FORM 8-K


               SECURITIES AND EXCHANGE COMMISSION

                     WASHINGTON, D.C. 20549


                         CURRENT REPORT


Pursuant to Section 13 or 15(d) of the Securities Exchange Act of
1934


Date  of  Report  (Date of  earliest event reported): January 11,
2008




                    IGENE BIOTECHNOLOGY, INC.
     ______________________________________________________
     (Exact name of registrant as specified in its charter)



          MARYLAND               0-15888        52-1230461
____________________________  ____________  ____________________
(State or other jurisdiction  (Commission   (IRS Employer
 of incorporation)            File Number)  Identification No.)




      9110 Red Branch Road
          Columbia, MD                          21045-2024
________________________________________  ______________________
(Address of principal executive offices)        (Zip Code)


Registrant's telephone number, including area code: (410) 997-
2599

                               -1-

Item 4. Changes in Registrant's Certifying Accountant

a)   Termination   of   previous  independent  registered  public
     accounting firm.

As  of  January 11, 2008, the Registrant dismissed J.H. Cohn  LLP
("Cohn") as its independent registered public accounting firm  as
approved by the Audit Committee of the Board of Directors.

The  audit  report  issued by Cohn on the consolidated  financial
statements  of  the  Registrant as of and  for  the  years  ended
December 31, 2006 and 2005, included in the Registrant's  amended
annual report on Form 10-KSB/A filed on December 21, 2007 did not
contain  an adverse opinion or a disclaimer of opinion,  and  was
not  qualified  or modified, as to uncertainty,  audit  scope  or
accounting principles, except as follows:

     Cohn's  report  contains an explanatory paragraph.  The
     paragraph   states  that  the  Company   has   suffered
     recurring  losses from operations since  inception  and
     has   a   working   capital  deficiency   that   raises
     substantial  doubt about its ability to continue  as  a
     going concern. The consolidated financial statements do
     not  include any adjustments that might result from the
     outcome of that uncertainty.

During  years  ended December 31, 2006 and 2005 and  the  interim
period  through  January 11, 2008, the date of  their  dismissal,
there have been no disagreements between the Registrant and  Cohn
on  any  matter of accounting principles or practices,  financial
statement  disclosure,  or  auditing scope  or  procedure,  which
disagreements, if not resolved to the satisfaction of Cohn, would
have  caused Cohn to make reference to the subject matter thereof
in   its   report  on  the  Registrant's  consolidated  financial
statements for such periods other than as follows:

There  was  a  disagreement related to the  Registrant's  initial
accounting  for warrants issued in connection with  certain  debt
that  arose  in connection with Cohn's review of the Registrant's
quarterly  report on Form 10-QSB for the quarterly  period  ended
June  30,  2007. The accounting treatment was discussed with  the
Audit  Committee  of the Board of Directors and resolved  to  the
satisfaction  of Cohn. As a result, the Registrant  restated  the
financial statements included in its annual report on Form 10-KSB
for the year ended December 31, 2006, and the Form 10-QSB for the
three months ended March 31, 2007.  The Registrant has authorized
Cohn  to  respond fully to the inquiries of McElravy,  Kinchen  &
Associates, P.C. ("McElravy") if any, concerning the matter.

During  the year ended December 31, 2006 and 2005 and the interim
period  through  January  11,  2008,  Cohn  did  not  advise  the
Registrant  of  any reportable event under Item  304(a)(1)(v)  of
regulation  S-K other than as follows:  In connection with  their
audit  of the Registrant's consolidated financial statements  for
the  years  ended  December 31, 2006 and 2005, Cohn  advised  the
Registrant's management and the Audit Committee of the  Board  of
Directors of the Registrant that the Registrant did not have  the
internal  controls  necessary for the  non-routine  recording  of
warrants   issued  in  connection  with  certain  of   our   debt
obligations.

                              -2-

The  Registrant  has  provided Cohn with  a  copy  of  the  above
disclosure  as  required  by Item 304(a)  of  Regulation  S-K  in
conjunction  with the filing of this report.  The Registrant  has
requested  that  Cohn  deliver to it a letter  addressed  to  the
Securities  and Exchange Commission stating whether  Cohn  agrees
with  the disclosure made by the Registrant  in response to  Item
304(a)  of  Regulation S-K, and if not, stating the  respects  in
which  it  does not agree.  Cohn's letter is filed as Exhibit  16
hereto and incorporated herein by reference.

(b)    Engagement of new independent registered public accounting
       firm.

The  Registrant  has  appointed McElravy as its  new  independent
registered  public accounting firm effective as  of  January  15,
2008.   The  selection  of McElravy was  approved  by  the  Audit
Committee of the Board of Directors of the Registrant on  January
15, 2008.


                               -3-


SIGNATURES

      Pursuant to the requirements of the Securities Exchange Act
of  1934, as amended, the registrant has duly caused this  report
to  be  signed  on its behalf by the undersigned  thereunto  duly
authorized.


                                     IGENE Biotechnology, Inc.
                                     ____________________________
                                     (Registrant)


                            By:       /S/ STEPHEN F. HIU
                                      _____________________
                            Name:         STEPHEN F. HIU
                            Title:        President


Dated:  January 22, 2008

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