$2,000,000.00 REVOLVING CREDIT LOAN




                                 AMENDMENT NO. 1

                                       TO

                           LOAN AND SECURITY AGREEMENT

                    originally dated as of December 26, 2000

                                 by and between

                              GISH BIOMEDICAL, INC.
                                  ("Borrower")

                                       and

                         HELLER HEALTHCARE FINANCE, INC.
                                   ("Lender")





                         Amended as of February 9, 2002







                 AMENDMENT NO. 1 TO LOAN AND SECURITY AGREEMENT
                 ----------------------------------------------


     THIS AMENDMENT NO. 1 TO LOAN AND SECURITY  AGREEMENT (the  "Amendment")  is
made as of this 9th day of February, 2002, by and among GISH BIOMEDICAL, INC., a
California  corporation  ("Borrower"),  and HELLER HEALTHCARE  FINANCE,  INC., a
Delaware corporation ("Lender").


                                    RECITALS
                                    --------

     A. Pursuant to that certain Loan and Security  Agreement dated December 26,
2000 by and between Borrower and Lender (as amended hereby and as may be further
amended from time to time, the "Loan  Agreement"),  the parties have established
certain  financing  arrangements that allow Borrower to borrow funds from Lender
in accordance with the terms and conditions set forth in the Loan Agreement.

     B. The parties now desire to amend the Loan  Agreement in  accordance  with
the terms and conditions set forth below.

     C. Capitalized  terms used but not defined in this Amendment shall have the
meanings that are set forth in the Loan Agreement.


     NOW, THEREFORE, in consideration of the premises set forth above, the terms
and  conditions  contained  in this  Amendment,  and  other  good  and  valuable
consideration,  the receipt and  sufficiency  of which are hereby  acknowledged,
Lender  and  Borrower  have  agreed  to the  following  amendments  to the  Loan
Agreement:

     1. Amendments to Loan Agreement.
        ----------------------------

        (a) Section 1.17a of the Loan Agreement-Definition of "Foreign Account".
The following  definition of "Foreign  Account"  shall be added as a new Section
1.17a:

        "Section 1.17a Foreign Account. "Foreign  Account" shall mean an Account
                       ---------------
        to be paid by an Account Debtor whose principal place of business and/or
        executive office is  outside  of the  United  States  and which  Account
        is subject to a Guaranty from theExport-Import Bank of the United States
        ("Ex-Im Bank) of at least ninety-five  percent (95%).  Upon receipt of a
        Borrowing Base Certificate from Borrower,  Lender,  together  with EX-IM
        Bank and the Trade Finance division  of  GE Capital  Corporation,  shall
        determine, in their  collective  credit judgment,  whether   a   Foreign
        Account  shall  be  deemed  to be  a Qualified  Account, notwithstanding
        and  regardless  of  the  exclusions   set  forth  in  the definition of
        Qualified Account."




        (b)  Section  1.42(h) of the Loan Agreement - Definition  of  "Qualified
             -------------------------------------------------------------------
Account".  Section  1.42(h)  shall be deleted and  restated  in its  entirety as
- -------
follows:

        "(h) except  for  any  Foreign Account, the  Account is an Account of an
        Account Debtor having  its  principal place  of  business  or  executive
        office outside the United States;"

        (c) Section 1.46 of the Loan Agreement- Definition of "Termination Fee".
            --------------------------------------------------------------------
Section 1.46 shall be deleted and restated in its entirety as follows:

        "Section 1.46 Termination Fee."Termination Fee" shall mean a fee payable
                      ---------------
        upon termination of the Agreement, as yield  maintenance for the loss of
        bargain and not as a penalty,  equal to either (a) if the date of notice
        of  a  termination is  on  or  before the third (3rd) anniversary of the
        Closing Date, three percent (3%) of the Maximum Loan Amount,  and (b) if
        the date of a notice of termination is after the third (3rd) anniversary
        of the Closing Date and on  or  before  the  fourth  anniversary  of the
        Closing Date, two percent (2%)of the Maximum Loan Amount."

