UNITED STATES

               SECURITIES AND EXCHANGE COMMISSION

                     Washington, D.C. 20549

                           FORM 12b-25

                   NOTIFICATION OF LATE FILING

                Commission File Number: 000-15888



(Check One):   [ ]  Form 10-KSB   [ ]  Form 20-F    [ ]  Form 11-K
               [X]  Form 10-QSB   [ ]  Form N-SAR   [ ]  Form N-CSR

                For Period Ended:   June 30, 2005

     [ ]  Transition Report on Form 10-K and Form 10-KSB
     [ ]  Transition Report on Form 20-F
     [ ]  Transition Report on Form 11-K
     [ ]  Transition Report on Form 10-Q and Form 10-QSB
     [ ]  Transition Report on Form N-SAR

     For the Transition Period Ended: ______________________



     Nothing  in this form shall be construed to imply  that  the
Commission has verified any information contained herein.

     If  the  notification  relates to a portion  of  the  filing
checked  above,  identify the item(s) to which  the  notification
relates: _____________________________________________________



                             PART I
                     REGISTRANT INFORMATION

     Full Name of Registrant:  IGENE BIOTECHNOLOGY, INC.

     Former Name if Applicable:  NA

     Address of Principal Executive Office:  9110 RED BRANCH ROAD

     City, State and Zip Code:  COLUMBIA, MARYLAND 21045-2024


                             PART II
                     RULES 12b-25(b) AND (c)

     If   the   subject  report  could  not  be   filed   without
unreasonable  effort or expense and the registrant  seeks  relief
pursuant  to  Rule 12b-25(b), the following should be  completed.
(Check box if appropriate.)

          (a)  The  reasons  described  in  reasonable  detail in
               Part  III  of  this  form  could not be eliminated
               without unreasonable effort or expense;

          (b)  The  subject  annual  report,  semi-annual report,
               transition  report  on  Form 10-K, Form 20-F, Form
               11-K,   Form   N-SAR  or  Form N-CSR,  or  portion
               thereof,   will   be   filed  on   or  before  the
 [ ]           fifteenth  calendar  day  following the prescribed
               due  date;  or  the  subject  quarterly  report or
               transition report on Form 10-Q, or portion thereof
               will be filed on or before the  fifth calendar day
               following the prescribed due date; and

          (c)  The  accountant's  statement  or   other  exhibit
               required  by Rule 12b-25(c) has been attached  if
               applicable.


                            PART III
                            NARRATIVE

     State  below in reasonable detail the reasons why the  Forms
10-K, 20-F, 11-K, 10-Q, N-SAR, N-CSR, or the transition report or
portion  thereof, could not be filed within the  prescribed  time
period.

          Additional  time will be needed for the  Registrant  to
     complete the preparation of its Quarterly Report on Form 10-
     QSB (the "Form 10-QSB") for the quarter ended June 30, 2005.
     As  previously reported in its Current Report on  Form  8-K,
     filed  with  the  Securities and  Exchange  Commission  (the
     "SEC") on May 16, 2005, the Registrant received a letter  on
     May 12, 2005 from Berenson LLP ("Berenson"), its independent
     registered  public accounting firm, notifying the Registrant
     that  its Financial Statements (as defined below) should  no
     longer  be  relied upon because of errors in those Financial
     Statements.   Such   financial   statements   include    the
     Registrant's consolidated financial statements contained  in
     the  Registrant's Annual Report on Form 10-KSB for the  year
     ended  December 31, 2003 and consolidated interim  financial
     statements  contained in the Registrant's Quarterly  Reports
     on  Form  10-QSB for the quarterly periods ended  March  31,
     2003  and  2004, June 30, 2003 and 2004, and  September  30,
     2003  and  2004  (collectively, referred to  herein  as  the
     "Financial Statements").

          The errors in the Financial Statements referenced above
     relate  to the accounting treatment of the Registrant's  50%
     participation in a joint venture with Tate & Lyle PLC ("Tate
     &  Lyle"), which  joint venture produces Aquasta(TM) for the
     aquaculture  industry  at  Tate  &  Lyle's  Selby,   England
     facility   (the  "Joint  Venture").  For  a  more   detailed
     description of the accounting treatment of the Joint Venture
     see below under Part IV.



