BIOGEN, INC.
              1985 NON-QUALIFIED STOCK OPTION PLAN
(AS AMENDED THROUGH DECEMBER 6, 1996 AND REVISED TO REFLECT TWO-FOR-ONE STOCK 
               SPLIT EFFECTED IN NOVEMBER 1996)

 
I.   PURPOSE OF THE PLAN
 
The Plan is intended to encourage ownership of shares of Common Stock of the 
Company by certain employees and Directors of the Company and its Affiliates 
and to provide an additional incentive to those employees and Directors to 
promote the success of the Company and its Affiliates.
 
II.  DEFINITIONS
 
          1. "Company" means Biogen, Inc., a Massachusetts corporation.
 
          2. "Affiliate" means a corporation in respect of which the Company 
owns directly or indirectly fifty percent (50%) or more of the voting shares 
thereof or which is otherwise controlled by the Company.
 
      3. "Committee" means the Stock and Option Plan Administration Committee 
of the Board of Directors of the Company. 

      4. "Option" means a stock option granted under this Plan.
 
III.      SHARES SUBJECT TO THE PLAN
 
          The aggregate number of shares as to which Options may be granted 
from time to time shall be 18,454,000 of the shares of Common Stock of the 
Company (par value $.01); provided, however that such aggregate number shall 
be reduced by the number of shares which has been sold under, or may be sold 
pursuant to options granted from time to time under, the Company's 1982 
Incentive Stock Option Plan (the "ISO Plan"), to the same extent as if such 
sales had been made or options granted pursuant to this Plan.
 
 If any option granted under this Plan or the ISO Plan ceases to be 
"outstanding", in whole or in part, other than by reason of the exercise of 
such option, the shares which were subject to such option shall be available 
for the granting of other Options. Any option shall be treated as 
"outstanding" until such option is exercised in full, terminates under the 
provisions of this Plan or the ISO Plan, as the case may be, or expires by 
reason of lapse of time.
 
          

The aggregate number of shares as to which Options may be granted shall be 
subject to change only by means of an amendment adopted in accordance with 
Article XI below, subject to the provisions of Article VIII. 
 
IV.  ADMINISTRATION OF THE PLAN
 
          The Plan shall be administered by the Committee. The membership of 
the Committee shall be determined, and shall be subject to change without 
cause and without notice from time to time, by the Board of Directors of the 
Company. 

          The Committee is authorized to interpret the provisions of the Plan 
or of any Option and to make all rules and determinations necessary or 
advisable for the administration of the Plan. Subject to the provisions of the 
Plan, Options may be granted upon such terms and conditions as the Committee 
may prescribe.
 
          This Plan is intended to comply in all respects with Rule 16b-3 or 
its successors promulgated under the Securities Exchange Act of 1934 ("1934 
Act") with respect to participants who are subject to Section 16 of the 1934 
Act, and any provision in this Plan with respect to such persons contrary to 
Rule 16b-3 shall be deemed null and void to the extent permissible by law and 
deemed appropriate by the Committee.
 
V.   ELIGIBILITY FOR PARTICIPATION
 
          The Committee shall determine which employees and Directors shall be 
eligible to participate in the Plan. Without limiting the generality of the 
foregoing, Options may be awarded for reasons of performance, merit, 
promotion, bonus or upon new employees joining the Company or any Affiliate. 

          The Committee may grant to one or more such employees or Directors 
one or more Options, and shall designate the number of shares to be optioned 
under each Option so granted; provided, however, that no Options shall be 
granted after December 31, 2002.  In no event shall any employee be granted 
in any calendar year options to purchase or receive more than 1,200,000 shares 
of the Company's Common Stock pursuant to this Plan.
 
