SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 1996 ___ TRANSITION REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ___________ to ___________. Commission file number: 1-9813 GENENTECH, INC. TAX REDUCTION INVESTMENT PLAN (Full title of the Plan) GENENTECH, INC. (Name of issuer of the securities held pursuant to the Plan) 460 Point San Bruno Boulevard South San Francisco, California 94080 (address of principal executive office) Genentech, Inc. Tax Reduction Investment Plan Index to Financial Statements Item Page No. __________________________________________________________ _________ Statement Of Net Assets Available For Benefits With Fund Information At December 31, 1996 and 1995 3-4 Statement Of Changes In Net Assets Available For Benefits With Fund Information for Years Ended December 31, 1996 and 1995 5-8 Notes To Financial Statements 9-14 Report Of Ernst & Young LLP, Independent Auditors 15 Signatures 16 Page 2 Genentech, Inc. Tax Reduction Investment Plan Statement Of Net Assets Available For Benefits With Fund Information December 31, 1996 FIDELITY GENENTECH FIDELITY GROWTH FIDELITY FIDELITY COMMON MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $ 8,403,851 $33,142,803 $17,360,152 $27,078,832 $ 2,933,257 Contribution receivable from Genentech, Inc. 375,407 1,351,091 943,834 1,225,961 159,902 ___________ ___________ ___________ __________ __________ Net assets available for benefits $ 8,779,258 $34,493,894 $18,303,986 $28,304,793 $ 3,093,159 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $ 4,783,884 $14,115,444 $ 1,305,895 $ 1,396,410 $ 466,683 Contribution receivable from 303,851 563,957 87,305 128,964 33,340 Genentech, Inc. ___________ ___________ ___________ ___________ ___________ Net assets available for benefits $ 5,087,735 $14,679,401 $ 1,393,200 $ 1,525,374 $ 500,023 =========== =========== =========== =========== =========== FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ____________ ASSETS: Investments, at fair value $10,593,850 $ 5,680,716 $ 3,326,576 $130,588,353 Contribution receivable from Genentech, Inc. 537,155 340,828 0 6,051,595 ___________ ___________ ___________ ____________ Net assets available for benefits $11,131,005 $ 6,021,544 $ 3,326,576 $136,639,948 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page 3 Genentech, Inc. Tax Reduction Investment Plan Statement Of Net Assets Available For Benefits With Fund Information December 31, 1995 FIDELITY GENENTECH FIDELITY GROWTH FIDELITY FIDELITY COMMON MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ ASSETS: Investments, at fair value $ 9,153,498 $30,153,976 $11,291,205 $18,106,286 $ 2,428,446 Contribution receivable from Genentech, Inc. 459,360 1,493,479 719,731 994,786 159,680 ___________ ___________ ___________ ___________ ___________ Net assets available for benefits $ 9,612,858 $31,647,455 $12,010,936 $19,101,072 $ 2,588,126 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ __________ ___________ ___________ ASSETS: Investments, at fair value $ 3,238,236 $13,340,101 $ 719,994 $ 576,120 $ 193,856 Contribution receivable from Genentech, Inc. 272,473 646,863 63,926 66,657 20,398 ___________ ___________ __________ ___________ ___________ Net assets available for benefits $ 3,510,709 $13,986,964 $ 783,920 $ 642,777 $ 214,254 =========== =========== ========== =========== =========== FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ____________ ASSETS: Investments, at fair value $ 9,077,890 $ 2,653,009 $ 2,439,890 $103,372,507 Contribution receivable from Genentech, Inc. 526,864 166,368 - 5,590,585 ___________ ___________ ___________ ____________ Net assets available for benefits $ 9,604,754 $ 2,819,377 $ 2,439,890 $108,963,092 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page 4 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1996 FIDELITY GENENTECH FIDELITY GROWTH FIDELITY FIDELITY COMMON MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ 0 $ 5,213,751 $ 750,272 $ 1,296,172 $ 183,192 Realized/unrealized gain(loss), net 88,550 (1,673,186) 1,481,322 2,943,030 (86,751) ___________ ___________ ___________ ___________ ___________ Total investment income 88,550 3,540,565 2,231,594 4,239,202 96,441 Contributions: Basic 830,540 3,258,021 2,003,675 2,453,471 332,688 Rollover 38,368 271,323 359,704 504,153 95,272 Employer match 375,407 1,351,843 943,927 1,226,146 159,902 ___________ ___________ ___________ ___________ ___________ Total contributions 1,244,315 4,881,187 3,307,306 4,183,770 587,862 Distributions (517,198) (2,229,268) (906,200) (1,708,484) (88,385) Administrative fees (3,200) (3,823) (1,000) (1,563) (538) Transfers between funds (1,646,067) (3,342,222) 1,661,350 2,490,796 (90,347) ___________ ___________ ___________ ___________ ___________ Net change during the year (833,600) 2,846,439 6,293,050 9,203,721 505,033 Net assets available for benefits: Beginning of year 9,612,858 31,647,455 12,010,936 19,101,072 2,588,126 ___________ ___________ ___________ ___________ ___________ End of year $ 8,779,258 $34,493,894 $18,303,986 $28,304,793 $ 3,093,159 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ____________ ___________ ___________ ___________ Investment income: Interest and dividends $ 287,003 $ 655,819 $ 96,361 $ 116,370 $ 30,819 Realized/unrealized gain, net 216,397 558,546 33,525 44,844 735 ___________ ____________ ___________ ___________ ___________ Total investment income 503,400 1,214,365 129,886 161,214 31,554 Contributions: Basic 668,507 1,292,258 176,278 266,531 67,465 Rollover 104,656 183,831 46,839 147,071 33,493 Employer match 303,851 564,230 87,305 128,963 33,340 ___________ ____________ ___________ ___________ ___________ Total contributions 1,077,014 2,040,319 310,422 542,565 134,298 Distributions (462,876) (566,746) (15,720) (25,929) (33,219) Administrative fees (100) (1,825) (12) (37) 0 Transfers between funds 459,588 (1,993,676) 184,704 204,784 153,136 ___________ ____________ ___________ ___________ ___________ Net change during the year 1,577,026 692,437 609,280 882,597 285,769 Net assets available for benefits: Beginning of year 3,510,709 13,986,964 783,920 642,777 214,254 ___________ ____________ ___________ ___________ ___________ End of year $ 5,087,735 $ 14,679,401 $ 1,393,200 $ 1,525,374 $ 500,023 =========== ============ =========== =========== =========== Page 5 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1996 FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ____________ Investment income: Interest and dividends $ 504,185 $ 118,579 $ 278,216 $ 9,530,739 Realized/unrealized gain, net 0 735,934 0 4,342,946 ___________ ___________ ___________ ____________ Total investment income 504,185 854,513 278,216 13,873,685 Contributions: Basic 1,066,131 601,080 0 13,016,645 Rollover 183,294 236,167 0 2,204,171 Employer Match 537,758 341,013 0 6,053,685 ___________ ___________ ___________ ____________ Total contributions 1,787,183 1,178,260 0 21,274,501 Distributions (510,852) (265,711) (123,808) (7,454,396) Administrative fees (4,448) (388) 0 (16,934) Transfers between funds (249,817) 1,435,493 732,278 0 ___________ ___________ ___________ ____________ Net change during the year 1,526,251 3,202,167 886,686 27,676,856 Net assets available for benefits: Beginning of year 9,604,754 2,819,377 2,439,890 108,963,092 ___________ ___________ ___________ ____________ End of year $11,131,005 $ 6,021,544 $ 3,326,576 $136,639,948 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page 6 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1995 FIDELITY GENENTECH FIDELITY GROWTH FIDELITY FIDELITY COMMON MAGELLAN COMPANY GROWTH & INTERMEDIATE STOCK FUND FUND FUND INCOME FUND BOND FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ - $ 1,715,515 $ 502,859 $ 850,049 $ 132,127 Realized/unrealized gain, net 1,344,329 5,870,835 1,972,702 3,470,977 118,389 ___________ ___________ ___________ ___________ ___________ Total investment income 1,344,329 7,586,350 2,475,561 4,321,026 250,516 Contributions: Basic 1,143,846 2,910,678 1,273,734 1,946,677 310,787 Rollover 261,754 333,612 216,167 229,046 34,878 Employer match 459,360 1,493,959 720,374 995,699 159,680 ___________ ___________ ___________ ___________ ___________ Total contributions 1,864,960 4,738,249 2,210,275 3,171,422 505,345 Distributions (423,696) (1,801,816) (541,503) (619,711) (56,264) Administrative fees - (483) (312) (837) (388) Transfers between funds (2,823,235) 1,402,969 2,707,495 1,608,971 191,113 ___________ ___________ ___________ ___________ ___________ Net change during the year (37,642) 11,925,269 6,851,516 8,480,871 890,322 Net assets available for benefits: Beginning of year 9,650,500 19,722,186 5,159,420 10,620,201 1,697,804 ___________ ___________ ___________ ___________ ___________ End of year $ 9,612,858 $31,647,455 $12,010,936 $19,101,072 $ 2,588,126 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ___________ ___________ ___________ ___________ ___________ Investment income: Interest and dividends $ 75,747 $ 591,831 $ 18,933 $ 8,503 $ 7,705 