EXHIBIT 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         In  connection  with  the  Quarterly  Report  on Form  10-Q of  Cytogen
Corporation  (the  "Company")  for the period ended March 31, 2004 as filed with
the Securities and Exchange  Commission on the date hereof (the  "Report"),  the
undersigned,  Michael D. Becker, Chief Executive Officer of the Company,  hereby
certifies, pursuant to 18 U.S.C. Section 1350, that:

         (1) The Report fully complies with the requirements of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

         (2) The  information  contained in the Report fairly  presents,  in all
material  respects,  the  financial  condition  and results of operations of the
Company.

         A signed original of this written statement required by Section 906 has
been provided to Cytogen Corporation and will be retained by Cytogen Corporation
and  furnished  to the  Securities  and  Exchange  Commission  or its staff upon
request.



                                       /s/ Michael D. Becker
                                       -----------------------------------------
Dated:   May 7, 2004                   Michael D. Becker, President and Chief
                                       Executive Officer
                                       (Principal Executive Officer)