UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K X ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 1997 OR TRANSITION REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission file number: 1-9813 GENENTECH, INC. TAX REDUCTION INVESTMENT PLAN (Full title of the Plan) GENENTECH, INC. (Name of issuer of the securities held pursuant to the Plan) 1 DNA Way, South San Francisco, California 94080 (Address of principal executive offices and zip code) Genentech, Inc. Tax Reduction Investment Plan Index to Financial Statements Item Page No. - -------------------------------------------------------- --------- Statement of Net Assets Available for Benefits with Fund Information at December 31, 1997 and 1996 3-4 Statement of Changes in Net Assets Available for Benefits with Fund Information for Years Ended December 31, 1997 and 1996 5-8 Notes to Financial Statements 9-17 Report of Ernst & Young LLP, Independent Auditors 18 Signatures 19 Supplemental Schedules for the Year Ended December 31, 1997: Schedule I - Schedule of Assets Held for Investment Purposes 20 Schedule II - Schedule of Reportable Transactions 21 Page 2 Genentech, Inc. Tax Reduction Investment Plan Statement of Net Assets Available for Benefits with Fund Information December 31, 1997 FIDELITY FIDELITY GENENTECH FIDELITY GROWTH GROWTH & FIDELITY COMMON MAGELLAN COMPANY INCOME INTERMEDIATE STOCK FUND(2) FUND(1) FUND(1) PORTFOLIO(1) BOND FUND(1) ----------- ----------- ----------- ----------- ----------- ASSETS: Investments, at fair value $ 8,888,380 $42,752,024 $22,633,377 $41,214,011 $ 3,550,836 Contribution receivable from Genentech, Inc. 351,640 1,417,772 1,000,970 1,474,291 175,466 ----------- ----------- ----------- ----------- ----------- Net assets available for benefits $ 9,240,020 $44,169,796 $23,634,347 $42,688,302 $ 3,726,302 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND(1) FUND(1) FUND(1) GROWTH FUND(1) INCOME FUND(1) ----------- ----------- ----------- ----------- ----------- ASSETS: Investments, at fair value $ 6,371,403 $17,692,544 $ 1,712,971 $ 2,761,351 $ 561,511 Contribution receivable from Genentech, Inc. 332,306 534,069 94,157 182,941 32,191 ----------- ----------- ----------- ----------- ----------- Net assets available for benefits $ 6,703,709 $18,226,613 $ 1,807,128 $ 2,944,292 $ 593,702 =========== =========== =========== =========== =========== FIDELITY FIDELITY RETIREMENT SPARTAN MONEY MARKET U.S. EQUITY PARTICIPANT PORTFOLIO(1) INDEX FUND(1) LOANS TOTAL ----------- ----------- ----------- ------------ ASSETS: Investments, at fair value $12,205,141 $11,878,056 $ 4,571,014 $176,792,619 Contribution receivable from Genentech, Inc. 502,254 571,775 0 6,669,832 ----------- ----------- ----------- ------------ Net assets available for benefits $12,707,395 $12,449,831 $ 4,571,014 $183,462,451 =========== =========== =========== ============ <FN> See accompanying notes. (1) Fund shares are in registered investment companies. (2) A unitized stock fund. </FN> Page 3 Genentech, Inc. Tax Reduction Investment Plan Statement of Net Assets Available for Benefits with Fund Information December 31, 1996 FIDELITY FIDELITY GENENTECH FIDELITY GROWTH GROWTH & FIDELITY COMMON MAGELLAN COMPANY INCOME INTERMEDIATE STOCK FUND(2) FUND(1) FUND(1) PORTFOLIO(1) BOND FUND(1) ----------- ----------- ----------- ----------- ----------- ASSETS: Investments, at fair value $ 8,403,851 $33,142,803 $17,360,152 $27,078,832 $ 2,933,257 Contribution receivable from Genentech, Inc. 375,407 1,351,091 943,834 1,225,961 159,902 ----------- ----------- ----------- ----------- ----------- Net assets available for benefits $ 8,779,258 $34,493,894 $18,303,986 $28,304,793 $ 3,093,159 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND(1) FUND(1) FUND(1) GROWTH FUND(1) INCOME FUND(1) ----------- ---------- ----------- ----------- ----------- ASSETS: Investments, at fair value $ 4,783,884 $14,115,444 $ 1,305,895 $ 1,396,410 $ 466,683 Contribution receivable from 303,851 563,957 87,305 128,964 33,340 Genentech, Inc. ----------- ----------- ----------- ----------- ----------- Net assets available for benefits $ 5,087,735 $14,679,401 $ 1,393,200 $ 1,525,374 $ 500,023 =========== =========== =========== =========== =========== FIDELITY FIDELITY RETIREMENT SPARTAN MONEY MARKET U.S. EQUITY PARTICIPANT PORTFOLIO(1) INDEX FUND(1) LOANS TOTAL ----------- ----------- ----------- ------------ ASSETS: Investments, at fair value $10,593,850 $ 5,680,716 $ 3,326,576 $130,588,353 Contribution receivable from Genentech, Inc. 537,155 340,828 0 6,051,595 ----------- ----------- ----------- ------------ Net assets available for benefits $11,131,005 $ 6,021,544 $ 3,326,576 $136,639,948 =========== =========== =========== ============ <FN> See accompanying notes. (1) Fund shares are in registered investment companies. (2) A unitized stock fund. </FN> Page 4 Genentech, Inc. Tax Reduction Investment Plan Statement of Changes in Net Assets Available for Benefits with Fund Information Year Ended December 31, 1997 FIDELITY FIDELITY GENENTECH FIDELITY