GENENTECH, INC.

                        1991 Employee Stock Plan, as Amended

     1.  Purpose

     The purpose of this 1991 Employee Stock Plan (the "Plan") is to 
provide employees of Genentech, Inc. (the "Company"), and its U.S. 
subsidiaries designated by the Company's Board of Directors, who wish to 
become stockholders of the Company an opportunity to purchase Redeemable 
Common Stock of the Company (the "Shares").  The Plan is intended to 
qualify as an "employee stock purchase plan" within the meaning of Section 
423 of the Internal Revenue Code of 1986, as amended (the "Code").

     2.  Eligible Employees

     Subject to the provisions of Sections 7, 8 and 9 below, any individual 
who is in the full-time employment of the Company on the day on which a 
Grant Date (as defined in Section 3 below) occurs is eligible to 
participate in an offering of Shares made by the Company hereunder.  In 
addition, the board of Directors may at any time designate one or more of 
the Company's U.S. subsidiary corporations (as defined in Section 425(f) of 
the Code) to be included in an offering of Shares under the Plan.  Full-
time employment shall mean employment by the Company or its designated
U. S. subsidiary for:

          (a)  20 hours or more per week; and

          (b)  more than five months in the calendar year.

     3.  Grant Dates

     From time to time, the Board of Directors may fix a date (a "Grant 
Date") or a series of dates (each of which is a "Grant Date") on which the 
Company will grant rights to purchase Shares ("Rights") to employees 
eligible to participate.

     4.  Prices

     The purchase price per Share for Shares covered by a grant of Rights 
hereunder shall be determined by the Board of Directors, but in no event 
shall be less than the lesser of:

          (a)  eighty-five percent (85%) of the fair market value of a
               Share on the Grant Date on which such Right was granted; or

          (b)  eighty-five percent (85%) of the fair market value of a
               Share on the date such Right is exercised as to that Share.

     5.  Exercise of Rights and Method of Payment

          (a)  Rights granted under the Plan will be exercisable on
               specific dates as determined by the Board of Directors.

          (b)  The method of payment for Shares purchased upon exercise of
               Rights granted hereunder shall be through regular payroll
               deductions or by lump sum cash payment, or both, as
               determined by the Board of Directors.  No interest shall be
               paid upon payroll deductions or other payments in exercise
               of Rights unless specifically provided for by the Board of
               Directors.

     6.  Terms of Rights

     Rights granted hereunder shall be exercisable during a twenty-seven 
(27) month period or such shorter period as determined by the Board of 
Directors.  All Rights granted to an employee shall terminate upon 
termination of full-time employment of the employee.  Any payments received 
by the Company from a participating employee with respect to a Right 
granted hereunder and not utilized for the purchase of Shares upon exercise 
of such Right shall be promptly returned to such employee by the Company 
after termination of such Right, except that amounts that were not so 
utilized because such amounts were insufficient to purchase a whole Share 
may be applied toward the purchase of Shares pursuant to a Right 
subsequently granted hereunder, if any.

     7.     Shares Subject to the Plan

     No more than three million eight hundred thousand (3,800,000) Shares 
may be sold pursuant to Rights granted under the Plan.  Appropriate 
adjustments in the above figure, in the number of Shares covered by 
outstanding Rights granted hereunder, in the exercise price of the Rights 
and in the maximum number of Shares which an employee may purchase 
(pursuant to Section 9 below) shall be made to give effect to any mergers, 
consolidations, reorganizations, recapitalizations, stock splits, stock 
dividends or other relevant changes in the capitalization of the Company 
occurring after the effective date of the Plan, provided that no fractional 
Shares shall be subject to a Right and each Right shall be adjusted 
downward to the nearest full Share.  Any agreement of merger or 
consolidation will include provisions for protection of the then existing 
Rights of participating employees under the Plan.  Either authorized and 
unissued Shares or issued Shares heretofore or hereafter reacquired by the 
Company may be made subject to Rights under the Plan.  If for any reason 
any Right under the Plan terminates in whole or in part, Shares subject to 
such terminated Right may again be subject to a Right under the Plan.

