UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 10-K

(Mark One)
(X)        Annual  Report  Pursuant  to  Section  13 or 15(d) of the  Securities
           Exchange Act of 1934.
              For the fiscal year ended December 31, 1999 or

( )        Transition Report Pursuant  to  Section 13 or 15(d) of the Securities
           Exchange Act of 1934.
              For the transition period from__________ to __________.

           Commission file number   2-89283

                           IOWA FIRST BANCSHARES CORP.
             (Exact name of registrant as specified in its charter)

An Iowa Corporation                                         42-1211285
(State or other jurisdiction of                  (I.R.S. Employer incorporation
organization)                                         or Identification No.)

300 East Second Street, Muscatine, Iowa                        52761
(Address of principal executive offices)                     (Zip Code)

Registrant's telephone number, including area code   (319) 263-4221
Securities registered pursuant to Section 12(b) of the Act:  None
Securities registered pursuant to Section 12(g) of the Act:  None

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.

               X    Yes                     No
- --------------------        ----------------

Indicate by check mark if disclosure of delinquent  filers  pursuant to Item 405
of Regulation  S-K  is not contained  herein,  and will not be contained, to the
best of registrant's  knowledge, in definitive  proxy or information  statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K.   (X)

The  aggregate  market  value of the voting stock held by  nonaffiliates  of the
registrant as of February 28, 2000,  was  $28,512,525.  As of February 28, 2000,
1,536,701 shares of the Registrant's common stock were outstanding.

Documents incorporated by reference:

Portions of the registrant's  1999 Annual Report are incorporated in Parts I and
II of this Form 10-K.  Portions of the registrant's  Proxy Statement dated March
17, 2000 are incorporated in Part III of this Form 10-K.

The Exhibit Index is located on page 11.


                           ANNUAL REPORT ON FORM 10-K

                                TABLE OF CONTENTS

                                     PART I





Item  1.  Business
Item  2.  Properties
Item  3.  Legal Proceedings
Item  4.  Submission of Matters to a Vote of Security Holders
Table I.  Executive Officers of the Registrant

                                     PART II

Item  5.  Market for the Registrant's Common Equity and Related Stockholder
             Matters
Item  6.  Selected Financial Data
Item  7.  Management's Discussion and Analysis of Financial Condition and
             Results of Operations
Item  8.  Financial Statements and Supplementary Data
Item  9.  Changes in and Disagreements with Accountants on Accounting and
             Financial Disclosure


                                    PART III

Item 10.  Directors and Executive Officers of the Registrant
Item 11.  Executive Compensation
Item 12.  Security Ownership of Certain Beneficial Owners and Management
Item 13.  Certain Relationships and Related Transactions


                                     PART IV

Item 14.  Exhibits, Financial Statement Schedules, and Reports on Form 8-K
          Signatures
          Index of Exhibits




                           ANNUAL REPORT ON FORM 10-K

                                     PART I

ITEM 1. BUSINESS.
- ------------------

Iowa  First  Bancshares  Corp.  (the  "Company"),  is  a  bank  holding  company
headquartered in Muscatine,  Iowa. The Company owns all the outstanding stock of
two national banks in Iowa,  First National Bank of Muscatine and First National
Bank in Fairfield.

On a full-time  equivalent  basis,  year-end  employment for the Company and its
subsidiary banks totaled 127 employees.

First  National  Bank of Muscatine  has a total of five  locations in Muscatine,
Iowa. The First National Bank in Fairfield has two locations in Fairfield, Iowa.
Each bank is engaged in the general  commercial  banking  business  and provides
full service  banking to  individuals  and  businesses,  including  checking and
savings  accounts,  commercial  loans,  consumer loans,  real estate loans, safe
deposit  facilities,  transmitting  of funds,  trust  services,  and such  other
banking services as are usual and customary for commercial banks.

The commercial banking business is highly competitive.  Subsidiary banks compete
with other  commercial  banks and with other financial  institutions,  including
savings banks,  mortgage banking  companies,  credit unions and mutual funds. In
recent years,  competition  also has increased from  institutions not subject to
the same regulatory restrictions as banks and bank holding companies.