Realized/unrealized gain, net 227,256 1,308,728 82,033 95,392 15,324 ___________ ___________ ___________ ___________ ___________ Total investment income 303,003 1,900,559 100,966 103,895 23,029 Contributions: Basic 701,074 1,497,445 137,436 172,501 41,767 Rollover 46,623 72,763 53,228 51,973 16,076 Employer match 272,473 647,176 63,926 66,657 20,398 ___________ ___________ ___________ ___________ ___________ Total contributions 1,020,170 2,217,384 254,590 291,131 78,241 Distributions (198,043) (789,539) (15,891) (1,712) (1,239) Administrative fees - (1,938) - (25) - Transfers between funds (995,915) (2,869,930) 34,101 (277,403) 3,245 ___________ ___________ ___________ ___________ ___________ Net change during the year 129,215 456,536 373,766 115,886 103,276 Net assets available for benefits: Beginning of year 3,381,494 13,530,428 410,154 526,891 110,978 ___________ ___________ ___________ ___________ ___________ End of year $ 3,510,709 $13,986,964 $ 783,920 $ 642,777 $ 214,254 =========== =========== =========== =========== =========== Page 7 Genentech, Inc. Tax Reduction Investment Plan Statement Of Changes In Net Assets Available For Benefits With Fund Information Year Ended December 31, 1995 FIDELITY RETIREMENT FIDELITY MONEY U.S. EQUITY PARTICIPANT MARKET FUND INDEX FUND LOANS TOTAL ___________ ___________ ___________ ____________ Investment income: Interest and dividends $ 499,820 $ 52,206 $ 202,900 $ 4,658,195 Realized/unrealized gain, net - 442,105 - 14,948,070 ___________ ___________ ___________ ____________ Total investment income 499,820 494,311 202,900 19,606,265 Contributions: Basic 1,167,442 289,759 - 11,593,146 Rollover 32,259 78,812 - 1,427,191 Employer match 536,574 166,368 - 5,602,644 ___________ ___________ ___________ ____________ Total contributions 1,736,275 534,939 - 18,622,981 Distributions (643,106) (37,321) (57,769) (5,187,610) Administrative fees (3,450) (213) - (7,646) Transfers between funds (156,472) 988,470 186,591 - ___________ ___________ ___________ ____________ Net change during the year 1,433,067 1,980,186 331,722 33,033,990 Net assets available for benefits: Beginning of year 8,171,687 839,191 2,108,168 75,929,102 ___________ ___________ ___________ ____________ End of year $ 9,604,754 $ 2,819,377 $ 2,439,890 $108,963,092 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page 8 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements (1) Description of the Plan: The following description of the Genentech, Inc. Tax Reduction Investment Plan (Plan) provides only general information. Participants should refer to the Plan document for a more complete description of the Plan's provisions. The Plan was established, effective January 1, 1985, by Genentech, Inc. (the Company) for the benefit of eligible employees of the Company in order to provide them with a means of supplementing their retirement income on a tax- favored basis, an incentive to continue and increase their efforts to contribute to the success of the Company, and an opportunity to acquire an equity interest in the Company. The Plan accomplishes this through a savings program which is based on systematic salary reductions. The employee's salary is reduced by the amount elected to be saved on a pre-tax basis. The "deferred" part of the employee's salary is then invested in the Plan. An individual employee's account is credited with earnings or losses on a pro rata basis as the actual investment funds report their earnings performance. Individuals eligible to participate under the Plan must be employees of the Company or employees of an affiliate of the Company that adopts the Plan with the approval of the Board of Directors. However, the following employees or classes of employees are not eligible to participate: (i) any employee who is classified as temporary by the Company, unless such employee has completed at least 1,000 hours of service in a 12-month period; (ii) any part-time employee normally scheduled to work less than 20 hours per week, unless such employee has completed at least 1,000 hours of service in a 12-month period; (iii) any employee who is a member of a collective bargaining unit and who is covered by a collective bargaining agreement where retirement benefits were the subject of good faith bargaining; (iv) any individual employed by any corporation or other business entity that is merged or liquidated into the Company, unless the Company designates such employees as eligible employees; (v) any employee paid from a non-U.S. payroll; or (vi) any