SECURITIES PURCHASE AGREEMENT

     This  Securities  Purchase  Agreement  (this  "Agreement")  is  dated as of
                                                    ---------
December  13, 2005,  among  Cytogen  Corporation,  a Delaware  corporation  (the
"Company"),  and each purchaser  identified on the signature pages hereto (each,
 -------
including  its  successors  and assigns,  a  "Purchaser"  and  collectively  the
                                              ---------
"Purchasers").
 ----------

     WHEREAS,  subject to the terms and conditions set forth in this  Agreement,
the Company  desires to issue and sell to each  Purchaser,  and each  Purchaser,
severally and not jointly,  desires to purchase from the Company,  securities of
the Company as more fully described in this Agreement.

     NOW, THEREFORE,  in consideration of the mutual covenants contained in this
Agreement,  and for  other  good and  valuable  consideration  the  receipt  and
adequacy of which are hereby acknowledged,  the Company and each Purchaser agree
as follows:

                                   ARTICLE I.
                                   DEFINITIONS

     1.1  Definitions.  In  addition  to the  terms  defined  elsewhere  in this
          -----------
Agreement,  for all purposes of this  Agreement,  the  following  terms have the
meanings indicated in this Section 1.1:

          "Action"  shall  have the  meaning  ascribed  to such term in  Section
           ------
     3.1(j).

          "Affiliate" means any Person that,  directly or indirectly through one
           ---------
     or more  intermediaries,  controls or is  controlled  by or is under common
     control  with a Person as such terms are used in and  construed  under Rule
     144. With respect to a Purchaser,  any investment  fund or managed  account
     that is managed on a discretionary  basis by the same investment manager as
     such Purchaser will be deemed to be an Affiliate of such Purchaser.

          "Closing" means the closing of the purchase and sale of the Securities
           -------
     pursuant to Section 2.1.

          "Closing  Date"  means  the  Trading  Day when all of the  Transaction
           -------------
     Documents  have been  executed  and  delivered  by the  applicable  parties
     thereto, and all conditions precedent to (i) the Purchasers' obligations to
     pay the Subscription  Amount and (ii) the Company's  obligations to deliver
     the Securities have been satisfied or waived.

          "Closing  Price" means on any  particular  date (a) the last  reported
           --------------
     closing  bid price per  share of Common  Stock on such date on the  Trading
     Market (as reported by Bloomberg  L.P. at 4:15 PM (New York time)),  or (b)
     if there is no such price on such date,  then the  closing bid price on the
     Trading  Market on the date  nearest  preceding  such date (as  reported by
     Bloomberg  L.P. at 4:15 PM (New York time)),  or (c) if the Common Stock is
     not then  listed or  quoted on the  Trading  Market  and if prices  for the
     Common  Stock are then  reported  in the  "pink  sheets"  published  by the
     National Quotation Bureau


                                       1



     Incorporated  (or a  similar  organization  or  agency  succeeding  to  its
     functions of reporting prices),  the most recent bid price per share of the
     Common Stock so reported, or (d) if the shares of Common Stock are not then
     publicly  traded  the  fair  market  value of a share  of  Common  Stock as
     determined  by an appraiser  selected in good faith by the  Purchasers of a
     majority in interest of the Shares then outstanding.

          "Commission" means the Securities and Exchange Commission.
           ----------

          "Common Stock" means the common stock of the Company,  par value $0.01
           ------------
     per share, and any other class of securities into which such securities may
     hereafter have been reclassified or changed into.

          "Common Stock  Equivalents" means any securities of the Company or the
           -------------------------
     Subsidiaries  which would entitle the holder thereof to acquire at any time
     Common Stock,  including,  without limitation,  any debt,  preferred stock,
     rights,  options,  warrants  or  other  instrument  that  is  at  any  time
     convertible into or exercisable or exchangeable for, or otherwise  entitles
     the holder thereof to receive, Common Stock.

          "Company Counsel" means Morgan, Lewis & Bockius LLP.
           ---------------

          "Effective  Date" means the date that the  Registration  Statement was
           ---------------
     first declared effective by the Commission.

          "Evaluation  Date"  shall have the  meaning  ascribed  to such term in
           ----------------
     Section 3.1(r).

          "Exchange Act" means the Securities  Exchange Act of 1934, as amended,
           ------------
     and the rules and regulations promulgated thereunder.

          "Exempt  Issuance" means the issuance of (a) shares of Common Stock or
           ----------------
     options to employees,  officers or directors of the Company pursuant to any
     stock or option plan duly adopted by a majority of the non-employee members
     of the Board of  Directors of the Company or a majority of the members of a
     committee of  non-employee  directors  established  for such  purpose,  (b)
     securities upon the exercise or exchange of or conversion of any Securities
     issued  hereunder  and/or  securities  exercisable or  exchangeable  for or
     convertible  into shares of Common Stock issued and outstanding on the date
     of this  Agreement,  provided  that such  securities  have not been amended
     since the date of this Agreement to increase the number of such  securities
     or to  decrease  the  exercise,  exchange or  conversion  price of any such
     securities,  and (c) securities issued pursuant to acquisitions,  strategic
     transactions,   equipment   financings,   debt   financings  or  consulting
     relationships  approved  by a  majority  of  the  disinterested  directors,
     provided any such  issuance  shall not include a  transaction  in which the
     Company is issuing securities  primarily for the purpose of raising capital
     or to an entity whose primary business is investing in securities.

          "FW" means Feldman Weinstein LLP with offices located at 420 Lexington
           --
     Avenue, Suite 2620, New York, New York 10170-0002.


                                       2


          "GAAP" shall have the meaning ascribed to such term in Section 3.1(h).
           ----

          "Intellectual Property Rights" shall have the meaning ascribed to such
           ----------------------------
     term in Section 3.1(o).

          "Legend Removal Date" shall have the meaning  ascribed to such term in
           -------------------
     Section 4.1(c).

          "Liens" means a lien, charge, security interest, encumbrance, right of
           -----
     first refusal, preemptive right or other restriction.

          "Material Adverse Effect" shall have the meaning assigned to such term
           -----------------------
     in Section 3.1(b).

          "Material  Permits"  shall have the  meaning  ascribed to such term in
           -----------------
     Section 3.1(m).

          "Per Share  Purchase  Price"  equals the Closing Price on December 12,
           --------------------------
     2005,  subject to adjustment  for reverse and forward  stock splits,  stock
     dividends,  stock combinations and other similar transactions of the Common
     Stock that occur after the date of this Agreement.

          "Person"  means an  individual  or  corporation,  partnership,  trust,
           ------
     incorporated  or  unincorporated   association,   joint  venture,   limited
     liability  company,  joint  stock  company,  government  (or an  agency  or
     subdivision thereof) or other entity of any kind.

          "Proceeding" means an action, claim, suit, investigation or proceeding
           ----------
     (including,  without  limitation,  an investigation or partial  proceeding,
     such as a deposition), whether commenced or threatened.

          "Purchaser  Party"  shall have the  meaning  ascribed  to such term in
           ----------------
     Section 4.8.

          "Registration  Statement"  means  the  registration  statement  of the
           -----------------------
     Company, Commission File No. 333-120262 covering the sale to the Purchasers
     of the Shares, the Warrants and the Warrant Shares.

          "Required  Approvals"  shall have the meaning ascribed to such term in
           -------------------
     Section 3.1(e).

          "Rule 144" means Rule 144  promulgated by the  Commission  pursuant to
           --------
     the  Securities  Act, as such Rule may be amended from time to time, or any
     similar  rule or  regulation  hereafter  adopted by the  Commission  having
     substantially the same effect as such Rule.

          "SEC Reports" shall have the meaning  ascribed to such term in Section
           -----------
     3.1(h).

          "Securities" means the Shares, the Warrants and the Warrant Shares.
           ----------


                                       3



          "Securities Act" means the Securities Act of 1933, as amended.
           --------------

          "Shares"  means the shares of Common  Stock issued or issuable to each
           ------
     Purchaser pursuant to this Agreement.

          "Short  Sales" shall  include all "short sales" as defined in Rule 200
           ------------
     of  Regulation  SHO  under  the  Exchange  Act (but  shall not be deemed to
     include the location  and/or  reservation  of  borrowable  shares of Common
     Stock).

          "Subscription  Amount"  means,  as to each  Purchaser,  the  aggregate
           --------------------
     amount to be paid for Shares and Warrants purchased  hereunder as specified
     below such  Purchaser's  name on the signature  page of this  Agreement and
     next to the heading "Subscription  Amount", in United States Dollars and in
     immediately available funds.

          "Subsidiary"  means  any  subsidiary  of the  Company  as set forth on
           ----------
     Schedule 3.1(a).

          "Trading  Day"  means a day on which the  Common  Stock is traded on a
           ------------
     Trading Market.

          "Trading Market" means the following markets or exchanges on which the
           --------------
     Common Stock is listed or quoted for trading on the date in  question:  the
     Nasdaq  Capital  Market,  the American Stock  Exchange,  the New York Stock
     Exchange, the Nasdaq National Market or the OTC Bulletin Board.

          "Transaction  Documents" means this Agreement and the Warrants and any
           ----------------------
     other documents or agreements  executed in connection with the transactions
     contemplated hereunder.

          "Warrants" means collectively the Common Stock purchase  warrants,  in
           --------
     the form of  Exhibit  A  delivered  to the  Purchasers  at the  Closing  in
     accordance with Section 2.2(a) hereof,  which Warrants shall be exercisable
     only  after  six  months  after  the  date of  issuance  and have a term of
     exercise equal to 5 years.

          "Warrant  Shares"  means  the  shares of Common  Stock  issuable  upon
           ---------------
     exercise of the Warrants.

                                  ARTICLE II.
                                PURCHASE AND SALE

     2.1  Closing.  On the  Closing  Date,  upon the  terms and  subject  to the
          -------
conditions set forth herein,  concurrent with the execution and delivery of this
Agreement by the parties hereto,  the Company agrees to sell, and each Purchaser
agrees to purchase in the aggregate,  severally and not jointly, up to 3,729,556
Shares and Warrants to purchase up to 932,389  Shares.  The Purchaser  shall pay
$3.56 per unit,  and each unit shall  consist of one share of Common Stock and a
warrant to purchase .25 of a share of Common Stock; provided,  that, $3.52 shall
be allocated to the purchase price per share of Common Stock, and $0.04 shall be
allocated to the Warrant  portion (or it being  understood  that $0.125 shall be
allocated per whole Warrant Share).


