EXHIBIT 10.1



                          SECURITIES PURCHASE AGREEMENT

         This Securities  Purchase  Agreement (this  "Agreement") is dated as of
June 6, 2003, among Cytogen Corporation, a Delaware corporation (the "Company"),
and the purchasers  identified on the signature pages hereto (each a "Purchaser"
and collectively the "Purchasers"); and

         WHEREAS,  subject  to the  terms  and  conditions  set  forth  in  this
Agreement and pursuant to Section 4(2) of the Securities Act (as defined below),
and Rule 506  promulgated  thereunder,  the Company desires to issue and sell to
the  Purchasers,  and each  Purchaser,  severally  and not  jointly,  desires to
purchase  from the Company in the  aggregate,  up to $5,000,000 of the Company's
Common Stock and certain Warrants, as more fully described in this Agreement.

         NOW,  THEREFORE,  IN CONSIDERATION of the mutual covenants contained in
this Agreement,  and for other good and valuable  consideration  the receipt and
adequacy of which are hereby acknowledged, the Company and each Purchaser agrees
as follows:

ARTICLE I.
                                   DEFINITIONS

     1.1  Definitions.  In  addition  to the  terms  defined  elsewhere  in this
Agreement,  for all purposes of this  Agreement,  the  following  terms have the
meanings indicated in this Section 1.1:

                  "Action"  shall  have the  meaning  ascribed  to such  term in
         Section 3.1(j).

                  "Affiliate"  means any Person  that,  directly  or  indirectly
         through one or more intermediaries,  controls or is controlled by or is
         under  common  control  with a  Person  as such  terms  are used in and
         construed  under Rule 144. With respect to a Purchaser,  any investment
         fund or managed account that is managed on a discretionary basis by the
         same  investment  manager  as such  Purchaser  will be  deemed to be an
         Affiliate of such Purchaser.

                  "Business Day" means any day except  Saturday,  Sunday and any
         day which shall be a federal  legal  holiday or a day on which  banking
         institutions in the State of New York are authorized or required by law
         or other governmental action to close.

                  "Closing"  means the closing of the  purchase  and sale of the
         Common Stock and Warrant pursuant to Section 2.1.

                  "Closing Date" means the date of the Closing.

                  "Commission" means the Securities and Exchange Commission.

                  "Common  Stock" means the common  stock of the Company,  $0.01
         par value per share,  and any  securities  into which such common stock
         may hereafter be reclassified.

                  "Common Stock Equivalents" means any securities of the Company
         or the  Subsidiaries  which would entitle the holder thereof to acquire
         at any time  Common  Stock,  including  without  limitation,  any debt,

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         preferred stock, rights, options,  warrants or other instrument that is
         at any time convertible into or exchangeable for, or otherwise entitles
         the holder thereof to receive, Common Stock.

                  "Company  Counsel"  means  Hale and Dorr LLP,  counsel  to the
         Company.

                  "Disclosure   Schedules"   means  the   Disclosure   Schedules
         concurrently delivered herewith.

                  "Effective   Date"  means  the  date  that  the   Registration
         Statement is first declared effective by the Commission.

                  "Exchange Act" means the  Securities  Exchange Act of 1934, as
         amended.

                  "FW" means Feldman  Weinstein LLP with offices  located at 420
         Lexington Avenue, New York, New York 10170-0002.

                  "Intellectual Property Rights" shall have the meaning ascribed
         to such term in Section 3.1(o).

                  "Liens" means a lien, charge, security interest,  encumbrance,
         right of first refusal or other restriction.

                  "Material  Adverse Effect" shall have the meaning  ascribed to
         such term in Section 3.1(b).

                  "Material  Permits"  shall have the  meaning  ascribed to such
         term in Section 3.1(m).

                  "Per Share Purchase Price" equals $4.75, subject to adjustment
         for  reverse  and  forward  stock  splits,   stock   dividends,   stock
         combinations  and other similar  transactions  of the Common Stock that
         occur after the date of this Agreement.

                  "Person"  means an  individual  or  corporation,  partnership,
         trust,  incorporated  or  unincorporated  association,  joint  venture,
         limited  liability  company,  joint stock  company,  government  (or an
         agency or subdivision thereof) or other entity of any kind.

                  "Registration   Statement"  means  a  registration   statement
         meeting the requirements set forth in the Registration Rights Agreement
         and covering the resale by the Purchasers of the Shares and the Warrant
         Shares.

                  "Registration  Rights Agreement" means the Registration Rights
         Agreement,  dated as of the date of this  Agreement,  among the Company
         and each Purchaser, in the form of Exhibit B hereto.

                  "Rule  144,"  means  Rule 144  promulgated  by the  Commission
         pursuant to the Securities  Act, as such Rules may be amended from time
         to time,  or any similar rule or  regulation  hereafter  adopted by the
         Commission having substantially the same effect as such Rule.


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                  "SEC Reports" shall have the meaning  ascribed to such term in
         Section 3.1(h).

                  "Securities"  means the Shares,  the  Warrants and the Warrant
         Shares.

                  "Securities Act" means the Securities Act of 1933, as amended.

                  "Shares"  means the shares of Common  Stock issued or issuable
         to each Purchaser pursuant to this Agreement.

                  "Subscription  Amount"  means,  as to each  Purchaser  and the
         Closing,  the amounts set forth below such Purchaser's  signature block
         on  the  signature  page  hereto,  in  United  States  dollars  and  in
         immediately available funds.

                  "Subsidiary"  shall have the meaning  ascribed to such term in
         Section 3.1(a).

                  "Trading  Day"  means (i) a day on which the  Common  Stock is
         traded on a Trading  Market,  or (ii) if the Common Stock is not listed
         on a Trading  Market,  a day on which the Common Stock is traded on the
         over-the-counter  market,  as reported by the OTC  Bulletin  Board,  or
         (iii) if the Common  Stock is not quoted on the OTC Bulletin  Board,  a
         day on which the Common Stock is quoted in the over-the-counter  market
         as reported  by the  National  Quotation  Bureau  Incorporated  (or any
         similar  organization  or agency  succeeding its functions of reporting
         prices);  provided,  that in the  event  that the  Common  Stock is not
         listed  or quoted as set  forth in (i),  (ii) and  (iii)  hereof,  then
         Trading Day shall mean a Business Day.

                  "Trading  Market" means the following  markets or exchanges on
         which the Common  Stock is listed or quoted for  trading on the date in
         question: the American Stock Exchange, the New York Stock Exchange, the
         Nasdaq National Market or the Nasdaq SmallCap Market.

                  "Transaction Documents" means this Agreement, the Registration
         Rights  Agreement,  the Warrants and any other  documents or agreements
         executed in connection with the transactions contemplated hereunder.

                  "VWAP" means,  for any date, the price determined by the first
         of the following clauses that applies:  (a) if the Common Stock is then
         listed or quoted on a Trading Market, the daily volume weighted average
         price of the Common Stock for such date (or the nearest preceding date)
         on the  Trading  Market on which  the  Common  Stock is then  listed or
         quoted as reported by Bloomberg  Financial L.P. (based on a Trading Day
         from 9:30 a.m.  Eastern  Time to 4:02 p.m.  Eastern  Time);  (b) if the
         Common Stock is not then listed or quoted on the Trading  Market and if
         prices for the Common Stock are then quoted on the OTC Bulletin  Board,
         the volume weighted average price of the Common Stock for such date (or
         the  nearest  preceding  date) on the OTC  Bulletin  Board;  (c) if the
         Common Stock is not then listed or quoted on the OTC Bulletin Board and
         if prices for the Common Stock are then  reported in the "Pink  Sheets"
         published by the National  Quotation Bureau  Incorporated (or a similar
         organization  or  agency  succeeding  to  its  functions  of  reporting
         prices),  the most  recent bid price per share of the  Common  Stock so
         reported;  or (d) in all other cases,  the fair market value of a share

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         of Common Stock as determined by an independent  appraiser  selected in
         good faith by the Purchasers and reasonably acceptable to the Company.

