BIOGEN, INC.
             1987 SCIENTIFIC BOARD STOCK OPTION PLAN
 (AS AMENDED THROUGH DECEMBER 6, 1996 AND REVISED TO REFLECT TWO-FOR-ONE STOCK 
                  SPLIT EFFECTED IN NOVEMEBR 1996)
 
1. PURPOSE OF THE PLAN
 
The Biogen, Inc. 1987 Scientific Board Stock Option Plan (the "Plan") is 
intended to encourage ownership of shares of the common stock, $.01 par value
(the "Common Stock"), of the Company by members of the Scientific Board of the
Company and to provide an additional incentive to those scientific Board members
to promote the success of the Company and its Affiliates.
 
2.     DEFINITIONS
 
2.1  "Company" means Biogen, Inc. and any successor to its business.
 
       2.2  "Affiliate" means a corporation in respect of which the Company owns
directly or indirectly fifty percent (50%) or more of the voting shares thereof
or which is otherwise controlled by the Company.
 
2.3  "Committee" means the Stock and Option Plan Administration Committee of the
Board of Directors of the Company.
 
2.4  "Option" means a stock option granted under this Plan.
 
3.     SHARES SUBJECT TO THE PLAN
 
The aggregate number of shares as to which Options may be granted from time to 
time under this Plan shall be 3,000,000 of the shares of Common Stock.
 
If an Option ceases to be "outstanding", in whole or in part, other than by 
reason of the exercise of such Option, the shares which were subject to such 
Option shall be available for the granting of other Options. Any Option shall
be treated as "outstanding" until such Option is exercised in full, terminates
under the provisions of the Plan or expires by reason of lapse of time.
 
The aggregate number of shares as to which Options may be granted shall be 
subject to change only by means of an amendment of the Plan in accordance with
Article 11 below or pursuant to the provisions of Article 8 below.
 


4.     ADMINISTRATION OF THE PLAN
 
The Plan shall be administered by the Committee. The membership of the Committee
shall bedetermined, and shall be subject to change without cause and without 
notice from time to time, by the Board of Directors of the Company.
 
The Committee is authorized to interpret the provisions of the Plan or of any 
Option and to make all rules and determinations necessary or advisable for the
administration of the Plan. Subject to the provisions of the Plan, Options may
be granted upon such terms and conditions as the Committee may prescribe.
 
This Plan is intended to comply in all respects with Rule 16b-3 or its 
successors promulgated under the Securities Exchange Act of 1934 ("1934 Act")
with respect to participants who are subject to Section 16 of the 1934 Act, 
and any provision in this Plan with respect to such persons contrary to Rule 
16b-3 shall be deemed null and void to the extent permissible by law and deemed 
appropriate by the Committee.
 
5.     ELIGIBILITY FOR PARTICIPATION
 
The Committee shall determine which Scientific Board members shall be eligible 
to participate in the Plan, may grant to one or more such Scientific Board 
members one or more Options, and shall designate the number of shares to be 
optioned under each Option so granted; provided, however, that no Options shall
be granted after December 31, 1997.
 
6.     TERMS AND CONDITIONS OF OPTIONS
 
       No Option issued pursuant to this Plan shall be an incentive stock option
under Section 422 of the Internal Revenue Code of 1986, as amended (the "Code").
Each Option shall be set forth in an Option agreement, duly executed on behalf 
of the Company and by the person to whom such Option is granted. No Option shall
be deemed to have been granted and no purported grant of any Option shall be 
effective until such Option shall have been approved by the Committee. The 
Committee shall determine the terms and conditions of Options granted, 
including provisions relating to termination of the Option holder's 
consultancy, death and disability; provided, however, that each such Option 
agreement shall be subject to at least the following terms and conditions:
 
6.1    Option Price: Except as otherwise determined by the Committee, the Option
price per share for Options granted under the Plan shall be equal to the fair 
market value per share of Common Stock on the date of grant of the Option; 
provided, however, that in no event shall the Option price be less than the 
par value per share of the Common Stock. Fair market value shall be the average 
of the "high" and "low" sale prices as reported in the National Association of 
Securities Dealers Automated Quotation System ("NASDAQ") for the date of grant 
of the Option or, if none, for the most recent trading date thirty (30) days or 
less prior to the date of grant of the Option on which the Common Stock was 
traded.
 
6.2    Term of Option: Each Option shall terminate upon a date determined at the
time of grant by the Committee, but not later than ten (10) years from the date 
of the grant thereof.
 
6.3    Date of Exercise: The Committee may prescribe the date or dates on which 
the Option becomes exercisable, and may provide that the Option rights accrue or
become exercisable in installments over a period of months or years, or upon the
attainment of stated goals. The Committee may stipulate that any Option which 
becomes exercisable shall be subject to cancellation or that shares purchased 
upon the exercise of such Option shall be subject to repurchase rights in favor 
of the Company. In such event the Committee shall determine the date or dates, 
or event or events, upon which such cancellation or repurchase rights shall 
become effective or shall lapse, as the case may be.
 
