SECURITIES AND EXCHANGE COMMISSION

                          Washington, D.C. 20549

                                FORM 12b-25

                        Notification of Late Filing

                      Commission File Number: 0-15888

(Check one)

[x]  Form 10-K or 10-KSB  [ ]  Form 20-F  [ ]  Form 11-K
[ ]  Form 10-Q or 10-QSB  [ ]  Form 10-D  [ ]  Form N-SAR
[ ]  Form N-CSR

   For period ended December 31, 2007
                    _________________


     [ ]  Transition Report on Form 10-K

     [ ]  Transition Report on Form 20-F

     [ ]  Transition Report on Form 11-K

     [ ]  Transition Report on Form 10-Q

     [ ]  Transition Report on Form N-SAR

   For the transition period ended _______________



     Nothing in this form shall be construed to imply that the Commission
has verified any information contained herein.

     If  the  notification  relates  to  a  portion of the filing checked
above, identify the item(s) to which the notification relates:



                                  PART I
                          REGISTRANT INFORMATION

Full name of registrant:  IGENE Biotechnology, Inc.
                          _________________________


Former name if applicable:

Address of principal executive office (Street and Number):

9110 Red Branch Road
____________________

City, State and Zip Code:

Columbia, Maryland  21045
_________________________


                                   Page 1


                                  PART II
                          RULE 12B-25(b) AND (c)

     If  the  subject  report  could  not  be  filed  without  unreasonable
effort  or  expense  and  the  registrant  seeks  relief  pursuant  to Rule
12b-25(b), the following should be completed. (Check box if appropriate.)

    (a) The reasons described in reasonable detail in Part III of this form
        could not be eliminated without unreasonable effort or expense;
    (b) The subject annual report, semi-annual report, transition report on
        Form 10-K, Form 20-F, Form 11-K,  Form N-SAR,  or  Form  N-CSR,  or
        portion thereof, will be  filed on or before the fifteenth calendar
[x]     day following the  prescribed  due  date;  or the subject quarterly
        report or transition  report on Form 10-Q  or  subject distribution
        report on Form 10-D, or portion thereof, will be filed on or before
        the fifth calendar day following the prescribed due date; and
    (c) The accountant's statement  or  other  exhibit  required  by   Rule
        12b-25(c) has been attached if applicable.


                                 PART III
                                 NARRATIVE

State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-
SAR, N-CSR, or the transition report or portion thereof could not be filed
within the prescribed time period. (Attach extra sheets if needed.)

Although  the Company's management has been working diligently to  complete
all the required information for the Company's annual report on Form 10-KSB
for  the  year  ended  December 31, 2007, and a substantial  part  of  such
information  has  been  completed as of this  date,  the  Company  and  its
auditors  are unable, without unreasonable effort or expense,  to  complete
the  financial statements and other disclosures for the Form 10-KSB  on  or
before  March  31,  2008.  The delays in the  filing  are  related  to  the
resolution  of  an  accounting  issue discussed  with  the  Securities  and
Exchange Commission.  Management expects to file its annual report on  Form
10-KSB on or before April 15, 2008.


                                  PART IV
                             OTHER INFORMATION

     (1)  Name  and telephone number of person to contact in regard to this
notification.

                           Edward J. Weisberger
                              (410) 997-2599

     (2)  Have  all  other  periodic  reports  required under Section 13 or
15(d)  or  the  Securities  Exchange  Act  of  1934  or  Section  30 of the
Investment Company Act of 1940  during the preceding 12 months (or for such
shorter  period)  that  the  registrant was required to file such report(s)
been filed?  If the answer is no, identify report(s).

                                                    [x]  Yes     [ ]  No

     (3) Is  it  anticipated  that  any  significant  change  in results of
operations  from  the corresponding period for the last fiscal year will be
reflected  by  the earnings statements to be included in the subject report
or portion thereof?

                                                    [ ]  Yes     [x]  No

If so, attach an explanation of the anticipate change, both narratively and
quantitatively,  and,  if  appropriate,  state the reasons why a reasonable
estimate of the results cannot be made.

                                     Page 2

                         IGENE Biotechnology, Inc.
               (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
thereunto duly authorized.


Date:  March 31, 2008			By:   /S/ EDWARD J. WEISBERGER
                                          ________________________________
                                                  EDWARD J. WEISBERGER
                                                  Chief Financial Officer


                                     Page 3