The operations of the Company and its subsidiary banks are affected by state and
federal legislative  changes and by policies of various regulatory  authorities.
The Company is a registered  bank holding company under the Bank Holding Company
Act of 1956 (the "Act") and is subject to the supervision of, and regulation by,
the Board of Governors of the Federal  Reserve System (the  "Board").  Under the
Act, a bank  holding  company  may engage in banking,  managing  or  controlling
banks,  furnishing or performing services for banks it controls,  and conducting
activities that the Board has determined to be closely related to banking.

National  banks are  subject to the  supervision  of, and are  examined  by, the
Office of the Comptroller of the Currency.  Both subsidiary banks of the Company
are members of the  Federal  Deposit  Insurance  Corporation,  and as such,  are
subject to examination thereby. In practice, the primary federal regulator makes
regular examinations of each subsidiary bank subject to its regulatory review or
participates in joint examinations with other federal regulators.  Areas subject
to regulation by these  authorities  include capital  levels,  the allowance for
possible  loan losses,  investments,  loans,  mergers,  issuance of  securities,
payment of  dividends,  establishment  of  branches,  and many other  aspects of
operations.

Statistical  information  called for by this Item is contained in the  Company's
1999 Annual Report to Shareholders  which is incorporated by reference (pages 40
- - 51 of this Form 10-K).

ITEM 2.   PROPERTIES.
- --------------------

Since the Company commenced  business,  its principal  executive office has been
located at 300 East  Second  Street,  Muscatine,  Iowa,  which is the  principal
office of First National Bank of Muscatine, a national banking association and a
wholly owned subsidiary of the Company.

First National Bank of Muscatine  conducts its operations  from five  facilities
located in Muscatine.  The main bank is located at 300 East Second Street and is
a modern brick and steel  building  completed in 1979  containing  36,000 square
feet of floor space on three  floors.  The bank owns both the  building  and the
underlying real estate. All  administrative  functions of the bank are conducted
at its main offices.  Portions of the building are leased to commercial tenants.
During 1997,  a branch was opened  inside the  Wal-Mart  Supercenter  located on
highway 61 at Muscatine. This branch and the Wal-Mart Supercenter were the first
of their kind in Iowa.  The bank  operates  this branch  under a five year lease
agreement  with  Wal-Mart,  with two five year  renewal  options.  Additionally,
another new branch facility,  which includes  drive-through banking services and
is located across the alley from the main Muscatine  banking  headquarters,  was
completed in the fall of 1997. This branch replaced a previous  downtown branch.
The bank owns this facility and the underlying real estate.



Two locations,  in addition to the new Wal-Mart branch, provide banking services
outside  the  Muscatine  downtown  area.  The  office at the  Muscatine  Mall is
approximately  two miles northeast of the main bank. The facility contains 2,304
square feet of floor  space in a  one-story  concrete  and steel  building.  The
facility offers a walk-in lobby and night  depository.  The three-lane  drive-up
facility of this branch is located  approximately 500 feet west of the branch at
the parking lot of the mall. The building,  drive-up  facilities and real estate
are leased. The terms of the lease provide for monthly payments of $2,304 during
the  current  5-year  term of the  lease.  This lease  expired on May 31,  1999.
Management  is  negotiating  with  the new  owners  of the  Muscatine  Mall  for
construction of a freestanding  building on Mall property with a long-term lease
arrangement with First National Bank of Muscatine.

The  bank's  southside  office  at 608  Grandview  Avenue is  located  two miles
southwest of the main bank. The office contains 3,600 square feet of floor space
and is located in a one-story steel frame, concrete block building. The facility
offers a walk-in lobby and three  drive-up  lanes.  The building and  underlying
real  estate  are owned by the bank.  Portions  of the  building  are  leased to
commercial tenants.

First National Bank in Fairfield conducts its operations from a modern brick and
steel building  completed in 1968 containing 8,200 square feet of floor space on
two floors.  The bank owns both the  building  and the  underlying  real estate.
Portions of the building are leased to commercial tenants. A three-lane drive-up
facility  is  located  at the main  bank.  In the  spring of 1997,  a new branch
facility was opened at Fairfield, Iowa. The building, which is located in a high
traffic  area in front of the  local  Wal-Mart  store on  highway  34,  contains
several  private  offices for lending staff and management as well as teller and
deposit services, including several drive-through lanes.

The Company's  facilities are well maintained and are suitable for the Company's
business operations.