6.4    Medium of Payment: The option price shall be payable upon the exercise of
the Option. It shall be payable in cash or, if permitted by the Committee and 
permitted by law, in shares or other consideration.
 
  6.5  Exercise of Option and Issue of Shares: Options shall be exercised by 
giving written notice to the Company, addressed to the Company at the address
specified in the Option agreement, with which the Option holder shall tender 
the Option price. Such written notice shall be signed by the person exercising
the Option, shall state the number of shares with respect to which the Option is
being exercised, and shall contain any warranty required by Article 7 of the 
Plan. The issuance of the Option shares may be delayed by the Company if any 
law or regulation requires the Company to take any action with respect to the
Option shares prior to the issuance thereof. Without limiting the generality 
of the foregoing, nothing contained herein shall be deemed to require the 
Company to issue any Option shares if prohibited by law or applicable 
regulation.
 
  The shares shall, upon issuance, be evidenced by an appropriate certificate or
certificates in respect of paid-up, non-assessable shares.
 
6.6    Assignability and Transferability of Option: By its terms, an Option 
granted to an Option holder shall not be transferable by such Option holder 
other than (i) by will or by the laws of descent and distribution or (ii) 
pursuant to a qualified domestic relations order, as defined by the Code or 
Title 1 of the Employee Retirement Income Security Act or the rules thereunder,
or (iii) as otherwise determined by the Committee and set forth in the 
applicable Option agreement.  The designation of a beneficiary of an Option by
an Option holder shall not be deemed a transfer prohibited by this paragraph. 
Except as provided in the preceding sentence, an Option shall be exercisable,
during an Option holder's lifetime, only by the Option holder (or by his or her 
legal representative) and shall not be assigned, pledged or hypothecated in any 
way (whether by operation of law or otherwise) and shall not be subject to 
execution, attachment or similar process.  Any attempted transfer, assignment,
pledge, hypothecation, or other disposition of any Option or of any rights 
granted thereunder contrary to the provisions of this Plan, or the levy of any 
attachment or similar process upon an Option or other such rights shall be null 
and void.
 
6.7    Other Provisions: The Option agreements authorized under the Plan shall 
be subject to such additional terms and conditions, including, without 
limitation, restrictions upon the exercise of the Option, as the Committee 
shall deem advisable.
 
  6.8  Tax Withholding: In the event that any federal, state, or local income 
taxes, employment taxes, Federal Insurance Contributions Act ("F.I.C.A.") 
withholdings or other amounts are required by applicable law or governmental
regulation to be withheld from the Option holder's salary in connection with 
the exercise of an Option, the Option holder shall advance in cash to the 
Company, or to any Affiliate of the Company which employs or employed the 
Option holder, the amount of such withholdings unless a different withholding
arrangement, including the use of shares of the Company's Common Stock, is 
authorized by the Committee (and permitted by law), provided, however, that 
with respect to persons subject to Section 16 of the 1934 Act, any such  
withholding arrangement shall be in compliance with any applicable provisions
of Rule 16b-3 promulgated under Section 16 of the 1934 Act. For purposes 
hereof, the fair market value of the shares withheld for purposes of payroll 
withholding shall be determined in the manner provided in Article 6.1. above, as
of the most recent practicable date prior to the date of exercise. If the fair 
market value of the shares withheld is less than the amount of payroll 
withholdings required, the Option holder may be required to advance the 
difference in cash to the Company or the Affiliate employer.
 
  6.9  Reload Options: The Committee may authorize reload options ("Reload 
Options") to purchase for cash or shares a number of shares of Common Stock. 
The number of Reload Options shall equal (i) the number of shares of Common 
Stock used to exercise the underlying Options and (ii) to the extent authorized
by the Committee, the number of shares of Common Stock used to satisfy any tax
withholding requirement incident to the exercise of the underlying Options. The 
grant of a Reload Option will become effective upon the exercise of underlying 
Options through the use of shares of Common Stock held by the optionee for at 
least 6 months. Reload Options must be evidenced in Option agreements or 
amendments to those agreements. The Option price per share of Common Stock 
deliverable upon the exercise of a Reload Option shall be the fair market value 
of a share of Common Stock on the date the grant of the Reload Option becomes 
effective. The term of each Reload Option shall be equal to the remaining 
option term of the underlying Option.  No additional Reload Options shall be 
granted to Option holders when Options and/or Reload Options are exercised 
pursuant to the terms of this Plan following termination of the Option holder's
employment or on account of death or total and permanent disability. All other 
provisions of this Plan with respect to Options shall apply equally to Reload 
Options.
 