                  "Warrants"  means the Common Stock Purchase  Warrants,  in the
         form of Exhibit C, issuable to the  Purchasers  at the Closing,  with a
         term of exercise of 5 years beginning  immediately upon issuance and an
         exercise price equal to $6.91, subject to adjustment therein.

                  "Warrant  Shares"  means the shares of Common  Stock  issuable
         upon exercise of the Warrants.

                                   ARTICLE II.
                                PURCHASE AND SALE

     2.1 Closing. At the Closing,  the Purchasers shall purchase,  severally and
not  jointly,  and the Company  shall issue and sell,  in the  aggregate,  up to
$5,000,000 of Common Stock,  together with the Warrants.  Each  Purchaser  shall
purchase  from  the  Company,  and the  Company  shall  issue  and  sell to each
Purchaser,  (a) a number of Shares equal to such Purchaser's Subscription Amount
divided  by the Per Share  Purchase  Price and (b) the  Warrants  as  determined
pursuant to Section 2.2(a).

     2.2 Closing Conditions.

          (a) At the Closing (unless  otherwise  specified  below),  the Company
     shall deliver or cause to be delivered to each Purchaser the following:

               (i) this Agreement duly executed by the Company;

               (ii)  within  3  Trading  Days  of  the  Closing,  a  certificate
          evidencing a number of Shares equal to such  Purchaser's  Subscription
          Amount divided by the Per Share Purchase Price, registered in the name
          of such Purchaser;

               (iii) a legal opinion of Company Counsel,  in the form of Exhibit
          A hereto, addressed to the Purchasers;


               (iv) the  Registration  Rights  Agreement  duly  executed  by the
          Company; and

               (v) a Warrant, registered in the name of such Purchaser, pursuant
          to which  such  Purchaser  shall  have the right to  acquire up to the
          number  of shares of  Common  Stock  equal to 30% of the  Shares to be
          issued to such Purchaser at the Closing.

          (b) At the  Closing  each  Purchaser  shall  deliver  or  cause  to be
     delivered to the Company the following:

               (i) this Agreement duly executed by such;

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               (ii) such Purchaser's  Subscription  Amount as to such Closing by
          wire   transfer  to  the  account  of  the  Company  per  the  written
          instructions of the Company; and

               (iii) the  Registration  Rights  Agreement  duly executed by such
          Purchaser.

          (c) As of the Closing Date,  there shall have been no Material Adverse
     Effect with respect to the Company since the date hereof.

          (d) From the date  hereof to the Closing  Date,  trading in the Common
     Stock  shall not have been  suspended  by the  Commission  (except  for any
     suspension of trading of limited  duration agreed to by the Company,  which
     suspension  shall be  terminated  prior to the  Closing),  and, at any time
     prior to Closing  Date,  trading in  securities  generally  as  reported by
     Bloomberg  Financial  Markets shall not have been suspended or limited,  or
     minimum prices shall not have been  established on securities  whose trades
     are reported by such service, or on any Trading Market.

                                  ARTICLE III.
                         REPRESENTATIONS AND WARRANTIES

     3.1  Representations  and  Warranties  of the Company.  Except as set forth
under the corresponding  section of the Disclosure  Schedules or as set forth in
the SEC Reports,  the Company  hereby makes the  following  representations  and
warranties as of the date hereof to each Purchaser:

          (a) Subsidiaries.  The Company has no direct or indirect subsidiaries.
     The Company owns, directly or indirectly,  all of the capital stock of each
     Subsidiary  free  and  clear  of  any  lien,  charge,   security  interest,
     encumbrance,  right of first  refusal or other  restriction  (collectively,
     "Liens"),  and all the issued and  outstanding  shares of capital  stock of
     each Subsidiary are validly issued and are fully paid,  non-assessable  and
     free of preemptive and similar rights.  If the Company has no subsidiaries,
     then references in the Transaction  Documents to the  Subsidiaries  will be
     disregarded.

          (b)  Organization  and  Qualification.  Each  of the  Company  and the
     Subsidiaries is an entity duly incorporated or otherwise organized, validly
     existing and in good  standing  under the laws of the  jurisdiction  of its
     incorporation or organization (as applicable), with the requisite power and
     authority  to own and use its  properties  and  assets  and to carry on its
     business as currently conducted.  Neither the Company nor any Subsidiary is
     in violation of any of the  provisions  of its  respective  certificate  or
     articles  of  incorporation,  bylaws  or other  organizational  or  charter
     documents.  Each of the Company and the  Subsidiaries  is duly qualified to
     conduct business and is in good standing as a foreign  corporation or other
     entity in each  jurisdiction in which the nature of the business  conducted
     or property owned by it makes such  qualification  necessary,  except where
     the failure to be so  qualified  or in good  standing,  as the case may be,
     would not have or  reasonably  be  expected  to  result  in (i) a  material
     adverse  effect  on  the  legality,   validity  or  enforceability  of  any
     Transaction  Document,  (ii) a material  adverse  effect on the  results of
     operations,  assets, business or financial condition of the Company and the
     Subsidiaries,  taken as a whole,  or (iii)  adversely  impair the Company's

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     ability  to  perform  in  any  material  respect  on  a  timely  basis  its
     obligations  under any  Transaction  Document (any of (i), (ii) or (iii), a
     "Material Adverse Effect").

          (c)  Authorization;   Enforcement.   The  Company  has  the  requisite
     corporate  power  and  authority  to  enter  into  and  to  consummate  the
     transactions   contemplated  by  each  of  the  Transaction  Documents  and
     otherwise  to carry  out its  obligations  thereunder.  The  execution  and
     delivery  of each  of the  Transaction  Documents  by the  Company  and the
     consummation by it of the transactions  contemplated thereby have been duly
     authorized  by all  necessary  action  on the  part of the  Company  and no
     further  action is required by the Company in  connection  therewith.  Each
     Transaction  Document  has been (or upon  delivery  will  have  been)  duly
     executed by the Company and, when  delivered in  accordance  with the terms
     hereof,  will  constitute  the valid and binding  obligation of the Company
     enforceable  against the Company in accordance with its terms except (i) as
     limited by applicable bankruptcy,  insolvency,  reorganization,  moratorium
     and other laws of general application  affecting  enforcement of creditors'
     rights  generally and (ii) as limited by laws relating to the  availability
     of specific performance, injunctive relief or other equitable remedies.

          (d) No  Conflicts.  The  execution,  delivery and  performance  of the
     Transaction Documents by the Company and the consummation by the Company of
     the transactions contemplated thereby do not and will not (i) conflict with
     or violate any provision of the Company's or any  Subsidiary's  certificate
     or articles of  incorporation,  bylaws or other  organizational  or charter
     documents, or (ii) conflict with, or constitute a default (or an event that
     with notice or lapse of time or both would become a default) under, or give
     to  others  any  rights  of   termination,   amendment,   acceleration   or
     cancellation  (with or  without  notice,  lapse of time or  both)  of,  any
     agreement,  credit facility, debt or other instrument (evidencing a Company
     or  Subsidiary  debt or  otherwise)  or other  understanding  to which  the
     Company or any  Subsidiary  is a party or by which any property or asset of
     the Company or any  Subsidiary  is bound or affected,  or (iii) result in a
     violation of any law, rule, regulation, order, judgment, injunction, decree
     or other  restriction of any court or  governmental  authority to which the
     Company or a Subsidiary is subject  (including federal and state securities
     laws and regulations),  or by which any property or asset of the Company or
     a Subsidiary  is bound or  affected;  except in the case of each of clauses
     (ii) and (iii),  such as would not have or reasonably be expected to result
     in a Material Adverse Effect.

          (e) Filings,  Consents and  Approvals.  The Company is not required to
     obtain any consent, waiver,  authorization or order of, give any notice to,
     or make any filing or registration with, any court or other federal, state,
     local or other  governmental  authority or other Person in connection  with
     the execution,  delivery and  performance by the Company of the Transaction
     Documents,   other  than  (a)  the  filing  with  the   Commission  of  the
     Registration  Statement,  the application(s) to each Trading Market for the
     listing of the Shares and Warrant  Shares for  trading  thereon in the time
     and manner required thereby, and applicable Blue Sky filings or (b) such as
     have already been obtained or such exemptive  filings as are required to be
     made under applicable securities laws.