     8.  Limitations on Grants

     Anything to the contrary notwithstanding, pursuant to Section 423 of 
the Code:

          (a)  No employee shall be granted a Right hereunder if such
               employee, immediately after the Right is granted, owns stock
               possessing five percent (5%) or more of the total combined
               voting power or value of all classes of stock of the
               Company, its parent corporation (as defined in Section
               425(c) of the Code) or any subsidiary corporation, in each
               case computed in accordance with Section 423(b)(3) of the
               Code.

          (b)  No employee shall be granted a Right which permits his
               Rights to purchase Shares under all employee stock purchase
               plans of the Company and its subsidiaries to accrue at a
               rate which exceeds twenty-five thousand dollars ($25,000)
              (or such other maximum as may be prescribed from time to time
               by the Code) of fair market value of such Shares (determined
               at the time such Right is granted) for each calendar year in
               which such Right is outstanding at any time, all in
               accordance with the provisions of Section 423(b)(8) of the
               Code.



     9.  Limits on Participation

      (a)  Participation shall be limited to eligible employees who enroll
           under the Plan.

      (b)  No Right granted to any participating employee shall cover more
           than twelve thousand (12,000) Shares.

      (c)  No more than One Hundred Eighty Thousand (180,000) Shares may be
           purchased during any calendar quarter upon the exercise of
           Rights granted under the Plan; provided, however, that for those
           calendar quarters in which the Company pays regular annual
           bonuses to eligible employees, the maximum aggregate numbers of
           Shares which may be purchased upon the exercise of Rights shall
           be Two Hundred Thousand (200,000) Shares.  If the aggregate
           purchases of Shares upon exercises of Rights granted under the
           Plan would exceed the applicable maximum number for a particular
           calendar quarter, the maximum permitted number of Shares shall
           be allocated to the exercising participants in proportion to the
           number of Shares they would otherwise purchase during such
           calendar quarter.

     10.  Employee's Rights as Stockholder
     No participating employee shall have any Rights as a stockholder in 
the Shares covered by a Right granted hereunder until such Right has been 
exercised, full payment has been made for the corresponding Shares and the 
purchase has been entered in the records of the Transfer Agent for the 
Shares.

     11.  Rights Not Transferable

     Rights under the Plan are not assignable or transferable by a 
participating employee.

     12.  Amendments or Discontinuance of the Plan

      The Board of Directors of the Company shall have the right to amend, 
modify or terminate the Plan at any time without notice; provided, however, 
that the then existing Rights of all participating employees shall not be 
adversely affected thereby, except that in the case of a participating 
employee of a foreign branch of the Company or a designated U.S. subsidiary 
corporation  the Plan may be varied to conform with local laws, and 
provided further that, subject to the provisions of Section 7 above, no 
such amendment to the Plan shall, without the approval of the stockholders 
of the Company:

          (a)  Increase the total number of Shares which may be offered
               under the Plan;

          (b)  Amend the Plan in any manner which would render Rights
               granted hereunder unqualified for special tax treatment
               under Section 421 of the Code.









     13.  Effective Date and Approvals.

     The Plan shall become effective as of January 1, 1991.  The Company's 
obligation to offer, sell or deliver its Shares under the Plan is subject 
to the approval of the Company's stockholders and any governmental approval 
required in connection with the authorized issuance or sale of such Shares 
and is further subject to the determination by the Company that all 
applicable securities laws have been complied with. 

     14.  Administration of the Plan

     The Board of Directors or any committee or person(s) to whom it 
delegates its authority (the "Administrator") shall administer, interpret 
and apply all provisions of the Plan.  The Administrator may waive such 
provisions of the Plan as it deems necessary to meet special circumstances 
not anticipated or covered expressly by the Plan.  Nothing contained in 
this Section shall be deemed to authorize the Administrator to alter or 
administer the provisions of the Plan in a manner inconsistent with the 
provisions of Section 423 of the Code.