GROWTH GROWTH & FIDELITY COMMON MAGELLAN COMPANY INCOME INTERMEDIATE STOCK FUND FUND FUND PORTFOLIO BOND FUND ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 2,750,590 $ 2,145,451 $ 1,818,911 $ 202,838 Realized/unrealized gain, net 1,064,766 6,176,380 1,317,558 7,244,757 31,914 ----------- ----------- ----------- ----------- ----------- Total investment income 1,064,766 8,926,970 3,463,009 9,063,668 234,752 Contributions: Basic 753,851 3,090,832 2,466,941 3,262,951 346,819 Rollover 74,297 524,508 594,466 876,250 73,487 Employer match 351,706 1,417,772 1,000,970 1,474,290 175,466 ----------- ----------- ----------- ----------- ----------- Total contributions 1,179,854 5,033,112 4,062,377 5,613,491 595,772 Distributions (580,069) (2,207,055) (1,251,010) (1,781,627) (104,830) Administrative fees (6,879) (10,596) (2,875) (1,600) (262) Transfers between funds (1,196,910) (2,066,529) (941,140) 1,489,577 (92,289) ----------- ----------- ----------- ----------- ----------- Net change during the year 460,762 9,675,902 5,330,361 14,383,509 633,143 Net assets available for benefits: Beginning of year 8,779,258 34,493,894 18,303,986 28,304,793 3,093,159 ----------- ----------- ----------- ----------- ----------- End of year $ 9,240,020 $44,169,796 $23,634,347 $42,688,302 $ 3,726,302 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 315,655 $ 2,137,796 $ 150,048 $ 288,624 $ 35,605 Realized/unrealized gain, net 260,194 1,197,001 175,607 199,601 20,246 ----------- ----------- ----------- ----------- ----------- Total investment income 575,849 3,334,797 325,655 488,225 55,851 Contributions: Basic 786,540 1,169,646 232,970 421,800 80,368 Rollover 162,672 105,177 27,903 116,327 9,704 Employer match 332,306 534,842 94,288 182,942 32,191 ----------- ----------- ----------- ----------- ----------- Total contributions 1,281,518 1,809,665 355,161 721,069 122,263 Distributions (360,071) (608,106) (92,999) (144,742) (26,766) Administrative fees (50) (625) (113) (100) 0 Transfers between funds 118,728 (988,519) (173,776) 354,466 (57,669) ----------- ----------- ----------- ----------- ----------- Net change during the year 1,615,974 3,547,212 413,928 1,418,918 93,679 Net assets available for benefits: Beginning of year 5,087,735 14,679,401 1,393,200 1,525,374 500,023 ----------- ----------- ----------- ----------- ----------- End of year $ 6,703,709 $18,226,613 $ 1,807,128 $ 2,944,292 $ 593,702 =========== =========== =========== =========== =========== Page 5 Genentech, Inc. Tax Reduction Investment Plan Statement of Changes in Net Assets Available for Benefits with Fund Information Year Ended December 31, 1997 FIDELITY FIDELITY RETIREMENT SPARTAN MONEY MARKET U.S. EQUITY PARTICIPANT PORTFOLIO INDEX FUND LOANS TOTAL ----------- ----------- ----------- ------------ Investment income: Interest and dividends $ 632,790 $ 236,710 $ 406,602 $ 11,121,620 Realized/unrealized gain, net 0 2,203,451 0 19,891,475 ----------- ----------- ----------- ------------ Total investment income 632,790 2,440,161 406,602 31,013,095 Contributions: Basic 1,044,944 1,207,435 0 14,865,097 Rollover 246,640 635,082 0 3,446,513 Employer match 502,926 571,775 0 6,671,474 ----------- ----------- ----------- ------------ Total contributions 1,794,510 2,414,292 0 24,983,084 Distributions (1,154,113) (619,367) (218,297) (9,149,052) Administrative fees (1,287) (237) 0 (24,624) Transfers between funds 304,490 2,193,438 1,056,133 0 ----------- ----------- ----------- ------------ Net change during the year 1,576,390 6,428,287 1,244,438 46,822,503 Net assets available for benefits: Beginning of year 11,131,005 6,021,544 3,326,576 136,639,948 ----------- ----------- ----------- ------------ End of year $12,707,395 $12,449,831 $ 4,571,014 $183,462,451 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page 6 Genentech, Inc. Tax Reduction Investment Plan Statement of Changes in Net Assets Available for Benefits with Fund Information Year Ended December 31, 1996 FIDELITY FIDELITY GENENTECH FIDELITY GROWTH GROWTH & FIDELITY COMMON MAGELLAN COMPANY INCOME INTERMEDIATE STOCK FUND FUND FUND PORTFOLIO BOND FUND ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 5,213,751 $ 750,272 $ 1,296,172 $ 183,192 Realized/unrealized gain(loss), net 88,550 (1,673,186) 1,481,322 2,943,030 (86,751) ----------- ----------- ----------- ----------- ----------- Total investment income 88,550 3,540,565 2,231,594 4,239,202 96,441 Contributions: Basic 830,540 3,258,021 2,003,675 2,453,471 332,688 Rollover 38,368 271,323 359,704 504,153 95,272 Employer match 375,407 1,351,843 943,927 1,226,146 159,902 ----------- ----------- ----------- ----------- ----------- Total contributions 1,244,315 4,881,187 3,307,306 4,183,770 587,862 Distributions (517,198) (2,229,268) (906,200) (1,708,484) (88,385) Administrative fees (3,200) (3,823) (1,000) (1,563) (538) Transfers between funds (1,646,067) (3,342,222) 1,661,350 2,490,796 (90,347) ----------- ----------- ----------- ----------- ----------- Net change during the year (833,600) 2,846,439 6,293,050 9,203,721 