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                                                               December 13, 2005

Michael Becker
President & Chief Executive Officer
Cytogen Corporation
650 College Road East, Suite 3100
Princeton, NJ 08540


Dear Mr. Becker:

     The purpose of this letter agreement (the  "Agreement") is to set forth the
terms and  conditions  pursuant to which  Rodman & Renshaw,  LLC  ("R&R")  shall
introduce  Cytogen  Corporation  (the  "Company")  to one or more  investors  in
connection  with the proposed  offering  (the  "Offering")  of  securities  (the
"Securities")  of the Company.  The terms of such  Offering  and the  Securities
shall  be  mutually  agreed  upon  by the  Company  and the  investor(s).  R&R's
engagement  under this Agreement shall be exclusive until December 12, 2005, and
thereafter shall be non-exclusive.  The identities of the investors to which R&R
introduces the Company shall be proprietary  information of R&R and shall not be
divulged to third  parties by the Company,  nor used by the Company  outside the
scope of R&R's engagement as described herein.

     As  compensation  for the services  provided by R&R hereunder,  the Company
agrees to pay to R&R:

     (A) The fees set forth below with respect to the Offering:

          a)   A cash fee payable  immediately upon the  closing of the Offering
               and  equal to 5% of  the aggregate  gross proceeds  raised in the
               Offering.

          b)   Warrants to purchase that number of shares of common stock of the
               Company ("Shares") equal to 5% of the aggregate number of  Shares
               sold in the Offering. Such warrants shall have the same  terms as
               the warrants (if any) issued to investors in the Offering.

     (B) The Company also agrees to reimburse  R&R's expenses up to a maximum of
         $25,000. Such reimbursement shall be payable immediately upon (but only
         in the event of) the closing of the Offering.

     This  Agreement  shall be governed by and construed in accordance  with the
laws of the State of New York,  without  regard to conflicts of law  principles.
Any dispute  arising out of this Agreement shall be adjudicated in the courts of
the State of New York or in the federal courts sitting in the Southern  District
of New York,  and each of the parties hereto agrees that service of process upon
it by  registered  or  certified  mail at its address set forth  herein shall be
deemed  adequate  and  lawful.  The  Company  shall  indemnify  R&R  against any
liabilities  arising under the Securities Act of 1933, as amended,  attributable
to any  information  supplied or omitted to be  supplied to any  investor by the
Company pursuant to this Agreement. The Company acknowledges and agrees that R&R
is not and shall not be  construed  as a fiduciary of the Company and shall have
no duties or  liabilities  to the equity holders or the creditors of the Company
or any  other  person  by  virtue  of this  Agreement  or the  retention  of R&R
hereunder, all of which are hereby expressly waived.

     This Agreement  constitutes the entire  understanding and agreement between
the  parties  hereto  with  respect  to its  subject  matter  and  there  are no
agreements or understandings with respect to the subject matter hereof which are
not contained in this Agreement.  This Agreement may be modified only in writing
signed by the party to be charged hereunder.


If the foregoing  correctly  sets forth our  agreement,  please  confirm this by
signing and returning to us the duplicate copy of this letter.

                                                Very truly yours,

                                                RODMAN & RENSHAW, LLC


                                                By: /s/ Edward Rubin
                                                   -----------------------------
                                                   Name:  Edward Rubin
                                                   Title:  Managing Director

Agreed to and accepted
as of the date first written above:

CYTOGEN CORPORATION

By: /s/ William J. Thomas
   -----------------------------------------
   Name: William J. Thomas
   Title: Senior Vice President and General Counsel

                     1270 Avenue of the Americas, 16th Floor
                               New York, NY 10020