[SCIOS LOGO]
                              820 West Maude Avenue
                               Sunnyvale, CA 94086
                                www.sciosinc.com

CONTACT:
Wendy Carhart                                           For Randal J. Kirk:
Scios Inc.                                              Caroline Gentile
408/616-8325                                            Kekst and Company
or                                                      212/521-4800
Stanley J. Kay
MacKenzie Partners, Inc.
212/929-5940

FOR IMMEDIATE RELEASE:

                 SCIOS AND R. J. KIRK AGREE TO END PROXY CONTEST

                  Parties Focused On Building Stockholder Value

SUNNYVALE,  CALIFORNIA  and  RADFORD,  VIRGINIA--January  31,  2000--Scios  Inc.
(NASDAQ:SCIO) and Randal J. Kirk jointly announced today a definitive  agreement
which  enables Scios  management to move forward with its business  strategy and
expands the board of directors,  if elected by  stockholders,  to one that will,
together with management,  report beneficial  ownership of nearly ten percent of
the company's fully diluted shares.

Under the  agreement,  which ends Mr. Kirk's proxy  solicitation  to elect a new
slate of directors,  Mr. Kirk will be added to the slate of candidates nominated
by the Scios Board for  election  as  directors  at the 2000  annual  meeting of
stockholders  to be held on  February  28,  2000.  This will raise the number of
Board  candidates to eight,  including the seven current Scios Board members who
are  standing  for  re-election.  If  elected,  Mr.  Kirk as  well as all  other
directors will serve for a one-year term.

Accordingly,  Mr. Kirk and certain entities he controls, which own approximately
5.2% of Scios'  outstanding  shares will vote their Scios shares in favor of the
Board's nominees at the upcoming annual meeting.

                                   -- more --

                                                                January 31, 2000
                                                                          Page 2

Randal J. Kirk stated, "I strongly believe that there is substantial shareholder
value to be realized at Scios as evidenced by the size of my holdings,  and I am
pleased  to be  nominated  to a  slate  of this  caliber.  I am  convinced  that
Natrecor(R),  for example,  is a product with  extremely  attractive  commercial
potential, and that Scios' management should be in a position to devote its full
energies to obtaining  FDA approval for this product.  At the same time,  Scios'
offer to have me on its board will enable me, if elected, to work with the other
directors and management to build value for all Scios stockholders."

Donald B. Rice,  Scios'  Chairman,  and Richard B. Brewer,  President  and Chief
Executive  Officer,  said, "The priority of the board and management of Scios is
to achieve  enhanced value for all  stockholders.  This negotiated  agreement is
consistent  with that  priority.  By ending a  distractive  situation we can now
devote everyone's  energies to the business of growing Scios. Scios can now move
forward with a board that is strong in business  experience,  industry expertise
and  stockholder  representation.  We  believe  Mr.  Kirk can  bring a  valuable
perspective to the board."

Consistent with the agreement's spirit of cooperation, Mr. Kirk and his entities
have agreed to certain  "stand  still"  provisions.  Both  parties will file the
definitive  settlement  agreement  with  the  SEC  shortly  and  Scios  will  be
supplementing its proxy statement to add Mr. Kirk as a nominee to its Board.

Scios, Inc.

Scios is a biopharmaceutical company engaged in the discovery,  development, and
commercialization of novel human therapeutics.  Scios has commercial or research
and   development   relationships   with   Chiron   Corporation,    The   DuPont
Pharmaceuticals   Company,   Eli  Lilly  and   Company,   GenVec   Inc.,   Kaken
Pharmaceutical  Co., Ltd., and Novo Nordisk A/S of Denmark.  Scios'  Psychiatric
Sales and Marketing Division  successfully  markets seven psychiatric  products,
including co-promotion  arrangements with Janssen  Pharmaceutica's  Risperdal(R)
(risperidone)  and SmithKline  Beecham's  Paxil(R)  (paroxetine  hydrochloride).
Additional  information  on  Scios  is  available  at its web  site  located  at
www.sciosinc.com  and in the Company's  various  filings with the Securities and
Exchange Commission.

                                    -- end --