          (f) Issuance of the Securities. The Securities are duly authorized and
     the Shares and Warrant Shares,  when issued and paid for in accordance with
     the Transaction Documents,  will be duly and validly issued, fully paid and

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     nonassessable,  free and clear of all Liens.  The Company has reserved from
     its duly  authorized  capital stock the maximum  number of shares of Common
     Stock issuable pursuant to this Agreement and the Warrants.

          (g) Capitalization.  The capitalization of the Company is as described
     in the Company's most recent periodic report filed with the Commission. The
     Company  has not issued any  capital  stock  since such  filing  other than
     pursuant to the  exercise of employee  stock  options  under the  Company's
     stock  option  plans,  the  issuance of shares of Common Stock to employees
     pursuant to the Company's  employee stock purchase plan and pursuant to the
     conversion or exercise of outstanding Common Stock  Equivalents.  No Person
     has any right of first refusal,  preemptive right,  right of participation,
     or any similar right to participate in the transactions contemplated by the
     Transaction  Documents.  Except as a result of the purchase and sale of the
     Securities,  there are no outstanding options,  warrants,  script rights to
     subscribe to, calls or commitments of any character whatsoever relating to,
     or securities,  rights or obligations convertible into or exchangeable for,
     or giving any Person any right to subscribe  for or acquire,  any shares of
     Common Stock, or contracts, commitments,  understandings or arrangements by
     which  the  Company  or any  Subsidiary  is or may  become  bound  to issue
     additional  shares of Common Stock, or securities or rights  convertible or
     exchangeable  into  shares  of  Common  Stock.  The  issue  and sale of the
     Securities will not obligate the Company to issue shares of Common Stock or
     other  securities  to any Person (other than the  Purchasers)  and will not
     result  in a right of any  holder  of  Company  securities  to  adjust  the
     exercise, conversion, exchange or reset price under such securities.

          (h) SEC  Reports;  Financial  Statements.  The  Company  has filed all
     reports  required  to be  filed  by it  under  the  Securities  Act and the
     Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the
     two years  preceding the date hereof (or such shorter period as the Company
     was  required  by law to file  such  material)  (the  foregoing  materials,
     including the exhibits thereto,  being  collectively  referred to herein as
     the "SEC  Reports"  and,  together  with the  Disclosure  Schedules to this
     Agreement,  the "Disclosure Materials") on a timely basis or has received a
     valid  extension  of such time of filing and has filed any such SEC Reports
     prior to the  expiration  of any  such  extension.  As of their  respective
     dates,  the  SEC  Reports  complied  in  all  material  respects  with  the
     requirements  of the  Securities Act and the Exchange Act and the rules and
     regulations of the Commission promulgated  thereunder,  and none of the SEC
     Reports,  when filed,  contained any untrue statement of a material fact or
     omitted to state a material fact required to be stated therein or necessary
     in order  to make the  statements  therein,  in light of the  circumstances
     under which they were made, not misleading. The financial statements of the
     Company  included in the SEC Reports  comply in all material  respects with
     applicable  accounting  requirements  and the rules and  regulations of the
     Commission  with respect  thereto as in effect at the time of filing.  Such
     financial  statements  have been  prepared  in  accordance  with  generally
     accepted  accounting  principles  applied on a consistent  basis during the
     periods  involved  ("GAAP"),  except as may be otherwise  specified in such
     financial  statements  or the  notes  thereto  and  except  that  unaudited
     financial  statements  may not contain all footnotes  required by GAAP, and
     fairly  present in all  material  respects  the  financial  position of the
     Company and its  consolidated  subsidiaries as of and for the dates thereof

                                       7


     and the results of  operations  and cash flows for the periods  then ended,
     subject,  in the case of unaudited  statements,  to normal  year-end  audit
     adjustments.

          (i) Material  Changes.  Since the date of the latest audited financial
     statements included within the SEC Reports,  except as disclosed in the SEC
     Reports,  (i) there has been no event,  occurrence or development  that has
     had or that could  reasonably  be expected to result in a Material  Adverse
     Effect,  (ii) the Company has not incurred any  liabilities  (contingent or
     otherwise) other than (A) trade payables and accrued  expenses  incurred in
     the  ordinary  course of business  consistent  with past  practice  and (B)
     liabilities  not  required  to be  reflected  in  the  Company's  financial
     statements  pursuant to GAAP or required to be  disclosed  in filings  made
     with the  Commission,  and (iii) the  Company has not altered its method of
     accounting,  (iv) the  Company  has not  declared  or made any  dividend or
     distribution  of cash or other property to its  stockholders  or purchased,
     redeemed  or made any  agreements  to  purchase or redeem any shares of its
     capital  stock and (v) the Company has not issued any equity  securities to
     any officer,  director or Affiliate,  except  pursuant to existing  Company
     stock option plans. The Company does not have pending before the Commission
     any request for confidential treatment of information.

          (j)  Litigation.  Except as disclosed in the SEC Reports,  there is no
     action,  suit,  inquiry,  notice of violation,  proceeding or investigation
     pending  or,  to  the  knowledge  of the  Company,  threatened  against  or
     affecting the Company, any Subsidiary or any of their respective properties
     before or by any court,  arbitrator,  governmental or administrative agency
     or  regulatory  authority  (federal,   state,  county,  local  or  foreign)
     (collectively,  an "Action") which (i) adversely  affects or challenges the
     legality, validity or enforceability of any of the Transaction Documents or
     the Securities or (ii) could, if there were an unfavorable  decision,  have
     or reasonably be expected to result in a Material  Adverse Effect.  Neither
     the Company nor any Subsidiary,  nor any director or officer thereof, is or
     has been the  subject of any Action  involving a claim of  violation  of or
     liability  under federal or state  securities  laws or a claim of breach of
     fiduciary  duty.  There has not been,  and to the knowledge of the Company,
     there is not pending or contemplated,  any  investigation by the Commission
     involving  the Company or any current or former  director or officer of the
     Company.  The  Commission  has not  issued  any stop  order or other  order
     suspending the  effectiveness  of any  registration  statement filed by the
     Company or any Subsidiary under the Exchange Act or the Securities Act.

          (k) Labor  Relations.  No  material  labor  dispute  exists or, to the
     knowledge of the Company,  is imminent with respect to any of the employees
     of the Company  which could  reasonably be expected to result in a Material
     Adverse Effect.

          (l)  Compliance.  Except as disclosed in the SEC Reports,  neither the
     Company nor any  Subsidiary (i) is in default under or in violation of (and
     no event has occurred  that has not been waived that,  with notice or lapse
     of time or both, would result in a default by the Company or any Subsidiary
     under),  nor has the Company or any Subsidiary  received  notice of a claim
     that it is in default under or that it is in violation  of, any  indenture,
     loan or credit  agreement or any other  agreement or instrument to which it
     is a party or by which it or any of its properties is bound (whether or not
     such default or  violation  has been  waived),  (ii) is in violation of any

                                       8


     order of any court,  arbitrator  or  governmental  body, or (iii) is or has
     been in violation of any statute,  rule or regulation  of any  governmental
     authority,  including without  limitation all foreign,  federal,  state and
     local laws  applicable to its business,  except in the case of clauses (i),
     (ii) and (iii) as would not have or  reasonably  be expected to result in a
     Material Adverse Effect.

          (m) Regulatory Permits.  The Company and the Subsidiaries  possess all
     certificates, authorizations and permits issued by the appropriate federal,
     state, local or foreign regulatory  authorities  necessary to conduct their
     respective  businesses  as described  in the SEC Reports,  except where the
     failure to possess such permits would not have or reasonably be expected to
     result in a Material Adverse Effect ("Material  Permits"),  and neither the
     Company nor any Subsidiary has received any notice of proceedings  relating
     to the revocation or modification of any Material Permit.

