates whose Matching Contributions and Core Contributions are
  limited under the Amgen Inc. Retirement and Savings Plan (the
  "Retirement Plan").  The Company intends that the Plan will aid in
  retaining and attracting employees of exceptional ability by providing
  them with these benefits.


                                   ARTICLE II
                                  DEFINITIONS

  For the purposes of this Plan, the following terms, when capitalized,
  have the following meanings, and, except as provided otherwise below,
  the terms defined in the Retirement Plan shall have the meanings
  provided in the Retirement Plan.

  2.1  Account means the Account maintained by the Company in accordance
  with Article IV with respect to Matching Credits, Core Credits and
  Earnings.

  2.2  Beneficiary means the person, persons or entity entitled under
  Article VI to receive Plan benefits payable in the event of your
  death.

  2.3  Board means the Board of Directors of the Company.

  2.4  Code means the Internal Revenue Code of 1986, as amended.

  2.5  Committee means the Compensation Committee of the Company's
  Board.

  2.6  Company means Amgen Inc. or any subsidiary or affiliate of Amgen
  Inc. selected by the Board or the Committee to participate in the
  Plan.

  2.7  Compensation has the same meaning as such term has under the
  Retirement Plan, except that, for purposes of this Plan, Compensation
  is not limited by the Salary Cap and Compensation for purposes of this
  Plan will not include any foreign assignment differential, that is, an
  amount paid to you to compensate for costs unique to an overseas
  assignment.

  2.8  Core Credit means the amount credited to your Account under
  Section 4.2(a) of the Plan.
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  2.9  Deferral Commitment means the election to defer "Participant
  Elected Contributions" under the Retirement Plan.

  2.10  Earnings means the amount credited to your Account under Article
  IV.

  2.11  Matching Credit refers to amounts credited to your Account under
  Section 4.2(b) of the Plan.

  2.12  Normal Retirement Date means the first day of the month
  coincident with or next following your attainment of age 65.

  2.13  Participation Agreement means the agreement you file with the
  Committee acknowledging the terms of the Plan and enrolling in the
  Plan.

  2.14  Retirement Plan means the Amgen Inc. Retirement and Savings
  Plan.

  2.15  Salary Cap means the highest level of compensation that can be
  considered for the purpose of calculating benefits under Section
  401(a)(17) of the Code ($160,000 for 1998).

  2.16  Spouse means your wife or husband who is lawfully married to the
  you at the time of your death.


                                ARTICLE III
                       ELIGIBILITY AND PARTICIPATION

  3.1  Eligibility.  You are eligible to participate in the Plan if you
  are an employee of the Company whose compensation for a particular
  year is in excess of the Salary Cap.

  3.2  Participation.  If you are eligible, you may elect to participate
  in the Plan with respect to any calendar year by submitting a
  Participation Agreement to the Committee by the last day of the
  calendar year in which you are eligible and wish to participate.  Your
  participation in the Plan will continue unless and until you submit a
  new Participation Agreement changing or canceling your participation.


                                ARTICLE IV
                          CREDITS TO YOUR ACCOUNT

  4.1  Account.  For record keeping purposes only, an Account will be
  maintained for you.  Your Account will be used solely to determine the
  amounts to be paid to you under the Plan.  Your Account will not
  constitute or be treated as a trust fund for your benefit.

  4.2  Credits.  As of the last day of each calendar month, the Company
  will credit your Account with your share of Matching Credits and Core
  Credits

  (a)  Core Credits.  The amount of Core Credits to be credited to your
  account will be determined by calculating first what you would have
  received as a Core Contribution under the Retirement Plan without
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  considering the Salary Cap, less the amount of core contributions that
  were actually contributed on your behalf to the Retirement Plan.

  (b)  Matching Credits.  The amount of Matching Credits to be credited
  to your account will be the amount of matching contributions that
  would have been made on your behalf under the Retirement Plan as if
  the Salary Cap were not in effect, based on your Deferral Commitment
  in effect at the time the Salary Cap is reached for the year (provided
  that you demonstrate to the Company that you have set aside for
  investment an amount equal to the amount you were prevented from
  deferring because of the Salary Cap) less the amount of matching
  contributions that were actually contributed on your behalf to the
  Retirement Plan.

  4.3  Earnings.  On the last day of each calendar month, your Account
  will be credited with Earnings with respect to the investments of the
  Core and Matching Credits credited to your Account.  Notwithstanding
  the foregoing, if you terminate service as a result of Normal
  Retirement, death or Disability (as defined in the Retirement Plan),
  you will be entitled to Earnings up to the date of distribution of
  your Account.  Earnings will be credited at the rate declared by the
  Committee, acting in its sole discretion, after taking into account
  the investment performance of the investment vehicles selected by the
  Committee, or, if the Committee permits, selected by you from among
  the investment vehicles available under the Retirement Plan.