ITEM 3.   LEGAL PROCEEDINGS.
- ---------------------------

The Company has no pending legal proceedings which are material.

ITEM 4.   SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.
- -------------------------------------------------------------

None.






                                 PART I, TABLE I
                                 ---------------
                      EXECUTIVE OFFICERS OF THE REGISTRANT
                      ------------------------------------


                             Family                              Held      Business Experience
Name                 Age  Relationship       Position            Since     During Past Five Years
- ----------------------------------------------------------------------------------------------------
                                                                      
George A. Shepley    77       None     Chairman of the Board      1983     President of the Company,
                                       Chief Executive Officer    1983     January 1989 to 1996;
                                       Director                   1983     Chairman of the Board,
                                                                           Chief Executive Officer
                                                                           of the Company, 1983 to
                                                                           present; Chairman of the
                                                                           Board, 1987 to present,
                                                                           President, 1963 to
                                                                           January 1989, First
                                                                           National Bank of
                                                                           Muscatine; Chairman of
                                                                           the Board, 1986 to
                                                                           present, First National
                                                                           Bank in Fairfield.


Kim K. Bartling      42       None     Executive Vice President   1996     Executive Vice President,
                                       Chief Operating Officer    1996     Chief Operating Officer
                                       Treasurer                  1988     and Treasurer of the
                                       Director                   1994     Company, December 1996 to
                                                                           present;
                                                                           Senior Vice President, Chief
                                                                           Financial Officer and Treasurer
                                                                           of the Company, April 1988 to
                                                                           December 1996; Director of the
                                                                           Company since 1994; Director
                                                                           First National Bank of
                                                                           Muscatine, 1989 to present;
                                                                           Executive Vice President and
                                                                           Chief Financial Officer, First
                                                                           National Bank of Muscatine, 1996 to
                                                                           present; Senior Vice President/Chief
                                                                           Financial Officer, First National
                                                                           Bank of Muscatine, 1987 to
                                                                           1996; Director First National
                                                                           Bank in Fairfield, 1990 to present.

D. Scott Ingstad     49       None     Vice Chairman              1999     Vice Chairman of the Board,
                                       President                  1996     October 1999 to present,
                                       Director                   1990     Director, 1990 to present, President,
                                                                           1996 to present, of the Company;
                                                                           Director, President and CEO of
                                                                           First National Bank of Muscatine,
                                                                           1990 to present.

Patricia R.          52       None     Secretary                  1986     Corporate Secretary of
Thirtyacre                                                                 the Company, October 1986
                                                                           to present.



                                     PART II
                                     -------

    ITEM 5. MARKET FOR THE REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER
    -------------------------------------------------------------------------
                                    MATTERS
                                    -------

     The brokerage firms of Howe Barnes Investments, Inc. and Mesirow Financial,
Inc. make a market for the Company's common stock.

     High and low common stock prices and dividends for the last two years were:

1999 by                                                                Dividend
Quarters                              High              Low           Per Share
- --------------------------------------------------------------------------------
First .....................       $   32.50         $   31.00         $   0.21
Second ....................           32.50             29.50             0.21
Third .....................           29.50             25.50             0.21
Fourth ....................           27.50             23.88             0.21

Total Dividend
Paid ......................                                           $   0.84

1998 by                                                               Dividend
Quarters                              High              Low           Per Share
- --------------------------------------------------------------------------------
First .....................       $   31.25         $   31.00         $   0.21
Second ....................           32.00             30.00             0.21
Third .....................           34.00             30.38             0.21
Fourth ....................           32.50             30.50             0.21

Total Dividend
Paid ......................                                           $   0.84

The above  quotations were furnished by the brokerage firms that serve as market
makers for the Company's stock. The quotations  represent prices between dealers
and do not include retail markup, markdown, or commissions.

Future dividends are dependent on future earnings,  regulatory restrictions (see
Management's  Discussion  and  Analysis of  Financial  Condition  and Results of
Operations  on  pages 40 - 51 of this  Form  10-K;  and Note 9 to the  Company's
Consolidated  Financial  Statements  in the  Company's  1999  Annual  Report  to
Shareholders  which is  incorporated  by  reference,  pages 30 - 32 of this Form
10-K), capital requirements, and the Company's financial condition.

