Exhibit 10.11 FIRST AMENDMENT TO INDENTURE, SECURITIES, WARRANT AGREEMENT AND WARRANT CERTIFICATES THIS FIRST AMENDMENT TO INDENTURE, SECURITIES, WARRANT AGREEMENT AND WARRANT CERTIFICATES (this "First Amendment") is made as of and shall be effective for all purposes as of the 18th day of March, 2003, by and between Igene Biotechnology, Inc., a Maryland corporation (the "Company"), and American Stock Transfer & Trust Company, a New York corporation, its successors and assigns, as Trustee (the "Trustee") and as Warrant Agent (the "Warrant Agent"). RECITALS WHEREAS, pursuant to the terms of an Indenture dated as of March 31, 1998 (the "Indenture") between the Company and the Trustee, the Company issued and sold $5,000,000 of its 8% notes due March 31, 2003 (collectively the "Securities"); and WHEREAS, concurrently with the issue of the Securities, the Company issued, pursuant to a Warrant Agreement dated as of March 31, 1998 (the "Warrant Agreement"), 50,000,000 warrants to purchase shares of the Company's Common Stock for $.10 per share, as adjusted in accordance with the terms of the Warrant Agreement; and WHEREAS, the Company and the Consenting Holders (as defined below) desire to amend the Indenture and Securities as hereinafter provided to reflect the extension of the maturity date on the Securities from March 31, 2003 until March 31, 2006; and WHEREAS, the Company and the Consenting Holders desire to amend the terms of the Warrant Agreement and each of the Warrant Certificates (within the meaning of the Warrant Agreement) as hereinafter provided to reduce the Warrant Price (as defined in the Warrant Agreement) from $.10 to $.075; and WHEREAS, the terms contained in this First Amendment are consented to by the holders of at least two-thirds principal amount of all Securities (collectively, the "Consenting Holders"); NOW, THEREFORE, in consideration of the foregoing recitals, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties to this First Agreement hereby agree as follows: 1. Incorporation of Recitals. The foregoing Recitals are incorporated in this First Amendment and made a part hereof by this reference to the same extent as if set forth herein in full. All section references shall, unless otherwise expressly indicated, mean the corresponding section of the Indenture. 2. Definitions. All capitalized terms used but not defined herein shall have the meanings given such terms in the Indenture. 3. Amendment of the Indenture and Securities. The Indenture and each of the Securities is hereby amended to replace "March 31, 2003" with "March 31, 2006" wherever such term may appear, thereby extending the maturity date of the Securities until March 31, 2006. The Indenture is hereby amended to delete, in its entirety, Section 9.03 thereof. 4. Amendment of Warrant Agreement. The Warrant Agreement and each Warrant Certificate is hereby amended to replace "$.10" with ".075" wherever such term may appear. 5. Ratification of Indenture, Securities, Warrant Agreement and Warrant Certificates. Except as set forth in this First Amendment, all the terms and conditions contained in the Indenture, Securities, Warrant Agreement or Warrant Certificate are hereby ratified and shall remain in full force and effect. In the event that any of the terms, conditions and provisions of this First Amendment shall conflict with any of the terms, conditions and provisions of the Indenture, Securities, Warrant Agreement or Warrant Certificates then, and in such event, the terms, conditions and provisions of this First Amendment shall prevail and be controlling. Hereafter, all references to the Indenture, Securities, Warrant Agreement or any Warrant Certificate shall mean the Indenture, Securities, Warrant Agreement or such Warrant Certificate, respectively, as amended by this First Amendment. 6. Effective Date of First Amendment. The effective date of this First Amendment shall be March 18, 2003. 7. Counterparts. This First Amendment may be executed in any number of counterparts, each of which shall be deemed an original, and all of which, when taken together, shall be deemed to be a single instrument. 8. Applicable Law. This First Amendment shall be governed by the laws of the State of New York, without regard to its conflicts of law rules. 9. Disclaimer. In accordance with Section 7.04 of the Indenture, American Stock Transfer and Trust Company makes no representation or warranty as to the validity or adequacy of this First Amendment and shall not be responsible for any of the recitals set forth herein. [Signature Page Follows] IN WITNESS WHEREOF, and intending to be legally bound, the Company, Trustee and Warrant Agent have caused this First Amendment to be executed on their behalf by their duly authorized representatives as of the date set forth above. ATTEST: THE COMPANY: IGENE BIOTECHNOLOGY, INC. _________________________ By: _______________________ Name: _______________________ Title: _______________________ ATTEST: THE TRUSTEE AND WARRANT AGENT: AMERICAN STOCK TRANSFER & TRUST COMPANY _________________________ By: _______________________ Name: _______________________ Title: _______________________ CONSENT AND WAIVER OF CONSENTING HOLDERS Each of the undersigned, constituting holders of at least two-thirds in principal amount of all Securities, do hereby irrevocably consent, on behalf of all holders of Securities pursuant to and in accordance with the terms of the Indenture, to the amendment of the Securities and the Indenture, as set forth in this First Amendment. Each of the persons signing below in their capacity as trustee on behalf of any trust represent that they currently serve as trustee under the trust(s) listed immediately above their names, and have the trust power and authority to sign below and to bind the trust(s) listed immediately above their names to this Consent and Waiver of Consenting Holders in accordance with its terms. CONSENTING HOLDERS: WITNESS: THOMAS L. KEMPNER: ______________________________ ______________________________ Thomas L. Kempner, record holder of $32,395 principal amount of Securities WITNESS: SIDNEY R. KNAFEL: ______________________________ ______________________________ Sidney R. Knafel, record 				 holder of $1,244,329 principal amount of Securities WITNESS: Trust U/W of Carl M. Loeb FBO Thomas L. Kempner, record holder of $944,933 principal amount of Securities ______________________________ By:___________________________ Thomas L. Kempner Trustee ______________________________ By:___________________________ William Perlmuth Trustee WITNESS: Trust U/W of Carl M. Loeb FBO Alan H. Kempner, record holder of $942,773 principal amount of Securities ______________________________ By:___________________________ Thomas L. Kempner Trustee ______________________________ By:___________________________ William Perlmuth Trustee WITNESS: Trust U/A dated 9/13/1978 FBO Andrew G. Knafel, holder of $340,341 principal amount of Securities ______________________________ By:___________________________ Name: Trustee WITNESS: Trust U/A dated 9/13/1978 FBO Douglas R. Knafel, holder of $340,341.50 principal amount of Securities ______________________________ By:___________________________ Name: Trustee WITNESS: Bear Stearns Securities Corp. confirms that it holds $944,933 principal amount of Securities on behalf of Trust U/W of Carl M. Loeb FBO Thomas L. Kempner and that said trust has the authority to provide the above consent and waiver with respect to said Securities and Bear Stearns Securities Corp. hereby consents to the actions contemplated hereby with respect to said Securities. _______________________________ By:____________________________ Name: Title: WITNESS: Bear Stearns Securities Corp. represents that it holds $942,773 principal amount of Securities on behalf of Trust U/W of Carl M. Loeb FBO Alan H. Kempner and that said trust has the authority to provide the above consent and waiver with respect to said Securities, and Bear Stearns Securities Corp. hereby consents to the actions contemplated hereby with respect to said Securities. _______________________________ By:____________________________ Name: Title: