SECURITIES AND EXCHANGE COMMISSION

                    Washington, D.C.  20549
                      __________________

                           FORM 8-K
                      __________________

                        CURRENT REPORT

            PURSUANT TO SECTION 13 OR 15(d) OF THE
                SECURITIES EXCHANGE ACT OF 1934

 Date of Report (Date of earliest event reported):  March 28,
                             2006
                      __________________

                   IGENE BIOTECHNOLOGY, INC.
    (Exact Name of registrant as specified in its charter)

                   _________________________

      Maryland              01-15888             52-1230461
  (State or other       (Commission File        (IRS Employer
  jurisdiction of           Number)          Identification No.)
   incorporation)

     9110 Red Branch Road
         Columbia, MD                       21045-2024
(Address of Principal Executive             (Zip Code)
           Offices)

Registrant's telephone number, including area code:
                        (410) 997-2599

 Former Name or Former Address, if Changed Since Last Report:
                        Not applicable

Check the appropriate box below if the Form 8-K filing is
intended to simultaneously satisfy the filing obligation of
the registrant under any of the following provisions:

[ ] Written communications pursuant to Rule 425 under the
Securities Act (17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the
Exchange Act (17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b)
under the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-4(c))


       SECTION 1 - REGISTRANT'S BUSINESS AND OPERATIONS

ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT

Pursuant  to the terms of an Indenture dated as of  March  31,
1998, as amended (the "Indenture") between the Registrant  and
American  Stock  Transfer  & Trust Company,  as  Trustee  (the
"Trustee"), the Company issued and sold $5,000,000 of  its  8%
notes  (the "Securities").  Concurrently with the issuance  of
the  Securities,  the Company issued, pursuant  to  a  Warrant
Agreement  by  and  between  Registrant  and  American   Stock
Transfer  &  Trust  Company, as warrant  agent  (the  "Warrant
Agent")  dated as of March 31, 1998, as amended (the  "Warrant
Agreement"),  50,000,000 warrants to purchase  shares  of  the
Registrants  common  stock for $.10 per  share.   The  warrant
purchase  price  under the Warrant Agreement  was  reduced  to
$.075  per  share,  and the maturity date  of  the  Securities
extended  to March 31, 2006, by an amendment to the  Indenture
and Warrant Agreement dated March 18, 2003 and approved by the
requisite number of holders of the Securities.

On  March 28, 2006, the Registrant, Trustee and Warrant  Agent
entered  into  a  Second  Amendment to Indenture,  Securities,
Warrant   Agreement  and  Warrant  Certificates  (the  "Second
Amendment") that extended the maturity date of the  Securities
to  March  31,  2009, and reduced the warrant  purchase  price
under the Warrant Agreement from $.075 to $.056 per share.

The  Second Amendment was approved by more than two-thirds  in
principal amount of the holders of Securities effective  March
28, 2006, in accordance with Section 6.07 and Section 9.02  of
the Indenture.  Section 6.07 provides that:

          The  right of any Holder of a Security  to
          receive  payment of the principal  of  and
          interest on the Security, on or after  the
          respective  due  dates  expressed  in  the
          Security,  or  to  bring  suit   for   the
          enforcement  of  any such  payment  on  or
          after   the  respective  dates,   is   not
          absolute  and may be impaired or  affected
          without the consent of the Holder  if  the
          Holders   of   at   least  two-thirds   in
          principal amount of Securities so  approve
          such action.

The  Registrant sent written notice to each of the Holders  of
the amendments made to the Securities by the Second Amendment.

          SECTION 3 - SECURITIES AND TRADING MARKETS

ITEM 3.03 MATERIAL MODIFICATION TO RIGHTS OF SECURITY HOLDERS

The  disclosures provided in Item 1.01 above are  incorporated
into this Item 3.03 by reference.



                          SIGNATURES

Pursuant  to  the requirements of the Securities Exchange Act
of  1934,  the  Registrant  has duly caused this report to be
signed  on  its  behalf  by  the  undersigned  hereunto  duly
authorized.

                                IGENE Biotechnology, Inc.
                                (Registrant)


Date: March 30, 2006      By:   /s/ STEPHEN F. HIU
                                _____________________________
                                    STEPHEN F. HIU



                         EXHIBIT INDEX



Exhibit 4 - Second Amendment to Indenture, Securities, Warrant
            Agreement and Warrant Certificates.