UNITED STATES

               SECURITIES AND EXCHANGE COMMISSION

                     Washington, D.C. 20549

                           FORM 12b-25

                   NOTIFICATION OF LATE FILING

                Commission File Number: 000-15888



(Check One):  [x] Form 10-KSB    [ ] Form 20-F    [ ] Form 11-K

              [ ] Form 10-QSB    [ ] Form N-SAR   [ ] Form N-CSR

              For Period Ended:   December 31, 2005

     [ ]  Transition Report on Form 10-K and Form 10-KSB
     [ ]  Transition Report on Form 20-F
     [ ]  Transition Report on Form 11-K
     [ ]  Transition Report on Form 10-Q and Form 10-QSB
     [ ]  Transition Report on Form N-SAR

     For the Transition Period Ended: ______________________



     Nothing  in this form shall be construed to imply  that  the
Commission has verified any information contained herein.

     If  the  notification  relates to a portion  of  the  filing
checked  above,  identify the item(s) to which  the  notification
relates: _____________________________________________________



                             PART I
                     REGISTRANT INFORMATION

     Full Name of Registrant:  IGENE BIOTECHNOLOGY, INC.

     Former Name if Applicable:  NA

     Address of Principal Executive Office:  9110 RED BRANCH ROAD

     City, State and Zip Code:  COLUMBIA, MARYLAND 21045-2024


                             PART II
                     RULES 12b-25(b) AND (c)

     If   the   subject  report  could  not  be   filed   without
unreasonable  effort or expense and the registrant  seeks  relief
pursuant  to  Rule 12b-25(b), the following should be  completed.
(Check box if appropriate.)

         (a)   The reasons described in reasonable detail in Part
               III of  this  form could not be eliminated without
               unreasonable effort or expense;

         (b)   The  subject  annual  report,  semi-annual report,
               transition   report   on  Form  10-K,  Form  20-F,
               Form  11-K, Form  N-SAR  or Form N-CSR, or portion
  [x]          thereof, will be filed on or  before the fifteenth
               calendar day following the prescribed due date; or
               the  subject quarterly report or transition report
               on Form 10-Q, or  portion thereof will be filed on
               or  before  the  fifth  calendar day following the
               prescribed due date; and

         (c)   The  accountant's  statement   or  other   exhibit
               required  by  Rule 12b-25(c) has been attached  if
               applicable.


                            PART III
                            NARRATIVE

     State  below in reasonable detail the reasons why the  Forms
10-K, 20-F, 11-K, 10-Q, N-SAR, N-CSR, or the transition report or
portion  thereof, could not be filed within the  prescribed  time
period.

          Additional  time is needed for the Registrant  to  have
     its  audit completed and file its Annual Report on Form  10-
     KSB for the year ended December 31, 2005.  Berenson LLP, its
     independent  registered public accounting firm, is  awaiting
     certain financial information and related documentation from
     the  Registrant but primarily the joint venture in which the
     Registrant  is a 50% participant together with Tate  &  Lyle
     PLC ("Tate & Lyle").  The joint venture produces Aquasta(TM)
     for the aquaculture industry at Tate & Lyle's Selby, England
     facility.   Due to the multiple and geographic locations  of
     the   accounting  records  for  the  joint   venture,   this
     information  gathering process is made  more  difficult.   A
     statement signed by Berenson LLP stating the reasons why  it
     is unable to furnish the required certification at this time
     is attached as an exhibit and incorporated by reference.

          Based   upon   its  current  schedule,  the  Registrant
     anticipates that it will be in a position to file  its  Form
     10-KSB by the 15th calendar day following the prescribed due
     date of the Form 10-KSB.



                            PART  IV
                        OTHER INFORMATION


(1)  Name and telephone number of person to contact in regard  to
     this notification.

     Edward J. Weisberger                          (410) 997-2599
     ____________________________________________________________
     (Name)                        (Area Code) (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or
     15(d) of the Securities  Exchange  Act of 1934 or Section 30
     of  the  Investment Company Act of 1940 during the preceding
     12 months or for such shorter period that the registrant was
     required to file such report(s) been filed? If answer is no,
     identify report(s).
                                               [x] Yes     [ ] No

(3)  Is  it anticipated that any significant change in results of
     operations from the corresponding period for the last fiscal
     year  will  be  reflected  by  the earnings statements to be
     included in the subject report or portion thereof?

                                               [ ] Yes     [x] No

     If so, attach an explanation of the anticipated change, both
     narratively  and quantitatively, and, if appropriate,  state
     the  reasons why a reasonable estimate of the results cannot
     be made.



                    IGENE BIOTECHNOLOGY, INC.
          ____________________________________________
          (Name of Registrant as Specified in Charter)

     Has  caused this notification to be signed on its behalf  by
the undersigned thereunto duly authorized.



     Date: March 28, 2006         By: /s/ EDWARD J. WEISBERGER
                                      ___________________________
                                          EDWARD J. WEISBERGER
                                          Chief Financial Officer


                               EXHIBIT INDEX


Exhibit 99 - Auditor's Statement