UNITED STATES

               SECURITIES AND EXCHANGE COMMISSION
                     WASHINGTON, D.C. 20549


                         CURRENT REPORT

                            FORM 8-K
   Pursuant to Section 13 or 15(d) of the Securities Exchange
                          Act of 1934


Date of Report (Date of earliest event reported): February 16,
2005


                    IGENE BIOTECHNOLOGY, INC.
     ______________________________________________________

     (Exact name of registrant as specified in its charter)


      MARYLAND               0-15888              52-1230461
_____________________    ________________    ___________________
(State or other            (Commission          (IRS Employer
 jurisdiction of            File Number)     Identification No.)
 incorporation)


          9110 Red Branch Road
              Columbia, MD                       21045-2024
  ________________________________________     ______________
  (Address of principal executive offices)       (Zip Code)


Registrant's telephone number, including area code:
(410) 997-2599

Check  the  appropriate  box  below  if  the  Form  8-K filing is
intended  to  simultaneously satisfy the filing obligation of the
registrant  under  any  of  the following provisions:

__  Written  communication  pursuant  to  Rule  425   under   the
    Securities Act (17 CFR 230.425)
__  Solicitating  material  pursuant to  Rule  14a-12  under  the
    Exchange Act (17CFR 240.14a.12)
__  Pre-commencement  communications pursuant  to  Rule  14d-2(b)
    under the Exchange Act (17  CFR 240.14d-2(b))
__  Pre-commencement communications pursuant to Rule 13e-4(c)under
    the Exchange Act (17 CFR 240.13e-4(c))

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        Section 4 - Matters  Related  to  Accountants
                  and Financial Statements


Item 4.01.  Changes in Registrant's Certifying Accountant

(a)  Termination of previous independent accountants.

     As  of  February  15,  2005,  the Registrant  dismissed  its
independent accountant, Stegman & Company ("Stegman"), due to the
Registrant's  increased international audit requirements  brought
about  by  the Registrant's 50% participation in a joint  venture
with  Tate & Lyle PLC (Tate & Lyle), which joint venture produces
AstaXin(R)  for the aquaculture industry at Tate & Lyle's  Selby,
England   facility.    The  decision  to  dismiss   Stegman   was
recommended by the Board of Directors of the Registrant during  a
meeting held on February 8, 2005.     The audit reports issued by
Stegman   on  the  consolidated  financial  statements   of   the
Registrant  as  of  and for the years ended  December  31,  2003,
December  31, 2002 and prior, did not contain an adverse  opinion
or  a  disclaimer of opinion, and were not qualified or modified,
as  to  uncertainty, audit scope or accounting principles, except
as follows:

          Stegman's  reports,   contain  explanatory
          paragraphs. The paragraph  states that the
          Company has suffered recurring losses from
          operations  since  inception  and  has   a
          working  capital  deficiency  that  raises
          substantial  doubt about  its  ability  to
          continue  as   a  going   concern.     The
          consolidated  financial statements  do not
          include  any adjustments that might result
          from the outcome of that uncertainty.

     During these periods,  there  have  been  no   disagreements
between the Registrant and Stegman on any  matter  of  accounting
principles  or  practices,  financial  statement  disclosure,  or
auditing scope or procedure, which disagreements, if not resolved
to the satisfaction of Stegman, would have caused Stegman to make
reference  to  the  subject  matter thereof  in its report on the
Registrant's consolidated financial statements for such periods.

     A letter from Stegman addressed to the Securities & Exchange
Commission   ("SEC")  stating  that  Stegman  agrees   with   the
statements contained herein has been filed as an exhibit to  this
report.

(b)  Engagement of new independent accountants.

     The   Registrant   has   appointed  Berenson   and   Company
("Berenson") as its new independent public accountants  effective
as  of  February 14, 2005. The selection of Berenson was approved
by  the  Audit  Committee  of  the  Board  of  Directors  of  the
Registrant on February 8, 2005.

          Section 9 - Financial Statements and Exhibits

Item 9.01.  Financial Statements and Exhibits

(c)  Exhibits.

     EX-16.    Letter of Agreement from Stegman & Company

                             Page 2

SIGNATURES

     Pursuant  to the requirements of the Securities Exchange Act
of  1934, as amended, the registrant has duly caused this  report
to  be  signed  on its behalf by the undersigned  thereunto  duly
authorized.


                         IGENE Biotechnology, Inc.
                         (Registrant)


                         By: /s/ STEPHEN F. HIU
                         _______________________
                         Name:   STEPHEN F. HIU
                         Title:  President


Dated:  February 16, 2005

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