505,033 Net assets available for benefits: Beginning of year 9,612,858 31,647,455 12,010,936 19,101,072 2,588,126 ----------- ----------- ----------- ----------- ----------- End of year $ 8,779,258 $34,493,894 $18,303,986 $28,304,793 $ 3,093,159 =========== =========== =========== =========== =========== FIDELITY FIDELITY FIDELITY FIDELITY FIDELITY ASSET ASSET ASSET OVERSEAS BALANCED MANAGER MANAGER: MANAGER: FUND FUND FUND GROWTH FUND INCOME FUND ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 287,003 $ 655,819 $ 96,361 $ 116,370 $ 30,819 Realized/unrealized gain, net 216,397 558,546 33,525 44,844 735 ----------- ----------- ----------- ----------- ----------- Total investment income 503,400 1,214,365 129,886 161,214 31,554 Contributions: Basic 668,507 1,292,258 176,278 266,531 67,465 Rollover 104,656 183,831 46,839 147,071 33,493 Employer match 303,851 564,230 87,305 128,963 33,340 ----------- ----------- ----------- ----------- ----------- Total contributions 1,077,014 2,040,319 310,422 542,565 134,298 Distributions (462,876) (566,746) (15,720) (25,929) (33,219) Administrative fees (100) (1,825) (12) (37) 0 Transfers between funds 459,588 (1,993,676) 184,704 204,784 153,136 ----------- ----------- ----------- ----------- ----------- Net change during the year 1,577,026 692,437 609,280 882,597 285,769 Net assets available for benefits: Beginning of year 3,510,709 13,986,964 783,920 642,777 214,254 ----------- ----------- ----------- ----------- ----------- End of year $ 5,087,735 $14,679,401 $ 1,393,200 $ 1,525,374 $ 500,023 =========== =========== =========== =========== =========== Page 7 Genentech, Inc. Tax Reduction Investment Plan Statement of Changes in Net Assets Available for Benefits with Fund Information Year Ended December 31, 1996 FIDELITY FIDELITY RETIREMENT SPARTAN MONEY MARKET U.S. EQUITY PARTICIPANT PORTFOLIO INDEX FUND LOANS TOTAL ----------- ----------- ----------- ------------ Investment income: Interest and dividends $ 504,185 $ 118,579 $ 278,216 $ 9,530,739 Realized/unrealized gain, net 0 735,934 0 4,342,946 ----------- ----------- ----------- ------------ Total investment income 504,185 854,513 278,216 13,873,685 Contributions: Basic 1,066,131 601,080 0 13,016,645 Rollover 183,294 236,167 0 2,204,171 Employer Match 537,758 341,013 0 6,053,685 ----------- ----------- ----------- ------------ Total contributions 1,787,183 1,178,260 0 21,274,501 Distributions (510,852) (265,711) (123,808) (7,454,396) Administrative fees (4,448) (388) 0 (16,934) Transfers between funds (249,817) 1,435,493 732,278 0 ----------- ----------- ----------- ------------ Net change during the year 1,526,251 3,202,167 886,686 27,676,856 Net assets available for benefits: Beginning of year 9,604,754 2,819,377 2,439,890 108,963,092 ----------- ----------- ----------- ------------ End of year $11,131,005 $ 6,021,544 $ 3,326,576 $136,639,948 =========== =========== =========== ============ <FN> See accompanying notes. </FN> Page Genentech, Inc. Tax Reduction Investment Plan Notes to Financial Statements (1) Description of the Plan: The following description of the Genentech, Inc. Tax Reduction Investment Plan (the Plan) provides only general information. Participants should refer to the Plan document for a more complete description of the Plan's provisions. The Plan was established, effective January 1, 1985, by Genentech, Inc. (the Company) for the benefit of eligible employees of the Company in order to provide them with a means of supplementing their retirement income on a tax-favored basis, an incentive to continue and increase their efforts to contribute to the success of the Company, and an opportunity to acquire an equity interest in the Company. The Plan accomplishes this through a savings program that is based on systematic salary reductions. The employee's salary is reduced by the amount elected to be saved on a pre-tax basis. The "deferred" part of the employee's salary is then invested in the Plan. An individual employee's account is credited with earnings or losses on a pro rata basis as the actual investment funds report their earnings performance. Individuals eligible to participate under the Plan must be employees of the Company or employees of an affiliate of the Company that adopts the Plan with the approval of the Board of Directors. However, the following employees or classes of employees are not eligible to participate: (i) any employee who is classified as temporary by the Company, unless such employee has completed at least 1,000 hours of service in a 12-month period beginning on his or her hire date or any anniversary thereof; (ii) any part-time employee normally scheduled to work less than 20 hours per week, unless such employee has completed at least 1,000 hours of service in a 12-month period beginning on his or her hire date or any anniversary thereof; (iii) any employee who is a member of a collective bargaining unit and who is covered by a collective bargaining agreement where retirement benefits were the subject of good faith bargaining; (iv) any individual