          (n) Title to Assets.  The Company and the  Subsidiaries  have good and
     marketable  title in fee simple to all real property  owned by them that is
     material to the business of the Company and the  Subsidiaries  and good and
     marketable title in all personal property owned by them that is material to
     the  business of the Company  and the  Subsidiaries,  in each case free and
     clear of all Liens,  except for Liens as do not materially affect the value
     of such  property  and do not  materially  interfere  with the use made and
     proposed to be made of such  property  by the Company and the  Subsidiaries
     and Liens for the payment of federal,  state or other taxes, the payment of
     which is neither delinquent nor subject to penalties. Any real property and
     facilities held under lease by the Company and the Subsidiaries are held by
     them under valid,  subsisting and  enforceable  leases of which the Company
     and the Subsidiaries are in compliance.

          (o) Patents and  Trademarks.  To the knowledge of the Company and each
     Subsidiary,  the Company and the Subsidiaries  have, or have rights to use,
     all  patents,  patent  applications,  trademarks,  trademark  applications,
     service marks, trade names,  copyrights,  licenses and other similar rights
     that are necessary or material for use in connection with their  respective
     businesses as described in the SEC Reports and which the failure to so have
     could have or reasonably be expected to result in a Material Adverse Effect
     (collectively, the "Intellectual Property Rights"). Neither the Company nor
     any Subsidiary has received a written notice ------------------------------
     that the Intellectual Property Rights used by the Company or any Subsidiary
     violates or infringes  upon the rights of any Person.  To the  knowledge of
     the Company, all such Intellectual Property Rights are enforceable.

          (p)  Insurance.  The  Company  and the  Subsidiaries  are  insured  by
     insurers of  recognized  financial  responsibility  against such losses and
     risks and in such amounts as are prudent and customary in the businesses in
     which the Company and the Subsidiaries are engaged. Neither the Company nor
     any  Subsidiary has any reason to believe that it will not be able to renew
     its existing  insurance  coverage as and when such  coverage  expires or to
     obtain  similar  coverage  from  similar  insurers as may be  necessary  to
     continue its business without a significant increase in cost.

          (q) Transactions With Affiliates and Employees. Except as set forth in
     the SEC  Reports,  none of the officers or directors of the Company and, to
     the  knowledge  of the  Company,  none of the  employees  of the Company is
     presently a party to any  transaction  with the  Company or any  Subsidiary
     (other than for services as employees,  officers and directors),  including

                                       9


     any contract,  agreement or other arrangement  providing for the furnishing
     of services to or by, providing for rental of real or personal  property to
     or from, or otherwise  requiring payments to or from any officer,  director
     or such employee or, to the  knowledge of the Company,  any entity in which
     any officer,  director,  or any such employee has a substantial interest or
     is an  officer,  director,  trustee or  partner,  in each case in excess of
     $60,000  other  than (a) for  payment  of  salary  or  consulting  fees for
     services rendered, (b) reimbursement for expenses incurred on behalf of the
     Company  and  (c) for  other  employee  benefits,  including  stock  option
     agreements under any stock option plan of the Company.

          (r)  Internal  Accounting  Controls.  The  Company  and  each  of  its
     subsidiaries  maintains a system of internal accounting controls sufficient
     to provide  reasonable  assurance  that (i)  transactions  are  executed in
     accordance  with  management's  general or  specific  authorizations,  (ii)
     transactions  are recorded as necessary to permit  preparation of financial
     statements in conformity  with GAAP and to maintain  asset  accountability,
     (iii) access to assets is permitted  only in accordance  with  management's
     general or specific authorization, and (iv) the recorded accountability for
     assets is compared  with the existing  assets at  reasonable  intervals and
     appropriate  action is taken with respect to any  differences.  The Company
     has established  disclosure controls and procedures (as defined in Exchange
     Act Rules 13a-14 and 15d-14) for the Company and designed such  disclosures
     controls and procedures to ensure that material information relating to the
     Company,  including  its  subsidiaries,  is made  known  to the  certifying
     officers by others within those entities, particularly during the period in
     which  the  Company's  Form  10-K or 10-Q,  as the  case  may be,  is being
     prepared.   The   Company's   certifying   officers   have   evaluated  the
     effectiveness of the Company's  controls and procedures as of a date within
     90 days prior to the filing date of the Form 10-K for the fiscal year ended
     December 31, 2002 (such date, the "Evaluation Date"). The Company presented
     in its most recently  filed Form 10-K or Form 10-Q the  conclusions  of the
     certifying  officers about the effectiveness of the disclosure controls and
     procedures based on their  evaluations as of the Evaluation Date. Since the
     Evaluation  Date,  there have been no significant  changes in the Company's
     internal controls (as such term is defined in Item 307(b) of Regulation S-K
     under the Exchange  Act) or, to the Company's  knowledge,  in other factors
     that could significantly affect the Company's internal controls.

          (s) Certain Fees. No brokerage or finder's fees or commissions  are or
     will  be  payable  by the  Company  to any  broker,  financial  advisor  or
     consultant,  finder,  placement  agent,  investment  banker,  bank or other
     Person with respect to the transactions contemplated by this Agreement. The
     Purchasers  shall  have no  obligation  with  respect  to any  fees or with
     respect to any claims  made by or on behalf of other  Persons for fees of a
     type  contemplated  in this Section that may be due in connection  with the
     transactions contemplated by this Agreement.

          (t)  Private  Placement.  Assuming  the  accuracy  of  the  Purchasers
     representations  and warranties  set forth in Section 3.2, no  registration
     under  the  Securities  Act is  required  for  the  offer  and  sale of the
     Securities by the Company to the  Purchasers as  contemplated  hereby.  The
     issuance and sale of the Securities hereunder does not contravene the rules
     and regulations of the Trading Market.

                                       10



          (u)  Investment  Company.  The Company is not, and is not an Affiliate
     of, an "investment  company"  within the meaning of the Investment  Company
     Act of 1940, as amended.

          (v) Registration  Rights. No Person has any right to cause the Company
     to effect the  registration  under the  Securities Act of any securities of
     the Company.

          (w) Listing and Maintenance Requirements.  The Company has not, in the
     12 months  preceding  the date  hereof,  received  notice  from any Trading
     Market on which  the  Common  Stock is or has been  listed or quoted to the
     effect  that  the  Company  is  not  in  compliance  with  the  listing  or
     maintenance requirements of such Trading Market. The Company is, and has no
     reason to believe that it will not in the  foreseeable  future  continue to
     be, in compliance with all such listing and maintenance requirements.

          (x) Application of Takeover Protections.  The Company and its Board of
     Directors  have  taken all  necessary  action,  if any,  in order to render
     inapplicable any control share acquisition,  business  combination,  poison
     pill (including any distribution under a rights agreement) or other similar
     anti-takeover  provision under the Company's  Certificate of  Incorporation
     (or similar  charter  documents) or the laws of its state of  incorporation
     that is or could become  applicable  to the  Purchasers  as a result of the
     Purchasers and the Company fulfilling their obligations or exercising their
     rights under the Transaction  Documents,  including without  limitation the
     Company's  issuance of the Securities and the Purchasers'  ownership of the
     Securities.

          (y) Disclosure. The Company confirms that, neither the Company nor any
     other Person  acting on its behalf has provided  any of the  Purchasers  or
     their  agents or counsel with any  information  that  constitutes  or might
     constitute material,  non-public  information.  The Company understands and
     confirms that the Purchasers will rely on the foregoing representations and
     covenants in effecting  transactions in securities of the Company.  Neither
     this Agreement,  nor any Exhibit attached hereto provided to the Purchasers
     regarding  the  Company,  its business  and the  transactions  contemplated
     hereby, including the Disclosure Schedules to this Agreement,  furnished by
     or on behalf of the  Company  are true and  correct  and do not contain any
     untrue  statement  of a material  fact or omit to state any  material  fact
     necessary in order to make the  statements  made  therein,  in light of the
     circumstances under which they were made, not misleading.