        (d) Section 2.1(a) of the Loan Agreement - Maximum Loan  Amount. Section
            ------------------------------------------------------------
2.1(a) shall be deleted and restated in its entirety as follows:

        "(a) The maximum aggregate principal amount of credit extended by Lender
        to  Borrower under this Agreement (the  "Loan") that will be outstanding
        at  any  time  is  Four  Million and No/100 Dollars ($4,000,000.00) (the
        "Maximum Loan  Amount"). Notwithstanding anything in this Loan Agreement
        to the contrary, the Maximum Loan Amount will be subject to  a  sublimit
        of Seven Hundred Fifty Thousand and  No/100  Dollars  ($750,000.00)  for
        Revolving Credit Loans advanced on Foreign  Accounts,  and  any  funding
        above such sublimit shall in each  instance  be  subject to the  written
        approval  of  Lender's  credit  committee,  exercising  its  sole credit
        judgment."

        (e) Section 2.1(d) of  the  Loan  Agreement - Advance  Rate.  The  first
            --------------------------------------------------------
sentence  of  Section  2.1(d)  shall be deleted  and restated in its entirety as
follows:

        "Subject to the terms and conditions of this Agreement,  advances  under
        the Loan shall be made against a borrowing  base  equal  to  eighty-five
        percent (85%) of Qualified Accounts due  and  owing  from  any   Account
        Debtor (the "Borrowing Base")."

        (f) Section 2.4(c) of the Loan Agreement - Loan Management Fee.The first
            ----------------------------------------------------------
sentence  of Section  2.4(c)  shall be deleted and  restated in its  entirety as
follows:

        "For  so  long  as  the  Loan  is  available to Borrower, Borrower shall
        unconditionally pay to Lender a monthly loan management  fee (the  "Loan
        Management Fee") equal to (i) one-fifth of one  percent  (0.20%) of  the
        average amount of the outstanding principal  balance  of  the  Revolving

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        Credit Loans that are  advanced  during the preceding month against non-
        Foreign Accounts,and (ii) one-tenth of one percent(0.10%) of the average
        amount  of  the  outstanding principal balance of the  Revolving  Credit
        Loans that are  advanced  during  the  preceding  month  against Foreign
        Accounts."

        (g)  Section 2.8(a) of the Loan Agreement - Extension  of Term.  Section
             ----------------------------------------------------------
2.8(a) shall be deleted and restated in its entirety as follows:

        "(a) Subject to Lender's right to cease making Revolving Credit Loans to
        Borrower upon or after any Event of Default,  this Agreement shall be in
        effect until February 1, 2005,  unless  terminated  as  provided in this
        Section 2.8 (the"Term"),and this Agreement shall be renewed for one-year
        periods thereafter upon the mutual written agreement of the parties."

        (h) Section 6.23 of the Loan  Agreement - Net Worth.  Section 6.23 shall
            ------------------------------------------------
be deleted and restated in its entirety as follows:

        "Section  6.23.  Net Worth. Borrower will not at any time  allow its net
                         ---------
        worth, as computed in accordance with GAAP, to fall below Seven  Million
        and No/100  Dollars ($7,000,000)."

        (i) Section 6.24 of the Loan Agreement - Net Income. The following shall
            -----------------------------------------------
be added as a new Section 6.24 to the Agreement:

        "Section 6.24. Net Income. Borrower shall achieve Net Income of at least
                       -----------
        One Dollar ($1.00) for the three (3) month period  beginning  on June 1,
        2002 and ending on August 31, 2002. Thereafter,  Borrower shall maintain
        positive Net Income for  each three (3) month period, as calculated on a
        rolling basis. For  purposes  of  this  Agreement, the term "Net Income"
        shall be computed in accordance with GAAP, but which  computation  shall
        be  subject  to  Lender's  sole  credit   judgment.  Notwithstanding the
        provisions of Section 2.8, if Borrower fails to comply with this Section
        6.24 and  Lender determines  to terminate the Loan solely as a result of
        such  non-compliance,  Borrower  shall  not  be  obligated  to  pay  the
        Termination Fee to Lender."

        (j) Section 6.25 of the Loan Agreement -EX-IM Bank Insurance Policy. The
            ----------------------------------------------------------------
following shall be added as a new Section 6.25 to the Agreement:

        "Section 6.25. Compliance  with EX-IM Bank  Insurance  Policy.  Borrower
                       -----------------------------------------------
        shall comply with all reporting and other  requirements set forth in the
        policy of insurance issued by EX-IM Bank  and shall  take all  necessary
        action to keep such policy in full force and effect."