  4.4  Vesting of Your Account.  Your Account will become fully vested
  upon termination of employment with the Company on or after (1) your
  Normal Retirement Date, (2) the date you become disabled (as
  determined under the terms of the Retirement Plan), or (3) your death.
  If your employment with the Company is terminated for any other
  reason, your Account will be vested in accordance with the following
  schedule:

          Years of Service         Vested Percentage

          Less than 5                    0%
          5 but less than 6             50%
          6 but less than 7             60%
          7 but less than 8             70%
          8 but less than 9             80%
          9 but less than 10            90%
          10 or more                   100%

  However, your entire Account will be subject to the creditors of the
  Company in the event of the insolvency of the Company.

  4.5  Determination of Accounts.  Your Account will consist of all your
  credited Matching Credits, Core Credits, and Earnings.

  4.6  Statement of Accounts.  Prior to March 1 of each year or at such
  other time as determined by the Committee, the Committee will
  distribute statements to you showing the balance of your Account.




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                                 ARTICLE V
                               DISTRIBUTIONS
  
  5.1  Distributions.  Following the termination of your employment with
  the Company, the Company will pay you the vested balance in your
  Account.  The payments will be made to you in cash and may be paid
  either in a lump sum or in periodic installments at such time and in
  such form as determined by the Committee.  If you are paid in periodic
  installments, the amount of each installment will be equal to the
  vested balance in your Account divided by the number of remaining
  installments that you are to receive.  Any unpaid balance will
  continue to receive Earnings.  In the event of your death prior to
  receiving your full distribution, the unpaid balance will be paid to
  your Beneficiary at such times and in such form as the Committee
  determines in its sole discretion.

  5.2  Withholding; Payroll Taxes.  The Company will withhold any taxes
  required to be withheld from payments made from the Plan to satisfy
  any federal, state, or local requirements regarding tax withholding.

  5.3  Payment to Guardian.  If a Plan benefit is payable to a minor, a
  person declared incompetent or a person incapable of handling the
  disposition of property, the Committee may direct payment of such Plan
  benefit to the guardian, legal representative or person having the
  care and custody of such minor, incompetent or person.  The Committee
  may require proof of incompetency, minority, incapacity or
  guardianship as may be appropriate prior to distribution of the Plan
  benefit.  Such distribution completely discharges the Committee and
  the Company from all liability with respect to such benefit.


                               ARTICLE VI
                        BENEFICIARY DESIGNATION

  6.1  Beneficiary Designation.  Your Beneficiary under the Plan will be
  the same Beneficiary you select under the Retirement Plan.  If you
  change your Beneficiary designation made under the Retirement Plan you
  will automatically change the Beneficiary designation under the Plan.

  6.2  No Beneficiary Designation.  If you fail to designate a
  Beneficiary under the Retirement Plan, or if the Beneficiary you
  designate dies before you or before complete distribution of your
  benefits, your designated Beneficiary will be the first of the
  following classes in which there is a survivor:

  (a)  your surviving Spouse;

  (b)  your children, except if any of the children predecease you but
  leave surviving issue, then such issue will take by right of
  representation the share the parent would have taken if living;

  (c)  your estate.

  6.3  Effect of Payment.  The payment to the Beneficiary completely
  discharges Company's obligations under this Plan.

  
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                              ARTICLE VII
                             ADMINISTRATION
  
  7.1  Committee; Duties.  This Plan is administered by the Committee.
  The Committee is responsible for making such rules, interpretations
  and computations as may be appropriate. Any decision of the Committee
  with respect to the Plan including, without limitation, any
  determination of eligibility to participate in the Plan and any
  calculation of Plan benefits, is conclusive and binding on all
  persons.  The Committee may appoint a panel consisting of any number
  of individuals, who may or may not be employees of the Company, to
  carry out the Committee's duties and responsibilities under the Plan.

  7.2  Agents.  The Committee may employ other agents and delegate to
  them such administrative duties as it sees fit, and may from time to
  time consult with counsel who may be counsel to the Company.

  7.3  Binding Effect of Decisions.  The decisions or actions of the
  Committee with respect to any question arising out of or in connection
  with the administration, interpretation or application of the Plan and
  the rules or regulations promulgated hereunder will be final,
  conclusive and binding upon all persons having any interest in the
  Plan.

  7.4  Indemnity of Committee.  The Company will indemnify and hold
  harmless the members of the Committee against any and all claims,
  loss, damage, expense or liability arising from any action or failure
  to act with respect to this Plan, except in the case of the
  Committee's gross negligence or willful misconduct.

  7.5  Claims Procedure.  The Claims Procedure under the Plan is the
  same as that under the Retirement Plan, except that the Committee will
  be substituted for the Review Panel.


                              ARTICLE VIII
                   AMENDMENT AND TERMINATION OF PLAN

  8.1  Amendment.  The Committee may at any time amend the Plan in whole
  or in part.  No amendment may decrease or restrict the amount accrued
  in any Account maintained under the Plan through the date of
  Amendment.

