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 CYTOGEN ANNOUNCES RETIREMENT OF THOMAS LYTLE AS SENIOR VICE PRESIDENT OF SALES
                                  AND MARKETING

PRINCETON,  N.J.,  (September 26, 2005) -- Cytogen  Corporation  (Nasdaq:  CYTO)
today  announced  that  Thomas S.  Lytle,  59, has  decided  to retire  from his
position as senior vice president of sales and marketing  effective  October 31,
2005.

Mr. Lytle will become a consultant  to the  company,  focusing on expanding  its
relationships  with key  physicians  and customers and  developing new models to
improve patient access to Cytogen's oncology products. In this capacity, he will
continue to work with key customers and accounts in developing and  implementing
these concepts.

Michael D. Becker, Cytogen's president and chief executive officer, stated: "Tom
Lytle has played an important  role in expanding  our sales force and  marketing
programs  during  the  past  year.  We have  benefited  from the  knowledge  and
experience he gained  through 35 years in the  pharmaceutical  industry and wish
him all the best during this next chapter of his life."

The  company  has no  current  plans to fill  Mr.  Lytle's  position.  Effective
immediately,  Mr.  Becker  will  assume a broader  role in leading the sales and
marketing team at Cytogen.

ABOUT CYTOGEN CORPORATION
- -------------------------

Founded  in 1980,  Cytogen  Corporation  of  Princeton,  NJ is a  product-driven
biopharmaceutical  company that develops and commercializes innovative molecules
that  can be used to  build  leading  franchises.  Cytogen's  marketed  products
include QUADRAMET(R)  (samarium Sm-153 lexidronam  injection) and PROSTASCINT(R)
(capromab pendetide) kit for the preparation of Indium In-111 capromab pendetide
in the United States.  Cytogen also has exclusive United States marketing rights
to COMBIDEX(R) (ferumoxtran-10) for all applications, and the exclusive right to
market and sell ferumoxytol  (previously Code 7228) for oncology applications in
the United  States.  Cytogen's  development  pipeline  consists of  therapeutics
targeting  prostate-specific membrane antigen (PSMA), a protein highly expressed
on the surface of prostate cancer cells and the  neovasculature of solid tumors.
Full  prescribing  information  for  the  Company's  products  is  available  at
www.cytogen.com or by calling 1-800-833-3533. For more information, please visit
the  Company's  website  at  www.cytogen.com,  which is not  part of this  press
release.


This press release  contains  certain  "forward-looking"  statements  within the
meaning of the Private Securities  Litigation Reform Act of 1995 and Section 21E
of the Securities Exchange Act of 1934, as amended.  All statements,  other than
statements of  historical  facts,  included in this press release  regarding our
strategy,  future operations,  financial  position,  future revenues,  projected
costs,  prospects,  plans  and  objectives  of  management  are  forward-looking
statements.  Such  forward-looking  statements  involve  a number  of risks  and
uncertainties  and investors are cautioned not to put any undue  reliance on any
forward-looking  statement.  There are a number of important  factors that could
cause  Cytogen's  results  to differ  materially  from those  indicated  by such
forward-looking  statements.  In particular,  Cytogen's business is subject to a
number of significant risks, which include,  but are not limited to: the risk of
obtaining  the  necessary  regulatory  approvals;  the risk of whether  products
result  from  development  activities;  the  risk of  shifts  in the  regulatory
environment affecting sales of



Cytogen's  products such as third-party  payor  reimbursement  issues;  the risk
associated with Cytogen's  dependence on its partners for development of certain
projects,  as well as other  factors  expressed  from time to time in  Cytogen's
periodic filings with the Securities and Exchange  Commission (the "SEC").  As a
result, this press release should be read in conjunction with Cytogen's periodic
filings with the SEC. The forward-looking  statements  contained herein are made
only as of the date of this press release,  and Cytogen undertakes no obligation
to publicly update such forward-looking  statements to reflect subsequent events
or circumstances.

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