SECURITIES AND EXCHANGE COMMISSION
                     WASHINGTON, D.C. 20549

                            Form 8-K/A

                         CURRENT REPORT

               PURSUANT TO SECTION 13 OR 15(d) OF
               THE SECURITIES EXCHANGE ACT OF 1934

 Date of Report (Date of earliest event reported): May 12, 2005

                    IGENE BIOTECHNOLOGY, INC.
     ______________________________________________________
     (Exact Name of Registrant as Specified in its Charter)

                            Maryland
 ______________________________________________________________
 (State or Other Jurisdiction of Incorporation or Organization)

           0-15888                           52-1230461
        _____________                   ___________________
         (Commission                      (I.R.S. Employer
          File No.)                     Identification No.)

     9110 Red Branch Road, Columbia, Maryland     21045-2024
     ________________________________________     __________
     (Address of Principal Executive Offices)     (Zip Code)

                         (410) 997-2599
      ____________________________________________________
      (Registrant's Telephone Number, Including Area Code)

                               N/A
  _____________________________________________________________
  (Former Name or Former Address, if Changed Since Last Report)


   Check  the  appropriate box below if the Form  8-K  filing  is
intended to simultaneously satisfy the filing obligation  of  the
registrant  under  any of the following provisions  (see  General
Instruction A.2. below):

   [ ]  Written communications pursuant to  Rule  425  under  the
Securities Act (17 CFR 230.425)

   [ ]  Soliciting material pursuant to  Rule  14a-12  under  the
Exchange Act (17 CFR 240.14a-12)

   [ ]  Pre-commencement communications pursuant to Rule 14d-2(b)
under the Exchange Act (17 CFR 240.14d-2(b))

   [ ]  Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))

                               -1-

ITEM 4.02 Non-Reliance on Previously Issued Financial Statements
          or a Related Audit Report or Completed Interim Review.

       As  disclosed in the Notification of Late Filing filed  by
Igene  Biotechnology, Inc. (the "Registrant") with the Commission
on April 1, 2005 (the "Notification"), Berenson LLP ("Berenson"),
the  Registrant's independent registered public accounting  firm,
has  questioned the Registrant's historical method  of  recording
the  value of its 50% interest in its joint venture with  Tate  &
Lyle  PLC (the "Joint Venture"), as reflected in the Registrant's
previously issued consolidated financial statements contained  in
the  Registrant's Annual Report on Form 10-KSB for the year ended
December  31, 2003 and consolidated interim financial  statements
contained  in the Registrant's Quarterly Reports on  Form  10-QSB
for the quarterly periods ended March 31, 2003 and 2004, June 30,
2003 and 2004, and September 30, 2003 and 2004 (collectively, the
"Financial  Statements").   Berenson's  position  is   that   the
Registrant's  interest  in  the Joint Venture  should  have  been
recorded at an amount equal to the Registrant's book value of the
consideration paid (which was zero), rather than the  fair  value
of the investment, as it was recorded, as discussed below.

     As disclosed in the Notification, the Registrant was working
with  Berenson  and  its  former  independent  registered  public
accounting  firm,  Stegman & Company,  in  formulating  a  letter
directed to the Office of Chief Accountant of the Commission  for
further guidance on this accounting matter.  The Registrant  sent
the  letter dated April 14, 2005 to the Commission and has  since
such time engaged in discussions with the Staff of the Commission
relating to the accounting treatment of the Registrant's interest
in  the  Joint  Venture.  In a letter dated  May  12,  2005,  and
received  by the Company on the same date, Berenson notified  the
Registrant  that  the Financial Statements should  no  longer  be
relied upon because of errors in those Financial Statements.  The
Registrant is in the process of determining the nature and amount
of  corrections  necessary to restate the  Financial  Statements.
The  Registrant plans to file such restated Financial  Statements
as  soon  as is practicable after the necessary corrections  have
been determined.    It is the Registrant's intent to complete one
restatement per week,  beginning with the restatement of the June
30, 2003 Q estimated to be filed on June 10, 2005, and expects to
complete and fle one restatement per week, until all restatements
are completed.

     In  the  Financial Statements, as filed with the Commission,
the  Registrant's  investment  in  the  Joint  Venture  has  been
accounted for under the equity method of accounting as a one-line
caption  on  its  consolidated  balance  sheet  and  consolidated
statement  of  operations with the excess of fair value  of  such
investment  in the Joint Venture over the historical  cost  basis
(or  book  value)  of  consideration  paid  for  such  investment
reflected as an adjustment to additional paid-in capital.

     The   corrections   necessary  to  restate   the   Financial
Statements pertain to the manner in which the Registrant recorded
the  investment in the Joint Venture in the Financial Statements.
The  Registrant  has  been  advised by Berenson  that  while  the
Registrant's  investment in the Joint Venture has been  correctly
accounted for under the equity method of accounting as a one-line
caption  on  its  consolidated balance  sheets  and  consolidated
statements  of  operations, the Registrant's  investment  in  the
Joint Venture should have been recorded at an amount equal to the
book  value of the Registrant's consideration contributed at  the
creation of the Joint Venture (not as the excess of fair value of
the  Registrant's  investment  in  the  Joint  Venture  over  the

                               -2-

historical  cost  basis (or book value)).  As a result,  Berenson
has  advised  the  Registrant that its investment  in  the  Joint
Venture should have been recorded with a book value of zero;  not
the  twelve  million dollars ($12,000,000) initially recorded  in
the Financial Statements.

     The  Registrant's Audit Committee has discussed the  matters
disclosed in this Current Report with Berenson on May 12, 2005.

      A  letter  dated  May  13, 2005 from Berenson  to  the  U.S.
Securities and Exchange Commission, in which Berenson states that
it  is in agreement with the statements made by the Registrant in
the Current Report, is attached as Exhibit 99 and is incorporated
herein by reference.

ITEM 9.01 Financial Statements and Exhibits

     (c)  Exhibits

     Exhibit   Description
     _______   ___________

     99        Letter,  dated May 13, 2005 from Berenson  LLP to
               the U.S. Securities and Exchange Commission.


                               -3-

                            Signature

     Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned hereunto duly authorized.

                              IGENE BIOTECHNOLOGY, INC.


                              By: /s/ STEPHEN F. HIU
                                  ______________________
                                      STEPHEN F. HIU
                                      President



Date:  May 25, 2005

                              -4-


                          EXHIBIT INDEX

Exhibit   Description
_______   ___________

99        Letter,  dated May 13, 2005 from Berenson  LLP to  the
          U.S. Securities and Exchange Commission.