SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the year ended: December 31, 1994 ___ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ___________ to ___________. Commission file number: 1-9813 GENENTECH, INC. TAX REDUCTION INVESTMENT PLAN (Full title of the Plan) GENENTECH, INC. (Name of issuer of the securities held pursuant to the Plan) 460 Point San Bruno Boulevard South San Francisco, California 94080 (address of principal executive office) Genentech, Inc. Tax Reduction Investment Plan Index to Financial Statements Item Page No. __________________________________________________________ _________ Statement Of Net Assets Available For Benefits With Fund Information at December 31, 1994 and 1993 3-4 Statement Of Changes in Net Assets Available For Benefits With Fund Information for Years Ended December 31, 1994 and 1993 5-8 Notes to Financial Statements 9-13 Report of Ernst & Young LLP, Independent Auditors 14 Page 2 Genentech, Inc. Tax Reduction Investment Plan Statement Of Net Assets Available For Benefits With Fund Information December 31, 1994 FIDELITY FIDELITY GROWTH FIDELITY FIDELITY GENENTECH MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ __________ ____________ ASSETS: Investments, at fair value $ 9,090,200 $18,511,180 $ 4,725,960 $ 9,837,949 $ 1,567,685 Contribution receivable from Genentech, Inc. 560,300 1,211,006 433,460 782,252 130,119 ___________ ___________ ___________ ___________ ___________ Net assets available for benefits $ 9,650,500 $19,722,186 $ 5,159,420 $10,620,201 $ 1,697,804 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ __________ ___________ ___________ ASSETS: Investments, at fair value $ 3,079,304 $12,769,920 $ 379,027 $ 479,134 $ 100,471 Contribution receivable from Genentech, Inc. 302,190 760,508 31,127 47,757 10,507 ___________ ___________ __________ ___________ ___________ Net assets available for benefits $ 3,381,494 $13,530,428 $ 410,154 $ 526,891 $ 110,978 =========== =========== ========== =========== =========== FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $7,476,596 $ 766,488 $ 2,108,168 $70,892,082 Contribution receivable from Genentech, Inc. 695,091 72,703 - 5,037,020 ___________ ___________ ___________ ___________ Net assets available for benefits $8,171,687 $ 839,191 $ 2,108,168 $75,929,102 =========== =========== =========== =========== <FN> See accompanying notes. Page 3 Genentech, Inc. Tax Reduction Investment Plan Statement Of Net Assets Available For Benefits With Fund Information December 31, 1993 FIDELITY FIDELITY GROWTH FIDELITY FIDELITY GENENTECH MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $ 7,906,574 $15,970,535 $ 3,536,048 $ 7,659,408 $ 1,505,628 Contribution receivable from Genentech, Inc. 490,233 1,168,119 367,222 677,284 130,259 ___________ ___________ ___________ ___________ ___________ Net assets available for benefits $ 8,396,807 $17,138,654 $ 3,903,270 $ 8,336,692 $ 1,635,887 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ __________ ___________ ___________ ASSETS: Investments, at fair value $ 1,298,281 $12,978,484 $ - $ - $ - Contribution receivable from Genentech, Inc. 150,843 820,353 - - - ___________ ___________ __________ ___________ ___________ Net assets available for benefits $ 1,449,124 $13,798,837 $ - $ - $ - =========== =========== ========== =========== =========== FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $ 6,162,063 $ 577,657 $ 1,932,356 $59,527,034 Contribution receivable from Genentech, Inc. 552,308 61,793 - 4,418,414 ___________ ___________ ___________ ___________ Net assets available for benefits $ 6,714,371 $ 639,450 $ 1,932,356 $63,945,448 =========== =========== =========== =========== <FN> See accompanying notes. Page 4 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1994 FIDELITY FIDELITY GROWTH FIDELITY FIDELITY GENENTECH MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ - $ 714,604 $ 184,569 $ 685,781 $ 114,297 Realized/unrealized gain (loss) (866,955) (1,093,888) (291,449) (510,850) (149,764) ___________ ___________ ___________ ___________ ___________ Total investment income (loss) (866,955) (379,284) (106,880) 174,931 (35,467) Contributions: Basic 1,071,061 2,667,629 970,509 1,573,614 290,105 Rollover 210,014 329,653 152,702 133,718 61,131 Match 560,300 1,211,006 433,460 782,252 130,119 ___________ ___________ ___________ ___________ ___________ Total contributions 1,841,375 4,208,288 1,556,671 2,489,584 481,355 Distributions (296,105) (1,122,164) (214,079) (462,304) (63,090) Administrative fees - (263) (138) (488) (213) Transfers between funds 575,378 (123,045) 