SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 __________________ FORM 8-K __________________ CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 28, 2006 __________________ IGENE BIOTECHNOLOGY, INC. (Exact Name of registrant as specified in its charter) _________________________ Maryland 01-15888 52-1230461 (State or other (Commission File (IRS Employer jurisdiction of Number) Identification No.) incorporation) 9110 Red Branch Road Columbia, MD 21045-2024 (Address of Principal Executive (Zip Code) Offices) Registrant's telephone number, including area code: (410) 997-2599 Former Name or Former Address, if Changed Since Last Report: Not applicable Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: [ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) [ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) [ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) [ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) SECTION 1 - REGISTRANT'S BUSINESS AND OPERATIONS ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT Pursuant to the terms of an Indenture dated as of March 31, 1998, as amended (the "Indenture") between the Registrant and American Stock Transfer & Trust Company, as Trustee (the "Trustee"), the Company issued and sold $5,000,000 of its 8% notes (the "Securities"). Concurrently with the issuance of the Securities, the Company issued, pursuant to a Warrant Agreement by and between Registrant and American Stock Transfer & Trust Company, as warrant agent (the "Warrant Agent") dated as of March 31, 1998, as amended (the "Warrant Agreement"), 50,000,000 warrants to purchase shares of the Registrants common stock for $.10 per share. The warrant purchase price under the Warrant Agreement was reduced to $.075 per share, and the maturity date of the Securities extended to March 31, 2006, by an amendment to the Indenture and Warrant Agreement dated March 18, 2003 and approved by the requisite number of holders of the Securities. On March 28, 2006, the Registrant, Trustee and Warrant Agent entered into a Second Amendment to Indenture, Securities, Warrant Agreement and Warrant Certificates (the "Second Amendment") that extended the maturity date of the Securities to March 31, 2009, and reduced the warrant purchase price under the Warrant Agreement from $.075 to $.056 per share. The Second Amendment was approved by more than two-thirds in principal amount of the holders of Securities effective March 28, 2006, in accordance with Section 6.07 and Section 9.02 of the Indenture. Section 6.07 provides that: The right of any Holder of a Security to receive payment of the principal of and interest on the Security, on or after the respective due dates expressed in the Security, or to bring suit for the enforcement of any such payment on or after the respective dates, is not absolute and may be impaired or affected without the consent of the Holder if the Holders of at least two-thirds in principal amount of Securities so approve such action. The Registrant sent written notice to each of the Holders of the amendments made to the Securities by the Second Amendment. SECTION 3 - SECURITIES AND TRADING MARKETS ITEM 3.03 MATERIAL MODIFICATION TO RIGHTS OF SECURITY HOLDERS The disclosures provided in Item 1.01 above are incorporated into this Item 3.03 by reference. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. IGENE Biotechnology, Inc. (Registrant) Date: March 30, 2006 By: /s/ STEPHEN F. HIU _____________________________ STEPHEN F. HIU EXHIBIT INDEX Exhibit 4 - Second Amendment to Indenture, Securities, Warrant Agreement and Warrant Certificates.