EXHIBIT 32.1


                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Cytogen Corporation (the
"Company")  for the period ended June 30, 2004 as filed with the  Securities and
Exchange Commission on the date hereof (the "Report"), the undersigned,  Michael
D. Becker, Chief Executive Officer of the Company, hereby certifies, pursuant to
18 U.S.C. Section 1350, that, based upon my knowledge:

     (1) The Report fully  complies  with the  requirements  of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

     (2)  The  information  contained  in the  Report  fairly  presents,  in all
material  respects,  the  financial  condition  and results of operations of the
Company.

A signed  original of this  written  statement  required by Section 906 has been
provided to Cytogen  Corporation and will be retained by Cytogen Corporation and
furnished to the Securities and Exchange Commission or its staff upon request.



                                       /s/ Michael D. Becker
                                       --------------------------------------
Dated:   August 9, 2004                Michael D. Becker, President and Chief
                                       Executive Officer
                                       (Principal Executive Officer)