UNITED STATES

               SECURITIES AND EXCHANGE COMMISSION

                     Washington, D.C. 20549

                           FORM 12b-25

                   NOTIFICATION OF LATE FILING

                Commission File Number: 000-15888



(Check One):  [ ] Form 10-KSB   [ ] Form 20-F    [ ] Form 11-K
              [X] Form 10-QSB   [ ] Form N-SAR   [ ] Form N-CSR

               For Period Ended:   March 31, 2006

     [ ]  Transition Report on Form 10-K and Form 10-KSB
     [ ]  Transition Report on Form 20-F
     [ ]  Transition Report on Form 11-K
     [ ]  Transition Report on Form 10-Q and Form 10-QSB
     [ ]  Transition Report on Form N-SAR

     For the Transition Period Ended: ______________________



     Nothing  in this form shall be construed to imply  that  the
Commission has verified any information contained herein.

     If  the  notification  relates to a portion  of  the  filing
checked  above,  identify the item(s) to which  the  notification
relates: _____________________________________________________



                             PART I
                     REGISTRANT INFORMATION

     Full Name of Registrant:  IGENE BIOTECHNOLOGY, INC.

     Former Name if Applicable:  NA

     Address of Principal Executive Office:  9110 RED BRANCH ROAD

     City, State and Zip Code:  COLUMBIA, MARYLAND 21045-2024

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                             PART II
                     RULES 12b-25(b) AND (c)

     If   the   subject  report  could  not  be   filed   without
unreasonable  effort or expense and the registrant  seeks  relief
pursuant  to  Rule 12b-25(b), the following should be  completed.
(Check box if appropriate.)

          (a)  The  reasons  described  in  reasonable detail  in
               Part  III  of  this  form  could not be eliminated
               without unreasonable effort or expense;

          (b)  The  subject  annual  report,  semi-annual report,
               transition  report  on  Form 10-K, Form 20-F, Form
               11-K,  Form  N-SAR  or  Form  N-CSR,  or   portion
               thereof, will be filed on or  before the fifteenth
     [X]       calendar day following the prescribed due date; or
               the subject  quarterly report or transition report
               on Form 10-Q, or  portion thereof will be filed on
               or  before  the  fifth  calendar day following the
               prescribed due date; and

          (c)  The  accountant's  statement   or   other  exhibit
               required  by  Rule 12b-25(c) has been attached  if
               applicable.


                            PART III
                            NARRATIVE

     State  below in reasonable detail the reasons why the  Forms
10-K, 20-F, 11-K, 10-Q, N-SAR, N-CSR, or the transition report or
portion  thereof, could not be filed within the  prescribed  time
period.

          Additional  time is needed for the Registrant  to  have
     its  review completed and file its Quarterly Report on  Form
     10-QSB for the quarter ended March 31, 2006.  Berenson  LLP,
     its  independent  registered  public  accounting  firm,   is
     awaiting   certain   financial   information   and   related
     documentation  from the Registrant but primarily  the  joint
     venture  in  which  the  Registrant  is  a  50%  participant
     together  with Tate & Lyle PLC ("Tate & Lyle").   The  joint
     venture produces Aquasta(TM) for the aquaculture industry at
     Tate  & Lyle's Selby, England facility.  Due to the multiple
     and  geographic locations of the accounting records for  the
     joint  venture, this information gathering process  is  made
     more  difficult.  A statement signed by Berenson LLP stating
     the  reasons  why  it  is  unable to  furnish  the  required
     certification  at this time is attached as  an  exhibit  and
     incorporated by reference.

          Based   upon   its  current  schedule,  the  Registrant
     anticipates that it will be in a position to file  its  Form
     10-QSB by the 5th calendar day following the prescribed  due
     date of the Form 10-QSB.

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                               PART IV
                          OTHER INFORMATION

(1)  Name  and telephone number of person to contact in regard to
     this notification.

     Edward J. Weisberger                          (410) 997-2599
     ____________________________________________________________
     (Name)                        (Area Code) (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or
     15(d)  of  the Securities Exchange Act of 1934 or Section 30
     of  the  Investment Company Act of 1940 during the preceding
     12 months or for such shorter period that the registrant was
     required to file such report(s) been filed? If answer is no,
     identify report(s).
                                                 [X] Yes   [ ] No

(3)  Is  it anticipated that any significant change in results of
     operations from the corresponding period for the last fiscal
     year  will  be  reflected  by  the earnings statements to be
     included in the subject report or portion thereof?
                                                 [ ] Yes   [X] No

     If so, attach an explanation of the anticipated change, both
     narratively  and quantitatively, and, if appropriate,  state
     the  reasons why a reasonable estimate of the results cannot
     be made.



                      IGENE BIOTECHNOLOGY, INC.
            ____________________________________________
            (Name of Registrant as Specified in Charter)

     Has  caused this notification to be signed on its behalf  by
the undersigned thereunto duly authorized.



     Date: May 15, 2006           By: /S/ EDWARD J. WEISBERGER
                                      ___________________________
                                          EDWARD J. WEISBERGER
                                          Chief Financial Officer

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                          EXHIBIT INDEX


Exhibit 99 - Auditor's Statement

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