As of February 28, 2000, the Company had  approximately  475 shareholders of its
outstanding  class of common stock.  The Iowa First  Bancshares  Corp.  Employee
Stock Ownership Plan with 401(k) Provisions is considered one shareholder as all
shares owned by this plan are voted by the trustees of said plan unless the vote
in  question  encompasses  approval  or  disapproval  of any  corporate  merger,
consolidation, dissolution, or similar transaction.

ITEM 6.   SELECTED FINANCIAL DATA.
- ---------------------------------

The  information  called for by this Item is  contained  in the  Company's  1999
Annual Report to  Shareholders  which is  incorporated  by reference (page 39 of
this Form 10-K).

ITEM 7.  MANAGEMENT'S  DISCUSSION AND ANALYSIS OF FINANCIAL  CONDITION
           AND RESULTS OF OPERATIONS.
- ----------------------------------------------------------------------

The  information  called for by this Item is  contained  in the  Company's  1999
Annual Report to Shareholders  which is incorporated by reference (pages 40 - 51
of this Form 10-K).



ITEM 8.   FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.
- -----------------------------------------------------

The  information  called for by this Item is  contained  in the  Company's  1999
Annual Report to Shareholders  which is incorporated by reference (pages 18 - 39
of this Form 10-K).

ITEM 9.   CHANGES IN  AND  DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING
            AND FINANCIAL DISCLOSURE.
- -----------------------------------------------------------------------

None.


                                    PART III
                                    --------

ITEM 10.   DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT
- -------------------------------------------------------------

The information called for by this Item is contained in the Company's 1999 Proxy
Statement which is incorporated by reference (page 55 of this Form 10-K).

Director Compensation
- ---------------------

The annual retainer that each outside  Director of the Company  received in 1999
was $5,300.  The Company paid $100 for attendance at each committee  meeting and
special Board of Directors  meeting.  During 1999,  each Director of the Company
served  as  Director  and  member  of  committees  for  subsidiary   boards  and
committees,  with the  exception of Mr.  Carver who served only as a Director of
the Company.  The annual retainer fee paid to each outside  subsidiary  Director
was $4,000, plus $50 to $150 for attendance at each committee meeting. Executive
officers who also serve on the Board of  Directors do not receive such  retainer
or committee fees.


ITEM 11.  EXECUTIVE COMPENSATION
- --------------------------------

The information called for by this Item is contained in the Company's 1999 Proxy
Statement which is incorporated by reference (pages 56 - 58 of this Form 10-K).

ITEM 12.  SECURITY OWNERHSIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
- ------------------------------------------------------------------------

The information called for by this Item is contained in the Company's 1999 Proxy
Statement  which is  incorporated  by  reference  (pages  54 and 55 of this Form
10-K).

ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.
- --------------------------------------------------------

Officers  and  Directors of the Company and its  subsidiaries  have had, and may
have in the future,  banking  transactions in the ordinary course of business of
the Company's subsidiaries.  All such transactions are on substantially the same
terms, including interest rates on loans and collateral,  as those prevailing at
the time for comparable  transactions with others,  and involve no more than the
normal risk of collectibility.




                                     PART IV

   ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K.

(a) Documents Filed with This Report:
- -------------------------------------

(1) Financial Statements. The following consolidated financial statements of the
    Company and its  subsidiaries  are  incorporated  by reference from the 1999
    Annual Report to Shareholders of the Company:


        Consolidated balance sheets--dated December 31, 1999 and 1998.

        Consolidated statements of income--years ended December 31,
          1999, 1998, and 1997

        Consolidated statements of changes in stockholders' equity--
          years ended December 31, 1999, 1998, and 1997.

        Consolidated statements of cash flows--years ended  December 31,
          1999, 1998, and 1997.

        Notes to consolidated financial statements.

        Opinion of independent accountants.

(2) Financial Statement Schedules.    All schedules are omitted because they are
    not applicable,  are  not  required,  or because the required information is
    included in the financial statements or the notes thereto.

(b) Reports on Form 8-K.
    No reports on Form 8-K have been filed during the last quarter of the period
    covered by this report.

(c) Exhibits.
    The  following exhibits are attached pursuant to Item 601 of Regulation S-K:


         (13)   Registrant's 1999 Annual Report to Shareholders
         (20)   Registrant's Proxy Statement dated March 17, 2000
         (24)   Power of Attorney
         (27)   Financial Data Schedule

See Exhibit Index on page 11 hereof for a complete list of management  contracts
and  arrangements  required  by  this  item  and all  other  Exhibits  filed  or
incorporated by reference as a part of this report.



