EXHIBIT 32.1


                            CERTIFICATION PURSUANT TO
            SECTION 1350, CHAPTER 63 OF TITLE 18, UNITED STATES CODE,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002



Pursuant to Section 1350, Chapter 63 of Title 18, United States Code, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, the undersigned, as
chief executive officer of MacroChem Corporation (the "Company"), does hereby
certify that to the undersigned's knowledge:

1)   the Company's Quarterly Report on Form 10-Q/A for the period ended June 30,
     2006 as filed with the Securities and Exchange Commission (the "Form 10-Q")
     fully complies with the requirements of Section 13(a) or 15(d) of the
     Securities Exchange Act of 1934; and

2)   the information contained in the Company's Form 10-Q fairly presents, in
     all material respects, the financial condition and results of operations of
     the Company.

                                    /s/  Robert J. DeLuccia
                                    -------------------------------------
                                    Robert J. DeLuccia
                                    President and Chief Executive Officer

Dated:  April 11, 2007



A signed original of this written statement required by Section 906 has been
provided to MacroChem Corporation and will be retained by MacroChem Corporation
and furnished to the Securities and Exchange Commission or its staff upon
request.






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