          (z) No  Integrated  Offering.  Neither  the  Company,  nor  any of its
     affiliates,  nor any Person acting on its or their behalf has,  directly or
     indirectly,  made any  offers or sales of any  security  or  solicited  any
     offers to buy any  security,  under  circumstances  that  would  cause this
     offering of the  Securities  to be integrated  with prior  offerings by the
     Company for purposes of the Securities  Act or any  applicable  shareholder
     approval  provisions,  including,  without limitation,  under the rules and
     regulations of any exchange or automated  quotation  system on which any of
     the securities of the Company are listed or designated.

     3.2  Representations  and  Warranties  of the  Purchasers.  Each  Purchaser
hereby, for itself and for no other Purchaser, represents and warrants as of the
date hereof and as of the Closing Date to the Company as follows:


                                       11


          (a)  Organization;   Authority.  Such  Purchaser  is  an  entity  duly
     organized,  validly  existing  and in good  standing  under the laws of the
     jurisdiction of its organization with full right,  corporate or partnership
     power  and  authority  to enter  into and to  consummate  the  transactions
     contemplated  by the  Transaction  Documents and otherwise to carry out its
     obligations  thereunder.  The execution,  delivery and  performance by such
     Purchaser of the transactions  contemplated by this Agreement has been duly
     authorized by all necessary corporate action on the part of such Purchaser.
     Each  Transaction  Document to which it is party has been duly  executed by
     such  Purchaser,  and when delivered by such  Purchaser in accordance  with
     terms hereof,  will constitute the valid and legally binding  obligation of
     such Purchaser, enforceable against it in accordance with its terms.

          (b) Investment Intent. Such Purchaser  understands that the Securities
     are  "restricted  securities"  and  have  not  been  registered  under  the
     Securities Act or any applicable  state securities law and is acquiring the
     Securities  as principal for its own account for  investment  purposes only
     and not with a view to or for  distributing or reselling such Securities or
     any part  thereof,  has no present  intention of  distributing  any of such
     Securities and has no arrangement or  understanding  with any other persons
     regarding the  distribution of such  Securities  (this  representation  and
     warranty  not  limiting  such  Purchaser's  right  to sell  the  Securities
     pursuant to the  Registration  Statement or otherwise  in  compliance  with
     applicable  federal and state securities laws). Such Purchaser is acquiring
     the  Securities  hereunder in the  ordinary  course of its  business.  Such
     Purchaser  does  not have  any  agreement  or  understanding,  directly  or
     indirectly, with any Person to distribute any of the Securities.

          (c)  Purchaser  Status.  At the time such  Purchaser  was  offered the
     Securities,  it was, and at the date hereof it is an "accredited  investor"
     as defined in Rule 501(a) under the  Securities  Act. Such Purchaser is not
     required  to be  registered  as a  broker-dealer  under  Section  15 of the
     Exchange Act.

          (d)  Experience of such  Purchaser.  Such  Purchaser,  either alone or
     together with its representatives,  has such knowledge,  sophistication and
     experience  in  business  and  financial  matters  so as to be  capable  of
     evaluating  the  merits  and  risks of the  prospective  investment  in the
     Securities,  and has so evaluated the merits and risks of such  investment.
     Such  Purchaser is able to bear the economic  risk of an  investment in the
     Securities  and, at the present  time, is able to afford a complete loss of
     such investment.

          (e)  General  Solicitation.  Such  Purchaser  is  not  purchasing  the
     Securities  as a result  of any  advertisement,  article,  notice  or other
     communication regarding the Securities published in any newspaper, magazine
     or similar media or broadcast over  television or radio or presented at any
     seminar or any other general solicitation or general advertisement.

     The Company  acknowledges  and agrees that each  Purchaser does not make or
has not made any  representations or warranties with respect to the transactions
contemplated hereby other than those specifically set forth in this Section 3.2.

                                       12


                                  ARTICLE IV.
                         OTHER AGREEMENTS OF THE PARTIES

     4.1 Transfer Restrictions.


          (a) The  Securities  may only be disposed of in compliance  with state
     and federal  securities laws. In connection with any transfer of Securities
     other than pursuant to an effective registration statement, to the Company,
     to  an  Affiliate  of a  Purchaser  or  in  connection  with  a  pledge  as
     contemplated  in Section  4.1(b),  the Company  may require the  transferor
     thereof  to provide to the  Company an opinion of counsel  selected  by the
     transferor,  the form and  substance of which  opinion  shall be reasonably
     satisfactory  to the  Company,  to the effect that such  transfer  does not
     require  registration of such  transferred  Securities under the Securities
     Act. As a condition of transfer, any such transferee shall agree in writing
     to be bound by the terms of this  Agreement  and shall have the rights of a
     Purchaser under this Agreement and the Registration Rights Agreement.

          (b) The Purchasers agree to the imprinting,  so long as is required by
     this Section 4.1(b),  of a legend on any of the Securities in the following
     form:

          THESE  SECURITIES  HAVE NOT BEEN  REGISTERED  WITH THE  SECURITIES AND
          EXCHANGE  COMMISSION  OR THE  SECURITIES  COMMISSION  OF ANY  STATE IN
          RELIANCE UPON AN EXEMPTION FROM REGISTRATION  UNDER THE SECURITIES ACT
          OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND, ACCORDINGLY,  MAY NOT
          BE  OFFERED  OR SOLD  EXCEPT  PURSUANT  TO AN  EFFECTIVE  REGISTRATION
          STATEMENT  UNDER  THE  SECURITIES  ACT  OR  PURSUANT  TO AN  AVAILABLE
          EXEMPTION FROM, OR IN A TRANSACTION  NOT SUBJECT TO, THE  REGISTRATION
          REQUIREMENTS  OF THE SECURITIES ACT AND IN ACCORDANCE  WITH APPLICABLE
          STATE  SECURITIES  LAWS AS EVIDENCED BY A LEGAL  OPINION OF COUNSEL TO
          THE  TRANSFEROR  TO SUCH  EFFECT,  THE  SUBSTANCE  OF  WHICH  SHALL BE
          REASONABLY ACCEPTABLE TO THE COMPANY.  THESE SECURITIES MAY BE PLEDGED
          IN  CONNECTION  WITH A BONA  FIDE  MARGIN  ACCOUNT  WITH A  REGISTERED
          BROKER-DEALER  OR OTHER LOAN WITH A FINANCIAL  INSTITUTION  THAT IS AN
          "ACCREDITED  INVESTOR" AS DEFINED IN RULE 501(a) UNDER THE  SECURITIES
          ACT.

          The Company  acknowledges and agrees that a Purchaser may from time to
     time  pledge  pursuant to a bona fide margin  agreement  with a  registered
     broker-dealer or grant a security interest in some or all of the Securities
     to a financial  institution that is an "accredited  investor" as defined in
     Rule 501(a) under the  Securities  Act and, if required  under the terms of
     such arrangement, such Purchaser may transfer pledged or secured Securities
     to the pledgees or secured parties.  Such a pledge or transfer would not be
     subject to approval of the Company and no legal opinion of legal counsel of
     the  pledgee,  secured  party or pledgor  shall be required  in  connection
     therewith.  Further,  no notice  shall be required of such  pledge.  At the
     appropriate  Purchaser's expense, the Company will execute and deliver such
     reasonable  documentation  as a pledgee or secured party of Securities  may

                                       13


     reasonably  request  in  connection  with  a  pledge  or  transfer  of  the
     Securities, including the preparation and filing of any required prospectus
     supplement  under Rule 424(b)(3) of the Securities Act or other  applicable
     provision of the Securities Act to appropriately  amend the list of Selling
     Stockholders thereunder.