20,576 81,786 (320,668) ___________ ___________ ___________ ___________ ___________ Net change during the year 1,253,693 2,583,532 1,256,150 2,283,509 61,917 Net assets available for benefits: Beginning of year 8,396,807 17,138,654 3,903,270 8,336,692 1,635,887 ___________ ___________ ___________ ___________ ___________ End of year $9,650,500 $19,722,186 $5,159,420 $10,620,201 $1,697,804 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ____________ ___________ ___________ ___________ Investment income: Interest and dividends $ 51,194 $ 415,428 $ 6,639 $ 11,389 $ 2,387 Realized/unrealized gain (loss) (89,011) (1,161,346) (17,164) (27,207) (3,234) ___________ ____________ ___________ ___________ __________ Total investment income (loss) (37,817) (745,918) (10,525) (15,818) (847) Contributions: Basic 558,867 1,710,194 35,174 46,145 7,013 Rollover 115,244 129,549 17,876 26,360 15,792 Match 302,190 760,508 31,127 47,757 10,507 ___________ ____________ ___________ ___________ __________ Total contributions 976,301 2,600,251 84,177 120,262 33,312 Distributions (95,208) (426,289) (11) (222) - Administrative fees - (1,075) - - - Transfers between funds 1,089,094 (1,695,378) 336,513 422,669 78,513 ___________ ____________ ___________ ___________ __________ Net change during the year 1,932,370 (268,409) 410,154 526,891 110,978 Net assets available for benefits: Beginning of year 1,449,124 13,798,837 - - - ___________ ____________ ___________ ___________ __________ End of year $3,381,494 $13,530,428 $ 410,154 $ 526,891 $ 110,978 =========== ============ =========== =========== ========== Page 5 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1994 FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ 284,770 $ 22,532 $ 164,622 $2,658,212 Realized/unrealized gain (loss) - (19,448) - (4,230,316) ___________ ___________ ___________ ___________ Total investment income (loss) 284,770 3,084 164,622 (1,572,104) Contributions: Basic 1,064,080 169,751 - 10,164,142 Rollover 105,180 59,664 - 1,356,883 Match 695,091 72,703 - 5,037,020 ___________ ___________ ___________ ___________ Total contributions 1,864,351 302,118 - 16,558,045 Distributions (265,257) (15,510) (37,377) (2,997,616) Administrative fees (2,369) (125) - (4,671) Transfers between funds (424,179) (89,826) 48,567 - ___________ ___________ ___________ ___________ Net change during the year 1,457,316 199,741 175,812 11,983,654 Net assets available for benefits: Beginning of year 6,714,371 639,450 1,932,356 63,945,448 ___________ ___________ ___________ ___________ End of year $ 8,171,687 $ 839,191 $ 2,108,168 $75,929,102 =========== =========== =========== =========== <FN> See accompanying notes. Page 6 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1993 FIDELITY FIDELITY GROWTH FIDELITY FIDELITY GENENTECH MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ - $ 1,443,725 $ 318,451 $ 417,782 $ 110,909 Realized/unrealized gain (loss) 2,101,951 1,437,269 94,725 720,966 44,894 ___________ ___________ ___________ ___________ ___________ Total investment income (loss) 2,101,951 2,880,994 413,176 1,138,748 155,803 Contributions: Basic 999,575 2,235,134 683,575 1,360,576 269,116 Rollover 32,428 165,756 60,128 102,202 28,921 Match 490,233 1,168,119 367,222 677,284 130,259 ___________ ___________ ___________ ___________ ___________ Total contributions 1,522,236 3,569,009 1,110,925 2,140,062 428,296 Distributions (276,300) (749,327) (89,426) (503,419) (173,785) Administrative fees - - - - - Transfers between funds (548,703) (198,861) 719,956 522,703 (172,398) ___________ ___________ ___________ ___________ ___________ Net change during the year 2,799,184 5,501,815 2,154,631 3,298,094 237,916 Net assets available for benefits: Beginning of year 5,597,623 11,636,839 1,748,639 5,038,598 1,397,971 ___________ ___________ ___________ ___________ ___________ End of year $ 8,396,807 $17,138,654 $3,903,270 $8,336,692 $1,635,887 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ 18,557 $ 1,098,241 $ - $ - $ - Realized/unrealized gain (loss) 192,698 829,887 - - - ___________ ___________ ___________ ___________ ___________ Total investment income (loss) 211,255 1,928,128 - - - Contributions: Basic 177,706 1,726,754 - - - Rollover 53,001 132,984 - - - Match 150,843 820,353 - - - ___________ ___________ ___________ ___________ ___________ Total contributions 381,550 2,680,091 - - - Distributions (64,465) (563,198) - - - Administrative fees - - - - - Transfers between funds 511,417 171,516 - - - ___________ ___________ ___________ ___________ ___________ Net change during the year 