employed by any corporation or other business entity that is merged or liquidated into the Company, unless the Company designates such employees as eligible employees; (v) any employee paid from a non-U.S. payroll; or (vi) any employee classified or treated as an independent contractor, consultant, leased employee (as defined under the Internal Revenue Code of 1986, as amended (the Code)), or an employee of an employment agency or other entity, even if subsequently determined to have been a common-law employee of the Company. The Board of Directors of the Company has the right under the Plan to alter, amend or terminate the Plan, or any part thereof, in such a manner as it may determine. If the Plan is terminated, the interests of all Plan members would remain fully (100%) vested and nonforfeitable. The balances credited to their accounts would remain with the Plan trustee until they become distributable in accordance with the Plan. The Company matches a portion of employee contributions, up to a maximum of 4% of a participant's eligible compensation (the Match). The Match is effective December 31st of each year (the Effective Date) and contributions under the Match are fully vested at that time. The Match is funded in the first quarter of the subsequent year. In the first quarter of 1998 and 1997, the Company contributed approximately $6.7 million and $6.1 million, respectively, to the Plan in accordance with the terms of the Plan. Page 9 The Plan trustee is Fidelity Management Trust Company (the Plan Trustee). All amounts contributed to the Plan are deposited in a trust account with the Plan Trustee. The Plan Trustee's fees and expenses are paid by the Company and are not charged to the Plan. Accounts of terminated employees who continue to hold an account under the Plan as non-employee participants are charged an annual fee of $50.00 by the Company. The Plan Trustee has blanket bond insurance covering the full market value of the securities and investments of which it has custody. Effective as of May 8, 1996, the Company changed the mechanics of its Genentech Common Stock Fund (the Stock Fund) to a unitized fund that assigns units to participants rather than shares of the Company's stock. These units represent a proportionate interest in all of the assets of the Stock Fund, which includes shares of the Company's callable putable common stock (Special Common Stock) and a small percentage (approximately 2%, although the percentage may vary over time) in short-term investments. A net asset value per unit will be determined daily for each unit outstanding in the Stock Fund. The return earned by the Stock Fund will represent a combination of the dividends paid on the shares of the Company's Special Common Stock (the Company's Special Common Stock currently does not pay a dividend) held by the Stock Fund, gains or losses realized on sales of the Company's Special Common Stock, appreciation or depreciation in the market price of those shares owned, and interest on the short-term investments held by the Stock Fund. On May 21, 1997, the Plan employee eligibility provisions were amended (retroactively effective to January 1, 1985) to clarify that independent contractors, consultants, leased employees (as defined in the Code), and employees of employment agencies or other entities are not eligible to participate in the Plan, even if subsequently determined to have been common- law employees of the Company. On December 31, 1997, the Plan was amended (retroactively effective to January 1, 1985) to clarify in the Plan the manner in a participant's Plan account is treated if and when the Company receives notice that a domestic relations order specifying such account as a source of payment is being sought. The outstanding units and net asset values for the Stock Fund are calculated at the end of each month by the Plan Trustee. The monthly Stock Fund units and net asset value per unit for 1997 and 1996 are as follows: Page 1 Number Net Net Asset For the Period Ending January 31, 1997 of Asset Value through December 31, 1997 Units Value Per Unit - ---------------------------------------- ------- ------------- ----------- January 31, 1997: Genentech Common Stock Fund 158,035 $ 8,672,171 $ 54.88 Fidelity Institutional Cash Portfolio: Money Market Fund 123,528 123,528 1.00 February 28, 1997: Genentech Common Stock Fund 155,434 8,568,299 55.12 Fidelity Institutional Cash Portfolio: Money Market Fund 125,545 125,545 1.00 March 31, 1997: Genentech Common Stock Fund 154,628 8,833,124 57.12 Fidelity Institutional Cash Portfolio: Money Market Fund 126,485 126,485 1.00 April 30, 1997: Genentech Common Stock Fund 155,559 9,119,646 58.62 Fidelity Institutional Cash Portfolio: Money Market Fund 141,233 141,233 1.00 May 31, 1997: Genentech Common Stock Fund 157,059 9,207,584 58.63 Fidelity Institutional Cash Portfolio: Money Market Fund 137,963 137,963 1.00 June 30, 1997: Genentech Common Stock Fund 157,610 9,289,139 58.94 Fidelity Institutional Cash Portfolio: Money Market Fund 121,349 121,349 1.00 