                                   SIGNATURES

         Pursuant to the  requirements  of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.

                           IOWA FIRST BANCSHARES CORP.

Date:  March 10, 2000                       /s/ George A. Shepley
       --------------                        ---------------------
                                             George A. Shepley
                                             Chairman of the  Board

Date:  March 10, 2000                        /s/ Kim K. Bartling
       --------------                        --------------------
                                             Kim K. Bartling, Executive Vice
                                             President, Chief Operating Officer,
                                             Treasurer and Director (Principal
                                             Financial and Accounting Officer)

We, the undersigned  directors of Iowa First Bancshares  Corp.  hereby severally
constitute George A. Shepley and Kim K. Bartling, and each of them, our true and
lawful  attorneys  with full power to them, and each of them, to sign for us and
in our name, the capacities  indicated below, Annual Report of From 10-K of Iowa
First  Bancshares Corp. for the fiscal year ended December 31, 1999, to be filed
herewith and any  amendments  to said Annual  Report,  and generally do all such
things in our name and behalf in our  capacities  as  directors  to enable  Iowa
First Bancshares Corp. to comply with the provisions of the Securities  Exchange
Act of 1934 as amended,  and all  requirements  of the  Securities  and Exchange
Commission, hereby ratifying and confirming our signatures as they may be signed
by our said attorneys, or either of them, to said Annual Report on Form 10-K and
any and all amendments thereto.

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
this  report has been  signed  below by the  following  persons on behalf of the
registrant and in the capacities and on the dates indicated.

      Signature                           Title                      Date

/s/ Roy J. Carver, Jr.                   Director              February 17, 2000
- ----------------------                                         -----------------
Roy J. Carver, Jr.

/s/ Larry L. Emmert                      Director              February 17, 2000
- -------------------                                            -----------------
Larry L. Emmert

/s/ Craig R. Foss                        Director              February 17, 2000
- -----------------                                              -----------------
Craig R. Foss

/s/ Donald R. Heckman                    Director              February 17, 2000
- ---------------------                                          -----------------
Donald R. Heckman

/s/ Dean H. Holst                        Director              February 17, 2000
- -----------------                                              -----------------
Dean H. Holst

/s/ David R. Housley                     Director              February 17, 2000
- --------------------                                           -----------------
David R. Housley

/s/ D. Scott Ingstad                     Director              February 17, 2000
- --------------------                                           -----------------
D. Scott Ingstad

/s/ Victor G. McAvoy                     Director              February 17, 2000
- --------------------                                           -----------------
Victor G. McAvoy

/s/ John "Jay" S. McKee                  Director              February 17, 2000
- -----------------------                                        -----------------
John "Jay" S. McKee

/s/ Beverly J. White                     Director              February 17, 2000
- --------------------                                           -----------------
Beverly J. White



                       ITEM 14 (a) (3) - INDEX OF EXHIBITS
                       -----------------------------------

         Exhibit                                            Page
         -------                                            ----

(3)   Articles of Incorporation, as amended      Incorporated by reference to
                                                 Exhibit (3) to the registrant's
                                                 Annual Report on Form 10-K for
                                                 the fiscal year ended December
                                                 31, 1996.


(10a) Employment Agreement                       Incorporated by reference to
                                                 Exhibit (10a) to the
                                                 registrant's Annual Report on
                                                 Form 10-K for the fiscal year
                                                 ended December 31, 1995.

(10b) Change in Control Employment Agreement     Incorporated by reference to
                                                 Exhibit (10b) to the
                                                 registrant's Annual Report on
                                                 Form 10-K for the fiscal year
                                                 ended December 31, 1995.

(13)  Registrant's 1999 Annual Report to
      Shareholders

(20)  Registrant's Proxy Statement Dated
      March 17, 2000

(21)  Subsidiaries of Registrant                 Incorporated by reference to
                                                 Exhibit 21 to the registrant's
                                                 Annual Report on Form 10-K for
                                                 the fiscal year ended December
                                                 31, 1995.

(24)  Power of Attorney

(27)  Financial Data Schedule