                                       4



Each  Purchaser  shall  deliver to the Company via wire  transfer or a certified
check  immediately  available funds equal to their  Subscription  Amount and the
Company shall deliver to each Purchaser their respective  Shares and Warrants as
determined  pursuant to Section  2.2(a) and the other items set forth in Section
2.2 issuable at the Closing.  Upon  satisfaction  of the conditions set forth in
Sections  2.2 and 2.3,  the  Closing  shall  occur at the offices of FW, or such
other location as the parties shall mutually agree.

     2.2  Deliveries.
          ----------

          (a) On or prior to the  Closing  Date,  the Company  shall  deliver or
     cause to be delivered to each Purchaser the following:

               (i)   this Agreement duly executed by the Company;

               (ii)  a legal opinion of Company  Counsel, in the form of Exhibit
                                                                         -------
          B attached hereto;
          -

               (iii) the  receipt  by each  Purchaser  in its  account  with The
          Depository  Trust  Company via DWAC the number of Shares equal to such
          Purchaser's  Subscription  Amount  divided  by the Per Share  Purchase
          Price, registered in the name of such Purchaser;

               (iv)  an officer's certificate of the Company's  Chief  Executive
          Officer or Chief Financial Officer,  in form reasonably  acceptable to
          the  Purchasers,  certifying the continuing  material  accuracy of the
          Company's  representations  and warranties  made in this Agreement and
          the Company's performance in all material respects of the covenants to
          be performed by it pursuant to this  Agreement at or prior to Closing;
          and

               (v)   a  Warrant registered in the  name  of  such  Purchaser  to
          purchase up to a number of shares of Common Stock equal to 25% of such
          Purchaser's  Subscription Amount divided by the Closing Price, with an
          exercise price equal to $4.25 per Warrant Share, subject to adjustment
          therein.

          (b)  On or prior to the Closing Date, each Purchaser  shall deliver or
     cause to be delivered to the Company the following:

               (i)   this Agreement duly executed by such Purchaser; and

               (ii)  such  Purchaser's Subscription  Amount by wire  transfer to
          the account as specified in writing by the Company.

     2.3  Closing Conditions.
          ------------------

          (a)  The obligations of the Company  hereunder in connection  with the
     Closing are subject to the following conditions being met:


                                       5



               (i)   the accuracy in all material respects  when made and on the
          Closing Date of the  representations  and warranties of the Purchasers
          contained herein;

               (ii)  all obligations, covenants and agreements of the Purchasers
          required to be  performed  at or prior to the Closing  Date shall have
          been performed in all material respects; and

               (iii) the  delivery by the  Purchasers  of the items set forth in
          Section 2.2(b) of this Agreement.

          (b)  The  respective   obligations  of  the  Purchasers  hereunder  in
     connection with the Closing are subject to the following  conditions  being
     met:

               (i)   the  accuracy in all material  respects on the Closing Date
          of the representations and warranties of the Company contained herein;

               (ii)  all obligations,  covenants  and  agreements of the Company
          required to be  performed  at or prior to the Closing  Date shall have
          been performed in all material respects;

               (iii) the  delivery  by  the  Company  of the  items set forth in
          Section 2.2(a) of this Agreement;

               (iv)  there  shall  have been no  Material  Adverse  Effect  with
          respect to the Company since the date hereof; and

               (v)   from the date hereof to the  Closing  Date, trading  in the
          Common Stock shall not have been  suspended by the  Commission  or the
          Company's  principal  Trading  Market  (except for any  suspension  of
          trading of limited duration agreed to by the Company, which suspension
          shall be terminated  prior to the Closing),  and, at any time prior to
          the  Closing  Date,  trading in  securities  generally  as reported by
          Bloomberg  Financial Markets shall not have been suspended or limited,
          or minimum prices shall not have been  established on securities whose
          trades are reported by such  service,  or on any Trading  Market,  nor
          shall a banking  moratorium  have been  declared  either by the United
          States or New York State authorities nor shall there have occurred any
          material  outbreak or escalation of  hostilities  or other national or
          international  calamity  of such  magnitude  in its  effect on, or any
          material  adverse change in, any financial market which, in each case,
          in the reasonable  judgment of each Purchaser,  makes it impracticable
          or inadvisable to purchase the Shares at the Closing.


                                       6



                                  ARTICLE III.
                         REPRESENTATIONS AND WARRANTIES

     3.1  Representations and Warranties of the Company.  Except as set forth in
          ---------------------------------------------
the SEC Reports,  which SEC Reports  shall be deemed a part hereof,  the Company
hereby  makes  the  representations  and  warranties  set  forth  below  to each
Purchaser:

          (a)  Subsidiaries.  All of the direct and indirect subsidiaries of the
               ------------
     Company are set forth on Exhibit 23.1 to the  Company's  SEC  Reports.  The
     Company  owns,  directly or  indirectly,  all of the capital stock or other
     equity  interests of each Subsidiary  free and clear of any Liens,  and all
     the issued and  outstanding  shares of capital stock of each Subsidiary are
     validly  issued and are fully paid,  non-assessable  and free of preemptive
     and similar rights to subscribe for or purchase securities.  If the Company
     has no  subsidiaries,  then references in the Transaction  Documents to the
     Subsidiaries will be disregarded.

          (b)  Organization  and  Qualification.  The  Company  and  each of the
               --------------------------------
     Subsidiaries is an entity duly incorporated or otherwise organized, validly
     existing and in good  standing  under the laws of the  jurisdiction  of its
     incorporation or organization (as applicable), with the requisite power and
     authority  to own and use its  properties  and  assets  and to carry on its
     business as currently conducted.  Neither the Company nor any Subsidiary is
     in  violation  or  default  of  any  of the  provisions  of its  respective
     certificate or articles of incorporation, bylaws or other organizational or
     charter  documents.  Each  of the  Company  and  the  Subsidiaries  is duly
     qualified  to  conduct  business  and  is in  good  standing  as a  foreign
     corporation or other entity in each jurisdiction in which the nature of the
     business  conducted  or  property  owned  by it  makes  such  qualification
     necessary, except where the failure to be so qualified or in good standing,
     as the case may be, could not have or  reasonably  be expected to result in
     (i) a material adverse effect on the legality,  validity or  enforceability
     of any Transaction Document,  (ii) a material adverse effect on the results
     of operations,  assets, business, or financial condition of the Company and
     the  Subsidiaries,  taken as a whole, or (iii) a material adverse effect on
     the Company's  ability to perform in any material respect on a timely basis
     its obligations under any Transaction  Document (any of (i), (ii) or (iii),
     a "Material  Adverse  Effect") and no Proceeding has been instituted in any
        -------------------------
     such  jurisdiction  revoking,  limiting or curtailing or seeking to revoke,
     limit or curtail such power and authority or qualification.

          (c)  Authorization;   Enforcement.   The  Company  has  the  requisite
               ----------------------------
     corporate  power  and  authority  to  enter  into  and  to  consummate  the
     transactions   contemplated  by  each  of  the  Transaction  Documents  and
     otherwise  to carry  out its  obligations  hereunder  and  thereunder.  The
     execution and delivery of each of the Transaction  Documents by the Company
     and the  consummation by it of the transactions  contemplated  thereby have
     been duly authorized by all necessary action on the part of the Company and
     no further action is required by the Company, its board of directors or its
     stockholders  in connection  therewith  other than in  connection  with the
     Required  Approvals.  Each Transaction  Document has been (or upon delivery
     will have been)  duly  executed  by the  Company  and,  when  delivered  in
     accordance with the terms hereof and thereof, will constitute the valid and
     binding  obligation  of the  Company  enforceable  against  the  Company in


                                       7



     accordance  with its terms except (i) as limited by applicable  bankruptcy,
     insolvency,   reorganization,   moratorium   and  other   laws  of  general
     application  affecting  enforcement of creditors' rights generally and (ii)
     as limited by laws relating to the  availability  of specific  performance,
     injunctive relief or other equitable remedies.

          (d)  No Conflicts.  The  execution,  delivery and  performance  of the
               ------------
     Transaction  Documents by the Company,  the issuance and sale of the Shares
     and the consummation by the Company of the other transactions  contemplated
     hereby and  thereby do not and will not (i)  conflict  with or violate  any
     provision of the Company's or any  Subsidiary's  certificate or articles of
     incorporation, bylaws or other organizational or charter documents, or (ii)
     conflict  with,  or  constitute  a default (or an event that with notice or
     lapse of time or both would become a default) under, result in the creation
     of any Lien upon any of the  properties  or assets  of the  Company  or any
     Subsidiary,  or  give to  others  any  rights  of  termination,  amendment,
     acceleration  or  cancellation  (with or without  notice,  lapse of time or
     both)  of,  any  agreement,  credit  facility,  debt  or  other  instrument
     (evidencing   a  Company  or   Subsidiary   debt  or  otherwise)  or  other
     understanding to which the Company or any Subsidiary is a party or by which
     any  property  or  asset  of the  Company  or any  Subsidiary  is  bound or
     affected,  or (iii)  subject to the Required  Approvals,  conflict  with or
     result  in a  violation  of any law,  rule,  regulation,  order,  judgment,
     injunction,  decree  or other  restriction  of any  court  or  governmental
     authority  to which the  Company  or a  Subsidiary  is  subject  (including
     federal  and  state  securities  laws and  regulations),  or by  which  any
     property  or asset of the  Company or a  Subsidiary  is bound or  affected;
     except in the case of each of  clauses  (ii) and  (iii),  such as could not
     have or reasonably be expected to result in a Material Adverse Effect.

