EXHIBIT 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the Quarterly Report on Form 10-Q of Cytogen Corporation
(the  "Company")  for the  period  ended  September  30,  2005 as filed with the
Securities  and  Exchange  Commission  on the date  hereof (the  "Report"),  the
undersigned,  Michael D. Becker,  President and Chief  Executive  Officer of the
Company, hereby certifies,  pursuant to 18 U.S.C. Section 1350, that, based upon
my knowledge:

     (1)  The Report fully complies  with the  requirements  of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

     (2)  The  information  contained  in the  Report  fairly  presents,  in all
material  respects,  the  financial  condition  and results of operations of the
Company.

     A signed  original of this  written  statement  required by Section 906 has
been  provided to the Company and will be retained by the Company and  furnished
to the Securities and Exchange Commission or its staff upon request.



                                      /s/ Michael D. Becker
                                      ------------------------------------------
Dated:   November 14, 2005            Michael D. Becker, President
                                      and Chief Executive Officer
                                      (Principal Executive Officer)