1,039,757 4,216,537 - - - Net assets available for benefits: Beginning of year 409,367 9,582,300 - - - ___________ ___________ ___________ ___________ ___________ End of year $ 1,449,124 $13,798,837 $ - $ - $ - =========== =========== =========== =========== =========== Page 7 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1993 FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ 198,008 $ 22,614 $ 131,638 $ 3,759,925 Realized/unrealized gain (loss) - 28,243 - 5,450,633 ___________ ___________ ___________ ___________ Total investment income (loss) 198,008 50,857 131,638 9,210,558 Contributions: Basic 1,195,261 151,249 - 8,798,946 Rollover 34,166 42,877 - 652,463 Match 552,308 61,793 - 4,418,414 ___________ ___________ ___________ ___________ Total contributions 1,781,735 255,919 - 13,869,823 Distributions (308,243) (56,928) (28,516) (2,813,607) Administrative fees - - - - Transfers between funds (1,496,740) (60,513) 551,623 - ___________ ___________ ___________ ___________ Net change during the year 174,760 189,335 654,745 20,266,774 Net assets available for benefits: Beginning of year 6,539,611 450,115 1,277,611 43,678,674 ___________ ___________ ___________ ___________ End of year $6,714,371 $ 639,450 $1,932,356 $63,945,448 =========== =========== =========== =========== <FN> See accompanying notes. Page 8 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Description of the Plan: The following description of the Genentech, Inc. Tax Reduction Investment Plan ("Plan") provides only general information. Participants should refer to the Plan document for a more complete description of the Plan's provisions. The Plan was established, effective January 1, 1985, by Genentech, Inc. ("Company") for the benefit of eligible employees of the Company in order to provide them with a means of supplementing their retirement income on a tax- favored basis, an incentive to continue and increase their efforts to contribute to the success of the Company, and an opportunity to acquire an equity interest in the Company. The Plan accomplishes this through a savings program which is based on systematic salary reductions. The employee's salary is reduced by the amount elected to be saved on a pre-tax basis. The "deferred" part of the employee's salary is then invested in the Plan. An individual employee's account is credited with earnings or losses on a pro rata basis as the actual investment funds report their earnings performance. Individuals eligible to participate under the Plan must be employees of the Company or employees of an affiliate of the Company that adopts the Plan with the approval of the Board of Directors. However, the following employees or classes of employees are not eligible to participate: (i) any employee who is classified as temporary by the Company; (ii) any part-time employee normally scheduled to work less than 20 hours per week, unless such employee has completed at least 1,000 hours of service in a 12-month period; (iii) any employee who is a member of a collective bargaining unit and who is covered by a collective bargaining agreement where retirement benefits were the subject of good faith bargaining; (iv) any individual employed by any corporation or other business entity that is merged or liquidated into the Company, unless the Company designates such employees as eligible employees; (v) any employee paid from a non-U.S. payroll; or (vi) any leased employee as defined under the Internal Revenue Code of 1986, as amended ("Code"). The Board of Directors of the Company has the right under the Plan to alter, amend or terminate the Plan, or any part thereof, in such a manner as it may determine. If the Plan is terminated, the interests of all Plan members remain fully (100%) vested and nonforfeitable. The balances credited to their accounts shall remain with the plan trustee until they become distributable in accordance with the Plan. The Company matches a portion of employee contributions, up to a maximum of 4% of a participant's eligible compensation ("Match"). The Match is effective December 31st of each year ("Effective Date") and contributions under the Match are fully vested at that time. The Match is funded in the first quarter of the subsequent year. In the first quarter of 1995 and 1994, the Company contributed approximately $5.0 million and $4.4 million, respectively, to the Plan in accordance with the terms of the Match. The plan trustee ("Plan Trustee") is Fidelity Management Trust Company. All amounts contributed to the Plan are deposited in a trust account with the Plan Trustee. The Plan