EXHIBIT 5.1

                                HALE AND DORR LLP
                                COUNSELORS AT LAW
                   650 COLLEGE ROAD EAST, PRINCETON, NJ 08540
                         609-750-7600 o FAX 609-750-7700




                                                  October 28, 2003





Cytogen Corporation
650 College Road East
CN 5308, Suite 3100
Princeton, New Jersey 08540

Registration Statement on Form S-3

Ladies and Gentlemen:

         This  opinion is  furnished to you in  connection  with a  Registration
Statement  on Form  S-3 (the  "Registration  Statement")  to be  filed  with the
Securities and Exchange  Commission (the "Commission")  under the Securities Act
of 1933, as amended (the "Securities Act"), for the registration of an aggregate
of up to  $60,000,000  in shares of Common Stock,  $.01 par value per share (the
"Shares"), of Cytogen Corporation,  a Delaware corporation (the "Company").  All
of the Shares are being registered on behalf of the Company.

         We are  acting  as  counsel  for the  Company  in  connection  with the
registration of the Shares.  We have examined signed copies of the  Registration
Statement to be filed with the Commission. We have also examined and relied upon
minutes  of  meetings  of the  stockholders  and the Board of  Directors  of the
Company as provided to us by the  Company,  stock record books of the Company as
provided to us by the Company,  the Certificate of Incorporation  and By-Laws of
the Company,  each as restated  and/or amended to date, and such other documents
as we have deemed  necessary for purposes of rendering the opinions  hereinafter
set forth.

         In our  examination  of the  foregoing  documents,  we have assumed the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to
us as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

         We assume that the appropriate action will be taken, prior to the offer
and sale of the Shares,  to  register  and qualify the Shares for sale under all
applicable state securities or "blue sky" laws.

         We  express  no  opinion  herein  as  to  the  laws  of  any  state  or
jurisdiction other than the General Corporation Law of the State of Delaware and
the federal laws of the United States of America.

         Based  upon  and   subject  to  the   foregoing   and  subject  to  the
qualifications  herein  stated,  we are of the opinion  that with respect to any
offering  of the Shares if: (i) the  Shares  are sold  pursuant  to a  purchase,



underwriting  or  similar  agreement,  such  purchase,  underwriting  or similar
agreement  has been duly  authorized,  executed and delivered by the Company and
the other  parties  thereto and has become a valid and binding  agreement of the
Company;  (ii) the terms of the Shares and of their  issuance and sale have been
duly  established in conformity with the operative  certificate of incorporation
and bylaws of the Company and the Delaware General  Corporation Law so as to not
violate any applicable law, the operative certificate of incorporation or bylaws
of the  Company  or  result in a default  under or  breach of any  agreement  or
instrument  binding upon the Company and so as to comply with any requirement or
restriction  imposed by any court or governmental body having  jurisdiction over
the  Company;  and (iii) the Company has  received  all  requisite  consents and
waivers,  if any, of its stockholders,  then the Shares, when issued and sold in
accordance with a duly authorized, executed and delivered purchase, underwriting
or similar  agreement,  if any, will be duly authorized,  validly issued,  fully
paid and  nonassessable,  assuming that a sufficient  number of shares of Common
Stock are  authorized  or  reserved  and  available  for  issuance  and that the
consideration  for the  issuance and sale of the Shares is not less than the par
value of the Company's Common Stock.

         It is  understood  that this  opinion is to be used only in  connection
with the  offer and sale of the  Shares  while the  Registration  Statement,  as
finally amended (including all necessary post-effective amendments) is in effect
and an  appropriate  prospectus  supplement  with respect to the Shares has been
prepared,  delivered and filed in  compliance  with the  Securities  Act and all
applicable rules promulgated thereunder.

         Please note that we are opining  only as to the matters  expressly  set
forth herein,  and no opinion should be inferred as to any other  matters.  This
opinion  is based upon  currently  existing  statutes,  rules,  regulations  and
judicial  decisions,  and we disclaim any obligation to advise you of any change
in any of these sources of law or subsequent legal or factual developments which
might affect any matters or opinions set forth herein.

         We hereby  consent to the filing of this opinion with the Commission as
an exhibit to the Registration  Statement in accordance with the requirements of
Item  601(b)(5) of Regulation S-K under the Securities Act and to the use of our
name therein and in the related prospectus under the caption "Legal Matters." In
giving  such  consent,  we do not hereby  admit that we are in the  category  of
persons whose consent is required  under Section 7 of the  Securities Act or the
rules and regulations of the Commission.


                                                  Sincerely,

                                                  /s/ Hale and Dorr LLP

                                                  HALE AND DORR LLP