VI.  TERMS AND CONDITIONS OF OPTIONS
 
          No Option issued pursuant to this Plan shall be an incentive stock 
option under Section 422 of the Internal Revenue Code of 1986, as amended. 
Each Option shall be set forth in writing in an Option agreement, duly 
executed on behalf of the Company and by the person to whom such Option
is granted. No Option shall be deemed to have been granted and no purported 
grant of any Option shall be effective until such Option shall have been 
approved by the Committee. The Committee may provide that Options be granted 
subject to such conditions as the Committee may deem appropriate, including 
without limitation, subsequent approval by the shareholders of the Company
of this Plan or any amendments thereto. Each such Option agreement shall be 
subject to at least the following terms and conditions: 

 
          A.   Option Price: Except as otherwise determined by the Committee, 
the Option price per share for Options granted under the Plan shall be equal 
to the fair market value per share of Common Stock on the date of grant of 
the Option; provided, however, that in no event shall the Option price be 
less than the par value per share of Common Stock. Fair market value shall be 
the average of the "high" and "low" sale prices as reported in the National 
Association of Securities Dealers Automated Quotation System ("NASDAQ") for 
the date of grant of the Option or, if none, for the most recent trading date
thirty (30) days or less prior to the date of grant of the Option on which the
Common Stock was traded.
 
          B.   Term of Option: Each Option shall terminate not more than ten 
(10) years from the date of the grant thereof, or at such earlier or later 
time as the Committee shall expressly resolve.
 
          C.   Date of Exercise: The Committee may prescribe the date or dates 
on which the Option becomes exercisable, and may provide that the Option rights
accrue or become exercisable in installments over a period of months or years, 
or upon the attainment of stated goals.
 
          D.   Cancellation and Repurchase Rights: The Committee may stipulate 
that any Option which becomes exercisable shall be subject to cancellation or 
that shares purchased upon the exercise of such Option shall be subject to 
repurchase rights in favor of the Company. In such event the Committee shall 
determine the date or dates, or event or events, upon which such cancellation
or repurchase rights shall become effective or shall lapse, as the case may be.
 
      E.  Medium of Payment: The Option price shall be payable upon the exercise
of the Option. It shall be payable in cash, or, if permitted by the Committee, 
in shares or other consideration.
 
      F.  Termination of Employment: An Option holder who ceases (for any reason
other than death or total and permanent disability or termination of employment 
for cause) to be an employee or Director of the Company or of an Affiliate may 
exercise any Option granted to the extent that the right to purchase shares 
thereunder has accrued on the date of such termination. Such Option shall
be exercisable only within three (3) months after such date of termination, 
or, if earlier, within the originally prescribed term of the Option, unless 
the Committee shall authorize a different period.  Employment shall not be 
deemed terminated by reason of a transfer to another employer which is
the Company or an Affiliate.
 
          An Option holder whose employment with the Company or an Affiliate is 
terminated by his/her employer for cause or a Director who is removed from the 
Board of Directors for cause shall forthwith upon such termination cease to have
any right to exercise any Option. For purposes of this paragraph, "cause" shall 
be deemed to include dishonesty with respect to the employer, insubordination,
substantial malfeasance or non-feasance of duty, unauthorized disclosure of
confidential information, and conduct substantially prejudicial to the business
of the Company or any Affiliate. The determination of the Committee as to the 
existence of cause shall be conclusive.
 


     An Option holder to whom an Option has been granted under the Plan who is 
absent from work with the Company or with an Affiliate because of temporary 
disability, or who is on a permitted leave of absence for any purpose, shall 
not, during the period of any such absence, be deemed by virtue of such 
absence alone, to have terminated his employment with the Company or with an 
Affiliate except as the Committee may otherwise expressly provide. 

          G.   Total and Permanent Disability: If an Option holder ceases to be 
an employee or Director of the Company or of an Affiliate by reason of total 
and permanent disability, as determined by the Committee, any Option held by 
him or her on the date of disability shall be exercisable as to all or any 
part of the shares subject to the Option, all of which shares shall be fully
vested as of the date of such disability. A disabled Option holder may 
exercise such Option only within a period of one (1) year after the date as of
which the Committee determines that he or she became disabled or within such 
different period as may be determined by the Committee, or, if earlier, within
the originally prescribed term of the Option.
 