          (e)  Filings, Consents and  Approvals.  The Company is not required to
               --------------------------------
     obtain any consent, waiver,  authorization or order of, give any notice to,
     or make any filing or registration with, any court or other federal, state,
     local or other  governmental  authority or other Person in connection  with
     the execution,  delivery and  performance by the Company of the Transaction
     Documents,  other than (i) filings required pursuant to Section 4.4 of this
     Agreement and (ii) such filings as are required to be made under applicable
     state securities laws (collectively, the "Required Approvals").
                                               ------------------

          (f)  Issuance of the Securities; Registration. The Securities are duly
               ----------------------------------------
     authorized  and, when issued and paid for in accordance with the applicable
     Transaction  Documents,  will be duly and  validly  issued,  fully paid and
     nonassessable,  free and clear of all Liens  imposed by the  Company  other
     than  restrictions on transfer  provided for in the Transaction  Documents.
     The  Warrant  Shares,  when  issued  in  accordance  with the  terms of the
     Transaction   Documents,   will  be   validly   issued,   fully   paid  and
     nonassessable,  free and clear of all Liens  imposed  by the  Company.  The
     Company has reserved  from its duly  authorized  capital  stock the maximum
     number of shares of Common Stock  issuable  pursuant to this  Agreement and
     the  Warrants.  The  issuance  by the  Company of the  Securities  has been
     registered  under the  Securities  Act and all of the Securities are freely
     transferable and tradable by the Purchasers without restriction (other than
     any  restrictions  arising  solely from an act or omission of a Purchaser).
     The Securities are being issued pursuant to the Registration  Statement and
     the issuance of the Securities has been registered by the Company under the
     Securities Act. The  Registration  Statement is


                                       8



     effective and available for the issuance of the  Securities  thereunder and
     the Company has not received any notice that the  Commission  has issued or
     intends to issue a stop-order with respect to the Registration Statement or
     that the Commission  otherwise has suspended or withdrawn the effectiveness
     of the  Registration  Statement,  either  temporarily  or  permanently,  or
     intends or has  threatened in writing to do so. The "Plan of  Distribution"
     section under the Registration  Statement  permits the issuance and sale of
     the Securities  hereunder.  Upon receipt of the Securities,  the Purchasers
     will have good and marketable title to such Securities,  and so long as the
     Registration  Statement  remains  effective,  the Securities will be freely
     tradable on the Trading Market.

          (g)  Capitalization. The capitalization of the Company is as set forth
               --------------
     in the Company's SEC Reports.  The Company has not issued any capital stock
     since its most recently filed periodic report under the Exchange Act, other
     than pursuant to the exercise of employee stock options under the Company's
     stock  option  plans,  the  issuance of shares of Common Stock to employees
     pursuant to the Company's  employee stock purchase plan and pursuant to the
     conversion or exercise of outstanding Common Stock  Equivalents.  No Person
     has any right of first refusal,  preemptive right,  right of participation,
     or any similar right to participate in the transactions contemplated by the
     Transaction  Documents.  Except as a result of the purchase and sale of the
     Securities,  and  except  as set  forth in the SEC  Reports,  there  are no
     outstanding  options,  warrants,  script  rights to subscribe  to, calls or
     commitments of any character whatsoever relating to, or securities,  rights
     or obligations  convertible  into or exercisable  or  exchangeable  for, or
     giving any  Person any right to  subscribe  for or  acquire,  any shares of
     Common Stock, or contracts, commitments,  understandings or arrangements by
     which  the  Company  or any  Subsidiary  is or may  become  bound  to issue
     additional shares of Common Stock or Common Stock Equivalents. The issuance
     and sale of the Securities will not obligate the Company to issue shares of
     Common Stock or other  securities to any Person (other than the Purchasers)
     and will not  result in a right of any  holder  of  Company  securities  to
     adjust  the  exercise,  conversion,  exchange  or reset  price  under  such
     securities.  All of the outstanding  shares of capital stock of the Company
     are  validly  issued,  fully paid and  nonassessable,  have been  issued in
     compliance  with all federal and state  securities  laws,  and none of such
     outstanding  shares was issued in  violation  of any  preemptive  rights or
     similar rights to subscribe for or purchase securities. No further approval
     or authorization of any stockholder,  the Board of Directors of the Company
     or others is required for the issuance  and sale of the  Securities.  There
     are  no  stockholders  agreements,   voting  agreements  or  other  similar
     agreements with respect to the Company's capital stock to which the Company
     is a party or, to the knowledge of the Company, between or among any of the
     Company's stockholders.

          (h)  SEC  Reports; Financial  Statements.  The  Company  has filed all
               -----------------------------------
     reports,  schedules,  forms,  statements and other documents required to be
     filed  by it under  the  Securities  Act and the  Exchange  Act,  including
     pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the
     date hereof (or such  shorter  period as the Company was required by law to
     file such  material)  (the  foregoing  materials,  including  the  exhibits
     thereto and documents incorporated by reference therein, being collectively
     referred to herein as the "SEC  Reports") on a timely basis or has received
                                ------------
     a valid extension of such time of filing and has filed any such SEC Reports
     prior to the


                                       9



     expiration of any such extension.  As of their  respective  dates,  the SEC
     Reports  complied in all material  respects  with the  requirements  of the
     Securities  Act and the Exchange Act and the rules and  regulations  of the
     Commission promulgated thereunder, and none of the SEC Reports, when filed,
     contained  any untrue  statement  of a material  fact or omitted to state a
     material fact  required to be stated  therein or necessary in order to make
     the statements  therein, in the light of the circumstances under which they
     were made, not misleading. The financial statements of the Company included
     in  the  SEC  Reports  comply  in all  material  respects  with  applicable
     accounting  requirements  and the rules and  regulations  of the Commission
     with  respect  thereto as in effect at the time of filing.  Such  financial
     statements  have been prepared in accordance  with United States  generally
     accepted  accounting  principles  applied on a consistent  basis during the
     periods  involved  ("GAAP"),  except as may be otherwise  specified in such
                          ----
     financial  statements  or the  notes  thereto  and  except  that  unaudited
     financial  statements  may not contain all footnotes  required by GAAP, and
     fairly  present in all  material  respects  the  financial  position of the
     Company and its  consolidated  subsidiaries as of and for the dates thereof
     and the results of  operations  and cash flows for the periods  then ended,
     subject,  in the  case of  unaudited  statements,  to  normal,  immaterial,
     year-end audit adjustments.

          (i) Material Changes; Undisclosed Events, Liabilities or Developments.
              -----------------------------------------------------------------
     Since the date of the latest audited financial  statements  included within
     the SEC Reports,  except as specifically  disclosed in the SEC Reports, (i)
     there has been no event,  occurrence  or  development  that has had or that
     could reasonably be expected to result in a Material  Adverse Effect,  (ii)
     the Company has not  incurred any  liabilities  (contingent  or  otherwise)
     other than (A) trade payables and accrued expenses incurred in the ordinary
     course of business  consistent  with past practice and (B)  liabilities not
     required to be reflected in the Company's financial  statements pursuant to
     GAAP or required to be disclosed in filings made with the Commission, (iii)
     the Company has not altered its method of accounting,  (iv) the Company has
     not declared or made any dividend or distribution of cash or other property
     to its  stockholders  or  purchased,  redeemed  or made any  agreements  to
     purchase or redeem any shares of its capital  stock and (v) the Company has
     not issued any equity  securities  to any officer,  director or  Affiliate,
     except  pursuant to existing  Company  stock option  plans.  Except for the
     issuance of the Securities  contemplated  by this Agreement or as set forth
     in the  Company's  SEC  Reports,  no event,  liability or  development  has
     occurred or exists with respect to the Company or its Subsidiaries or their
     respective business,  properties,  operations or financial condition,  that
     would  be  required  to  be  disclosed  by  the  Company  under  applicable
     securities laws at the time this  representation  is made that has not been
     publicly disclosed 1 Trading Day prior to the date that this representation
     is made.

          (j) Litigation.   There  is  no  action,  suit,  inquiry,  notice   of
              ----------
     violation,  proceeding or investigation pending or, to the knowledge of the
     Company, threatened against or affecting the Company, any Subsidiary or any
     of  their  respective  properties  before  or  by  any  court,  arbitrator,
     governmental or  administrative  agency or regulatory  authority  (federal,
     state,  county,  local or foreign)  (collectively,  an "Action")  which (i)
                                                             ------
     adversely affects or challenges the legality, validity or enforceability of
     any of the Transaction  Documents or the Securities or (ii) could, if there
     were an unfavorable decision, have or reasonably be expected to result in a
     Material  Adverse Effect.  Neither the Company nor


                                       10



     any  Subsidiary,  nor any director or officer  thereof,  is or has been the
     subject of any Action  involving a claim of violation of or liability under
     federal or state  securities  laws or a claim of breach of fiduciary  duty.
     There has not  been,  and to the  knowledge  of the  Company,  there is not
     pending,  any investigation by the Commission  involving the Company or any
     current or former  director or officer of the Company.  The  Commission has
     not issued any stop order or other order  suspending the  effectiveness  of
     any registration statement filed by the Company or any Subsidiary under the
     Exchange  Act  or  the  Securities  Act.  None  of  the  Company's  or  its
     Subsidiaries'  employees  is a  member  of a  union  that  relates  to such
     employee's relationship with the Company, and neither the Company or any of
     its Subsidiaries is a party to a collective bargaining  agreement,  and the
     Company and its Subsidiaries  believe that their  relationships  with their
     employees are good. No executive officer,  to the knowledge of the Company,
     is, or is now  expected to be, in  violation  of any  material  term of any
     employment contract, confidentiality, disclosure or proprietary information
     agreement or non-competition  agreement, or any other contract or agreement
     or any  restrictive  covenant,  and the  continued  employment of each such
     executive  officer does not subject the Company or any of its  Subsidiaries
     to any liability with respect to any of the foregoing matters.  The Company
     and its Subsidiaries are in compliance with all U.S. federal,  state, local
     and foreign laws and  regulations  relating to  employment  and  employment
     practices,  terms and conditions of employment and wages and hours,  except
     where the failure to be in  compliance  could not,  individually  or in the
     aggregate, reasonably be expected to have a Material Adverse Effect.

          (k)  Labor  Relations.  No  material labor  dispute  exists or, to the
               ----------------
     knowledge of the Company,  is imminent with respect to any of the employees
     of the Company  which could  reasonably be expected to result in a Material
     Adverse Effect.