          (c)  Certificates  evidencing  the Shares and Warrant Shares shall not
     contain any legend (including the legend set forth in Section 4.1(b)),  (i)
     while a  registration  statement  (including  the  Registration  Statement)
     covering the resale of such security is effective under the Securities Act,
     or (ii)  following  any sale of such Shares or Warrant  Shares  pursuant to
     Rule 144, or (iii) if such Shares or Warrant  Shares are  eligible for sale
     under Rule 144(k),  or (iv) if such legend is not required under applicable
     requirements of the Securities Act (including judicial  interpretations and
     pronouncements  issued by the Staff of the  Commission).  The Company shall
     cause its counsel to issue a legal opinion to the Company's  transfer agent
     promptly  after the Effective  Date if required by the  Company's  transfer
     agent to effect the removal of the legend hereunder.  If all or any portion
     of a Warrant is exercised at a time when there is an effective registration
     statement to cover the resale of the Warrant  Shares,  such Warrant  Shares
     shall be issued free of all legends.  The Company agrees that following the
     Effective  Date or at such time as such legend is no longer  required under
     this Section  4.1(c),  it will, no later than seven Trading Days  following
     the delivery by a Purchaser to the Company or the Company's  transfer agent
     of a certificate representing Shares or Warrant Shares, as the case may be,
     issued with a restrictive legend,  deliver or cause to be delivered to such
     Purchaser a certificate  representing such Securities that is free from all
     restrictive and other legends. The Company may not make any notation on its
     records or give  instructions  to any  transfer  agent of the Company  that
     enlarge the restrictions on transfer set forth in this Section.

          (d) In addition to such  Purchaser's  other  available  remedies,  the
     Company shall pay to a Purchaser, in cash, as liquidated damages and not as
     a penalty,  for each $1,000 of Shares or Warrant  Shares (based on the VWAP
     of the  Common  Stock on the date  such  Securities  are  submitted  to the
     Company's  transfer  agent) subject to Section  4.1(c),  $5 per Trading Day
     (increasing to $10 per Trading Day five (5) Trading Days after such damages
     have begun to accrue) for each Trading Day after such  seventh  Trading Day
     until such  certificate  is  delivered.  Nothing  herein  shall  limit such
     Purchaser's  right to pursue actual  damages for the  Company's  failure to
     deliver  certificates  representing  any  Securities  as  required  by  the
     Transaction  Documents,  and such Purchaser  shall have the right to pursue
     all  remedies  available  to it at  law  or in  equity  including,  without
     limitation, a decree of specific performance and/or injunctive relief.

     4.2 Furnishing of  Information.  As long as any Purchaser owns  Securities,
the Company  covenants to timely file (or obtain  extensions in respect  thereof
and file within the applicable grace period) all reports required to be filed by
the Company after the date hereof pursuant to the Exchange Act. Upon the request
of any such holder of  Securities,  the Company  shall  deliver to such holder a
written certification of a duly authorized officer as to whether it has complied
with the preceding  sentence.  As long as any Purchaser owns Securities,  if the
Company is not required to file reports  pursuant to such laws,  it will prepare
and furnish to the  Purchasers  and make publicly  available in accordance  with
Rule  144(c) such  information  as is required  for the  Purchasers  to sell the

                                       14


Securities under Rule 144. The Company further  covenants that it will take such
further action as any holder of Securities may  reasonably  request,  all to the
extent  required from time to time to enable such Person to sell such Securities
without  registration  under the  Securities  Act within the  limitation  of the
exemptions provided by Rule 144.

     4.3  Integration.  The  Company  shall not sell,  offer for sale or solicit
offers to buy or  otherwise  negotiate in respect of any security (as defined in
Section 2 of the Securities Act) that would be integrated with the offer or sale
of the  Securities  in a manner that would  require the  registration  under the
Securities Act of the sale of the Securities to the Purchasers, or that would be
integrated  with the offer or sale of the  Securities  for purposes of the rules
and regulations of any Trading Market.

     4.4 Participation in Future Financing.  From the date hereof until 6 months
from the Effective  Date, the Company shall not effect a financing of its Common
Stock or Common Stock  Equivalents  (a  "Subsequent  Financing")  unless (i) the
Company  delivers to each of such Purchasers a written notice at least 2 Trading
Days  prior  to the  closing  of  such  Subsequent  Financing  (the  "Subsequent
Financing Notice") of its intention to effect such Subsequent  Financing,  which
Subsequent  Financing  Notice shall  describe in reasonable  detail the proposed
terms of such Subsequent Financing, the amount of proceeds intended to be raised
thereunder,  the Person with whom such  Subsequent  Financing  is proposed to be
effected,  and  attached  to which  shall be a term  sheet or  similar  document
relating  thereto and (ii) such Purchaser shall not have notified the Company by
6:30 p.m. (New York City time) on the second (2nd) Trading Day after its receipt
of the Subsequent  Financing  Notice of its  willingness to provide (or to cause
its  designee  to  provide),   subject  to  completion  of  mutually  acceptable
documentation,  up to 50% of Subsequent  Financing gross proceeds to the Company
("Over-Allotment  Amount")  on the  same  terms  set  forth  in  the  Subsequent
Financing  Notice.  Notwithstanding  anything herein to the contrary,  if one or
more  Purchasers  elects to exercise  the right to  participate  hereunder,  the
Company shall have the right to increase the size of the Subsequent Financing by
an amount equal to the amount to be purchased by such exercising  Purchasers and
effect such increase in the  Subsequent  Financing with the Persons set forth in
the Subsequent  Financing  Notice.  If one or more  Purchasers  shall fail to so
notify  the  Company  of their  willingness  to  participate  in the  Subsequent
Financing,  the  Company  may effect the  remaining  portion of such  Subsequent
Financing on the terms and to the Persons set forth in the Subsequent  Financing
Notice;  provided  that the Company  must provide the  Purchasers  with a second
Subsequent  Financing  Notice,  and the Purchasers  will again have the right of
first refusal set forth above in this Section 4.4, if the  Subsequent  Financing
subject to the initial  Subsequent  Financing  Notice is not consummated for any
reason  on the terms set forth in such  Subsequent  Financing  Notice  within 60
Trading Days after the date of the initial Subsequent  Financing Notice with the
Person  identified in the Subsequent  Financing Notice. In the event the Company
receives  responses to Subsequent  Financing Notices from Purchasers  seeking to
purchase  more  than the  financing  sought  by the  Company  in the  Subsequent
Financing  such  Purchasers  shall  have the  right to  purchase  their Pro Rata
Portion (as defined below) of the Over-Allotment  Amount.  "Pro Rata Portion" is
the ratio of (x) such Purchaser's  Subscription Amount and (y) the aggregate sum
of all of the Subscription Amounts. If any Purchaser no longer holds any Shares,
then the Pro Rata Portions shall be re-allocated among the remaining Purchasers.
Notwithstanding  anything to the  contrary  herein,  this  Section 4.4 shall not
apply to the following  (a) the granting of options to  employees,  officers and
directors  of the Company  pursuant to any stock  option plan duly  adopted by a
majority of the non-employee members of the Board of Directors of the Company or

                                       15


a majority of the members of a committee of non-employee  directors  established
for such purpose,  or (b) the exercise of any security  issued by the Company in
connection with the offer and sale of this Company's securities pursuant to this
Agreement,  or (c) the exercise of or conversion of any convertible  securities,
options or warrants  issued and  outstanding  on the date hereof,  provided such
securities have not been amended since the date hereof,  or (d)  acquisitions or
strategic investments, the primary purpose of which is not to raise capital.

     4.5 Securities  Laws  Disclosure;  Publicity.  The Company shall,  within 1
Trading Day of the Closing Date,  issue a press release or file a Current Report
on Form 8-K, in each case reasonably acceptable to each Purchaser disclosing the
transactions  contemplated hereby and make such other filings and notices in the
manner and time required by the Commission. The Company and each Purchaser shall
consult  with each  other in  issuing  any press  releases  with  respect to the
transactions  contemplated  hereby,  and neither  the Company nor any  Purchaser
shall issue any such press release or otherwise  make any such public  statement
without the prior  consent of the Company,  with respect to any press release of
any Purchaser,  or without the prior consent of each Purchaser,  with respect to
any press  release of the  Company,  which  consent  shall not  unreasonably  be
withheld,  except if such  disclosure  is  required  by law,  in which  case the
disclosing  party shall  promptly  provide the other party with prior  notice of
such public  statement or  communication.  Notwithstanding  the  foregoing,  the
Company shall not publicly  disclose the name of any  Purchaser,  or include the
name of any Purchaser in any filing with the Commission or any regulatory agency
or Trading Market,  without the prior written consent of such Purchaser,  except
(i) as required by federal  securities law in connection  with the  registration
statement  contemplated  by the  Registration  Rights  Agreement and (ii) to the
extent such  disclosure  is required by law or Trading  Market  regulations,  in
which case the Company  shall provide the  Purchasers  with prior notice of such
disclosure permitted under subclause (i) or (ii).