          H.   Death: If an Option holder dies while the Option holder is an 
employee or Director of the Company or of an Affiliate, any Option held by 
him or her at the date of death shall be exercisable as to all or any part of
the shares subject to the Option, all of which shares shall be fully vested as
of the date of the Option holder's death. A deceased Option holder's legal 
representatives or one who acquires the Option by will or by the laws of 
descent and distribution may exercise such Option only within a period of one
(1) year after the date of death or within such different period as may be 
determined by the Committee, or, if earlier, within the originally prescribed 
term of the Option.
 
     I.    Exercise of Option and Issue of Shares: Options shall be exercised by
giving written notice to the Company, addressed to the Company at the address 
specified in the Option agreement, with which the Option holder shall tender 
the Option price. Such written notice shall be signed by the person exercising
the Option, shall state the number of shares with respect to which the Option
is being exercised, and shall contain any warranty required by Article VII of
the Plan. The issuance of the Option shares may be delayed by the Company if 
any law or regulation requires the Company to take any action with respect to
the Option shares prior to the issuance thereof. Without limiting the 
generality of the foregoing, nothing contained herein shall be deemed to require
the Company to issue any Option shares if prohibited by law or applicable 
regulation.
 
          The shares shall, upon issuance, be evidenced by an appropriate 
certificate or certificates in respect of paid-up, non-assessable shares.
 
          J.   Assignability and Transferability of Option: By its terms, an 
Option granted to an Option holder shall not be transferable by such Option 
holder other than (i) by will or by the laws of descent and distribution or 
(ii) pursuant to a qualified domestic relations order, as defined by the Code 
or Title 1 of the Employee Retirement Income Security Act or the rules 
thereunder, or (iii) as otherwise determined by the Committee and set forth 
in the applicable Option agreement.  The designation of a beneficiary of an 
Option by an Option holder shall not be deemed a transfer prohibited by this 
paragraph.  Except as provided in the preceding sentence, an Option  shall be
exercisable, during an Option holder's lifetime, only by the Option holder 
(or by his or her legal representative) and shall not be assigned, pledged, 
or hypothecated in any way (whether by operation of law or otherwise) and 
shall not be subject to execution, attachment or similar process.  Any 
attempted transfer, assignment, pledge, hypothecation, or other disposition of 
any Option or of any rights granted thereunder contrary to the provisions of 
this Paragraph, or the levy of any attachment or similar process upon an 
Option or other such rights, shall be null and void. 


          K.   Other Provisions: The Option agreements authorized under the Plan
shall be subject to such other terms and conditions, including, without 
limitation, restrictions upon the exercise of the Option, as the Committee 
shall deem advisable.
 
          L.   Non-Employee, Non-Scientific Board Directors' Options: Each 
Director who is not (i) an employee of the Company or any of its Affiliates, 
or (ii) a member of the Scientific Board of the Company, or (iii) elected 
pursuant to an agreement or arrangement between shareholders of the Company 
or between the Company and its shareholders, upon first being appointed or 
elected to the Board of Directors, and upon every third anniversary thereof, 
shall be granted an Option to purchase 30,000 shares of Common Stock. Each 
such Option shall have an exercise price equal to the fair market value per 
share of Common Stock on the date of grant, as determined under Section VI.A.
above, and a term of ten (10) years, and shall be exercisable as to one-third
(1/3) of the shares subject thereto upon completion of one full year of 
service on the Board of Directors after the date of grant, and as to an 
additional one-third (1/3) upon completion of each full year of service
thereafter. For any such Director serving in office on December 6, 1991, the 
first such Option shall be granted on the date on which the most recent Option
previously granted to him, the vesting of which is contingent upon continued 
service on the Board of Directors, becomes fully vested, and subsequent 
Options under this Paragraph shall be granted on every third anniversary of such
date.  Notwithstanding the provision of Section XI concerning amendment of the 
Plan, the provisions of this Section VI.L. shall not be amended more than once 
every six months, other than to comport with changes in the Internal Revenue 
Code of 1986, as amended, the Employee Retirement Income Security Act, or the
rules thereunder. The grants of options under this Paragraph L are intended to
be non-discretionary formula awards within the meaning of Rule 16b-3(c)(2)(ii). 
Paragraph F of Article VI, which cancels the Options of any Participant 
determined by the Committee to have been terminated for cause, shall not 
apply to the awards under this Paragraph L.
 