July 31, 1997: Genentech Common Stock Fund 156,110 9,015,353 57.75 Fidelity Institutional Cash Portfolio: Money Market Fund 128,627 128,627 1.00 August 31, 1997: Genentech Common Stock Fund 156,710 8,952,059 57.13 Fidelity Institutional Cash Portfolio: Money Market Fund 122,445 122,445 1.00 September 30, 1997: Genentech Common Stock Fund 153,710 8,934,394 58.13 Fidelity Institutional Cash Portfolio: Money Market Fund 111,522 111,522 1.00 October 31, 1997: Genentech Common Stock Fund 146,410 8,500,931 58.06 Fidelity Institutional Cash Portfolio: Money Market Fund 95,885 95,885 1.00 November 30, 1997: Genentech Common Stock Fund 146,896 8,575,054 58.38 Fidelity Institutional Cash Portfolio: Money Market Fund 89,664 89,664 1.00 December 31, 1997: Genentech Common Stock Fund 144,903 8,782,485 60.61 Fidelity Institutional Cash Portfolio: Money Market Fund 105,895 105,895 1.00 Page 11 Number Net Net Asset For the Period Ending May 31, 1996 of Asset Value through December 31, 1996 Units Value Per Unit - ---------------------------------------- ------- ------------- ----------- May 31, 1996: Genentech Common Stock 170,901 $ 8,993,665 $52.62 Fidelity Institutional Cash Portfolio: Money Market Fund 122,580 122,580 1.00 June 30, 1996: Genentech Common Stock 169,001 8,851,427 52.37 Fidelity Institutional Cash Portfolio: Money Market Fund 45,181 45,181 1.00 July 31, 1996: Genentech Common Stock 164,601 8,662,128 52.63 Fidelity Institutional Cash Portfolio: Money Market Fund 127,632 127,632 1.00 August 31, 1996: Genentech Common Stock 162,080 8,509,200 52.50 Fidelity Institutional Cash Portfolio: Money Market Fund 49,181 49,181 1.00 September 30, 1996: Genentech Common Stock 158,380 8,374,343 52.88 Fidelity Institutional Cash Portfolio: Money Market Fund 120,408 120,408 1.00 October 31, 1996: Genentech Common Stock 156,780 8,446,523 53.88 Fidelity Institutional Cash Portfolio: Money Market Fund 108,720 108,720 1.00 November 30, 1996: Genentech Common Stock 155,268 8,403,881 54.13 Fidelity Institutional Cash Portfolio: Money Market Fund 84,407 84,407 1.00 December 31, 1996: Genentech Common Stock 154,568 8,292,400 53.65 Fidelity Institutional Cash Portfolio: Money Market Fund 111,451 111,451 1.00 Page 12 In 1997 and 1996, subject to limitations of the Code, each participant in the Plan could elect to defer up to the lower of (i) $9,500 or (ii) 15% and 12%, respectively, of his or her eligible compensation. For the plan years 1997 and 1996, each participant was required to direct the investment of his or her contributions to any of the following twelve investment funds of the Plan (or any combination thereof): Genentech Common Stock Fund This fund invests primarily in the Special Common Stock of the Company, which is purchased at full market price. In addition, a small percentage of this fund (approximately 2%, although the percentage may vary over time) invests in the Fidelity Institutional Cash Portfolios: Money Market Portfolio: Class A, (or other mutual funds or money market funds as may be agreed to by the Company and the Plan Trustee), to provide liquidity for the timely settlement of trades. The Special Common Stock of the Company does not currently pay dividends; therefore the return on this fund is largely dependent on the performance of the stock and, to a lesser degree, the interest received on the short-term investments. See above for information on the unitization of this fund. Fidelity Magellan, registered trademark, Fund The Fidelity Magellan Fund is a mutual fund managed by Fidelity Management and Research Company (FMR). The fund invests in the common stock, and securities convertible into common stock, of various types of domestic and foreign companies. Fidelity Growth Company Fund The Fidelity Growth Company Fund is a mutual fund managed by FMR. It invests primarily in common stock of companies that it believes have the potential for above-average growth. Fidelity Growth & Income Portfolio The Fidelity Growth & Income Portfolio is a mutual fund managed by FMR and invests primarily in securities of U.S. and foreign companies that it believes offer growth of earnings potential while paying current dividends. The Portfolio may also invest in bonds. Fidelity Intermediate Bond Fund The Fidelity Intermediate Bond Fund is a mutual fund managed by FMR. The fund invests in various types of U.S. and foreign bonds, including corporate or U.S. government issues. The fund selects bonds that it considers medium- to high-quality and normally maintains an average maturity of 3 to 10 years. Fidelity Overseas Fund The Fidelity Overseas Fund is a mutual fund managed by FMR. The fund invests in foreign securities including common stock and securities convertible to common stock of foreign businesses and debt instruments of foreign businesses and governments. Page 13 Fidelity Balanced Fund The Fidelity Balanced Fund is a mutual fund managed by FMR that invests in a broad variety of what it believes are high yielding U.S. and foreign securities. The fund maintains at least 25% of its assets in fixed