          (l)  Compliance.  Neither  the Company  nor any  Subsidiary  (i) is in
               ----------
     default  under or in violation  of (and no event has occurred  that has not
     been waived that,  with notice or lapse of time or both,  would result in a
     default by the Company or any Subsidiary under), nor has the Company or any
     Subsidiary  received  notice of a claim that it is in default under or that
     it is in violation of, any indenture, loan or credit agreement or any other
     agreement or instrument to which it is a party or by which it or any of its
     properties  is bound  (whether or not such  default or  violation  has been
     waived),  (ii) is in  violation  of any order of any court,  arbitrator  or
     governmental  body,  or (iii) is or has been in  violation  of any statute,
     rule  or  regulation  of  any  governmental  authority,  including  without
     limitation  all foreign,  federal,  state and local laws  applicable to its
     business and all such laws that affect the environment, except in each case
     as could not have a Material Adverse Effect.

          (m)  Regulatory Permits.  The Company and the Subsidiaries possess all
               ------------------
     certificates, authorizations and permits issued by the appropriate federal,
     state, local or foreign regulatory  authorities  necessary to conduct their
     respective  businesses  as described  in the SEC Reports,  except where the
     failure to possess such permits could not have or reasonably be expected to
     result in a Material Adverse Effect ("Material  Permits"),  and neither the
                                           -----------------
     Company nor any Subsidiary has received any notice of proceedings  relating
     to the revocation or modification of any Material Permit.


                                       11



          (n)  Title to Assets.  The Company and the Subsidiaries  have good and
               ---------------
     marketable  title in fee simple to all real property  owned by them that is
     material to the business of the Company and the  Subsidiaries  and good and
     marketable title in all personal property owned by them that is material to
     the  business of the Company  and the  Subsidiaries,  in each case free and
     clear of all Liens,  except for Liens as do not materially affect the value
     of such  property  and do not  materially  interfere  with the use made and
     proposed to be made of such  property  by the Company and the  Subsidiaries
     and Liens for the payment of federal,  state or other taxes, the payment of
     which is neither delinquent nor subject to penalties. Any real property and
     facilities held under lease by the Company and the Subsidiaries are held by
     them under valid,  subsisting and  enforceable  leases of which the Company
     and the Subsidiaries are in compliance.

          (o)  Patents and Trademarks. The Company and the Subsidiaries have, or
               ----------------------
     have rights to use, all issued patents, trademarks, trademark applications,
     service marks, trade names, trade secrets, inventions, copyrights, licenses
     and other similar  intellectual  property rights  necessary or material for
     use in connection with their respective  businesses as described in the SEC
     Reports  and which the  failure to so have  could  have a Material  Adverse
     Effect  (collectively,  the "Intellectual  Property  Rights").  Neither the
                                  ------------------------------
     Company nor any  Subsidiary  has received a notice  (written or  otherwise)
     that the Intellectual Property Rights used by the Company or any Subsidiary
     violates  or  infringes  upon the  rights of any  Person  that would have a
     Material  Adverse  Effect on the Company.  To the knowledge of the Company,
     all such  Intellectual  Property  Rights  are  enforceable  and there is no
     existing infringement by another Person of any of the Intellectual Property
     Rights of others that would have a Material  Adverse Effect on the Company.
     The Company and its Subsidiaries have taken reasonable security measures to
     protect the secrecy, confidentiality and value of all of their intellectual
     properties, except where failure to do so could not, individually or in the
     aggregate, reasonably be expected to have a Material Adverse Effect.

          (p)  Insurance.  The  Company  and the  Subsidiaries  are  insured  by
               ---------
     insurers of  recognized  financial  responsibility  against such losses and
     risks and in such amounts as are prudent and customary in the businesses in
     which the Company and the  Subsidiaries  are  engaged,  including,  but not
     limited to, directors and officers insurance coverage at least equal to the
     aggregate  Subscription Amount. To the best knowledge of the Company,  such
     insurance  contracts  and policies are accurate and  complete.  Neither the
     Company nor any  Subsidiary  has any reason to believe  that it will not be
     able to renew its  existing  insurance  coverage as and when such  coverage
     expires or to obtain  similar  coverage  from  similar  insurers  as may be
     necessary to continue its business without a significant increase in cost.

          (q)  Transactions  With Affiliates and  Employees. Except as set forth
               --------------------------------------------
     in  the SEC Reports, none of  the officers or directors of the Company and,
     to the  knowledge  of the Company, none of the employees  of the Company is
     presently a party to any  transaction  with the  Company or any  Subsidiary
     (other than for services as employees,  officers and directors),  including
     any contract,  agreement or other arrangement  providing for the furnishing
     of services to or by, providing for rental of real or personal  property to
     or from, or otherwise  requiring payments to or from any officer,  director
     or such


                                       12



     employee  or, to the  knowledge  of the  Company,  any  entity in which any
     officer, director, or any such employee has a substantial interest or is an
     officer,  director,  trustee or partner,  in each case in excess of $60,000
     other  than (i) for  payment  of salary  or  consulting  fees for  services
     rendered, (ii) reimbursement for expenses incurred on behalf of the Company
     and (iii) for other employee  benefits,  including stock option  agreements
     under any stock option plan of the Company.

          (r)  Sarbanes-Oxley;  Internal Accounting Controls.  The Company is in
               ---------------------------------------------
     material  compliance with all provisions of the  Sarbanes-Oxley Act of 2002
     which are  applicable  to it as of the  Closing  Date.  The Company and the
     Subsidiaries  maintain a system of internal  accounting controls sufficient
     to provide  reasonable  assurance  that (i)  transactions  are  executed in
     accordance  with  management's  general or  specific  authorizations,  (ii)
     transactions  are recorded as necessary to permit  preparation of financial
     statements in conformity  with GAAP and to maintain  asset  accountability,
     (iii) access to assets is permitted  only in accordance  with  management's
     general or specific authorization, and (iv) the recorded accountability for
     assets is compared  with the existing  assets at  reasonable  intervals and
     appropriate  action is taken with respect to any  differences.  The Company
     has established  disclosure controls and procedures (as defined in Exchange
     Act Rules  13a-15(e)  and  15d-15(e))  for the  Company and  designed  such
     disclosure  controls and  procedures  to ensure that  material  information
     relating to the Company,  including its Subsidiaries,  is made known to the
     certifying  officers by others within those entities,  particularly  during
     the period in which the Company's most recently filed periodic report under
     the  Exchange  Act, as the case may be, is being  prepared.  The  Company's
     certifying  officers  have  evaluated  the  effectiveness  of the Company's
     controls and procedures as of the date prior to the filing date of the most
     recently  filed  periodic  report under the  Exchange  Act (such date,  the
     "Evaluation  Date").  The  Company  presented  in its most  recently  filed
     periodic  report under the Exchange Act the  conclusions  of the certifying
     officers about the effectiveness of the disclosure  controls and procedures
     based on their  evaluations as of the Evaluation Date. Since the Evaluation
     Date,  there have been no  significant  changes in the  Company's  internal
     controls  (as such term is defined in Item 307(b) of  Regulation  S-K under
     the Exchange  Act) or, to the  knowledge of the Company,  in other  factors
     that  could   significantly   affect  the  Company's   internal   controls.
     Notwithstanding the foregoing,  each of the Purchasers acknowledge that he,
     she or it has read the  disclosure  pursuant to Item 307 of Regulation  S-K
     under the Exchange Act as set forth in the Company's  most recent  periodic
     report filed as of the Evaluation Date.

          (s)  Certain  Fees. Except for Rodman & Renshaw,  LLC, no brokerage or
               -------------
     finder's fees or  commissions  are or will be payable by the Company to any
     broker,   financial  advisor  or  consultant,   finder,   placement  agent,
     investment  banker,  bank or other Person with respect to the  transactions
     contemplated by the  Transaction  Documents.  The Purchasers  shall have no
     obligation  with  respect to any fees or with respect to any claims made by
     or on  behalf  of other  Persons  for fees of a type  contemplated  in this
     Section that may be due in connection with the transactions contemplated by
     the Transaction Documents.


                                       13



          (t)  Trading Market  Rules.  The issuance  and sale of the  Securities
               ---------------------
     hereunder  does not  contravene  the rules and  regulations  of the Trading
     Market.

          (u)  Investment Company.  The Company is  not, and is not an Affiliate
               ------------------
     of, and immediately  after receipt of payment for the Securities,  will not
     be or be an Affiliate of, an "investment company" within the meaning of the
     Investment  Company Act of 1940, as amended.  The Company shall conduct its
     business in a manner so that it will not become  subject to the  Investment
     Company Act.

          (v)  Registration  Rights. Other  than each  of  the  Purchasers,  and
               --------------------
     except as disclosed  in the SEC  Reports,  no Person has any right to cause
     the  Company to effect the  registration  under the  Securities  Act of any
     securities  of the  Company.  Notwithstanding  the  foregoing,  the parties
     hereto  acknowledge  that  the  Company  intends  to  file  a  registration
     statement covering the shares under its 2005 Employee Stock Purchase Plan.

          (w)  Listing and Maintenance Requirements.  The Company's Common Stock
               ------------------------------------
     is  registered  pursuant  to Section  12(g) of the  Exchange  Act,  and the
     Company  has taken no action  designed  to,  or which to its  knowledge  is
     likely to have the effect of,  terminating  the  registration of the Common
     Stock under the Exchange Act nor has the Company  received any notification
     that the Commission is  contemplating  terminating such  registration.  The
     Company  has not,  in the 12 months  preceding  the date  hereof,  received
     notice  from any  Trading  Market on which the Common  Stock is or has been
     listed or quoted to the effect that the Company is not in  compliance  with
     the listing or maintenance requirements of such Trading Market. The Company
     is, and has no reason to believe that it will not in the foreseeable future
     continue  to be,  in  compliance  with all  such  listing  and  maintenance
     requirements.