          M.   Tax Withholding: In the event that any federal, state, or local 
income taxes, employment taxes, Federal Insurance Contributions Act ("F.I.C.A.")
withholdings or other amounts are required by applicable law or governmental 
regulation to be withheld from the Option holder's salary in connection with 
the exercise of an Option, the Option holder shall advance in cash to the 
Company, or to any Affiliate of the Company which employs or employed the Option
holder, the amount of such withholdings unless a different withholding 
arrangement, including the use of shares of the Company's Common Stock, is 
authorized by the Committee (and permitted by law), provided, however, that 
with respect to persons subject to Section 16 of the 1934 Act, any such 
withholding arrangement shall be in compliance with any applicable provisions
of Rule 16b-3 promulgated under Section 16 of the 1934 Act. For purposes 
hereof, the fair market value of the shares withheld for purposes of payroll 
withholding shall be determined in the manner provided in Section VI.A. above,
as of the most recent practicable date prior to the date of exercise. If the 
fair market value of the shares withheld is less than the amount of payroll 
withholdings required, the Option holder may be required to advance the 
difference in cash to the Company or the Affiliate employer.
 
      N.  Reload Options: The Committee may authorize reload options ("Reload 
Options") to purchase for cash or shares a number of shares of Common Stock. 
The number of Reload Options shall equal (i) the number of shares of Common 
Stock used to exercise the underlying Options and (ii) to the extent authorized
by the Committee, the number of shares of Common Stock used to satisfy any tax
withholding requirement incident to the exercise of the underlying Options. The 
grant of a Reload Option will become effective upon the exercise of underlying 
Options through the use of shares of Common Stock held by the optionee for at 
least 6 months. Reload Options must be evidenced in Option agreements or 
amendments to those agreements. The Option price per share of Common Stock 
deliverable upon the exercise of a Reload Option shall be the fair market value
of a share of Common Stock on the date the grant of the Reload Option becomes
effective. The term of each Reload Option shall be equal to the remaining 
option term of the underlying Option. No additional Reload Options shall be 
granted to Option holders when Options and/or Reload Options
are exercised pursuant to the terms of this Plan following termination of the
Option holder's employment or on account of death or total and permanent 
disability. All other provisions of this Plan with respect to Options shall 
apply equally to Reload Options. 
         
          O.   Rights as a Shareholder: No Option holder shall have rights as a 
shareholder with respect to any shares covered by such Option except as to such 
shares as have been registered in the Company's share register in the name of 
such person upon the due exercise of the Option.
 
VII.      PURCHASE FOR INVESTMENT
 
          If and to the extent that the issuance of shares pursuant to the 
exercise of Options is deemed by the Company to be subject to the United 
States Securities Act of 1933, as now in force or hereafter amended 
("1933 Act"), or to the securities law of any other jurisdiction, the Company
shall be under no obligation to issue shares covered by such exercise unless 
the person or persons who exercises or who exercise such Option shall make 
such warranty or take such action as may be required by any applicable 
securities law of any applicable jurisdiction and shall, in the case of the
applicability of the 1933 Act, in the absence of an effective registration 
under such Act with respect to such shares, warrant to the Company, at the 
time of such exercise, that such person is or that they are acquiring the 
shares to be issued to such person or to them, pursuant to such exercise of the
Option, for investment and not with a view to, or for sale in connection with, 
the distribution of any such shares; and in such events the person or persons 
acquiring such shares shall be bound by the provisions of a legend endorsed 
upon any share certificates expressing the requirements of any applicable 
non-United States securities law, or, in cases deemed governed by the 1933 Act,
substantially the following legend, which shall be endorsed upon the certificate
or certificates evidencing the shares issued by the Company pursuant to such 
exercise:
 