          The  Registrant  is now in the process  of  filing  the
     corrections  necessary to restate the  Financial  Statements
     and  to appropriately prepare the Form 10-QSB.  As a result,
     the  Registrant is not currently in a position to  file  the
     Form 10-QSB.

          Based   upon   its  current  schedule,  the  Registrant
     anticipates  that it will not be in a position to  file  its
     Form 10-QSB by the 5th calendar day following the prescribed
     due date of the Form 10-QSB.

                             PART  IV

                        OTHER INFORMATION

(1)  Name and telephone number of person to contact in regard to
     this notification.

     Edward J. Weisberger                         (410) 997-2599
     ___________________________________________________________
     (Name)                       (Area Code) (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or
     15(d) of the Securities Exchange  Act  of 1934 or Section 30
     of  the Investment  Company Act of 1940 during the preceding
     12 months or for such shorter period that the registrant was
     required to file such report(s) been filed? If answer is no,
     identify report(s).                          [ ] Yes  [X] No

     The  Registrant's Annual Report on Form 10-KSB for the  year
     ended  December 31, 2004, which was due to be  filed  on  or
     before March 31, 2005, as well as the Registrant's Quarterly
     Report  on  Form  10-QSB, which was due to be  filed  on  or
     before May 15, 2005, have not yet been filed.

(3)  Is  it anticipated that any significant change in results of
     operations from the corresponding period for the last fiscal
     year  will  be  reflected  by  the earnings statements to be
     included in the subject report or portion thereof?
                                                  [X] Yes  [ ] No

     If so, attach an explanation of the anticipated change, both
     narratively  and quantitatively, and, if appropriate,  state
     the  reasons why a reasonable estimate of the results cannot
     be made.

          As  previously  reported  in the  Registrant's  Current
     Report  on Form 8-K filed with the SEC May 16, 2005 and  its
     Notification of Late Filing filed with the SEC on  April  1,
     2005,  the Registrant's investment in the Joint Venture  has
     been accounted for under the equity method of accounting  as
     a  one-line  caption on its consolidated balance sheets  and
     consolidated  statements  of  operations  contained  in  the
     Financial Statements with the excess of fair value  of  such
     investment  in the Joint Venture over historical cost  basis
     (or  book  value) of consideration paid for such  investment
     reflected as an adjustment to additional paid-in capital.

          As  mentioned above, the Registrant is currently in the
     process   of   restating  the  Financial  Statements.    The
     corrections  necessary to restate the  Financial  Statements
     pertain  to the manner in which the Registrant recorded  its
     investment  in  the  Joint Venture.  While the  Registrant's
     investment in the Joint Venture has been correctly accounted
     for  under  the  equity method of accounting as  a  one-line
     caption  on its consolidated balance sheets and consolidated



     statements  of operations, the Registrant and  Berenson  now
     believe  that  the  Registrant's  investment  in  the  Joint
     Venture should have been recorded at an amount equal to  the
     book value of the Registrant's consideration contributed  at
     the creation of the Joint Venture (not as the excess of fair
     value  of  the Registrant's investment in the Joint  Venture
     over  the  historical cost basis (or  book  value)).   As  a
     result,  the  Registrant's investment in the  Joint  Venture
     should have been recorded with a book value of zero; not the
     twelve  million dollars ($12,000,000) initially recorded  in
     the Financial Statements.

          As mentioned above, the Registrant is currently in  the
     process  of  restating  the   Financial  Statements,   which
     includes the results of operations for the period ended June
     30,  2004.  In addition, the Registrant is currently in  the
     process  of  preparing  its results of  operations  for  the
     quarter  ended  and six month period ending  June  30,  2005
     based on the revised treatment of the Joint Venture.   As  a
     result,  the Registrant cannot provide a reasonable estimate
     of  the  change  in  its results of operations  between  the
     quarter ended June 30, 2005 and the corresponding period for
     fiscal year 2004.

                       IGENE BIOTECHNOLOGY, INC.
             ____________________________________________
             (Name of Registrant as Specified in Charter)

     Has  caused this notification to be signed on its behalf  by
the undersigned thereunto duly authorized.



     Date: August 12, 2005        By: /s/ EDWARD J. WEISBERGER
                                      ___________________________
                                          EDWARD J. WEISBERGER
                                          Chief Financial Officer