  8.2  Company's Right to Terminate.  The Board may at any time
  partially or completely terminate the Plan if, in its judgment, the
  tax, accounting, or other effects of the continuance of the Plan, or
  potential payments thereunder, would not be in the best interests of
  the Company.


                               ARTICLE IX
                             MISCELLANEOUS

  9.1  Unfunded Plan.  This Plan is intended to be an unfunded plan for
  tax law purposes and for purposes of Title I of the Employee
  Retirement Income Act of 1974, as amended ("ERISA"), maintained
  primarily to provide benefits for a select group of management or
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  highly compensated employees.  This Plan is not intended to create an
  investment contract, but to provide tax planning opportunities and
  retirement benefits to eligible individuals who have elected to
  participate in the Plan.  Eligible individuals are members of
  management who, by virtue of their position with the Company, are
  uniquely informed as to the Company's operations and have the ability
  to materially affect the Company's profitability and operations.

  9.2  Unsecured General Creditor.  Neither you nor your Beneficiaries,
  heirs, successors and assigns will have any legal or equitable rights,
  interest or claims in any property or assets of Company, nor will they
  be Beneficiaries of, or have any rights, claims or interests in any
  life insurance policies, annuity contracts or the proceeds therefrom
  owned or which may be acquired by Company.  Such policies or other
  assets of Company will not be held under any trust for your benefit or
  that of your Beneficiaries, heirs, successors or assigns, or held in
  any way as collateral security for the fulfilling of the obligations
  of Company under this Plan.  Any and all of Company's assets and
  policies will be, and remain, the general, unpledged, unrestricted
  assets of Company.  Company's obligation under the Plan will be that
  of an unfunded and unsecured promise of Company to pay money in the
  future.

  9.3  Trust Fund.  The Company will pay all Plan benefits.  At its
  discretion, the Company may establish one or more trusts, with such
  trustees as the Board may approve, for the purpose of providing for
  the payment of such benefits.  Such trust or trusts may be
  irrevocable, but the assets thereof will be subject to the claims of
  the Company's creditors.  To the extent any benefits provided under
  the Plan are actually paid from any such trust, the Company will have
  no further obligation with respect thereto, but to the extent not so
  paid, such benefits will remain the obligation of, and paid by, the
  Company.

  9.4  Nonassignability.  Neither you nor any other person may commute,
  sell, assign, transfer, hypothecate or convey in advance of actual
  receipt the amounts, if any, payable hereunder, or any part thereof,
  which are expressly declared to be nonassignable and nontransferable.
  No part of the amounts payable will, prior to actual payment, be
  subject to seizure or sequestration for the payment of any debts,
  judgments, alimony or separate maintenance owed by you or any other
  person (other than amounts owed to the Company's creditors in the
  event of the Company's insolvency), nor be transferable by operation
  of law in the event of the bankruptcy or insolvency of you or any
  other person (other than the Company).  Notwithstanding the above,
  benefits will be payable to an individual other than you under this
  Plan upon the determination by the administrative committee of the
  Retirement Plan that a domestic relations order is a Qualified
  Domestic Relations Order (as such term is defined in Code Section
  414(p)).

  9.5  Not a Contract of Employment.  The terms and conditions of this
  Plan may not be construed to constitute a contract of employment
  between you and the Company and you (or your Beneficiary) will have no
  rights against the Company except as otherwise specifically provided
  herein.  Moreover, nothing in this Plan will be deemed to give you the
  right to be retained in the service of the Company or to interfere
  with the right of the Company to discipline or discharge you at any
  time.                           
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  9.6  Cooperation.  You are required to cooperate with the Company by
  furnishing any and all information requested by the Company in order
  to facilitate the payment of benefits hereunder.

  9.7  Terms.  Whenever words are used in this Plan in the masculine
  they will be construed as though they were used in the feminine in all
  cases where they would so apply; and whenever any words are used in
  this Plan in the singular or in the plural, they will be construed as
  though they were used in the plural or the singular, as the case may
  be, in all cases where they would so apply.

  9.8  Captions.  The captions of the articles, sections and paragraphs
  of this Plan are for convenience only and do not control or affect the
  meaning or construction of any of its provisions.

  9.9  Governing Law.  The provisions of this Plan is to be construed
  and interpreted according to the laws of the State of California to
  the extent that they have not been preempted by federal law.

  9.10  Validity.  In case any provision of this Plan is found to be
  held illegal or invalid for any reason, said illegality or invalidity
  will not affect the remaining parts hereof, but this Plan will be
  construed and enforced as if such illegal and invalid provision had
  never been inserted herein.

  Adopted this 16th day of February, 1998.



                                        /s/  Edward F. Garnett
                                        Edward F. Garnett
                                        Vice President, Human Resources

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