          "The shares have not been registered under the securities laws of any 
country, including the United States Securities Act of 1933, as amended, and the
Company may refuse to permit the sale or transfer of all or any of the shares 
until (1) the Company has received an  opinion of Counsel satisfactory to the
Company that any such transfer is exempt from registration under all applicable
securities laws or (2) in the case of sales or transfers to which the United 
States Securities Act of 1933 is applicable, unless a registration statement 
with respect to such shares shall be effective under such Act, as amended."
 
          Without limiting the generality of the foregoing, the Company may 
delay issuance of the shares until completion of any action or obtaining of 
any consent which the Company deems necessary under any applicable law 
(including without limitation state securities or "blue sky" laws).
 
VIII.     ADJUSTMENTS UPON CHANGES IN CAPITALIZATION
 
          In the event that the outstanding Common Stock, $.01 par value, of the
Company is changed into or exchanged for a different number or kind of shares or
other securities of the Company or of another corporation by reason of any 
reorganization, merger, consolidation, recapitalization, reclassification, 
change in par value, stock split-up, combination of shares or dividend payable 
in capital stock, or the like, appropriate adjustment shall be made in the 
number and kind of shares for the purchase of which Options may be granted 
under the Plan, including Options to be granted pursuant to Article VI L 
hereof, and, in addition, appropriate adjustment shall be made in the
number and kind of shares and in the Option price per share subject to 
outstanding Options so that each Option holder shall be in a position 
equivalent to the position the Option holder would have been in had the 
Option holder exercised the Options immediately prior to the applicable event.
 
IX.  DISSOLUTION OR LIQUIDATION OF THE COMPANY
 
          Upon the dissolution or liquidation of the Company other than in 
connection with transactions to which the preceding Article VIII is applicable,
all Options granted hereunder shall terminate and become null and void; 
provided, however, that if the rights hereunder of an Option holder or one who 
acquired an Option by will or by the laws of descent and distribution have not
otherwise terminated and expired, the Option holder or such person shall have 
the right immediately prior to such dissolution or liquidation to exercise 
any Option granted hereunder to the extent that the right to purchase shares 
thereunder has accrued as of the date of exercise immediately prior to such 
dissolution or liquidation.
 
X.   TERMINATION OF THE PLAN
 
          Unless the Committee shall decide to reduce or, subject to shareholder
approval, if required under Article XI, to extend the duration of the Plan, the 
Plan shall terminate on December 31, 2002.  Termination of the Plan shall not 
affect any Options granted or any Option agreements executed prior to the 
effective date of termination.
 
XI.  AMENDMENT OF THE PLAN
 
          The Plan may be amended by the Committee or the Board of Directors of 
the Company provided, however, that if the scope of any amendment is such as to 
require shareholder approval in order to comply with Rule 16b-3 under the 1934 
Act such amendment shall require approval by the shareholders. Any amendment 
shall not affect any Options theretofore granted and any Option agreements 
theretofore executed by the Company and any Option holder unless such amendment
shall expressly so provide. No amendment shall adversely affect any Option 
holder with respect to an outstanding Option without the written consent of 
such Option holder. With the consent of the Option holder affected, the 
Committee may amend any outstanding Option agreement in a manner not 
inconsistent with the Plan, including, without limitation, to accelerate the
date of exercise of any installment of any Option.
 
XII.      EMPLOYMENT RELATIONSHIP
 
          Nothing herein contained shall be deemed to prevent the Company or an 
Affiliate from terminating the employment of any employee, nor to prevent any 
employee from terminating his/her employment with the Company or an Affiliate. 

XIII.      EFFECTIVE DATE
 
          This Plan first became effective on January 2, 1985.


cooka.stock.1985nq.pln