     4.6  Shareholders  Rights Plan. The Purchaser is not an "Acquiring  Person"
under any shareholders rights plan or similar plan or arrangement in effect.

     4.7 Non-Public  Information.  The Company covenants and agrees that neither
it nor any other Person  acting on its behalf will provide any  Purchaser or its
agents or counsel with any  information  that the Company  believes  constitutes
material non-public information,  unless prior thereto such Purchaser shall have
executed  a written  agreement  regarding  the  confidentiality  and use of such
information.  The Company  understands and confirms that each Purchaser shall be
relying on the foregoing representations in effecting transactions in securities
of the Company.

     4.8 Use of Proceeds.  The Company  shall use the net proceeds from the sale
of the  Securities  hereunder  for  working  capital  purposes  and  not for the
satisfaction  of any portion of the Company's  debt (other than payment of trade
payables in the ordinary course of the Company's  business and prior practices),
to redeem any Company  equity or  equity-equivalent  securities or to settle any
outstanding litigation.

     4.9 Indemnification of Purchasers.  The Company will indemnify and hold the
Purchasers and their directors, officers, shareholders,  partners, employees and
agents  (each,  a  "Purchaser   Party")   harmless  from  any  and  all  losses,
liabilities,  obligations,  claims, contingencies,  damages, costs and expenses,
including all judgments, amounts paid in settlements, court costs and reasonable
attorneys'  fees and costs of  investigation  that any such Purchaser  Party may
suffer or incur as a result of or relating to any  misrepresentation,  breach or

                                       16


inaccuracy, or any allegation by a third party that, if true, would constitute a
breach or inaccuracy,  of any of the representations,  warranties,  covenants or
agreements  made by the Company in this  Agreement  or in the other  Transaction
Documents.  The Company will reimburse  such Purchaser for its reasonable  legal
and other expenses  (including the cost of any  investigation,  preparation  and
travel in  connection  therewith)  incurred  in  connection  therewith,  as such
expenses are incurred.

     4.10  Reservation of Common Stock.  As of the date hereof,  the Company has
reserved  and the Company  shall  continue to reserve and keep  available at all
times, free of preemptive  rights, a sufficient number of shares of Common Stock
for the  purpose of  enabling  the  Company  to issue  Shares  pursuant  to this
Agreement and Warrant Shares pursuant to any exercise of the Warrants.

     4.11  Listing  of  Common  Stock.4.12  The  Company  hereby  agrees  to use
commercially  reasonable  efforts to maintain the listing of the Common Stock on
the Trading Market, and as soon as reasonably  practicable following the Closing
(but not later than the earlier of the Effective Date and the first  anniversary
of the Closing  Date) to list the  applicable  Shares and Warrant  Shares on the
Trading Market.  The Company further agrees,  if the Company applies to have the
Common  Stock  traded on any  other  Trading  Market,  it will  include  in such
application the Shares and the Warrant  Shares,  and will take such other action
as is  necessary  or  desirable  in the opinion of the  Purchasers  to cause the
Shares and Warrant  Shares to be listed on such other Trading Market as promptly
as possible.  The Company will take all action reasonably  necessary to continue
the listing and trading of its Common Stock on a Trading  Market and will comply
in all respects with the Company's reporting, filing and other obligations under
the bylaws or rules of the Trading Market.

                                   ARTICLE V.
                                  MISCELLANEOUS

     5.1 Fees and  Expenses.  The Company shall pay $25,000 plus 4% of the gross
proceeds  raised  hereunder per the written  instructions of Bonanza Master Fund
Ltd. ("Bonanza") for Bonanza's legal, administrative, advisory and due diligence
fees and expenses  incurred in connection with the investigation and negotiation
of the  transaction  and the  preparation  and  negotiation  of the  Transaction
Documents ($15,000 of which has already been received).  Accordingly, in lieu of
the foregoing  payments,  the Company,  on the Closing Date, hereby directs that
the  Subscription  Amount paid by Bonanza  hereunder  will be reduced by $10,000
(the  remaining  portion  of the  $25,000  not yet  paid)  plus 4% of the  gross
proceeds raised hereunder. Except as otherwise set forth in this Agreement, each
party shall pay the fees and expenses of its advisers, counsel,  accountants and
other experts, if any, and all other expenses incurred by such party incident to
the  negotiation,  preparation,  execution,  delivery  and  performance  of this
Agreement.  The Company shall pay all stamp and other taxes and duties levied in
connection with the sale of the Securities.

     5.2 Entire Agreement. The Transaction Documents, together with the exhibits
and  schedules  thereto,  contain the entire  understanding  of the parties with
respect to the subject  matter  hereof and supersede  all prior  agreements  and
understandings, oral or written, with respect to such matters, which the parties
acknowledge have been merged into such documents, exhibits and schedules.

                                       17


     5.3  Notices.  Any and all notices or other  communications  or  deliveries
required or permitted to be provided  hereunder shall be in writing and shall be
deemed given and effective on the earliest of (a) the date of  transmission,  if
such notice or  communication is delivered via facsimile at the facsimile number
specified in this Section  prior to 6:30 p.m.  (New York City time) on a Trading
Day, (b) the next Trading Day after the date of transmission,  if such notice or
communication  is delivered via facsimile at the facsimile  number  specified in
this  Section on a day that is not a Trading  Day or later  than 6:30 p.m.  (New
York City time) on any Trading  Day, (c) the Trading Day  following  the date of
mailing, if sent by U.S. nationally recognized overnight courier service, or (d)
upon  actual  receipt by the party to whom such  notice is required to be given.
The address for such  notices  and  communications  shall be as set forth on the
signature pages attached hereto.

     5.4  Amendments;  Waivers.  No provision of this Agreement may be waived or
amended except in a written instrument  signed, in the case of an amendment,  by
the Company and each Purchaser or, in the case of a waiver, by the party against
whom  enforcement  of any such waiver is sought.  No waiver of any default  with
respect to any provision,  condition or  requirement of this Agreement  shall be
deemed to be a  continuing  waiver in the  future or a waiver of any  subsequent
default or a waiver of any other provision, condition or requirement hereof, nor
shall any delay or omission of either party to exercise  any right  hereunder in
any manner impair the exercise of any such right.

     5.5  Construction.  The headings  herein are for  convenience  only, do not
constitute a part of this  Agreement  and shall not be deemed to limit or affect
any of the provisions hereof. The language used in this Agreement will be deemed
to be the language chosen by the parties to express their mutual intent,  and no
rules of strict construction will be applied against any party.

     5.6 Successors and Assigns.  This Agreement shall be binding upon and inure
to the benefit of the parties and their  successors and permitted  assigns.  The
Company may not assign this  Agreement  or any rights or  obligations  hereunder
without the prior written  consent of each  Purchaser.  Any Purchaser may assign
any or all of its  rights  under  this  Agreement  to any  Person  to whom  such
Purchaser  assigns or transfers any Securities,  provided such transferee agrees
in  writing to be bound,  with  respect to the  transferred  Securities,  by the
provisions hereof that apply to the "Purchasers".

     5.7 No  Third-Party  Beneficiaries.  This  Agreement  is  intended  for the
benefit of the parties  hereto and their  respective  successors  and  permitted
assigns and is not for the benefit of, nor may any provision  hereof be enforced
by, any other Person, except as otherwise set forth in Sections 5.6 and 5.7.

