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MEDIA/INVESTORS CONTACT:
Jonathan Fassberg
The Trout Group
(212) 477-9007
jfassberg@troutgroup.com


           CYTOGEN CORPORATION ANNOUNCES PRELIMINARY FINANCIAL RESULTS
                      FOR THE YEAR ENDED DECEMBER 31, 2005

PRINCETON,  N.J., (JANUARY 9, 2006) -- Cytogen Corporation (Nasdaq:  CYTO) today
reported its preliminary financial results for the year ended December 31, 2005.

During the fourth  quarter of 2005,  Cytogen  recorded  total  product  sales of
approximately  $4.2 million compared to $3.7 million for the same period in 2004
and $3.5 million for the third quarter of 2005,  representing 13% revenue growth
year-over-year  and 20% sequential  growth from the third quarter of 2005. Total
product  sales for the year ended  December  31, 2005 were  approximately  $15.8
million  compared  to  $14.5  million  for the year  ended  December  31,  2004,
representing an increase of 9% over the prior year.

For the year ended  December  31, 2005,  average  gross margin is expected to be
approximately 40%. Selling,  general and administrative expenses are expected to
be approximately  $25 to $30 million.  Total internal and external joint venture
research and development expenses are expected to be approximately $10 million.

At December 31, 2005,  Cytogen had  approximately  $30.0  million in cash,  cash
equivalents and short-term  investments compared to $35.8 million as of December
31,  2004.  The  December  31,  2005  cash  position  included  the  receipt  of
approximately  $13.3 million in gross proceeds from the sale of common stock and
warrants in December 2005.

"We believe  Cytogen now has the  resources to advance its clinical  development
programs and leverage the benefits of the sales and marketing team built in 2005
to increase  product  sales," said Michael D. Becker,  Cytogen's  president  and
chief executive officer.

Cytogen  will report  final fourth  quarter and full year  financial  results on
Thursday,  February 23, 2006 before the financial markets open. The announcement
will be followed by a conference call with the investment community at 9:00 a.m.
EST.

ABOUT CYTOGEN CORPORATION
- -------------------------

Founded  in 1980,  Cytogen  Corporation  of  Princeton,  NJ is a  product-driven
biopharmaceutical company that acquires,  develops and commercializes innovative
molecules  targeting  the sites and  stages  of  cancer  progression.  Cytogen's
marketed products include  QUADRAMET(R)  (samarium Sm-153 lexidronam  injection)
and PROSTASCINT(R) (capromab pendetide) kit for the preparation of Indium In-111
capromab  pendetide  in the United  States.  Cytogen also has  exclusive  United
States marketing rights to COMBIDEX(R)  (ferumoxtran-10)  for all  applications,
and the exclusive right to market and sell  ferumoxytol  (previously  Code 7228)
for oncology  applications in the United States.  Cytogen's development pipeline
consists of therapeutics targeting  prostate-specific membrane antigen (PSMA), a
protein  highly  expressed  on the  surface  of  prostate  cancer  cells and the
neovasculature of solid tumors.  Full prescribing  information for the Company's
products is available at  http://www.cytogen.com  or by calling  1-800-833-3533.
For   more    information,    please    visit   the    Company's    website   at
http://www.cytogen.com, which is not part of this press release.





This press release  contains  certain  "forward-looking"  statements  within the
meaning of the Private Securities  Litigation Reform Act of 1995 and Section 21E
of the Securities Exchange Act of 1934, as amended.  All statements,  other than
statements of  historical  facts,  included in this press release  regarding our
strategy,  future operations,  financial  position,  future revenues,  projected
costs,  prospects,  plans  and  objectives  of  management  are  forward-looking
statements.  Such  forward-looking  statements  involve  a number  of risks  and
uncertainties  and investors are cautioned not to put any undue  reliance on any
forward-looking  statement.  There are a number of important  factors that could
cause  Cytogen's  results  to differ  materially  from those  indicated  by such
forward-looking  statements.  In particular,  Cytogen's business is subject to a
number of significant risks, which include,  but are not limited to: the risk of
obtaining  the  necessary  regulatory  approvals;  the risk of whether  products
result  from  development  activities;  the  risk of  shifts  in the  regulatory
environment  affecting  sales of Cytogen's  products such as  third-party  payor
reimbursement  issues;  the risk  associated  with  Cytogen's  dependence on its
partners for development of certain projects, as well as other factors expressed
from time to time in Cytogen's periodic filings with the Securities and Exchange
Commission  (the  "SEC").  As a result,  this  press  release  should be read in
conjunction with Cytogen's  periodic  filings with the SEC. The  forward-looking
statements  contained herein are made only as of the date of this press release,
and Cytogen  undertakes no obligation  to publicly  update such  forward-looking
statements to reflect subsequent events or circumstances.

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