6.10   Rights as a Shareholder: No Option holder shall have rights as a 
shareholder with respect to any shares covered by such Option except as to 
such shares as have been registered in the Company's share register in the 
name of such person upon the due exercise of the Option.
 
7.     PURCHASE FOR INVESTMENT
 
       If and to the extent that the issuance of shares pursuant to the exercise
 of Options is deemed by the Company to be subject to the United States 
Securities Act of 1933, as now in force or hereafter amended (the "Act"), or 
to the securities law of any other jurisdiction, the Company shall be under 
no obligation to issue shares covered by such exercise unless the person or 
persons who exercises or who exercise such Option shall make such warranty or
take such action as may be required by any applicable securities law or shall,
in the case of the applicability of the Act, in the absence of an effective 
registration under the Act with respect to such shares, warrant to the Company,
at the time of such exercise, that such person is or that they are acquiring the
shares to be issued to such person or to them, pursuant to such exercise of the 
Option, for investment and not with a view to, or for sale in connection with, 
the distribution of any such shares; and in such events the person or persons 
acquiring such shares shall be bound by the provisions of a legend endorsed upon
any share certificates expressing the requirements of any applicable non-United 
States securities law, or, in cases deemed governed by the Act, substantially 
the following legend, or such other legend as counsel for the Company shall 
deem appropriate, which shall be endorsed upon the certificate or certificates 
evidencing the shares issued by the Company pursuant to such exercise:
 
     "The securities represented by this certificate have not been registered 
     under the Securities Act of 1933 and may not be sold, assigned or 
     transferred in the absence of an effective registration  statement under
     said Act or an opinion of counsel satisfactory to the Company that such 
     registration is not, in the circumstances, required."
     
Without limiting the generality of the foregoing, the Company may delay 
issuance of the shares until completion of any action or obtaining of any 
consent which the Company deems necessary under any applicable law (including
without limitation state securities or "blue sky" laws
and federal or state payroll tax withholding laws).
 
8.     ADJUSTMENTS UPON CHANGES IN CAPITALIZATION
 
In the event that the outstanding Common Stock, $.01 par value, of the Company
is changed into or exchanged for a different number or kind of shares or other
securities of the Company or of another corporation by reason of any 
reorganization, merger, consolidation, recapitalization, reclassification, 
change in par value, stock split-up, combination of shares or dividend payable
in capital stock, or the like, appropriate adjustment shall be made in the 
number and kind of shares for the purchase of which Options may be granted 
under the Plan, and, in addition, appropriate adjustment shall be made in the 
number and kind of shares and in the option price per share subject to 
outstanding Options so that each Option holder shall be in a position 
equivalent to the position the Option holder would have been in had the Option 
holder exercised the Options immediately prior to the applicable event.
 
9.      DISSOLUTION OR LIQUIDATION OF THE COMPANY
 
Upon the dissolution or liquidation of the Company other than in connection with
a transaction to which the preceding Article 8 is applicable, all Options 
granted hereunder shall terminate and become null and void; provided, however,
that if the rights hereunder of an Option holder or one who acquired an Option
by will or by the laws of descent and distribution have not otherwise terminated
and expired, the Option holder or such person shall have the right immediately 
prior to such dissolution or liquidation to exercise any Option granted 
hereunder to the extent that the right to purchase shares thereunder has 
accrued as of the date of exercise immediately prior to such dissolution or 
liquidation.
 
10.    TERMINATION OF THE PLAN
 
Unless the Committee shall decide to reduce or, subject to shareholder approval,
extend the duration of the Plan, the Plan shall terminate on December 31, 1997. 
Termination of the Plan shall not affect any Options granted or any Option 
agreements executed prior to the effective date of termination.
 
11.    AMENDMENT OF THE PLAN
 
The Plan may be amended by the Committee or the Board of Directors of the 
Company, provided, however, that if the scope of any amendment is such as to 
require shareholder approval in order to comply with Rule 16b-3 under the 1934 
Act, then such amendment shall require approval by the shareholders. Any 
amendment shall not affect any Options theretofore granted and any Option 
agreements theretofore executed by the Company and any Option holder unless 
such amendment shall expressly so provide. No amendment shall adversely 
affect any Option holder with respect to an outstanding Option without the 
written consent of such Option holder. With the consent of the Option holder 
affected, the Committee may amend any outstanding Option agreement in a manner 
not inconsistent with the Plan, including, without limitation, to accelerate 
the date of exercise of any installment of any Option.
 
12.    EMPLOYMENT RELATIONSHIP
 
  Nothing herein contained shall be deemed to prevent the Company or an 
Affiliate from terminating the employment or consultancy of any Option holder,
nor to present any Option holder from terminating his/her employment or 
consultancy with the Company or an Affiliate.
 


13.    EFFECTIVE DATE
 
This Plan became effective as of March 6, 1987.
 

cooka.stock.1987sci.pln