leased employee as defined under the Internal Revenue Code of 1986, as amended (Code). The Board of Directors of the Company has the right under the Plan to alter, amend or terminate the Plan, or any part thereof, in such a manner as it may determine. If the Plan is terminated, the interests of all Plan members remain fully (100%) vested and nonforfeitable. The balances credited to their accounts shall remain with the Plan trustee until they become distributable in accordance with the Plan. The Company matches a portion of employee contributions, up to a maximum of 4% of a participant's eligible compensation (Match). The Match is effective December 31st of each year (Effective Date) and contributions under the Match are fully vested at that time. The Match is funded in the first quarter of the subsequent year. In the first quarter of 1997 and 1996, the Company contributed approximately $6.1 million and $5.6 million, respectively, to the Plan in accordance with the terms of the Plan. The Plan trustee is Fidelity Management Trust Company (Plan Trustee). All amounts contributed to the Plan are deposited in a trust account with the Plan Trustee. The Plan Trustee's fees and expenses are paid by the Company and are not charged to the Plan. Accounts of terminated employees who continue to hold an account under the Plan as non-employee participants are charged an annual fee of $50.00 by the Company. The Plan Trustee has blanket bond insurance covering the full market value of the securities and investments of which it has custody. Effective as of May 8, 1996, the Company changed the mechanics of its Genentech Common Stock Fund (Stock Fund) to a unitized fund which assigns units to participants rather than shares of the Company's stock. These units represent a proportionate interest in all of the assets of the Stock Fund, which includes shares of the Company's common stock and a small percentage (approximately 2%, although the percentage may vary over time) in short-term investments. A net asset value per unit will be determined daily for each unit outstanding in Page 9 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements the Stock Fund. The return earned by the Stock Fund will represent a combination of the dividends paid on the shares of the Company's common stock (the Company's common stock currently does not pay a dividend) held by the Stock Fund, gains or losses realized on sales of the Company's common stock, appreciation or depreciation in the market price of those shares owned, and interest on the short-term investments held by the Stock Fund. The outstanding units and net asset values for the Stock Fund are calculated at the end of each month by the Plan Trustee. The monthly Stock Fund units and net asset value per unit for the period ending May 31, 1996 through December 31, 1996 are as follows: Number Net Net Asset of Asset Value Units Value Per Unit ------- ------------- ----------- May 31, 1996: Genentech Common Stock 170,901 $ 8,993,665 $52.62 Fidelity Institutional Cash Portfolio: Money Market Fund 122,580 122,580 1.00 June 30, 1996: Genentech Common Stock 169,001 8,851,427 52.37 Fidelity Institutional Cash Portfolio: Money Market Fund 45,181 45,181 1.00 July 31, 1996: Genentech Common Stock 164,601 8,662,128 52.63 Fidelity Institutional Cash Portfolio: Money Market Fund 127,632 127,632 1.00 August 31, 1996: Genentech Common Stock 162,080 8,509,200 52.50 Fidelity Institutional Cash Portfolio: Money Market Fund 49,181 49,181 1.00 September 30, 1996: Genentech Common Stock 158,380 8,374,343 52.88 Fidelity Institutional Cash Portfolio: Money Market Fund 120,408 120,408 1.00 October 31, 1996: Genentech Common Stock 156,780 8,446,523 53.88 Fidelity Institutional Cash Portfolio: Money Market Fund 108,720 108,720 1.00 November 30, 1996: Genentech Common Stock 155,268 8,403,881 54.13 Fidelity Institutional Cash Portfolio: Money Market Fund 84,407 84,407 1.00 December 31, 1996: Genentech Common Stock 154,568 8,292,400 53.65 Fidelity Institutional Cash Portfolio: Money Market Fund 111,451 111,451 1.00 In 1996 and 1995, each participant in the Plan could elect to defer up to the lower of $9,500 ($9,240 in 1995) or 12% of his or her eligible compensation, subject to limitations of the Code. For the plan years 1996 and 1995, each participant directed the investment of his or her contributions in any of the following twelve investment funds of the Plan (or any combination thereof): Page 10 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Genentech