Trustee's fees and expenses that are related to the accounts of active employees are paid by the Company and are not charged to the Plan. Effective January 1, 1994, Trustee's fees associated with accounts of terminated employees are charged to such employee accounts. The Plan Trustee has blanket bond insurance covering the full market value of the securities and investments of which it has custody. Page 9 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements In 1994, each participant in the Plan could elect to defer up to the lower of $9,240 or 15% of his or her eligible compensation, and, in 1993, $8,994 or 15% of his or her eligible compensation, except that in 1994 highly compensated employees were limited to the lower of $9,240 or 9% of eligible compensation and, in 1993, $8,994 or 9% of eligible compensation in accordance with the Code. For plan year 1994, each participant directs the investment of his or her contributions in any of the following twelve investment funds of the Plan (or any combination thereof): Genentech Stock Fund This fund invests only in the Redeemable Common Stock of the Company, which is purchased at full market price. The Redeemable Common Stock of the Company does not currently pay dividends; therefore the return on this fund is dependent solely on the performance of the stock. Fidelity Magellan Fund The Fidelity Magellan Fund is a mutual fund managed by Fidelity Management and Research Company ("FMR"). The fund invests primarily in the stocks of domestic and foreign growth companies. Fidelity Growth Company Fund The Fidelity Growth Company Fund is a mutual fund managed by FMR. It invests primarily in common stock and securities convertible into common stock of companies which it believes have above-average growth characteristics. Fidelity Growth & Income Fund The Fidelity Growth & Income Fund is a mutual fund managed by FMR, which invests primarily in securities of companies that offer growth of earnings potential while paying current dividends. Fidelity Intermediate Bond Fund The Fidelity Intermediate Bond Fund is a mutual fund managed by FMR. The Fidelity Intermediate Bond Fund invests in high and upper-medium grade corporate debt obligations with intermediate maturities, as well as obligations of the U.S. government and its agencies and U.S. banks. Fidelity Overseas Fund The Fidelity Overseas Fund is a mutual fund managed by FMR. The fund invests in foreign securities including common stock, securities convertible to common stock and debt instruments of foreign businesses and governments. Fidelity Balanced Fund The Fidelity Balanced Fund is a mutual fund managed by FMR that invests in high-quality bonds and high-yielding stocks. It is a growth and income fund that seeks a high level of income while preserving capital. Fidelity Asset Manager Fund The Fidelity Asset Manager Fund is a mutual fund managed by FMR. The Asset Manager Fund allocates its assets among domestic and foreign equities, bonds and short-term instruments, attempting to achieve a high total return with reduced risk over the long-term. Fidelity Asset Manager: Growth Fund The Fidelity Asset Manager: Growth mutual fund, managed by FMR, invests in domestic and foreign stocks, bonds and short-term instruments, seeking to maximize its total long-term return. Page 10 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Fidelity Asset Manager: Income Fund The Fidelity Asset Manager: Income Fund is a mutual fund managed by FMR which invests in income-producing domestic and foreign stocks, bonds and short-term instruments, with the goal of achieving a high level of current income. Fidelity Retirement Money Market Fund The Fidelity Retirement Money Market Fund is a mutual fund managed by FMR. It invests in high-quality United States dollar-denominated money market instruments of U.S. and foreign issuers, including short-term corporate obligations, U.S. government obligations and certificates of deposit. Fidelity U.S. Equity Index Fund The Fidelity U.S. Equity Index Fund, a mutual fund managed by FMR, invests mostly in the common stocks of the 500 companies that make up the Standard & Poor's 500 Index. Participant Loans Loans are made only to Plan participants at fixed interest rates 2% above the then current bank prime interest rate subject to certain restrictions, principally related to a participant's account balance, permissible loan amount, and repayment through payroll withholding. Loans are repaid through monthly payroll deductions over three or five years. Conditions of Withdrawal Distributions under the Plan will be made