          (x)  Application of Takeover Protections. The Company and its Board of
               -----------------------------------
     Directors  have  taken all  necessary  action,  if any,  in order to render
     inapplicable any control share acquisition,  business  combination,  poison
     pill (including any distribution under a rights agreement) or other similar
     anti-takeover  provision under the Company's  Certificate of  Incorporation
     (or similar  charter  documents) or the laws of its state of  incorporation
     that is or could become  applicable  to the  Purchasers  as a result of the
     Purchasers and the Company fulfilling their obligations or exercising their
     rights under the Transaction  Documents,  including without limitation as a
     result of the  Company's  issuance of the  Securities  and the  Purchasers'
     ownership of the Securities.

          (y)  Disclosure.  The Company confirms that,  neither it nor any other
               ----------
     Person  acting on its behalf has  provided any of the  Purchasers  or their
     agents or counsel with any information that constitutes or might constitute
     material, non-public information. The Company understands and confirms that
     the Purchasers will rely on the foregoing  representations and covenants in
     effecting  transactions  in  securities  of  the  Company.  All  disclosure
     provided to the  Purchasers  regarding  the  Company,  its business and the
     transactions  contemplated hereby, furnished by or on behalf of the Company
     with respect to the representations and warranties made herein are true and
     correct  with respect to such  representations  and  warranties  and do not
     contain  any  untrue  statement  of a  material  fact or omit to state  any
     material fact  necessary in order to make the statements  made


                                       14



     therein,  in light of the  circumstances  under  which they were made,  not
     misleading.  The Company acknowledges and agrees that no Purchaser makes or
     has made any representations or warranties with respect to the transactions
     contemplated  hereby other than those specifically set forth in Section 3.2
     hereof.

          (z)  Solvency.  Based on the financial  condition of the Company as of
               --------
     the Closing Date after  giving  effect to the receipt by the Company of the
     proceeds from the sale of the Securities hereunder,  (i) the Company's fair
     saleable value of its assets exceeds the amount that will be required to be
     paid on or in respect of the Company's existing debts and other liabilities
     (including known contingent liabilities) as they mature; (ii) the Company's
     assets  do not  constitute  unreasonably  small  capital  to  carry  on its
     business for the current fiscal year as now conducted and as proposed to be
     conducted  including its capital  needs taking into account the  particular
     capital  requirements  of  the  business  conducted  by  the  Company,  and
     projected capital requirements and capital availability  thereof; and (iii)
     the  current  cash flow of the  Company,  together  with the  proceeds  the
     Company would receive, were it to liquidate all of its assets, after taking
     into account all anticipated  uses of the cash,  would be sufficient to pay
     all amounts on or in respect of its debt when such  amounts are required to
     be paid.  The Company  does not intend to incur debts beyond its ability to
     pay such debts as they mature  (taking  into account the timing and amounts
     of cash to be payable on or in respect  of its debt).  The  Company  has no
     knowledge  of any facts or  circumstances  which lead it to believe that it
     will  file for  reorganization  or  liquidation  under  the  bankruptcy  or
     reorganization  laws of any  jurisdiction  within one year from the Closing
     Date.  The SEC  Reports set forth as of the dates  thereof all  outstanding
     secured and unsecured Indebtedness of the Company or any Subsidiary, or for
     which the Company or any  Subsidiary has  commitments.  For the purposes of
     this Agreement,  "Indebtedness" shall mean (a) any liabilities for borrowed
                       ------------
     money or amounts  owed in excess of  $50,000  (other  than  trade  accounts
     payable  incurred in the ordinary course of business),  (b) all guaranties,
     endorsements and other contingent obligations in respect of Indebtedness of
     others, whether or not the same are or should be reflected in the Company's
     balance sheet (or the notes thereto),  except  guaranties by endorsement of
     negotiable instruments for deposit or collection or similar transactions in
     the  ordinary  course of business;  and (c) the present  value of any lease
     payments in excess of $50,000 due under leases  required to be  capitalized
     in  accordance  with GAAP.  Neither the Company  nor any  Subsidiary  is in
     default with respect to any Indebtedness.

          (aa) Tax Status. Except for matters that would not, individually or in
               ----------
     the  aggregate,  have or  reasonably  be  expected  to result in a Material
     Adverse  Effect,  the Company and each  Subsidiary  has filed all necessary
     federal, state and foreign income and franchise tax returns and has paid or
     accrued all taxes shown as due thereon, and the Company has no knowledge of
     a tax deficiency which has been asserted or threatened  against the Company
     or any Subsidiary.

          (bb) Foreign  Corrupt  Practices.  Neither  the  Company,  nor to the
               ---------------------------
     knowledge of the Company, any agent or other person acting on behalf of the
     Company,  has (i)  directly  or  indirectly,  used any funds  for  unlawful
     contributions,  gifts,  entertainment or other unlawful expenses related to
     foreign or domestic political  activity,  (ii) made any unlawful payment to
     foreign or domestic government  officials or employees or to any foreign or


                                       15



     domestic  political parties or campaigns from corporate funds, (iii) failed
     to  disclose  fully any  contribution  made by the  Company (or made by any
     person  acting on its  behalf of which the  Company  is aware)  which is in
     violation of law, or (iv) violated in any material respect any provision of
     the Foreign Corrupt Practices Act of 1977, as amended.

          (cc) Accountants.  The Company's current  accountants are set forth in
               -----------
     the SEC Reports. To the knowledge of the Company, such accountants, who the
     Company  expects will express  their  opinion with respect to the financial
     statements to be included in the  Company's  Annual Report on Form 10-K for
     the year ending December 31, 2005, are a registered  public accounting firm
     as required by the Securities Act.

          (dd) Acknowledgment Regarding Purchasers' Purchase of Securities.  The
               -----------------------------------------------------------
     Company  acknowledges  and  agrees  that each of the  Purchasers  is acting
     solely in the  capacity of an arm's  length  purchaser  with respect to the
     Transaction Documents and the transactions contemplated hereby. The Company
     further  acknowledges that no Purchaser is acting as a financial advisor or
     fiduciary of the Company (or in any similar  capacity) with respect to this
     Agreement and the transactions  contemplated hereby and any advice given by
     any  Purchaser  or any of their  respective  representatives  or  agents in
     connection with this Agreement and the transactions  contemplated hereby is
     merely  incidental  to the  Purchasers'  purchase  of the  Securities.  The
     Company further represents to each Purchaser that the Company's decision to
     enter  into  this  Agreement  has  been  based  solely  on the  independent
     evaluation of the transactions  contemplated  hereby by the Company and its
     representatives.

          (ee) Acknowledgement Regarding Purchasers' Trading Activity.  Anything
               ------------------------------------------------------
     in this  Agreement  or  elsewhere  herein to the  contrary  notwithstanding
     (except  for  Section  4.15  hereof),  it is  understood  and agreed by the
     Company (i) that none of the Purchasers  have been asked to agree,  nor has
     any Purchaser  agreed,  to desist from  purchasing or selling,  long and/or
     short,  securities  of the Company,  or  "derivative"  securities  based on
     securities  issued  by the  Company  or to  hold  the  Securities  for  any
     specified term; (ii) that past or future open market or other  transactions
     by any  Purchaser,  including  Short  Sales,  and  specifically  including,
     without  limitation,  Short Sales or "derivative"  transactions,  before or
     after the closing of this or future  private  placement  transactions,  may
     negatively  impact  the  market  price  of  the  Company's  publicly-traded
     securities;  (iii) that any Purchaser,  and counter parties in "derivative"
     transactions  to  which  any  such  Purchaser  is  a  party,   directly  or
     indirectly,  presently may have a "short" position in the Common Stock, and
     (iv) that each Purchaser shall not be deemed to have any  affiliation  with
     or  control  over  any  arm's  length  counter-party  in  any  "derivative"
     transaction.  The Company further understands and acknowledges that (a) one
     or more Purchasers may engage in hedging activities at various times during
     the  period  that the  Securities  are  outstanding  and (b)  such  hedging
     activities  (if any) could reduce the value of the  existing  stockholders'
     equity  interests  in the  Company  at and after the time that the  hedging
     activities  are  being  conducted.   The  Company  acknowledges  that  such
     aforementioned  hedging activities do not constitute a breach of any of the
     Transaction Documents.

          (ff) Manipulation of Price. The  Company has not, and to its knowledge
               ---------------------
     no one acting on its behalf has,  (i) taken,  directly or  indirectly,  any
     action designed to cause


                                       16



     or to  result  in the  stabilization  or  manipulation  of the price of any
     security  of the  Company  to  facilitate  the sale or resale of any of the
     Securities,  (ii) sold, bid for,  purchased,  or, paid any compensation for
     soliciting  purchases  of,  any of  the  Securities  (other  than  for  the
     placement agent's placement of the Securities),  or (iii) paid or agreed to
     pay to any person any compensation  for soliciting  another to purchase any
     other securities of the Company.

          (gg) Approvals.  Other  than the filing  with,  and  approval  by, the
               ---------
     Nasdaq National Market of the Notice of Listing of Additional  Shares,  the
     issuance  and  listing  on the  Nasdaq  National  Market of the  Shares and
     Warrant Shares requires no further approvals, including but not limited to,
     the approval of shareholders.

          (hh) Effective Registration Statement.  The Registration Statement has
               --------------------------------
     been  declared  effective  by the  Commission  and the Company  knows of no
     reason why the Registration Statement will not continue to remain effective
     for the foreseeable future.

     3.2  Representations  and  Warranties  of the  Purchasers.  Each  Purchaser
          ----------------------------------------------------
hereby, for itself and for no other Purchaser, represents and warrants as of the
date hereof and as of the Closing Date to the Company as follows:

          (a)  Organization;   Authority.  Such  Purchaser  is  an  entity  duly
               -------------------------
     organized,  validly  existing  and in good  standing  under the laws of the
     jurisdiction of its organization with full right,  corporate or partnership
     power  and  authority  to enter  into and to  consummate  the  transactions
     contemplated  by the  Transaction  Documents and otherwise to carry out its
     obligations   hereunder  and  thereunder.   The  execution,   delivery  and
     performance  by such  Purchaser of the  transactions  contemplated  by this
     Agreement have been duly  authorized by all necessary  corporate or similar
     action on the part of such Purchaser. Each Transaction Document to which it
     is a party has been duly executed by such Purchaser,  and when delivered by
     such  Purchaser in accordance  with the terms hereof,  will  constitute the
     valid and legally binding obligation of such Purchaser, enforceable against
     it in accordance with its terms, except (i) as limited by general equitable
     principles   and   applicable   bankruptcy,   insolvency,   reorganization,
     moratorium and other laws of general application  affecting  enforcement of
     creditors'  rights  generally,  (ii) as  limited  by laws  relating  to the
     availability of specific performance,  injunctive relief or other equitable
     remedies and (iii) insofar as indemnification  and contribution  provisions
     may be limited by applicable law.

          (b)  Understandings  or  Agreements.  Such Purchaser is purchasing the
               ------------------------------
     Securities  for its own account and not with a view  towards  distribution,
     and does not have any agreement or  understanding,  directly or indirectly,
     with any Person to distribute any of the Securities.

          (c)  Broker-Dealer  Status.  Such  Purchaser  is  not  required  to be
               ---------------------
     registered as a broker-dealer under Section 15 of the Exchange Act.

          (d)  Experience of Such  Purchaser.  Such  Purchaser,  either alone or
               -----------------------------
     together with its representatives,  has such knowledge,  sophistication and
     experience  in  business


                                       17



     and  financial  matters so as to be capable  of  evaluating  the merits and
     risks of the prospective investment in the Securities, and has so evaluated
     the merits and risks of such investment. Such Purchaser is able to bear the
     economic risk of an investment in the Securities  and, at the present time,
     is able to afford a complete loss of such investment.  Such Purchaser is an
     accredited investor as defined under the Securities Act. Such Purchaser has
     reviewed all of the SEC Reports.

          (e)  Short Sales and Confidentiality  Prior To The Date Hereof.  Other
               ---------------------------------------------------------
     than  the  transaction  contemplated  hereunder,  such  Purchaser  has  not
     directly or indirectly,  nor has any Person acting on behalf of or pursuant
     to  any  understanding  with  such  Purchaser,  executed  any  disposition,
     including  Short Sales,  in the securities of the Company during the period
     commencing  from the time that such  Purchaser  first received a term sheet
     from the Company or any other Person  setting  forth the material  terms of
     the transactions  contemplated hereunder until the date hereof ("Discussion
                                                                      ----------
     Time"). Notwithstanding the foregoing, in the case of a Purchaser that is a
     ----
     multi-managed investment vehicle whereby separate portfolio managers manage
     separate  portions of such  Purchaser's  assets and the portfolio  managers
     have no direct knowledge of the investment  decisions made by the portfolio
     managers   managing  other  portions  of  such  Purchaser's   assets,   the
     representation set forth above shall only apply with respect to the portion
     of  assets  managed  by the  portfolio  manager  that  made the  investment
     decision to purchase the Securities  covered by this Agreement.  Other than
     to other Persons party to this Agreement, such Purchaser has maintained the
     confidentiality  of all  disclosures  made to it in  connection  with  this
     transaction (including the existence and terms of this transaction).

     The Company  acknowledges  and agrees that each  Purchaser does not make or
has not made any  representations or warranties with respect to the transactions
contemplated hereby other than those specifically set forth in this Section 3.2.

                                  ARTICLE IV.
                         OTHER AGREEMENTS OF THE PARTIES

     4.1  Transfer Restrictions.
          ---------------------

          (a)  Certificates  evidencing  the Shares and  Warrants,  and  Warrant
     Shares  during any periods that the  Registration  Statement is  effective,
     shall not  contain  any legend  restricting  their  transferability  by the
     Purchasers.  During any  periods  that the  Registration  Statement  is not
     effective,  the Company shall use its  commercially  reasonable  efforts to
     promptly cause such  Registration  Statement to be effective or best effort
     to promptly file a new  registration  statement for the sale of the Warrant
     Shares to the  Purchasers.  The Company  shall cause its counsel to issue a
     legal opinion to the Company's  transfer agent if required by the Company's
     transfer agent to effect a transfer of any of the Securities.

          (b)  Until the 6 month anniversary of the Effective  Date, the Company
     shall not undertake a reverse or forward stock split or reclassification of
     the Common  Stock  without  the prior  written  consent  of the  Purchasers
     holding a majority in interest of the Shares.


                                       18



     4.2  Furnishing of Information.  As long as any Purchaser owns  Securities,
          -------------------------
the Company  covenants to timely file (or obtain  extensions in respect  thereof
and file within the applicable grace period) all reports required to be filed by
the Company  after the date hereof  pursuant to the Exchange Act. As long as any
Purchaser  owns  Securities,  if the  Company is not  required  to file  reports
pursuant to the Exchange Act, it will prepare and furnish to the  Purchasers and
make publicly  available in accordance  with Rule 144(c) such  information as is
required for the Purchasers to sell the  Securities  under Rule 144. The Company
further  covenants  that it will  take  such  further  action  as any  holder of
Securities may reasonably request,  all to the extent required from time to time
to enable such Person to sell such  Securities  without  registration  under the
Securities Act within the limitation of the exemptions provided by Rule 144.

     4.3  Integration.  The  Company  shall not sell,  offer for sale or solicit
          -----------
offers to buy or  otherwise  negotiate in respect of any security (as defined in
Section 2 of the Securities Act) that would be integrated with the offer or sale
of the  Securities  for  purposes  of the rules and  regulations  of any Trading
Market such that it would require  shareholder  approval prior to the closing of
such other  transaction  unless  shareholder  approval  is  obtained  before the
closing of such subsequent transaction.

     4.4  Securities Laws Disclosure; Publicity. The Company shall, by 8:30 a.m.
          -------------------------------------
Eastern time on the Trading Day immediately  following the date hereof,  issue a
Current Report on Form 8-K, reasonably  acceptable to each Purchaser  disclosing
the material terms of the transactions contemplated hereby, and shall attach the
Transaction Documents thereto. The Company and each Purchaser shall consult with
each other in issuing any other press releases with respect to the  transactions
contemplated  hereby,  and neither the Company nor any Purchaser shall issue any
such press release or otherwise make any such public statement without the prior
consent of the Company,  with respect to any press release of any Purchaser,  or
without the prior consent of each  Purchaser,  with respect to any press release
of the Company, which consent shall not unreasonably be withheld, except if such
disclosure is required by law, in which case the disclosing party shall promptly
provide  the  other  party  with  prior  notice  of  such  public  statement  or
communication.  Notwithstanding  the  foregoing,  the Company shall not publicly
disclose the name of any Purchaser,  or include the name of any Purchaser in any
filing with the Commission or any regulatory  agency or Trading Market,  without
the prior written consent of such  Purchaser,  except (i) as required by federal
securities  law and (ii) to the extent  such  disclosure  is  required by law or
Trading  Market  regulations,  in  which  case the  Company  shall  provide  the
Purchasers with prior notice of such disclosure permitted under subclause (i) or
(ii).

     4.5  Shareholder  Rights  Plan.  No claim will be made or  enforced  by the
          -------------------------
Company or, to the knowledge of the Company, any other Person that any Purchaser
is an "Acquiring  Person" under any  shareholder  rights plan or similar plan or
arrangement in effect or hereafter adopted by the Company, or that any Purchaser
could be deemed to trigger the  provisions of any such plan or  arrangement,  by
virtue of  receiving  Securities  under the  Transaction  Documents or under any
other  agreement  between  the  Company and the  Purchasers.  The Company  shall
conduct  its  business  in a manner so that it will not  become  subject  to the
Investment Company Act.

     4.6  Non-Public Information.  The Company covenants and agrees that neither
          ----------------------
it nor any other Person  acting on its behalf will provide any  Purchaser or its
agents or counsel with any


                                       19



information  that  the  Company   believes   constitutes   material   non-public
information,  unless prior thereto such Purchaser  shall have executed a written
agreement regarding the confidentiality and use of such information. The Company
understands  and confirms that each Purchaser  shall be relying on the foregoing
representations in effecting transactions in securities of the Company.

     4.7  Use of Proceeds.  The Company shall use the net proceeds from the sale
          ---------------
of the  Securities  hereunder  for research and  development  and other  working
capital  purposes and not for the  satisfaction  of any portion of the Company's
debt  (other  than  payment  of trade  payables  in the  ordinary  course of the
Company's  business and prior  practices),  to redeem any Common Stock or Common
Stock Equivalents or to settle any outstanding litigation.

     4.8  Indemnification  of  Purchasers.  Subject  to the  provisions  of this
          -------------------------------
Section  4.8,  the  Company  will  indemnify  and hold  each  Purchaser  and its
directors, officers, shareholders,  members, partners, employees and agents (and
any other Persons with a functionally  equivalent  role of a Person holding such
titles notwithstanding a lack of such title or any other title), each Person who
controls such Purchaser  (within the meaning of Section 15 of the Securities Act
and  Section 20 of the  Exchange  Act),  and the  directors,  officers,  agents,
members,  partners  or  employees  (and any other  Persons  with a  functionally
equivalent role of a Person holding such titles  notwithstanding  a lack of such
title or any other  title)  of such  controlling  persons  (each,  a  "Purchaser
                                                                       ---------
Party")  harmless  from any and all losses,  liabilities,  obligations,  claims,
- -----
contingencies,  damages,  costs and expenses,  including all judgments,  amounts
paid in  settlements,  court costs and reasonable  attorneys'  fees and costs of
investigation  that any such Purchaser  Party may suffer or incur as a result of
or  relating  to (a)  any  breach  of any  of the  representations,  warranties,
covenants or  agreements  made by the Company in this  Agreement or in the other
Transaction  Documents or (b) any action instituted against a Purchaser,  or any
of them or their respective Affiliates, by any stockholder of the Company who is
not an Affiliate  of such  Purchaser,  with  respect to any of the  transactions
contemplated  by the Transaction  Documents  (unless such action is based upon a
breach of such  Purchaser's  representations,  warranties or covenants under the
Transaction  Documents or any  agreements or  understandings  such Purchaser may
have with any such  stockholder  or any  violations by the Purchaser of state or
federal  securities  laws or any  conduct by such  Purchaser  which  constitutes
fraud, gross negligence, willful misconduct or malfeasance). If any action shall
be brought  against any  Purchaser  Party in respect of which  indemnity  may be
sought  pursuant to this  Agreement,  such Purchaser Party shall promptly notify
the  Company  in  writing,  and the  Company  shall have the right to assume the
defense thereof with counsel of its own choosing. Any Purchaser Party shall have
the right to employ  separate  counsel in any such action and participate in the
defense  thereof,  but the fees and  expenses  of such  counsel  shall be at the
expense of such  Purchaser  Party  except to the extent that (i) the  employment
thereof has been  specifically  authorized  by the Company in writing,  (ii) the
Company has failed after a reasonable  period of time to assume such defense and
to employ counsel or (iii) in such action there is, in the reasonable opinion of
such separate  counsel,  a material  conflict on any material  issue between the
position of the Company and the position of such  Purchaser  Party.  The Company
will not be liable to any  Purchaser  Party  under  this  Agreement  (i) for any
settlement by a Purchaser  Party  effected  without the Company's  prior written
consent,  which shall not be  unreasonably  withheld or delayed;  or (ii) to the
extent,  but only to the  extent  that a loss,  claim,  damage or  liability  is
attributable  to any  Purchaser  Party's  breach of any of the  representations,
warranties,  covenants or agreements made by the Purchasers in this Agreement or
in the other Transaction Documents.


                                       20



     4.9  Reservation  of Common Stock.  As of the date hereof,  the Company has
          ----------------------------
reserved  and the Company  shall  continue to reserve and keep  available at all
times, free of preemptive  rights, a sufficient number of shares of Common Stock
for the  purpose of  enabling  the  Company  to issue  Shares  pursuant  to this
Agreement and Warrant Shares pursuant to any exercise of the Warrants.

     4.10 Listing  of  Common  Stock.  The  Company  hereby  agrees  to use  its
          --------------------------
commercially reasonable efforts to maintain the listing of the Common Stock on a
Trading Market.  The Company further agrees,  if the Company applies to have the
Common  Stock  traded on any  other  Trading  Market,  it will  include  in such
application  all of the  Shares  and  Warrant  Shares,  and will take such other
action as is  necessary  to cause all of the  Shares  and  Warrant  Shares to be
listed on such other  Trading  Market as promptly as possible.  The Company will
take all action reasonably  necessary to continue the listing and trading of its
Common  Stock on a  Trading  Market  and will  comply in all  respects  with the
Company's  reporting,  filing and other obligations under the bylaws or rules of
the Trading Market.

     4.11 Equal Treatment of Purchasers.  No  consideration  shall be offered or
          -----------------------------
paid to any  person  to amend or  consent  to a waiver  or  modification  of any
provision of any of the Transaction  Documents unless the same  consideration is
also  offered  to  all  of  the  parties  to  the  Transaction  Documents.   For
clarification  purposes,  this provision constitutes a separate right granted to
each Purchaser by the Company and negotiated  separately by each Purchaser,  and
is intended to treat for the Company the  Purchasers as a class and shall not in
any way be  construed  as the  Purchasers  acting in  concert or as a group with
respect to the purchase, disposition or voting of Securities or otherwise.

     4.12 Subsequent Equity Sales.
          -----------------------

          (a)  From the date hereof until 30 days after the date hereof, neither
     the Company nor any Subsidiary shall issue shares of Common Stock or Common
     Stock Equivalents.

          (b)  Notwithstanding the foregoing,  this Section 4.12 shall not apply
     in respect of an Exempt Issuance.

     4.13 Short Sales and Confidentiality  After The Date Hereof. Each Purchaser
          ------------------------------------------------------
severally and not jointly with the other  Purchasers  covenants  that neither it
nor any affiliates acting on its behalf or pursuant to any understanding with it
will  execute any Short Sales during the period  after the  Discussion  Time and
ending at the time that the  transactions  contemplated  by this  Agreement  are
first publicly announced as described in Section 4.4. Each Purchaser,  severally
and not jointly with the other Purchasers, covenants that until such time as the
transactions  contemplated  by this  Agreement  are  publicly  disclosed  by the
Company  as  described  in  Section  4.4,  such  Purchaser  will  maintain,  the
confidentiality   of  all  disclosures  made  to  it  in  connection  with  this
transaction   (including   the  existence   and  terms  of  this   transaction).
Notwithstanding the foregoing,  no Purchaser makes any representation,  warranty
or covenant  hereby that it will not engage in Short Sales in the  securities of
the Company after the time that the transactions  contemplated by this Agreement
are first publicly  announced as described in Section 4.4.  Notwithstanding  the
foregoing, in the case of a Purchaser that is a multi-managed investment


                                       21



vehicle whereby  separate  portfolio  managers manage separate  portions of such
Purchaser's  assets and the portfolio  managers have no direct  knowledge of the
investment  decisions made by the portfolio  managers managing other portions of
such  Purchaser's  assets,  the  covenant  set forth above shall only apply with
respect to the portion of assets managed by the portfolio  manager that made the
investment decision to purchase the Securities covered by this Agreement.

                                   ARTICLE V.
                                  MISCELLANEOUS

     5.1  Termination. This Agreement may be terminated by any Purchaser,  as to
          -----------
such Purchaser's obligations hereunder only and without any effect whatsoever on
the obligations between the Company and the other Purchasers,  by written notice
to the other  parties,  if the  Closing  has not been  consummated  on or before
December 31, 2005; provided,  however,  that no such termination will affect the
                   --------   -------
right of any party to sue for any breach by the other party (or parties).

     5.2  Fees and Expenses.  The Company shall deliver, prior to the Closing, a
          -----------------
completed and executed copy of the Closing  Statement,  attached hereto as Annex
                                                                           -----
A. Except as expressly set forth in the  Transaction  Documents to the contrary,
- -
each party shall pay the fees and expenses of its advisers, counsel, accountants
and  other  experts,  if any,  and all other  expenses  incurred  by such  party
incident to the negotiation, preparation, execution, delivery and performance of
this Agreement.  The Company shall pay all transfer agent fees,  stamp taxes and
other taxes and duties levied in connection with the delivery of any Securities.

     5.3  Entire  Agreement.  The Transaction  Documents,   together  with   the
          -----------------
exhibits and schedules thereto,  contain the entire understanding of the parties
with respect to the subject matter hereof and supersede all prior agreements and
understandings, oral or written, with respect to such matters, which the parties
acknowledge have been merged into such documents, exhibits and schedules.

     5.4  Notices.  Any and all notices or other  communications  or  deliveries
          -------
required or permitted to be provided  hereunder shall be in writing and shall be
deemed given and effective on the earliest of (a) the date of  transmission,  if
such notice or  communication is delivered via facsimile at the facsimile number
set forth on the signature  pages  attached  hereto prior to 5:30 p.m. (New York
City  time)  on a  Trading  Day,  (b) the next  Trading  Day  after  the date of
transmission,  if such notice or communication is delivered via facsimile at the
facsimile  number set forth on the signature pages attached hereto on a day that
is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading
Day,  (c) the 2nd Trading  Day  following  the date of mailing,  if sent by U.S.
nationally  recognized  overnight courier service, or (d) upon actual receipt by
the party to whom such  notice is  required  to be given.  The  address for such
notices and communications shall be as set forth on the signature pages attached
hereto.

     5.5  Amendments;  Waivers.  No provision of this Agreement may be waived or
          --------------------
amended except in a written instrument  signed, in the case of an amendment,  by
the Company and each Purchaser or, in the case of a waiver, by the party against
whom  enforcement  of any such waiver is sought.  No waiver of any default  with
respect to any provision,  condition or  requirement of this Agreement  shall be
deemed to be a continuing waiver in the future or a


                                       22



waiver of any subsequent  default or a waiver of any other provision,  condition
or  requirement  hereof,  nor  shall any delay or  omission  of either  party to
exercise  any right  hereunder  in any manner  impair the  exercise  of any such
right.

     5.6  Headings.  The  headings  herein  are  for  convenience  only,  do not
          --------
constitute a part of this  Agreement  and shall not be deemed to limit or affect
any of the provisions hereof. The language used in this Agreement will be deemed
to be the language chosen by the parties to express their mutual intent,  and no
rules of strict construction will be applied against any party.

     5.7  Successors and Assigns. This Agreement shall be binding upon and inure
          ----------------------
to the benefit of the parties and their  successors and permitted  assigns.  The
Company may not assign this  Agreement  or any rights or  obligations  hereunder
without the prior written  consent of each  Purchaser.  Any Purchaser may assign
any or all of its  rights  under  this  Agreement  to any  Person  to whom  such
Purchaser  assigns or transfers any Securities,  provided such transferee agrees
in  writing to be bound,  with  respect to the  transferred  Securities,  by the
provisions hereof that apply to the "Purchasers".

     5.8  No Third-Party  Beneficiaries.  This  Agreement  is  intended  for the
          -----------------------------
benefit of the parties  hereto and their  respective  successors  and  permitted
assigns and is not for the benefit of, nor may any provision  hereof be enforced
by, any other Person, except as otherwise set forth in Section 4.8.

     5.9  Governing Law. All questions  concerning the  construction,  validity,
          -------------
enforcement and interpretation of the Transaction Documents shall be governed by
and construed and enforced in accordance  with the internal laws of the State of
New York,  without  regard to the  principles of conflicts of law thereof.  Each
party  agrees  that  all  legal  proceedings   concerning  the  interpretations,
enforcement and defense of the  transactions  contemplated by this Agreement and
any other Transaction  Documents  (whether brought against a party hereto or its
respective affiliates,  directors, officers, shareholders,  employees or agents)
shall be commenced  exclusively  in the state and federal  courts sitting in the
City of New  York.  Each  party  hereby  irrevocably  submits  to the  exclusive
jurisdiction  of the state and federal  courts  sitting in the City of New York,
borough  of  Manhattan  for the  adjudication  of any  dispute  hereunder  or in
connection  herewith or with any  transaction  contemplated  hereby or discussed
herein  (including  with respect to the  enforcement  of any of the  Transaction
Documents), and hereby irrevocably waives, and agrees not to assert in any suit,
action  or  proceeding,  any  claim  that it is not  personally  subject  to the
jurisdiction of any such court, that such suit, action or proceeding is improper
or inconvenient venue for such proceeding.  Each party hereby irrevocably waives
personal  service of process and  consents to process  being  served in any such
suit, action or proceeding by mailing a copy thereof via registered or certified
mail or  overnight  delivery  (with  evidence of  delivery) to such party at the
address in effect for  notices to it under this  Agreement  and agrees that such
service  shall  constitute  good and  sufficient  service of process  and notice
thereof.  Nothing contained herein shall be deemed to limit in any way any right
to serve  process in any manner  permitted by law. The parties  hereby waive all
rights  to a trial  by jury.  If  either  party  shall  commence  an  action  or
proceeding to enforce any  provisions  of the  Transaction  Documents,  then the
prevailing  party in such action or proceeding  shall be reimbursed by the other
party for its  attorneys'  fees and other costs and expenses  incurred  with the
investigation, preparation and prosecution of such action or proceeding.


