EXHIBIT 5.1


                                HALE AND DORR LLP
                                Counselors at Law
                              650 College Road East
                           Princeton, New Jersey 08540

                                                     August 12, 2003

Cytogen Corporation
650 College Road East
Suite 3100
Princeton, New Jersey 08540

         Re: Registration Statement
             ----------------------

Gentlemen:

         This  opinion is  furnished to you in  connection  with a  Registration
Statement  on Form  S-3 (the  "Registration  Statement")  to be  filed  with the
Securities and Exchange  Commission (the "Commission")  under the Securities Act
of 1933, as amended (the "Securities Act"), for the registration of an aggregate
of  1,368,422  shares  of the  common  stock,  $.01 par  value  per  share  (the
"Shares"), of Cytogen Corporation,  a Delaware corporation (the "Company").  All
of the Shares are being  registered  on behalf of  certain  stockholders  of the
Company.

         We have  acted  as  counsel  for the  Company  in  connection  with the
registration  for resale of the Shares.  We have  examined  signed copies of the
Registration  Statement to be filed with the  Commission.  We have also examined
and relied upon the minutes of  meetings  of the  stockholders  and the Board of
Directors of the Company as provided to us by the Company, stock record books of
the Company as provided to us by the Company,  the Certificate of  Incorporation
and By-Laws of the Company,  each as restated  and/or  amended to date, and such
other  documents  as we have deemed  necessary  for  purposes of  rendering  the
opinions hereinafter set forth.

         In our  examination  of the  foregoing  documents,  we have assumed the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to
us as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

         We assume that the  appropriate  action has been taken to register  and
qualify the Shares for sale under all applicable  state securities or "blue sky"
laws.

         We  express  no  opinion  herein  as  to  the  laws  of  any  state  or
jurisdiction other than the Delaware General Corporation Law.

         Based upon and subject to the  foregoing,  and  assuming the receipt of
the  appropriate  consideration  for the Shares,  we are of the opinion that the
Shares  have  been  duly  authorized,   are  validly  issued,   fully  paid  and
nonassessable.

         It is  understood  that this  opinion is to be used only in  connection
with the offer and sale of the Shares  while the  Registration  Statement  is in
effect.

         Please note that we are opining  only as to the matters  expressly  set
forth herein, and no opinion should be inferred as to any other matters.

         We hereby  consent to the filing of this opinion with the Commission as
an exhibit to the Registration  Statement in accordance with the requirements of
Item  601(b)(5) of Regulation S-K under the Securities Act and to the use of our



name therein and in the related prospectus under the caption "Legal Matters." In
giving  such  consent,  we do not hereby  admit that we are in the  category  of
persons whose consent is required  under Section 7 of the  Securities Act or the
rules and regulations of the Commission.

                                                     Very truly yours,

                                                     /s/ Hale and Dorr LLP

                                                     HALE AND DORR LLP