        (k) Section 9.1(b)  of  the Loan  Agreement -  Expenses  and  Fees.  The
            ---------------------------------------------------------------
following sentence shall be inserted after the first sentence of Section 9.1(b):

                                       3



                  "The fees described in the foregoing sentence shall include
                  fees incurred by the Trade Finance Division of GE Capital
                  Corporation to monitor and process information relating to
                  foreign Accounts, which fees shall include (i) a one-time
                  start-up fee equal to $3,500, (ii) an annual software
                  licensing fee of $6,000 per year, (iii) a quarterly actual
                  line use fee equal to .50% per annum, but of at least $1,000
                  per quarter, and (iv) any other similar fees of like kind
                  commensurate with the foregoing rates, subject, however, to
                  increases that are customary within the industry."

     2. Fees and  Costs.  Borrower  shall  unconditionally  pay to the  Lender a
        ---------------
commitment  fee equal to one percent  (1%) of the  increase in the Maximum  Loan
Amount,  or Twenty Thousand Dollars  ($20,000).  In addition,  Borrower shall be
responsible for the payment of all reasonable fees of Lender's  in-house counsel
incurred in connection  with the  preparation  of this Amendment and any related
documents.  Borrower  hereby  authorizes  Lender to deduct  all of such fees set
forth in this Section from the proceeds of the next Revolving Credit Loan.

     3. Confirmation of Representations and Warranties. Borrower hereby confirms
        -----------------------------------------------
that all of the  representations  and  warranties set forth in Article IV of the
Loan  Agreement  are true and correct as of the date  hereof,  and  specifically
represents and warrants to Lender that it has good and  marketable  title to all
of its respective Collateral, free and clear of any lien or security interest in
favor of any other person or entity.

     4. Updated  Schedules.  As a condition  precedent to Lender's  agreement to
        ------------------
enter into this  Amendment,  and in order for this  Amendment  to be  effective,
Borrower  shall  revise,  update and deliver to Lender all Schedules to the Loan
Agreement  to  update  all  information  as  necessary  to  make  the  Schedules
previously  delivered correct.  Borrower hereby represents and warrants that the
information  set forth on the  attached  Schedules is true and correct as of the
date of this Amendment.  The attached Schedules are hereby incorporated into the
Loan Agreement as if originally set forth therein.

     5. Reference to the Effect on the Loan Agreement.
        ---------------------------------------------

        (a) Upon the effectiveness of this Amendment, each reference in the Loan
Agreement  to "this  Agreement,"  "hereunder,"  "hereof,"  "herein"  or words of
similar import shall mean and be a reference to the Loan Agreement as amended by
this Amendment.

        (b) Except as specifically  amended  above, the  Loan Agreement, and all
other  Loan  Documents,  shall  remain in full force and effect,  and are hereby
ratified and confirmed.

        (c) The execution, delivery and effectiveness of  this  Amendment  shall
not, except as expressly provided in this Amendment, operate  as a waiver of any
right,  power or remedy of Lender,  nor  constitute a waiver of any provision of
the Loan Agreement, or any other documents,  instruments and agreements executed
or delivered in connection with the Loan Agreement.

     6.  Governing  Law.  This  Amendment  shall be governed by and construed in
         ---------------
accordance with the laws of the State of Maryland.

                                       4



     7.  Headings.   Section   headings  in  this  Amendment  are  included  for
         ---------
convenience  of reference only and shall not constitute a part of this Amendment
for any other purpose.

     8. Counterparts.  This Amendment may be executed in counterparts,  and both
        -------------
counterparts  taken  together  shall be  deemed to  constitute  one and the same
instrument.


     IN WITNESS  WHEREOF,  the parties have caused this Amendment to be executed
as of the date first written above.

                                     LENDER:

                                     HELLER HEALTHCARE FINANCE, INC.,
                                     a Delaware corporation


                                     By: /s/ Joseph Prandoni
                                         ------------------------------------
                                     Name: Joseph Prandoni
                                     Title: Vice President


                                     BORROWER:

                                     GISH BIOMEDICAL, INC.,
                                     a California corporation


                                     By: /s/ Leslie M. Taeger
                                         -------------------------------------
                                     Name: Leslie M. Taeger
                                     Title:   Chief Financial Officer





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