Common Stock Fund This fund invests primarily in the callable putable common stock of the Company, which is purchased at full market price. In addition, a small percentage of this fund (approximately 2%, although the percentage may vary over time) invests in the Fidelity Institutional Cash Portfolio: Money Market Fund to provide liquidity for the timely settlement of trades. The callable putable common stock of the Company does not currently pay dividends; therefore the return on this fund is largely dependent on the performance of the stock and to a lesser degree, the interest received on the short-term investments. See above for information on the unitization of this fund. Fidelity Magellan, registered trademark, Fund The Fidelity Magellan Fund is a mutual fund managed by Fidelity Management and Research Company (FMR). The fund invests in the common stocks, and securities convertible into common stocks, of all types of domestic and foreign companies. Fidelity Growth Company Fund The Fidelity Growth Company Fund is a mutual fund managed by FMR. It invests primarily in common stock of companies which it believes have the potential for above-average growth. Fidelity Growth & Income Portfolio The Fidelity Growth & Income Portfolio is managed by FMR and invests primarily in securities of U.S. and foreign companies that offer growth of earnings potential while paying current dividends. The Portfolio may also invest in bonds. Fidelity Intermediate Bond Fund The Fidelity Intermediate Bond Fund is a mutual fund managed by FMR. The fund invests in all types of U.S. and foreign bonds, including corporate or U.S. government issues. The fund selects bonds considered medium to high quality and normally maintains an average maturity of 3-10 years. Fidelity Overseas Fund The Fidelity Overseas Fund is a mutual fund managed by FMR. The fund invests in foreign securities including common stock, securities convertible to common stock and debt instruments of foreign businesses and governments. Fidelity Balanced Fund The Fidelity Balanced Fund is a mutual fund managed by FMR that invests in a broad variety of high yielding U.S. and foreign securities. The fund maintains at least 25% of its assets in fixed income securities (bonds) and preferred stocks. Fidelity Asset Manager, trademark, Fund The Fidelity Asset Manager Fund is a mutual fund managed by FMR. The Asset Manager Fund allocates its assets among domestic and foreign equities, bonds and short-term instruments, aiming for an investment mix of 40% stocks, 40% bonds and 20% short-term investments. Fidelity Asset Manager: Growth Fund The Fidelity Asset Manager: Growth Fund, managed by FMR, invests in domestic and foreign stocks, bonds and short-term instruments, aiming for an investment mix of 65% stocks, 30% bonds and 5% short-term investments. Page 11 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Fidelity Asset Manager: Income Fund The Fidelity Asset Manager: Income Fund is a mutual fund managed by FMR which invests in domestic and foreign stocks, bonds and short-term instruments, aiming for an investment mix of 20% stocks, 30% bonds and 50% short-term investments. Fidelity Retirement Money Market Portfolio The Fidelity Retirement Money Market Portfolio is a mutual fund managed by FMR. It invests in high-quality U.S. dollar-denominated money market instruments of U.S. and foreign issuers, including short-term corporate obligations and certificates of deposit. Fidelity U.S. Equity Index Portfolio The Fidelity U.S. Equity Index Portfolio, managed by FMR, invests mostly in the common stocks of the 500 companies that make up the Standard & Poor's Composite Index. Participant Loans Loans are made only to Plan participants, at fixed interest rates (presently 2% above the then current bank prime interest rate), subject to certain restrictions, principally related to a participant's account balance, permissible loan amount, and repayment through payroll withholding. Loans are repaid through monthly payroll deductions over three or five years, or fifteen years if the purpose of the loan is to purchase a participant's principal residence. Conditions of Withdrawal Distributions under the Plan will be made upon a participant's death, disability, retirement or other termination of employment with the Company, attainment of age 70-1/2, or authorized exercise of his or her withdrawal rights under the Plan. Participants must consent to a distribution unless he or she has attained age 62 or the balance credited to his