income securities (bonds) and preferred stocks. Fidelity Asset Manager, trademark, Fund The Fidelity Asset Manager Fund is a mutual fund managed by FMR. The Asset Manager Fund allocates its assets among domestic and foreign equities, bonds and short-term instruments, aiming for an investment mix of 40% stocks, 40% bonds and 20% short-term investments. Fidelity Asset Manager: Growth Fund The Fidelity Asset Manager: Growth Fund, a mutual fund managed by FMR, invests in domestic and foreign stocks, bonds and short-term instruments, aiming for an investment mix of 65% stocks, 30% bonds and 5% short-term investments. Fidelity Asset Manager: Income Fund The Fidelity Asset Manager: Income Fund is a mutual fund managed by FMR that invests in domestic and foreign stocks, bonds and short-term instruments, aiming for an investment mix of 20% stocks, 30% bonds and 50% short-term investments. Fidelity Retirement Money Market Portfolio The Fidelity Retirement Money Market Portfolio is a mutual fund managed by FMR. It invests in what it believes are high-quality U.S. dollar-denominated money market instruments of U.S. and foreign issuers, including short-term corporate obligations and certificates of deposit. Fidelity Spartan U.S. Equity Index Fund The Fidelity U.S. Equity Index Fund, a mutual fund managed by FMR, invests mostly in the common stocks of a variety of the 500 companies that make up the Standard & Poor's Composite Index. Participant Loans Loans are made to Plan participants, at fixed interest rates (presently 2% above the then-current bank prime interest rate), subject to certain restrictions, principally related to a participant's account balance, permissible loan amount, and repayment through payroll withholding. Loans are repaid through monthly payroll deductions over three or five years, or fifteen years if the purpose of the loan is to purchase a participant's principal residence. Conditions of Withdrawal Distributions under the Plan will be made upon a participant's death, disability, retirement or other termination of employment with the Company, attainment of age 70-1/2, or authorized exercise of his or her withdrawal rights under the Plan. A participant must consent to a distribution unless he or she has attained age 62 or the balance credited to his or her account Page 14 under the Plan does not exceed and has not exceeded $3,500. Distributions are made upon receipt of the participant's or beneficiary's election directing the method of distribution. Prior to termination of employment with the Company, the Plan administrator may grant a participant's request for a withdrawal if the Plan administrator makes a determination that such withdrawal is necessary in light of the immediate and heavy financial needs of the participant and is in accordance with the requirements of the Code and regulations promulgated thereunder. In addition, a Plan participant may withdraw up to the entire balance of his or her Plan account if over age 59-1/2 at the time of withdrawal. (2) Summary of Significant Accounting Policies: Investment Valuation Investments are stated at market value at year end. Fidelity Magellan Fund, Fidelity Growth Company Fund, Fidelity Growth & Income Portfolio, Fidelity Intermediate Bond Fund, Fidelity Overseas Fund, Fidelity Balanced Fund, Fidelity Asset Manager Fund, Fidelity Asset Manager: Growth Fund, Fidelity Asset Manager: Income Fund, and Fidelity Spartan U.S. Equity Index Fund securities are valued at the last reported sales price on the last business day of the year, which for the mutual funds represents the net asset values of shares held by the Plan at year end. The Fidelity Retirement Money Market Portfolio instruments is valued on the basis of historical cost that approximates fair value. Participant loans are valued at their outstanding balance which approximates fair value. See Note (1) for a description of the investment valuation of the Genentech Common Stock Fund. Contributions Basic contributions are accrued and vested when deducted from employee pay; the Match is accrued and vested on the Effective Date; and qualified rollover contributions are recorded and vested when received by the Plan Trustee. Contributions are invested pursuant to participants' directions to the Plan Trustee after receipt of contributions by the Plan Trustee. Participants may change the amount of contributions (as a percentage reduction of pre-tax eligible compensation) at any time by contacting the Plan Trustee. Transfers between funds and changes in investment allocations can be made at any time, up to ten times per year, effective upon direction by the participant to the Plan Trustee. Distributions Distributions are recorded when paid. Other All security transactions are recorded on the trade date. Gains and losses on the disposals of investments are determined based on the average cost of all securities. Dividend income is recorded on the effective date of a declared dividend. Income from other investments is recorded as earned on an accrual basis. Page 15 Use of Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires management to make certain estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. (3) Income Tax Status: The Internal Revenue Service (the IRS) has determined and informed the Company by letter dated September 25, 1995, that the December 21, 1984 Plan, as amended and restated, qualified in form under Section 401(a) of the Code and the underlying trust is, therefore, exempt from federal income taxes under Section 501(a) of the Code. Effective as of May 8, 1996, the Plan was again amended and restated. In May 1997 and December 1997, the amended and restated Plan was amended (retroactively effective to January 1, 1985). The changes made in the May 8, 1996 amendment and restatement, the May 1997 amendment and the December 1997 amendment were technical in nature, and in the opinion of the Company and its legal counsel, did not require another determination from the IRS concerning the Plan's tax exempt status. The Company believes that the Plan is designed and is currently being operated in compliance with the applicable requirements of the Code. (4) Related Party Transactions: Certain of the investment funds are managed by FMR, an affiliate of the Plan Trustee. Because of this relationship, transactions involving these funds qualify as party-in-interest transactions, as well as transactions in Genentech Special Common Stock and loans to Plan participants. Page 16 (5) Assets held for investment at December 31, 1997 were as follows: Number of Name of Issuer Shares, Units Fair and Title of Principal or Amount Cost Value - ----------------------------------------------- ------------- ------------ ------------ GENENTECH COMMON STOCK FUND Genentech, Inc. - Special Common Stock....................... 144,903 $ 6,199,615 $ 8,782,485 Fidelity Institutional Cash Portfolio: Money Market Fund.......................... 105,895 105,895 105,895 FIDELITY MAGELLAN, registered trademark, FUND Fidelity Magellan Fund....................... 448,746 34,428,835 42,752,024 FIDELITY GROWTH COMPANY FUND Fidelity Growth Company Fund ................ 522,469 19,285,747 22,633,377 FIDELITY GROWTH & INCOME PORTFOLIO Fidelity Growth & Income Portfolio........... 1,081,733 29,241,699 41,214,011 FIDELITY INTERMEDIATE BOND FUND Fidelity Intermediate Bond Fund.............. 349,148 3,560,542 3,550,836 FIDELITY OVERSEAS FUND Fidelity Overseas Fund ...................... 195,802 5,894,918 6,371,403 FIDELITY BALANCED FUND Fidelity Balanced Fund ...................... 1,158,647 15,506,958 17,692,544 FIDELITY ASSET MANAGER, trademark, FUND Fidelity Asset Manager Fund.................. 93,350 1,517,502 1,712,971 FIDELITY ASSET MANAGER: GROWTH FUND Fidelity Asset Manager: Growth Fund ......... 149,424 2,509,826 2,761,351 FIDELITY ASSET MANAGER: INCOME FUND Fidelity Asset Manager: Income Fund ........ 46,101 544,519 561,511 FIDELITY RETIREMENT MONEY MARKET PORTFOLIO Fidelity Retirement Money Market Portfolio .. 12,205,141 12,205,141 12,205,141 FIDELITY SPARTAN U.S. EQUITY INDEX FUND Fidelity Spartan U.S. Equity Index Fund ..... 339,567 8,954,526 11,878,056 PARTICIPANT LOANS Loans receivable from participants .......... 4,571,014 4,571,014 4,571,014 ------------ ------------ TOTAL INVESTMENTS ............................. $144,526,737 $176,792,619 ============ ============ Page 1 Report of Ernst & Young LLP, Independent Auditors To the Participants and Plan Administration Committee of the Genentech, Inc. Tax Reduction Investment Plan We have audited the accompanying statements of net assets available for benefits of the Genentech, Inc. Tax Reduction Investment Plan as of December 31, 1997 and 1996, and the related statements of changes in net assets available for benefits for the years then ended. These financial statements are the responsibility of the Plan's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the net assets available for benefits of the Genentech, Inc. Tax Reduction Investment Plan at December 31, 1997 and 1996, and the changes in its net assets available for benefits for the years then ended, in conformity with generally accepted accounting principles. Our audits were performed for the purpose of forming an opinion on the basic financial statements taken as a whole. The accompanying supplemental schedules of assets held for investment purposes as of December 31, 1997 and of reportable transactions for the year then ended, are presented for purposes of complying with the Department of Labor's Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974, and are not a required part of the basic financial statements. The Fund Information in the statement of net assets available for benefits and the statement of changes in net assets available for benefits is presented for purposes of additional analysis rather than to present the net assets available for benefits and changes in net assets available for benefits of each fund. The supplemental schedules and Fund Information have been subjected to the auditing procedures applied in our audits of the basic financial