                                       23



     5.10 Survival.  The representations  and warranties  contained herein shall
          --------
survive for 36 months  following  the Closing and the delivery of the Shares and
Warrant Shares.

     5.11 Execution. This Agreement may be executed in two or more counterparts,
          ---------
all of which when taken  together shall be considered one and the same agreement
and shall become effective when  counterparts have been signed by each party and
delivered to the other  party,  it being  understood  that both parties need not
sign the same  counterpart.  In the event that any  signature  is  delivered  by
facsimile  transmission,  such  signature  shall  create  a  valid  and  binding
obligation  of the  party  executing  (or on  whose  behalf  such  signature  is
executed)  with the same force and effect as if such  facsimile  signature  page
were an original thereof.

     5.12 Severability. If any provision of this Agreement is held to be invalid
          ------------
or  unenforceable  in  any  respect,  the  validity  and  enforceability  of the
remaining  terms  and  provisions  of  this  Agreement  shall  not in any way be
affected or impaired  thereby and the parties will attempt to agree upon a valid
and enforceable provision that is a reasonable substitute therefor,  and upon so
agreeing, shall incorporate such substitute provision in this Agreement.

     5.13 Rescission  and  Withdrawal  Right.  Notwithstanding  anything  to the
          ----------------------------------
contrary  contained in (and  without  limiting  any similar  provisions  of) the
Transaction  Documents,  whenever  any  Purchaser  exercises a right,  election,
demand or option  under a  Transaction  Document and the Company does not timely
perform its related  obligations within the periods therein provided,  then such
Purchaser may rescind or withdraw, in its sole discretion from time to time upon
written notice to the Company, any relevant notice,  demand or election in whole
or in part without prejudice to its future actions and rights.

     5.14 Replacement of Securities. If any certificate or instrument evidencing
          -------------------------
any Securities is mutilated,  lost, stolen or destroyed, the Company shall issue
or cause to be issued in exchange  and  substitution  for and upon  cancellation
thereof,  or  in  lieu  of  and  substitution  therefor,  a new  certificate  or
instrument,  but only upon receipt of evidence  reasonably  satisfactory  to the
Company  of such  loss,  theft  or  destruction  and  customary  and  reasonable
indemnity,  if requested.  The  applicants  for a new  certificate or instrument
under  such  circumstances  shall  also  pay any  reasonable  third-party  costs
associated with the issuance of such replacement Securities.

     5.15 Remedies.  In  addition  to  being  entitled  to  exercise  all rights
          --------
provided herein or granted by law,  including  recovery of damages,  each of the
Purchasers  and the Company will be entitled to specific  performance  under the
Transaction  Documents.  The  parties  agree that  monetary  damages  may not be
adequate  compensation  for  any  loss  incurred  by  reason  of any  breach  of
obligations  described in the  foregoing  sentence and hereby agrees to waive in
any action for specific  performance  of any such  obligation the defense that a
remedy at law would be adequate.

     5.16 Payment Set Aside.  To the extent that the Company  makes a payment or
          -----------------
payments to any Purchaser  pursuant to any  Transaction  Document or a Purchaser
enforces or exercises its rights thereunder, and such payment or payments or the
proceeds of such  enforcement  or exercise or any part thereof are  subsequently
invalidated,  declared to be fraudulent or  preferential,  set aside,  recovered
from, disgorged by or are required to be refunded,


                                       24



repaid or otherwise  restored to the Company,  a trustee,  receiver or any other
person under any law (including,  without limitation,  any bankruptcy law, state
or federal law, common law or equitable cause of action),  then to the extent of
any such  restoration the obligation or part thereof  originally  intended to be
satisfied  shall be revived  and  continued  in full force and effect as if such
payment had not been made or such enforcement or setoff had not occurred.

     5.17 Independent  Nature  of  Purchasers'   Obligations  and   Rights.  The
          ---------------------------------------------------------------
obligations of each Purchaser under any Transaction Document are several and not
joint with the  obligations of any other  Purchaser,  and no Purchaser  shall be
responsible  in any way for the  performance  of the  obligations  of any  other
Purchaser under any Transaction  Document.  Nothing  contained  herein or in any
Transaction  Document,  and no action taken by any Purchaser  pursuant  thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint  venture  or any other kind of entity,  or create a  presumption  that the
Purchasers  are in any way acting in concert or as a group with  respect to such
obligations or the transactions  contemplated by the Transaction Documents. Each
Purchaser  shall be  entitled to  independently  protect and enforce its rights,
including without limitation, the rights arising out of this Agreement or out of
the other  Transaction  Documents,  and it shall not be necessary  for any other
Purchaser  to be  joined  as an  additional  party  in any  proceeding  for such
purpose.  Each Purchaser has been  represented by its own separate legal counsel
in their review and  negotiation of the  Transaction  Documents.  For reasons of
administrative  convenience only,  Purchasers and their respective  counsel have
chosen to communicate  with the Company through FW. FW does not represent all of
the Purchasers  but only Rodman & Renshaw LLC, who has acted as placement  agent
to the  transaction.  The Company has elected to provide all Purchasers with the
same terms and Transaction  Documents for the convenience of the Company and not
because it was required or requested to do so by the Purchasers.

     5.18 Construction.  The  parties  agree  that  each of them  and/or  their
          ------------
respective counsel has reviewed and had an opportunity to revise the Transaction
Documents and, therefore, the normal rule of construction to the effect that any
ambiguities are to be resolved  against the drafting party shall not be employed
in the interpretation of the Transaction Documents or any amendments hereto.

                            (Signature Pages Follow)


                                       25



     IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase
Agreement to be duly executed by their respective  authorized  signatories as of
the date first indicated above.


CYTOGEN CORPORATION                            Address for Notice:
                                               -------------------


By:
   ----------------------------------
   Name:
   Title:

With a copy to (which shall not constitute notice):






                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                      SIGNATURE PAGE FOR PURCHASER FOLLOWS]






                                       26



        [PURCHASER SIGNATURE PAGES TO CYTO SECURITIES PURCHASE AGREEMENT]

     IN WITNESS WHEREOF,  the undersigned  have caused this Securities  Purchase
Agreement to be duly executed by their respective  authorized  signatories as of
the date first indicated above.


Name of Purchaser:
                  --------------------------------------------------------------
Signature of Authorized Signatory of Purchaser:
                                               ---------------------------------
Name of Authorized Signatory:
                             ---------------------------------------------------
Title of Authorized Signatory:
                              --------------------------------------------------
Email Address of Purchaser:
                           -----------------------------------------------------


Address for Notice of Purchaser:





Address  for Delivery  of Securities for  Purchaser  (if not same  as  above  or
DTC #           ):
     -----------





Subscription Amount:
Shares:
Warrant Shares:


                           [SIGNATURE PAGES CONTINUE]



                                       27



                                                                         ANNEX A

                                CLOSING STATEMENT

Pursuant to the attached  Securities  Purchase  Agreement,  dated as of the date
hereto,  the purchasers  shall purchase up to  $[            of Common Stock and
                                                 -----------
Warrants from Cytogen Corporation (the "Company").  All funds will be wired into
                                        -------
[a trust account maintained by             ,  counsel to the Company] [TBD]. All
                               ------------
funds will be disbursed in accordance with this Closing Statement.


DISBURSEMENT DATE:    [            , 2005
                       -------- ---

- --------------------------------------------------------------------------------

I.   PURCHASE PRICE
     --------------

          Gross Proceeds to be Received in Trust              $

II.  DISBURSEMENTS
     -------------
                                                              $
                                                              $
                                                              $
                                                              $
                                                              $

TOTAL AMOUNT DISBURSED:                                       $



WIRE INSTRUCTIONS:
- -----------------


To:
   -------------------------------------





To:
   -------------------------------------







                                       28



                             Schedule of Purchasers
                             ----------------------




Name                           Number of Shares           Number of Warrants            Purchase Price
- ----                           ----------------           ------------------            --------------

- -------------------------------------------------------------------------------------------------------------
                                                                                
Iroquois Master Fund, Ltd.          250,000                     62,500                   $890,000.00
- -------------------------------------------------------------------------------------------------------------
RAQ, LLC                             75,000                     18,750                   $267,000.00
- -------------------------------------------------------------------------------------------------------------
Valesco Healthcare
 Partners I, LP                      20,250                      5,063                    $72,090.00
- -------------------------------------------------------------------------------------------------------------
Valesco Healthcare
 Partners II, LP                     24,000                      6,000                    $85,440.00
- -------------------------------------------------------------------------------------------------------------
Valesco Healthcare
 Overseas Fund, Ltd                  30,750                      7,688                   $109,470.00
- -------------------------------------------------------------------------------------------------------------
Cranshire Capital, L.P.           1,000,000                    250,000                 $3,560,000.00
- -------------------------------------------------------------------------------------------------------------
Bristol Investment
 Fund, Ltd.                         200,000                     50,000                   $712,000.00
- -------------------------------------------------------------------------------------------------------------
Perceptive Life Sciences Master
 Fund Ltd.                          500,000                    125,000                 $1,780,000.00
- -------------------------------------------------------------------------------------------------------------
Smithfield Fiduciary
 LLC                              1,629,556                    407,389                 $5,801,219.36
- -------------------------------------------------------------------------------------------------------------