EXHIBIT 99.1





                               CYTOGEN CORPORATION
                              600 COLLEGE ROAD EAST
                           PRINCETON, NEW JERSEY 08540





                                                March 28, 2002



Securities and Exchange Commission
450 Fifth Street, N.W.
Judiciary Plaza
Washington, DC  20549



         Re:  Confirmation of Arthur Andersen Representations
              ------------------------------------------------

Ladies and Gentlemen:

         This letter confirms that Cytogen Corporation has received from Arthur
Andersen LLP, the independent public accountant engaged by the company to
examine the company's financial statements that are included in the Form 10-K to
which this letter is filed as an exhibit, a representation letter addressed to
the company and stating that:

  -  the audit  conducted by Andersen was subject to Andersen's  quality control
     system for the U.S.  accounting and auditing practice to provide reasonable
     assurance that the engagement was conducted in compliance with professional
     standards; and

  -  there was  appropriate  continuity  of  Andersen  personnel  working on the
     audit,  availability of national office  consultation  and  availability of
     personnel  at  foreign  affiliates  of  Andersen  to conduct  the  relevant
     portions of the audit.



                                                Very truly yours,


                                                Cytogen Corporation


                                                By: /s/ Lawrence R. Hoffman
                                                   -------------------------
                                                Name: Lawrence R. Hoffman
                                                Title: Vice President and
                                                        Chief Financial Officer