MACROCHEM CORPORATION
                              110 HARTWELL AVENUE
                         LEXINGTON, MASSACHUSETTS 02421
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                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                 JUNE 27, 2002
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     The undersigned hereby appoints Robert J. Palmisano and Bernard R.
Patriacca, or either of them, with power of substitution to each, proxies to
vote at the Annual Meeting of Stockholders of MacroChem Corporation, to be held
on June 27, 2002 at the offices of Ropes & Gray, One International Place, 36th
Floor, Boston, Massachusetts, at 10:00 a.m., local time, or at any adjournments
thereof, all of the shares of Common Stock, par value $.01 per share, of
MacroChem Corporation that the undersigned would be entitled to vote if
personally present. The undersigned instructs such proxies or their substitutes
to act on the following matters as specified by the undersigned, and to vote in
such manner as they may determine on any other matters that may properly come
before the meeting.

     This proxy when properly executed will be voted in the manner directed by
the undersigned stockholder(s).  If no contrary direction is made, this proxy
will be voted FOR the election of all nominees for director named on the
reverse, FOR the ratification of the selection of Deloitte & Touche LLP as
auditors for the fiscal year ending December 31, 2002, and in the discretion of
the named proxies as to any other matter that may properly come before the
meeting.

1.   Election of Directors:     FOR all nominees        _____
                                AGAINST all nominees    _____

     The undersigned hereby GRANTS authority to elect the following nominees as
     Directors.  Instruction:  To withhold authority to vote for any individual
     nominee, draw a line through that nominee's name.

     Nominee:   Robert J. Palmisano
                John L. Zabriskie
                Peter G. Martin
                Michael A. Davis
                Robert J. DeLuccia
                Paul S. Echenberg

2.   To ratify the appointment of Deloitte & Touche LLP, as independent auditors
     for the Corporation for the fiscal year ending December 31, 2002.

     FOR _____          AGAINST _____           ABSTAIN _____

3.   To consider and act upon any other matters that may properly come before
     the meeting or any adjournment thereof.

Please check the box at right if you plan to attend meeting in person.  _____

SIGNATURE
Title (if any)______________________________________________DATE______________

SIGNATURE
Title (if any)______________________________________________DATE______________

NOTE:  Please sign exactly as name appears on this card. All joint owners should
sign.  When signing as executor, attorney, administrator or guardian or as a
custodian for a minor, please give full title as such. If a corporation,  please
sign in full corporate name and indicate signer's office. If a partnership, sign
in the partnership name.