statements and, in our opinion, are fairly stated in all material respects in relation to the basic financial statements taken as a whole. ERNST & YOUNG LLP San Jose, California May 15, 1998 Page 18 Signatures Pursuant to the requirements of the Securities Exchange Act of 1934, the Plan administrator has duly caused this annual report to be signed by the undersigned hereunto duly authorized. Genentech, Inc. Tax Reduction Investment Plan by Genentech, Inc., Plan Administrator By: /S/LOUIS J. LAVIGNE, JR. Date: June 23, 1998 ---------------------------------- Louis J. Lavigne, Jr. Executive Vice President and Chief Financial Officer and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/JUDITH A. HEYBOER Date: June 23, 1998 ---------------------------------- Judith A. Heyboer Senior Vice President - Human Resources and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan By: /S/JAMES P. PANEK Date: June 23, 1998 ---------------------------------- James P. Panek Vice President - Manufacturing, Engineering and Facilities and Plan Administration Committee Member for Genentech, Inc. Tax Reduction Investment Plan Page 19 SCHEDULE I Genentech, Inc. Tax Reduction Investment Plan Item 27a Schedule of Assets Held For Investment Purposes December 31, 1997 Description Current Identity of Issue of Investment Cost Value - ---------------------------------------- ----------------- ------------ ------------ * GENENTECH COMMON STOCK FUND Genentech, Inc. - Common stock - Special Common Stock................. 144,903 units $ 6,199,615 $ 8,782,485 Fidelity Institutional Cash Portfolio: Mutual Fund Money Market Fund .................. 105,895 units 105,895 105,895 * FIDELITY MAGELLAN, registered trademark, FUND Mutual fund - Fidelity Magellan Fund................ 448,746 shares 34,428,835 42,752,024 * FIDELITY GROWTH COMPANY FUND Mutual fund - Fidelity Growth Company Fund ......... 522,469 shares 19,285,747 22,633,377 * FIDELITY GROWTH & INCOME PORTFOLIO Mutual fund - Fidelity Growth & Income Portfolio ... 1,081,733 shares 29,241,699 41,214,011 * FIDELITY INTERMEDIATE BOND FUND Mutual fund - Fidelity Intermediate Bond Fund ...... 349,148 shares 3,560,542 3,550,836 * FIDELITY OVERSEAS FUND Mutual fund - Fidelity Overseas Fund ............... 195,802 shares 5,894,918 6,371,403 * FIDELITY BALANCED FUND Mutual fund - Fidelity Balanced Fund ............... 1,158,647 shares 15,506,958 17,692,544 * FIDELITY ASSET MANAGER, trademark, FUND Mutual fund - Fidelity Asset Manager Fund........... 93,350 shares 1,517,502 1,712,971 * FIDELITY ASSET MANAGER: GROWTH FUND Mutual fund - Fidelity Asset Manager: Growth Fund .. 149,424 shares 2,509,826 2,761,351 * FIDELITY ASSET MANAGER: INCOME FUND Mutual fund - Fidelity Asset Manager: Income Fund .. 46,101 shares 544,519 561,511 * FIDELITY RETIREMENT MONEY MARKET PORTFOLIO Mutual fund - Fidelity Retirement Money Market Portfolio 12,205,141 shares 12,205,141 12,205,141 * FIDELITY SPARTAN U.S. EQUITY INDEX FUND Mutual fund - Fidelity Spartan U.S. Equity Index Fund 339,567 shares 8,954,526 11,878,056 * PARTICIPANT LOANS Loans receivable from participants ... (1) 4,571,014 4,571,014 ------------ ------------ TOTAL INVESTMENTS ...................... $144,526,737 $176,792,619 ============ ============ <FN> (1) Maturing at various dates through 2012 at interest rates ranging from 8.00% to 12.25%. * Party-in-interest. </FN> Page 20 SCHEDULE II Genentech, Inc. Tax Reduction Investment Plan Item 27d Schedule of Reportable Transactions For the Year ended December 31, 1997 Purchases Sales -------------------------- ------------------------------------------------ Description Number of Purchase Number of Selling Net of Asset Transactions Price Transactions Cost Price Gain/Loss - -------------------------------- ----------- ----------- ----------- ----------- --------- Fidelity Magellan Fund 240 $ 9,577,470 209 $ 5,247,344 $ 6,144,629 $ 897,285 Fidelity Growth Company Fund 224 8,053,465 181 3,323,469 4,097,798 774,329 Fidelity Growth & Income Portfolio 241 11,074,163 195 3,205,052 4,183,741 978,689 Fidelity Balanced Fund 185 4,490,884 155 1,845,720 2,110,785 265,065 Fidelity Retirement Money Market Portfolio 203 6,999,569 197 5,388,277 5,388,277 - Fidelity Spartan U.S. Equity Index Fund 202 5,647,821 126 1,303,873 1,653,932 350,059 <FN> Reportable transactions include any series of transactions that in the aggregate exceed five percent of the fair market value of Plan assets at the beginning of the year. The transactions can occur on a daily basis. These transactions represent Category (iii) reportable transactions in accordance with Department of Labor regulations. There were no other reportable transactions during 1997. </FN> Page 21 Genentech, Inc. Tax Reduction Investment Plan Index of Exhibits Filed with Form 11-K For the Year Ended December 31, 1997 Sequential Exhibit Number Description Page Numbers - -------------- --------------------------------------------------- ------------- 23 Consent of Ernst & Young LLP, Independent Auditors, filed with this document 23 Page 22