upon a participant's death, disability, retirement or other termination of employment with the Company, attainment of age 70-1/2, or authorized exercise of his or her withdrawal rights under the Plan (subject in all cases to regulation under the Code requiring the participant's consent to distribution unless he or she has attained age 62 or the balance credited to his or her account under the Plan does not exceed $3,500). Distributions are made upon receipt by the Plan administrator of the participant's or beneficiary's election directing the method of distribution. Prior to termination of employment with the Company, the Plan administrator may grant a participant's request for a withdrawal if either (i) the Plan administrator makes a determination that such withdrawal is necessary in light of the immediate and heavy financial needs of the participant and is in accordance with the requirements of the Code and regulations promulgated thereunder; or (ii) the participant is over age 59-1/2 at the time of withdrawal. (1) Summary of Significant Accounting Policies: Investment Valuation Investments are stated at market value at year end. Market values are determined as follows: The Genentech Stock Fund, Fidelity Magellan Fund, Fidelity Growth Company Fund, Fidelity Growth & Income Fund, Fidelity Intermediate Bond Fund, Fidelity Overseas Fund, Fidelity Balanced Fund, Fidelity Asset Manager Fund, Fidelity Asset Manager: Growth Fund, Fidelity Asset Manager: Income Fund, and Fidelity U.S. Equity Index Fund securities are valued at the last reported sales price on the last business day of the year, which represent the net asset values of shares held by the Plan at year end; the Fidelity Retirement Money Market Fund portfolio instruments are valued on the basis of historical cost which approximates fair value; and the Participant Loans are valued on the basis of cost, which approximates fair value. Page 11 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Contributions Basic contributions are accrued and vested when deducted from employee pay; the Match is accrued and vested on the Effective Date; and qualified rollover contributions are vested when received by the Plan Trustee. Contributions are invested pursuant to participants' directions to the Plan Trustee after receipt of contributions by the Plan Trustee. Participants may change the amount of contributions (as a percentage reduction of pre-tax eligible compensation) on a quarterly basis. Transfers between funds and changes in investment allocations can be made up to ten times per year on a daily basis effective upon request by the participant to Plan Trustee, except that transfers in and out of the Genentech Stock Fund are effected on a monthly cycle. Distributions Distributions are recorded when paid. Other All security transactions are recorded on the trade date. Gains and losses on the disposals of investments are determined based on the average cost of all securities. Dividend income is recorded on the effective date of a declared dividend. Income from other investments is recorded as earned on an accrual basis. All administrative costs of the Plan incurred by the Company are paid by the Company and are not charged to the Plan. (2) Income Tax Status: The Internal Revenue Service ruled on April 29, 1988 that the December 21, 1984 Plan, as amended, qualified in form under Section 401(a) of the Code and the underlying trust is, therefore, exempt from federal income taxes under Section 501(a) of the Code. The Plan is required to operate in conformity with the Code to maintain its qualification. The Plan has been subsequently audited and accepted by the Internal Revenue Service with no change through December 31, 1990. In December, 1990, an amended and restated Plan, effective as of January 1, 1991, was adopted by the Board of Directors of the Company. Effective as of June 30, 1991 and October 7, 1993 the first and second amendments to the amended and restated Plan were adopted. In January 1994, the second restatement of the Plan was adopted effective January 1, 1994. In July 1994, the Plan administrator filed for a favorable determination letter from the Internal Revenue Service seeking to substantiate that the current restated Plan and related trust meet the requirements of Section 401(a) of the Internal Revenue Code, as amended, and, as such, are exempt from federal income tax. A response regarding the filing for a determination letter has not yet been received. The Company is not aware of any events which would cause the Plan to become disqualified in operation. (3) Related Party Transactions: Certain of the investment funds are managed by Fidelity Management Research Company (FMR), an affiliate of the Plan Trustee. Because of this relationship, transactions involving these funds qualify as party-in-interest transactions. Page 12 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements (4) Assets held for investment at December 31, 1994 were as follows: Number of Name of Issuer Shares or Fair and Title of Principal Amount Cost Value __________________________________________ ___________ ____________ ___________ GENENTECH STOCK FUND Genentech, Inc. - Redeemable Common Stock............... 