     5.8 Governing  Law. All questions  concerning the  construction,  validity,
enforcement and interpretation of the Transaction Documents shall be governed by
and construed and enforced in accordance  with the internal laws of the State of
New York,  without  regard to the  principles of conflicts of law thereof.  Each
party  agrees  that  all  legal  proceedings   concerning  the  interpretations,
enforcement and defense of the  transactions  contemplated by this Agreement and
any other Transaction  Documents  (whether brought against a party hereto or its
respective affiliates,  directors, officers, shareholders,  employees or agents)
shall be commenced  exclusively  in the state and federal  courts sitting in the
City of New York. Each party hereto hereby irrevocably  submits to the exclusive
jurisdiction  of the state and federal  courts  sitting in the City of New York,

                                       18


New York for the adjudication of any dispute hereunder or in connection herewith
or with any transaction  contemplated hereby or discussed herein (including with
respect to the enforcement of the any of the Transaction Documents),  and hereby
irrevocably  waives, and agrees not to assert in any suit, action or proceeding,
any claim  that it is not  personally  subject to the  jurisdiction  of any such
court,  that such suit,  action or  proceeding  is  improper.  Each party hereto
hereby  irrevocably  waives personal  service of process and consents to process
being served in any such suit,  action or  proceeding  by mailing a copy thereof
via  registered  or  certified  mail or  overnight  delivery  (with  evidence of
delivery)  to such party at the  address in effect for  notices to it under this
Agreement  and agrees that such service  shall  constitute  good and  sufficient
service of process and notice thereof.  Nothing contained herein shall be deemed
to limit in any way any right to serve  process in any manner  permitted by law.
Each party hereto  (including its affiliates,  agents,  officers,  directors and
employees)  hereby  irrevocably  waives,  to the  fullest  extent  permitted  by
applicable  law,  any and all  right to trial  by jury in any  legal  proceeding
arising out of or relating to this  Agreement or the  transactions  contemplated
hereby.  If either party shall  commence an action or  proceeding to enforce any
provisions of a Transaction  Document,  then the prevailing party in such action
or proceeding  shall be reimbursed by the other party for its attorneys fees and
other  costs and  expenses  incurred  with the  investigation,  preparation  and
prosecution of such action or proceeding.

     5.9 Survival.  The  representations,  warranties,  agreements and covenants
contained  herein  shall  survive  the  Closing  for a period of 1 year from the
Closing Date.

     5.10 Execution. This Agreement may be executed in two or more counterparts,
all of which when taken  together shall be considered one and the same agreement
and shall become effective when  counterparts have been signed by each party and
delivered to the other  party,  it being  understood  that both parties need not
sign the same  counterpart.  In the event that any  signature  is  delivered  by
facsimile  transmission,  such  signature  shall  create  a  valid  and  binding
obligation  of the  party  executing  (or on  whose  behalf  such  signature  is
executed)  with the same force and effect as if such  facsimile  signature  page
were an original thereof.

     5.11 Severability. If any provision of this Agreement is held to be invalid
or  unenforceable  in  any  respect,  the  validity  and  enforceability  of the
remaining  terms  and  provisions  of  this  Agreement  shall  not in any way be
affected or impaired  thereby and the parties will attempt to agree upon a valid
and enforceable provision that is a reasonable substitute therefor,  and upon so
agreeing, shall incorporate such substitute provision in this Agreement.

     5.12 Replacement of Securities. If any certificate or instrument evidencing
any Securities is mutilated,  lost, stolen or destroyed, the Company shall issue
or cause to be issued in exchange  and  substitution  for and upon  cancellation
thereof,  or  in  lieu  of  and  substitution  therefor,  a new  certificate  or
instrument,  but only upon receipt of evidence  reasonably  satisfactory  to the
Company  of such  loss,  theft  or  destruction  and  customary  and  reasonable
indemnity,  if requested.  The  applicants  for a new  certificate or instrument
under  such  circumstances  shall  also  pay any  reasonable  third-party  costs
associated with the issuance of such replacement Securities.

     5.13  Remedies.  In  addition  to being  entitled  to  exercise  all rights
provided herein or granted by law,  including  recovery of damages,  each of the
Purchasers  and the Company will be entitled to specific  performance  under the
Transaction  Documents.  The  parties  agree that  monetary  damages  may not be

                                       19


adequate  compensation  for  any  loss  incurred  by  reason  of any  breach  of
obligations  described in the  foregoing  sentence and hereby agrees to waive in
any action for specific  performance  of any such  obligation the defense that a
remedy at law would be adequate.

     5.14 Payment Set Aside.  To the extent that the Company  makes a payment or
payments to any Purchaser  pursuant to any  Transaction  Document or a Purchaser
enforces or exercises its rights thereunder, and such payment or payments or the
proceeds of such  enforcement  or exercise or any part thereof are  subsequently
invalidated,  declared to be fraudulent or  preferential,  set aside,  recovered
from, disgorged by or are required to be refunded,  repaid or otherwise restored
to the  Company,  a  trustee,  receiver  or  any  other  person  under  any  law
(including, without limitation, any bankruptcy law, state or federal law, common
law or equitable  cause of action),  then to the extent of any such  restoration
the  obligation  or part thereof  originally  intended to be satisfied  shall be
revived and  continued  in full force and effect as if such payment had not been
made or such enforcement or setoff had not occurred.

     5.15  Independent  Nature  of  Purchasers'   Obligations  and  Rights.  The
obligations of each Purchaser under any Transaction Document are several and not
joint with the  obligations of any other  Purchaser,  and no Purchaser  shall be
responsible  in any way for the  performance  of the  obligations  of any  other
Purchaser under any Transaction  Document.  Nothing  contained  herein or in any
Transaction  Document,  and no action taken by any Purchaser  pursuant  thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint  venture  or any other kind of entity,  or create a  presumption  that the
Purchasers  are in any way acting in concert or as a group with  respect to such
obligations or the transactions  contemplated by the Transaction Document.  Each
Purchaser  shall be  entitled to  independently  protect and enforce its rights,
including without limitation, the rights arising out of this Agreement or out of
the other  Transaction  Documents,  and it shall not be necessary  for any other
Purchaser  to be  joined  as an  additional  party  in any  proceeding  for such
purpose.  Each Purchaser has been  represented by its own separate legal counsel
in their review and  negotiation of the  Transaction  Documents.  For reasons of
administrative  convenience only,  Purchasers and their respective  counsel have
chosen to communicate  with the Company through FW. FW does not represent all of
the  Purchasers  but only  Bonanza.  The  Company  has  elected to  provide  all
Purchasers with the same terms and Transaction  Documents for the convenience of
the  Company  and not  because  it was  required  or  requested  to do so by the
Purchasers.

                            (Signature Page Follows)


                                       20



                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Securities Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

CYTOGEN CORPORATION                                 Address for Notice:
                                                    ------------------
                                                    650 College Road East
                                                    CN 5308
By: /s/ Michael D. Becker                           Suite 3100
    ------------------------                        Princeton, New Jersey 08540
    Name:  Michael D. Becker                        Attn: Michael D. Becker
    Title:  President and Chief Executive Officer   Tel:  609-750-8201
                                                    Fax:  609-452-2476


                                       21



          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

BONANZA MASTER FUND LTD.                               Address for Notice:
                                                       ------------------
                                                       8235 Douglas, Suite 423
                                                       Dallas, TX 75205
                                                       P: 214.615.7090
By: /s/ Brian Ladin                                    F: 214.987.4342
    ------------------------                           Attn: Brian Ladin
    Name:  Brian Ladin
    Title: Managing Director

Subscription Amount: $2,500,000

With a copy to:

Feldman Weinstein LLP
Suite 2620
420 Lexington Avenue
New York, New York 10170
Tel: 212-931-8704
Fax: 212-401-4741
Attn:  Robert F. Charron

                           [SIGNATURE PAGE CONTINUES]





          [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

BAYSTAR CAPITAL II LP                              Address for Notice:
                                                   ------------------
                                                   80 E. Sir Francis Drake Blvd.
                                                   Suite 2B
                                                   Larkspur, CA 94939
By:/s/ Steve Derby                                 Attn: Steve Derby
   ----------------------------                    Tel:  203-967-5875
   Name:  Steve Derby                              Fax:  203-967-5851
   Title: Managing Member

Subscription Amount:  $2,500,000


                                       23