or her account under the Plan does not exceed and has not exceeded $3,500). Distributions are made upon receipt of the participant's or beneficiary's election directing the method of distribution. Prior to termination of employment with the Company, the Plan administrator may grant a participant's request for a withdrawal if the Plan administrator makes a determination that such withdrawal is necessary in light of the immediate and heavy financial needs of the participant and is in accordance with the requirements of the Code and regulations promulgated thereunder. In addition, Plan participants may withdraw up to the entire balance of Plan accounts if over age 59-1/2 at the time of withdrawal. (2) Summary of Significant Accounting Policies: Investment Valuation Investments are stated at market value at year end. The Genentech Common Stock Fund, Fidelity Magellan Fund, Fidelity Growth Company Fund, Fidelity Growth & Income Portfolio, Fidelity Intermediate Bond Fund, Fidelity Overseas Fund, Fidelity Balanced Fund, Fidelity Asset Manager Fund, Fidelity Asset Manager: Growth Fund, Fidelity Asset Manager: Income Fund, and Fidelity U.S. Equity Index Portfolio securities are valued at the last reported sales price on the last business day of the year, which for the mutual funds represents the net asset values of shares held by the Plan at year end; the Fidelity Retirement Money Market Portfolio instruments and Participant Loans are valued on the basis of historical cost which approximates fair value. Page 12 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements Contributions Basic contributions are accrued and vested when deducted from employee pay; the Match is accrued and vested on the Effective Date; and qualified rollover contributions are vested when received by the Plan Trustee. Contributions are invested pursuant to participants' directions to the Plan Trustee after receipt of contributions by the Plan Trustee. Participants may change the amount of contributions (as a percentage reduction of pre-tax eligible compensation) at any time by contacting the Plan Trustee. Transfers between funds and changes in investment allocations can be made at any time, up to ten times per year, effective upon request by the participant to the Plan Trustee. Distributions Distributions are recorded when paid. Other All security transactions are recorded on the trade date. Gains and losses on the disposals of investments are determined based on the average cost of all securities. Dividend income is recorded on the effective date of a declared dividend. Income from other investments is recorded as earned on an accrual basis. Use of Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires management to make certain estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. (3) Income Tax Status: The Internal Revenue Service ruled on April 29, 1988 that the December 21, 1984 Plan, as amended, qualified in form under Section 401(a) of the Code and the underlying trust is, therefore, exempt from federal income taxes under Section 501(a) of the Code. The Plan was subsequently audited and accepted by the Internal Revenue Service with no change through December 31, 1990. In December 1990, an amended and restated Plan, effective as of January 1, 1991, was adopted by the Board of Directors of the Company. Effective as of June 30, 1991 and October 7, 1993, the first and second amendments, respectively, to the amended and restated Plan were adopted. In January 1994, the second restatement of the Plan was adopted effective January 1, 1994. The Internal Revenue Service has determined and informed the Company by letter dated September 25, 1995, that the Plan and related trust are designed in accordance with applicable sections of the Code. Effective as of May 8, 1996, the Plan was again amended and restated. In May 1997, the amended and restated Plan was amended. The changes made in the May 8, 1996 amendment and restatement and the May 1997 amendment were technical in nature, and in the opinion of the Company and its legal counsel, did not require another determination from the Internal Revenue Service concerning the Plan's tax exempt status. The Company believes that the Plan is designed and is currently being operated in compliance with the applicable requirements of the Code. (4) Related Party Transactions: Certain of the investment funds are managed by FMR, an affiliate of the Plan Trustee. Because of this relationship, transactions involving these funds qualify as party-in-interest transactions, as well as transactions in Genentech Common Stock and Participant Loans. Page 13 Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements (5) Assets held for investment at December 31, 1996 were as follows: Number of Name of Issuer Shares, Units Fair and Title of Principal or Amount Cost Value _______________________________________________ _____________ ____________ ____________ GENENTECH COMMON STOCK FUND Genentech, Inc. - Callable Putable Common Stock.............. 