199,237 $ 7,085,865 $ 9,090,200 FIDELITY MAGELLAN FUND Fidelity Magellan Fund.................. 277,113 18,587,898 18,511,180 FIDELITY GROWTH COMPANY FUND Fidelity Growth Company Fund ........... 173,366 4,896,991 4,725,960 FIDELITY GROWTH & INCOME FUND Fidelity Growth & Income Fund .......... 466,475 9,800,926 9,837,949 FIDELITY INTERMEDIATE BOND FUND Fidelity Intermediate Bond Fund......... 159,480 1,670,265 1,567,685 FIDELITY OVERSEAS FUND Fidelity Overseas Fund ................. 112,795 3,069,389 3,079,304 FIDELITY BALANCED FUND Fidelity Balanced Fund ................. 1,039,050 13,130,786 12,769,920 FIDELITY ASSET MANAGER FUND Fidelity Asset Manager Fund ............ 27,406 396,164 379,027 FIDELITY ASSET MANAGER: GROWTH FUND Fidelity Asset Manager: Growth Fund .... 37,316 506,365 479,134 FIDELITY ASSET MANAGER: INCOME FUND Fidelity Asset Manager: Income Fund ... 9,642 103,692 100,471 FIDELITY RETIREMENT MONEY MARKET FUND Retirement Money Market Fund............ 7,476,596 7,476,596 7,476,596 FIDELITY U.S. EQUITY INDEX FUND Fidelity U.S. Equity Index Fund ........ 45,328 750,136 766,488 PARTICIPANT LOANS Loans receivable from participants ..... $2,108,168 2,108,168 2,108,168 ___________ ___________ TOTAL INVESTMENTS ........................ $69,583,241 $70,892,082 =========== =========== Page 13 Report of Ernst & Young LLP, Independent Auditors To the Participants and Plan Administration Committee of the Genentech, Inc. Tax Reduction Investment Plan We have audited the accompanying statements of net assets available for benefits with fund information of the Genentech, Inc. Tax Reduction Investment Plan as of December 31, 1994 and 1993, and the related statements of changes in net assets available for benefits with fund information for the years then ended. These financial statements are the responsibility of the Plan's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the net assets available for benefits of the Genentech, Inc. Tax Reduction Investment Plan at December 31, 1994 and 1993, and the changes in its net assets available for benefits for the years then ended in conformity with generally accepted accounting principles. Our audits were made for the purpose of forming an opinion on the basic financial statements taken as a whole. The accompanying supplemental schedules of assets held for investment purposes as of December 31, 1994 and of reportable transactions for the year then ended are presented for purposes of complying with the Department of Labor's Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974, and are not a required part of the basic financial statements. The Fund Information in the statement of net assets available for benefits and the statement of changes in net assets available for benefits is presented for purposes of additional analysis rather than to present the net assets available for benefits and changes in net assets available for benefits of each fund. The supplemental schedules and Fund Information have been subjected to the auditing procedures applied in our audit of the 1994 financial statements and, in our opinion, are fairly stated in all material respects in relation to the 1994 basic financial statements taken as a whole. ERNST & YOUNG LLP San Jose, California May 10, 1995 Page 14 Signatures Pursuant to the requirements of the Securities Exchange Act of 1934, the Plan administrator has duly caused this annual report to be signed by the undersigned hereunto duly authorized. Genentech, Inc. Tax Reduction Investment Plan by Genentech, Inc., Plan Administrator By: /S/ MARTY GLICK Date: June 29, 1995 ___________________________________ Marty Glick Vice President and Treasurer and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/ LOUIS J. LAVIGNE, JR. Date: June 29, 1995 ___________________________________ Louis J. Lavigne, Jr. Senior Vice President and Chief Financial Officer and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/ LARRY SETREN Date: June 29, 1995 ___________________________________ Larry Setren Vice President-Human Resources and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan Page 15 Index of Supplemental Schedules Filed with Form 11-K For the Year Ended December 31, 1994 Sequential Schedule Description Page Numbers ________ ___________________________________ ____________ I Assets Held for Investment Purposes 17 II Schedule of Reportable Transactions 18 Page 16 SCHEDULE I Genentech, Inc. Tax Reduction Investment Plan Item 27a Schedule of Assets Held For Investment Purposes December 31, 1994 Description Current Identity of Issue of Investment Cost Value ________________________________________ _________________ ____________ ___________ * GENENTECH STOCK FUND Genentech, Inc. - Common stock - Redeemable Common Stock ............. 199,237 shares $ 7,085,865 $ 9,090,200 * FIDELITY MAGELLAN FUND Mutual fund - Fidelity Magellan Fund ............... 277,113 shares 18,587,898 18,511,180 * FIDELITY GROWTH COMPANY FUND Mutual fund - Fidelity Growth Company Fund ......... 173,366 shares 4,896,991 4,725,960 * FIDELITY GROWTH & INCOME FUND Mutual fund - Fidelity Growth & Income Portfolio ... 466,475 shares 9,800,926 9,837,949 * FIDELITY INTERMEDIATE BOND FUND Mutual fund - Fidelity Intermediate Bond Fund ...... 159,480 shares 1,670,265 1,567,685 * FIDELITY OVERSEAS FUND Mutual fund - Fidelity Overseas Fund ............... 112,795 shares 3,069,389 3,079,304 * FIDELITY BALANCED FUND Mutual fund - Fidelity Balanced Fund ............... 1,039,050 shares 13,130,786 12,769,920 * FIDELITY ASSET MANAGER FUND Mutual fund - Fidelity Asset Manager Fund .......... 27,406 shares 396,164 379,027 * FIDELITY ASSET MANAGER: GROWTH FUND Mutual fund - Fidelity Asset Manager: Growth Fund .. 37,316 shares 506,365 479,134 * FIDELITY ASSET MANAGER: INCOME FUND Mutual fund - Fidelity Asset Manager: Income Fund .. 9,642 shares 103,692 100,471 * FIDELITY RETIREMENT MONEY MARKET FUND Mutual fund - Retirement Money Market Fund ......... 7,476,596 shares 7,476,596 7,476,596 * FIDELITY U.S. EQUITY INDEX FUND Mutual fund - Fidelity U.S. Equity Index Portfolio . 45,328 shares 750,136 766,488 * PARTICIPANT LOANS Loans receivable from participants ... (1) 2,108,168 2,108,168 ___________ ___________ TOTAL INVESTMENTS ...................... $69,583,241 $70,892,082 =========== =========== <FN> (1) Maturing at various dates through 1999 at interest rates ranging from 7.25% to 13.5%. * Party-in-interest. Page 17 SCHEDULE II Genentech, Inc. Tax Reduction Investment Plan Line 27d Schedule of Reportable Transactions For the Year ended December 31, 1994 Purchases Sales _________________________ _________________________________________________ Number of Dollar Number of Purchase Selling Realized Description Transactions Value Transactions Price Price Gain/Loss of Asset ____________________________ __________ ____________ __________ __________ _________ Genentech Stock 78 $2,967,986 38 $ 638,610 $ 917,405 $ 278,795 Fidelity Magellan Fund 184 6,165,473 122 2,491,836 2,530,940 39,104 Fidelity Growth Company Fund 145 2,337,954 75 854,846 856,593 1,747 Fidelity Growth & Income Fund 161 3,989,202 99 1,233,770 1,299,810 66,040 Fidelity Balanced Fund 166 3,537,876 133 2,571,594 2,585,095 13,501 Fidelity Retirement Money Market Fund 149 3,447,310 121 2,132,777 2,132,777 - <FN> Reportable transactions include any series of transactions that in the aggregate exceed five percent of the fair market value of Plan assets at the beginning of the year. The transactions can occur on a daily basis. These transactions represent Category (iii) reportable transactions in accordance with Department of Labor regulations. There were no other reportable transactions during 1994. Page 18 Genentech, Inc. Tax Reduction Investment Plan Index of Exhibits Filed with Form 11-K For the Year Ended December 31, 1994 Sequential Exhibit Number Description Page Numbers ________________ ______________________________________________ ____________ 1 Consent of Ernst & Young LLP, Independent Auditors, filed with this document 20 Page 19 EXHIBIT 1 Consent of Ernst & Young LLP, Independent Auditors We consent to the incorporation by reference in the Registration Statement on Form S-8 pertaining to the Genentech, Inc. Tax Reduction Investment Plan of our report dated May 10, 1995, with respect to the financial statements and supplemental schedules of the Genentech, Inc. Tax Reduction Investment Plan included in this Annual Report (Form 11-K) for the year ended December 31, 1994. ERNST & YOUNG LLP San Jose, California June 29, 1995 Page 20