154,568 $ 6,165,697 $ 8,292,400 Fidelity Institutional Cash Portfolio: Money Market Fund.......................... 111,451 111,451 111,451 FIDELITY MAGELLAN, registered trademark, FUND Fidelity Magellan Fund....................... 410,946 30,098,708 33,142,803 FIDELITY GROWTH COMPANY FUND Fidelity Growth Company Fund ................ 429,070 14,555,751 17,360 152 FIDELITY GROWTH & INCOME PORTFOLIO Fidelity Growth & Income Portfolio........... 881,185 21,372,588 27,078,832 FIDELITY INTERMEDIATE BOND FUND Fidelity Intermediate Bond Fund.............. 290,998 2,989,960 2,933,257 FIDELITY OVERSEAS FUND Fidelity Overseas Fund ...................... 155,119 4,430,398 4,783,884 FIDELITY BALANCED FUND Fidelity Balanced Fund ...................... 1,002,517 12,861,795 14,115,444 FIDELITY ASSET MANAGER, trademark, FUND Fidelity Asset Manager Fund.................. 79,289 1,217,772 1,305,895 FIDELITY ASSET MANAGER: GROWTH FUND Fidelity Asset Manager: Growth Fund ......... 85,407 1,304,373 1,396,410 FIDELITY ASSET MANAGER: INCOME FUND Fidelity Asset Manager: Income Fund ........ 40,197 460,029 466,683 FIDELITY RETIREMENT MONEY MARKET PORTFOLIO Retirement Money Market Portfolio............ 10,593,850 10,593,850 10,593,850 FIDELITY U.S. EQUITY INDEX PORTFOLIO Fidelity U.S. Equity Index Portfolio......... 210,787 4,610,577 5,680,716 PARTICIPANT LOANS Loans receivable from participants .......... $ 3,326,576 3,326,576 3,326,576 ____________ ____________ TOTAL INVESTMENTS ............................. $114,099,525 $130,588,353 ============ ============ Page 14 Report of Ernst & Young LLP, Independent Auditors To the Participants and Plan Administration Committee of the Genentech, Inc. Tax Reduction Investment Plan We have audited the accompanying statements of net assets available for benefits of the Genentech, Inc. Tax Reduction Investment Plan as of December 31, 1996 and 1995, and the related statements of changes in net assets available for benefits for the years then ended. These financial statements are the responsibility of the Plan's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the net assets available for benefits of the Genentech, Inc. Tax Reduction Investment Plan at December 31, 1996 and 1995, and the changes in its net assets available for benefits for the years then ended, in conformity with generally accepted accounting principles. Our audits were made for the purpose of forming an opinion on the basic financial statements taken as a whole. The accompanying supplemental schedules of assets held for investment purposes as of December 31, 1996 and of reportable transactions for the year then ended are presented for purposes of complying with the Department of Labor's Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974, and are not a required part of the basic financial statements. The Fund Information in the statement of net assets available for benefits and the statement of changes in net assets available for benefits is presented for purposes of additional analysis rather than to present the net assets available for benefits and changes in net assets available for benefits of each fund. The supplemental schedules and Fund Information have been subjected to the auditing procedures applied in our audit of the basic financial statements and, in our opinion, are fairly stated in all material respects in relation to the basic financial statements taken as a whole. ERNST & YOUNG LLP San Jose, California June 5, 1997 Page 15 Signatures Pursuant to the requirements of the Securities Exchange Act of 1934, the Plan administrator has duly caused this annual report to be signed by the undersigned hereunto duly authorized. Genentech, Inc. Tax Reduction Investment Plan by Genentech, Inc., Plan Administrator By: /S/LOUIS J. LAVIGNE, JR. Date: June 25, 1997 ___________________________________ Louis J. Lavigne, Jr. Executive Vice President and Chief Financial Officer and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/JUDY HEYBOER Date: June 25, 1997 ___________________________________ Judy Heyboer Senior Vice President - Human Resources and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/MARTY GLICK Date: June 25, 1997 ___________________________________ Marty Glick Vice President - Finance - Tax and Treasury and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan Page 16 Index of Supplemental Schedules Filed with Form 11-K For the Year Ended December 31, 1996 Sequential Schedule Description Page Numbers ________ _______________________________________________ ____________ I Schedule of Assets Held for Investment Purposes 18 II Schedule of Reportable Transactions 19 Page 17 SCHEDULE I Genentech, Inc. Tax Reduction Investment Plan Item 27a Schedule of Assets Held For Investment Purposes December 31, 1996 Description Current Identity of Issue of Investment Cost Value ________________________________________ _________________ ____________ ____________ * GENENTECH COMMON STOCK FUND Genentech, Inc. - Common stock - Callable Putable Common Stock ....... 154,568 units $ 6,165,697 $ 8,292,400 Fidelity Institutional Cash Portfolio: Mutual Fund Money Market Fund .................. 111,451 units 111,451 111,451 * FIDELITY MAGELLAN, registered trademark, FUND Mutual fund - Fidelity Magellan Fund................ 410,946 shares 30,098,708 33,142,803 * FIDELITY GROWTH COMPANY FUND Mutual fund - Fidelity Growth Company Fund ......... 429,070 shares 14,555,751 17,360,152 * FIDELITY GROWTH & INCOME PORTFOLIO Mutual fund - Fidelity Growth & Income Portfolio ... 881,185 shares 21,372,588 27,078,832 * FIDELITY INTERMEDIATE BOND FUND Mutual fund - Fidelity Intermediate Bond Fund ...... 290,998 shares 2,989,960 2,933,257 * FIDELITY OVERSEAS FUND Mutual fund - Fidelity Overseas Fund ............... 155,119 shares 4,430,398 4,783,884 * FIDELITY BALANCED FUND Mutual fund - Fidelity Balanced Fund ............... 1,002,517 shares 12,861,795 14,115,444 * FIDELITY ASSET MANAGER, trademark, FUND Mutual fund - Fidelity Asset Manager Fund........... 79,289 shares 1,217,772 1,305,895 * FIDELITY ASSET MANAGER: GROWTH FUND Mutual fund - Fidelity Asset Manager: Growth Fund .. 85,407 shares 1,304,373 1,396,410 * FIDELITY ASSET MANAGER: INCOME FUND Mutual fund - Fidelity Asset Manager: Income Fund .. 40,197 shares 460,029 466,683 * FIDELITY RETIREMENT MONEY MARKET PORTFOLIO Mutual fund - Retirement Money Market Portfolio..... 10,593,850 shares 10,593,850 10,593,850 * FIDELITY U.S. EQUITY INDEX PORTFOLIO Mutual fund - Fidelity U.S. Equity Index Portfolio . 210,787 shares 4,610,577 5,680,716 * PARTICIPANT LOANS Loans receivable from participants ... (1) 3,326,576 3,326,576 ____________ ____________ TOTAL INVESTMENTS ...................... $114,099,525 $130,588,353 ============ ============ <FN> (1) Maturing at various dates through 2011 at interest rates ranging from 8.00% to 12.25%. * Party-in-interest. </FN> Page 18 SCHEDULE II Genentech, Inc. Tax Reduction Investment Plan Item 27d Schedule of Reportable Transactions For the Year ended December 31, 1996 Purchases Sales _________________________ _________________________________________________ Number of Purchase Number of Selling Net Description Transactions Price Transactions Cost Price Gain/Loss of Asset ____________________________ ___________ ___________ ___________ ___________ _________ Genentech Common Stock 146 $10,918,480 116 $11,218,964 $11,756,676 $ 537,712 Fidelity Magellan Fund 220 11,819,577 187 6,818,123 7,157,565 339,442 Fidelity Growth Company Fund 211 6,669,203 141 1,756,130 2,081,578 325,448 Fidelity Growth & Income Fund 213 8,847,141 146 2,298,512 2,817,626 519,114 Fidelity Balanced Fund 179 3,145,155 146 2,788,893 2,928,358 139,465 Fidelity Retirement Money Market Fund 176 4,550,684 168 3,034,724 3,034,724 - <FN> Reportable transactions include any series of transactions that in the aggregate exceed five percent of the fair market value of Plan assets at the beginning of the year. The transactions can occur on a daily basis. These transactions represent Category (iii) reportable transactions in accordance with Department of Labor regulations. There were no other reportable transactions during 1996. </FN> Page 19 Genentech, Inc. Tax Reduction Investment Plan Index of Exhibits Filed with Form 11-K For the Year Ended December 31, 1996 Sequential Exhibit Number Description Page Numbers ________________ ______________________________________________ ____________ 23 Consent of Ernst & Young LLP, Independent Auditors, filed with this document 21 Page 20 SKELETON DRAFT 5-14-97